Developmental outcomes in children exposed to Zika virus in utero from a brazilian urban slum cohort study

Aguilar Ticona, Juan Pablo; Nery Junior, Nivison Ruy Rocha; Ladines-Lim, Joseph B.; Gambrah, Claudia; Sacramento, Gielson; Freitas, Bruno de Paula; Bouzon, Joseane; Oliveira Filho, Jamary; Borja, Ana; Adhikarla, Haritha; Montoya, Magelda; Chin, Athena; Wunder Junior, Elsio Augusto; Ballalai, Verena; Vieira, Carina; Belfort, Rubens; Almeida, Antonio R. P.; Reis, Mitermayer Galvão dos; Harris, Eva; Ko, Albert Icksang; Costa, Federico

Developmental outcomes in children exposed to Zika virus in utero from a brazilian urban slum cohort study

Detalhes bibliográficos
Autor(a) principal:	Aguilar Ticona, Juan Pablo
Data de Publicação:	2021
Outros Autores:	Nery Junior, Nivison Ruy Rocha, Ladines-Lim, Joseph B., Gambrah, Claudia, Sacramento, Gielson, Freitas, Bruno de Paula, Bouzon, Joseane, Oliveira Filho, Jamary, Borja, Ana, Adhikarla, Haritha, Montoya, Magelda, Chin, Athena, Wunder Junior, Elsio Augusto, Ballalai, Verena, Vieira, Carina, Belfort, Rubens, Almeida, Antonio R. P., Reis, Mitermayer Galvão dos, Harris, Eva, Ko, Albert Icksang, Costa, Federico
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/47663
Resumo:	National Institutes of Health (NIAID R01 AI052473 (AK), R25 U01AI088752 (AK), FIC R01 TW009504 (AK), R25 TW009338 (AK), F31 AI114245 (AK), R01 AI121207 (AK), D43 TW010540 (AK), P01 AI106695 (EH) (https://www.niaid.nih.gov/)

