Hoffman`s syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism

Detalhes bibliográficos
Autor(a) principal: Vasconcellos, L. F. R.
Data de Publicação: 2003
Outros Autores: Peixoto, M. C., Oliveira, T. N., Penque, G., Leite, A. C. C. B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33197
Resumo: Ana Claudia Celestino Leite. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
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spelling Vasconcellos, L. F. R.Peixoto, M. C.Oliveira, T. N.Penque, G.Leite, A. C. C. B.2019-05-23T15:04:33Z2019-05-23T15:04:33Z2003VASCONCELLOS, Luiz Felipe Rocha et al. Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Arquivos de Neuro-Psiquiatria, v. 61, n. 3B, p. 851-854, 2003.0004-282Xhttps://www.arca.fiocruz.br/handle/icict/3319710.1590/S0004-282X20030005000271678-4227Ana Claudia Celestino Leite. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.A frequência de miopatia no hipotireoidismo varia de 30% a 80%. Os sintomas relacionados ao acometimento muscular são fraqueza, cãimbras e mialgias. A forma pseudo-hipertrófica éÈ denominada síndrome de Hoffman. O estudo eletrofisiológico pode revelar padrão miopático, neuropático ou misto. A investigação laboratorial em geral mostra aumento das enzimas musculares e redução dos níveis de hormônio tireoidiano com TSH elevado. O tratamento consiste na reposição oral de hormônio e o prognóstico é bom na maioria dos casos. Relatamos o caso de um adulto que apresentou cãimbras, mialgia, fraqueza com pseudohipertrofia muscular associados a edema facial e alteraço da voz. As enzimas musculares estavam elevadas e o nÌvel de T4 foi indetectável com aumento de TSH. A miopatia foi manifestação inicial de hipotireoidismo neste caso.The frequency of myopathy in hypothyroidism ranges from 30 to 80%. The major symptoms related are weakness, muscular cramps and myalgia. The pseudohyperthrophic form is called Hoffman's syndrome. The electrophysiological study reveals myopathy, neuropathy or mixed pattern. Laboratorial investigation generally shows increased levels of muscle enzymes and low serum thyroid hormones, with thyrotrophic-stimulating hormone (TSH) elevated. The treatment consists in hormone replacement and the prognosis is good in most of the cases. We report an adult male who developed muscular cramps, myalgia, weakness, pseudohyperthrophy, associated with facial edema and alteration of his voice. The muscle enzymes were increased and T4 was undetectable with a raised level of TSH. The myopathy was the initial manifestation of hypothyroidism in this case.Federal University of Rio de Janeiro. University Hospital Clementino Fraga Filho. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Institute of Neurology Deolindo Couto. Rio de Janeiro, RJ, Brazil.Federal University of Rio de Janeiro. University Hospital Clementino Fraga Filho. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Institute of Neurology Deolindo Couto. Rio de Janeiro, RJ, Brazil.Federal University of Rio de Janeiro. University Hospital Clementino Fraga Filho. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Institute of Neurology Deolindo Couto. Rio de Janeiro, RJ, Brazil.Federal University of Rio de Janeiro. Institute of Neurology Deolindo Couto. Rio de Janeiro, RJ, Brazil.Federal University of Rio de Janeiro. University Hospital Clementino Fraga Filho. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Institute of Neurology Deolindo Couto. Rio de Janeiro, RJ, Brazil.engAcademia Brasileira de NeurologiaMiopatiaHipotireoidismoHipotireoidismoMyopathyHypothyroidismPseudohypertrophyHoffman`s syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidismSíndrome de Hoffman: miopatia pseudohipertrófica como manifestação inicial de hipotireoidismo: relato de casoinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/33197/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Vasconcellos_Felipe_etal_INI_2003.pdfve_Vasconcellos_Felipe_etal_INI_2003.pdfapplication/pdf371992https://www.arca.fiocruz.br/bitstream/icict/33197/2/ve_Vasconcellos_Felipe_etal_INI_2003.pdfd09f6b9f3e2d0b757e11c789ed12f59dMD52TEXTve_Vasconcellos_Felipe_etal_INI_2003.pdf.txtve_Vasconcellos_Felipe_etal_INI_2003.pdf.txtExtracted texttext/plain16279https://www.arca.fiocruz.br/bitstream/icict/33197/3/ve_Vasconcellos_Felipe_etal_INI_2003.pdf.txtf2f1d6d68b594d9cdcd457cc392f827eMD53icict/331972019-05-24 02:01:39.675oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-05-24T05:01:39Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Hoffman`s syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism
dc.title.alternative.pt_BR.fl_str_mv Síndrome de Hoffman: miopatia pseudohipertrófica como manifestação inicial de hipotireoidismo: relato de caso
title Hoffman`s syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism
spellingShingle Hoffman`s syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism
Vasconcellos, L. F. R.
Miopatia
Hipotireoidismo
Hipotireoidismo
Myopathy
Hypothyroidism
Pseudohypertrophy
title_short Hoffman`s syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism
title_full Hoffman`s syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism
title_fullStr Hoffman`s syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism
title_full_unstemmed Hoffman`s syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism
title_sort Hoffman`s syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism
author Vasconcellos, L. F. R.
author_facet Vasconcellos, L. F. R.
Peixoto, M. C.
Oliveira, T. N.
Penque, G.
Leite, A. C. C. B.
author_role author
author2 Peixoto, M. C.
Oliveira, T. N.
Penque, G.
Leite, A. C. C. B.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Vasconcellos, L. F. R.
Peixoto, M. C.
Oliveira, T. N.
Penque, G.
Leite, A. C. C. B.
dc.subject.other.pt_BR.fl_str_mv Miopatia
Hipotireoidismo
Hipotireoidismo
topic Miopatia
Hipotireoidismo
Hipotireoidismo
Myopathy
Hypothyroidism
Pseudohypertrophy
dc.subject.en.pt_BR.fl_str_mv Myopathy
Hypothyroidism
Pseudohypertrophy
description Ana Claudia Celestino Leite. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2019-05-23T15:04:33Z
dc.date.available.fl_str_mv 2019-05-23T15:04:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv VASCONCELLOS, Luiz Felipe Rocha et al. Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Arquivos de Neuro-Psiquiatria, v. 61, n. 3B, p. 851-854, 2003.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33197
dc.identifier.issn.pt_BR.fl_str_mv 0004-282X
dc.identifier.doi.none.fl_str_mv 10.1590/S0004-282X2003000500027
dc.identifier.eissn.none.fl_str_mv 1678-4227
identifier_str_mv VASCONCELLOS, Luiz Felipe Rocha et al. Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Arquivos de Neuro-Psiquiatria, v. 61, n. 3B, p. 851-854, 2003.
0004-282X
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