Metadados do item

id	CRUZ_5c404db6d0f612ccfe0fc98d5cb9e649
oai_identifier_str	oai:www.arca.fiocruz.br:icict/47663
network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Aguilar Ticona, Juan PabloNery Junior, Nivison Ruy RochaLadines-Lim, Joseph B.Gambrah, ClaudiaSacramento, GielsonFreitas, Bruno de PaulaBouzon, JoseaneOliveira Filho, JamaryBorja, AnaAdhikarla, HarithaMontoya, MageldaChin, AthenaWunder Junior, Elsio AugustoBallalai, VerenaVieira, CarinaBelfort, RubensAlmeida, Antonio R. P.Reis, Mitermayer Galvão dosHarris, EvaKo, Albert IcksangCosta, Federico2021-06-14T13:40:11Z2021-06-14T13:40:11Z2021AGUILAR TICONA, Juan Pablo et al. Developmental outcomes in children exposed to Zika virus in utero from a brazilian urban slum cohort study. PLoS Neglected Tropical Diseases, v. 15, n. 2, p. 1-15, 5 Feb. 2021.1935-2727https://www.arca.fiocruz.br/handle/icict/4766310.1371/journal.pntd.00091621935-2735National Institutes of Health (NIAID R01 AI052473 (AK), R25 U01AI088752 (AK), FIC R01 TW009504 (AK), R25 TW009338 (AK), F31 AI114245 (AK), R01 AI121207 (AK), D43 TW010540 (AK), P01 AI106695 (EH) (https://www.niaid.nih.gov/)Wellcome Trust (102330/Z/13/Z https://wellcome.ac.uk/)Bahia State Research Support Foundation (FAPESB) ZIKA-FAPESB T.O. n˚ PET0021/2016 (www.fapesb.ba.gov.br)Coordination for the Improvement of Higher Education (CAPES) from Brazil (https://www.capes.gov.br/)Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA.Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Hospital Geral Roberto Santos. Salvador, BA, Brasil / Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brasil.Hospital Geral Roberto Santos. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Fonoaudiologia. Salvador, BA, Bahia.Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA.University of California. School of Public Health. Division of Infectious Diseases and Vaccinology. Berkeley, CA, USA.University of California. School of Public Health. Division of Infectious Diseases and Vaccinology. Berkeley, CA, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA.Hospital Geral Roberto Santos. Salvador, BA, Brasil.Hospital Geral Roberto Santos. Salvador, BA, Brasil.Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brasil.Hospital Geral Roberto Santos. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil.University of California. School of Public Health. Division of Infectious Diseases and Vaccinology. Berkeley, CA, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA.Background: The prevalence of developmental alterations associated with in-utero Zika virus (ZIKV) exposure in children is not well understood. Furthermore, estimation of the Population Attributable Fraction (PAF) of developmental alterations attributed to ZIKV has not been performed due to lack of population-based cohorts with data on symptomatic and asymptomatic ZIKV exposures and an appropriate control group. The aim of this study was to characterize neurodevelopmental outcomes of children at 11 to 32 months of age with intrauterine ZIKV exposure and estimate the PAF of alterations secondary to ZIKV exposure. Methodology/Principal findings: We performed a cohort of biannual community-based prospective serosurveys in a slum community in Salvador, Brazil. We recruited women participating in our cohort, with a documented pregnancy from January 2015 to December 2016 and children born to those mothers. Children were classified as ZIKV exposed in utero (born from women with ZIKV seroconversion during pregnancy) or unexposed (born from women without ZIKV seroconversion or that seroconverted before/after pregnancy) by using an IgG monoclonal antibody blockade-of-binding (BoB). We interviewed mothers and performed anthropometric, audiometric, ophthalmological, neurologic, and neurodevelopmental evaluations of their children at 11 to 32 months of age. Among the 655 women participating in the cohort, 66 (10%) were pregnant during the study period. 46 (70%) of them completed follow-up, of whom ZIKV seroconversion occurred before, during, and after pregnancy in 25 (54%), 13 (28%), and 1 (2%), respectively. The rest of women, 7 (21.2%), did not present ZIKV seroconversion. At 11 to 32 months of life, the 13 ZIKV-exposed children had increased risk of mild cognitive delay (RR 5.1; 95%CI 1.1–24.4) compared with the 33 children unexposed, with a PAF of 53.5%. Exposed children also had increased risk of altered auditory behavior (RR 6.0; 95% CI 1.3–26.9), with a PAF of 59.5%. Conclusions: A significant proportion of children exposed in utero to ZIKV developed mild cognitive delay and auditory behavioral abnormalities even in the absence of gross birth defects such as microcephaly and other neurodevelopmental domains. Furthermore, our findings suggest that over half of these abnormalities could be attributed to intrauterine ZIKV exposure.engPublic Library of ScienceZika VírusPrevalênciaRiscoSoroconversãoMãesZika VirusPrevalenceRiskSeroconversionMothersDevelopmental outcomes in children exposed to Zika virus in utero from a brazilian urban slum cohort studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/47663/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALTicona, Juan P Aguilar Development....pdfTicona, Juan P Aguilar Development....pdfapplication/pdf1551197https://www.arca.fiocruz.br/bitstream/icict/47663/2/Ticona%2c%20Juan%20P%20Aguilar%20%20Development....pdf6957627f05e09c869a18b5bfd691d394MD52TEXTTicona, Juan P Aguilar Development....pdf.txtTicona, Juan P Aguilar Development....pdf.txtExtracted texttext/plain51193https://www.arca.fiocruz.br/bitstream/icict/47663/3/Ticona%2c%20Juan%20P%20Aguilar%20%20Development....pdf.txt53f29c2fb875d35de9dd502dbddb7108MD53icict/476632023-03-15 14:34:26.836oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:26Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en.fl_str_mv	Developmental outcomes in children exposed to Zika virus in utero from a brazilian urban slum cohort study
title	Developmental outcomes in children exposed to Zika virus in utero from a brazilian urban slum cohort study
spellingShingle	Developmental outcomes in children exposed to Zika virus in utero from a brazilian urban slum cohort study Aguilar Ticona, Juan Pablo Zika Vírus Prevalência Risco Soroconversão Mães Zika Virus Prevalence Risk Seroconversion Mothers
title_short	Developmental outcomes in children exposed to Zika virus in utero from a brazilian urban slum cohort study
title_full	Developmental outcomes in children exposed to Zika virus in utero from a brazilian urban slum cohort study
title_fullStr	Developmental outcomes in children exposed to Zika virus in utero from a brazilian urban slum cohort study
title_full_unstemmed	Developmental outcomes in children exposed to Zika virus in utero from a brazilian urban slum cohort study
title_sort	Developmental outcomes in children exposed to Zika virus in utero from a brazilian urban slum cohort study
author	Aguilar Ticona, Juan Pablo
author_facet	Aguilar Ticona, Juan Pablo Nery Junior, Nivison Ruy Rocha Ladines-Lim, Joseph B. Gambrah, Claudia Sacramento, Gielson Freitas, Bruno de Paula Bouzon, Joseane Oliveira Filho, Jamary Borja, Ana Adhikarla, Haritha Montoya, Magelda Chin, Athena Wunder Junior, Elsio Augusto Ballalai, Verena Vieira, Carina Belfort, Rubens Almeida, Antonio R. P. Reis, Mitermayer Galvão dos Harris, Eva Ko, Albert Icksang Costa, Federico
author_role	author
author2	Nery Junior, Nivison Ruy Rocha Ladines-Lim, Joseph B. Gambrah, Claudia Sacramento, Gielson Freitas, Bruno de Paula Bouzon, Joseane Oliveira Filho, Jamary Borja, Ana Adhikarla, Haritha Montoya, Magelda Chin, Athena Wunder Junior, Elsio Augusto Ballalai, Verena Vieira, Carina Belfort, Rubens Almeida, Antonio R. P. Reis, Mitermayer Galvão dos Harris, Eva Ko, Albert Icksang Costa, Federico
author2_role	author author author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Aguilar Ticona, Juan Pablo Nery Junior, Nivison Ruy Rocha Ladines-Lim, Joseph B. Gambrah, Claudia Sacramento, Gielson Freitas, Bruno de Paula Bouzon, Joseane Oliveira Filho, Jamary Borja, Ana Adhikarla, Haritha Montoya, Magelda Chin, Athena Wunder Junior, Elsio Augusto Ballalai, Verena Vieira, Carina Belfort, Rubens Almeida, Antonio R. P. Reis, Mitermayer Galvão dos Harris, Eva Ko, Albert Icksang Costa, Federico
dc.subject.other.pt_BR.fl_str_mv	Zika Vírus Prevalência Risco Soroconversão Mães
topic	Zika Vírus Prevalência Risco Soroconversão Mães Zika Virus Prevalence Risk Seroconversion Mothers
dc.subject.en.pt_BR.fl_str_mv	Zika Virus
dc.subject.en.en.fl_str_mv	Prevalence Risk Seroconversion Mothers
description	National Institutes of Health (NIAID R01 AI052473 (AK), R25 U01AI088752 (AK), FIC R01 TW009504 (AK), R25 TW009338 (AK), F31 AI114245 (AK), R01 AI121207 (AK), D43 TW010540 (AK), P01 AI106695 (EH) (https://www.niaid.nih.gov/)
publishDate	2021
dc.date.accessioned.fl_str_mv	2021-06-14T13:40:11Z
dc.date.available.fl_str_mv	2021-06-14T13:40:11Z
dc.date.issued.fl_str_mv	2021
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	AGUILAR TICONA, Juan Pablo et al. Developmental outcomes in children exposed to Zika virus in utero from a brazilian urban slum cohort study. PLoS Neglected Tropical Diseases, v. 15, n. 2, p. 1-15, 5 Feb. 2021.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/47663
dc.identifier.issn.pt_BR.fl_str_mv	1935-2727
dc.identifier.doi.pt_BR.fl_str_mv	10.1371/journal.pntd.0009162
dc.identifier.eissn.pt_BR.fl_str_mv	1935-2735
identifier_str_mv	AGUILAR TICONA, Juan Pablo et al. Developmental outcomes in children exposed to Zika virus in utero from a brazilian urban slum cohort study. PLoS Neglected Tropical Diseases, v. 15, n. 2, p. 1-15, 5 Feb. 2021. 1935-2727 10.1371/journal.pntd.0009162 1935-2735
url	https://www.arca.fiocruz.br/handle/icict/47663
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Public Library of Science
publisher.none.fl_str_mv	Public Library of Science
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/47663/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/47663/2/Ticona%2c%20Juan%20P%20Aguilar%20%20Development....pdf https://www.arca.fiocruz.br/bitstream/icict/47663/3/Ticona%2c%20Juan%20P%20Aguilar%20%20Development....pdf.txt
bitstream.checksum.fl_str_mv	36b51ef91c52b5338d9d29ba0cc807bc 6957627f05e09c869a18b5bfd691d394 53f29c2fb875d35de9dd502dbddb7108
bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5 MD5
repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
_version_	1813009034649796608

Developmental outcomes in children exposed to Zika virus in utero from a brazilian urban slum cohort study

Registros relacionados