Genomic and temporal analyses of Mycobacterium bovis in southern Brazil

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Rudielle de Arruda
Data de Publicação: 2021
Outros Autores: Araújo, Flábio Ribeiro, Dávila, Alberto Martín Rivera, Etges, Rodrigo Nestor, Parkhill, Julia, van Tonder, J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/48067
Resumo: Universidade Federal do Mato Grosso do Sul. Faculdade de Medicina Veterinária e Zootecnia. Programa de Pós-Graduação em Ciência Veterinária. Campo Grande, MS, Brasil.
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spelling Rodrigues, Rudielle de ArrudaAraújo, Flábio RibeiroDávila, Alberto Martín RiveraEtges, Rodrigo NestorParkhill, Juliavan Tonder, J.2021-07-08T14:37:06Z2021-07-08T14:37:06Z2021RODRIGUES, Rudielle de Arruda et al. Genomic and temporal analyses of Mycobacterium bovis in southern Brazil. Microbial Genomics, v. 7, 000569, 13 p, 2021.2057-5858https://www.arca.fiocruz.br/handle/icict/4806710.1099/mgen.0.000569engMicrobiology SocietyMycobacterium bovisAnálises genômicasAnálises temporaisSul do BrasilMycobacterium bovisTemporal analysesGenomic analysesSouthern BrazilGenomic and temporal analyses of Mycobacterium bovis in southern Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Mato Grosso do Sul. Faculdade de Medicina Veterinária e Zootecnia. Programa de Pós-Graduação em Ciência Veterinária. Campo Grande, MS, Brasil.Embrapa Gado de Corte. Campo Grande, MS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Computacional e de Sistemas. Programa de Pós Graduação em Biodiversidade e Saúde. Rio de Janeiro, RJ, Brasil.Secretaria de Agricultura, Pecuária e Irrigação. Porto Alegre, RS, Brasil.Department of Veterinary Medicine,. University of Cambridge. Cambridge, UK..Department of Veterinary Medicine,. University of Cambridge. Cambridge, UK..Mycobacterium bovis is a causal agent of bovine tuberculosis (bTB), one of the most important diseases currently facing the cattle industry worldwide. Tracing the source of M. bovis infections of livestock is an important tool for understanding the epidemiology of bTB and defining control/eradication strategies. In this study, whole genome sequencing (WGS) of 74 M. bovis isolates sourced from naturally infected cattle in the State of Rio Grande do Sul (RS), southern Brazil, was used to evaluate the population structure of M. bovis in the region, identify potential transmission events and date the introduction of clonal complex (CC) European 2 (Eu2). In silico spoligotyping identified 11 distinct patterns including four new profiles and two CCs, European 1 (Eu1) and Eu2. The analyses revealed a high level of genetic diversity in the majority of herds and identified putative transmis sion clusters that suggested that within- and between-herd transmission is occurring in RS. In addition, a comparison with other published M. bovis isolates from Argentina, Brazil, Paraguay and Uruguay demonstrated some evidence for a possible cross-border transmission of CC Eu1 into RS from Uruguay or Argentina. An estimated date for the introduction of CC Eu2 into RS in the middle of the 19th century correlated with the historical introduction of cattle into RS to improve existing local breeds. These findings contribute to the understanding of the population structure of M. bovis in southern Brazil and highlight the poten tial of WGS in surveillance and helping to identify bTB transmission.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/48067/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAlbertoMartinR_Davila_etal_IOC_2021.pdfAlbertoMartinR_Davila_etal_IOC_2021.pdfapplication/pdf3884011https://www.arca.fiocruz.br/bitstream/icict/48067/2/AlbertoMartinR_Davila_etal_IOC_2021.pdf276bf6796dfabeaa468720efc7f066d7MD52TEXTAlbertoMartinR_Davila_etal_IOC_2021.pdf.txtAlbertoMartinR_Davila_etal_IOC_2021.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Genomic and temporal analyses of Mycobacterium bovis in southern Brazil
title Genomic and temporal analyses of Mycobacterium bovis in southern Brazil
spellingShingle Genomic and temporal analyses of Mycobacterium bovis in southern Brazil
Rodrigues, Rudielle de Arruda
Mycobacterium bovis
Análises genômicas
Análises temporais
Sul do Brasil
Mycobacterium bovis
Temporal analyses
Genomic analyses
Southern Brazil
title_short Genomic and temporal analyses of Mycobacterium bovis in southern Brazil
title_full Genomic and temporal analyses of Mycobacterium bovis in southern Brazil
title_fullStr Genomic and temporal analyses of Mycobacterium bovis in southern Brazil
title_full_unstemmed Genomic and temporal analyses of Mycobacterium bovis in southern Brazil
title_sort Genomic and temporal analyses of Mycobacterium bovis in southern Brazil
author Rodrigues, Rudielle de Arruda
author_facet Rodrigues, Rudielle de Arruda
Araújo, Flábio Ribeiro
Dávila, Alberto Martín Rivera
Etges, Rodrigo Nestor
Parkhill, Julia
van Tonder, J.
author_role author
author2 Araújo, Flábio Ribeiro
Dávila, Alberto Martín Rivera
Etges, Rodrigo Nestor
Parkhill, Julia
van Tonder, J.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Rodrigues, Rudielle de Arruda
Araújo, Flábio Ribeiro
Dávila, Alberto Martín Rivera
Etges, Rodrigo Nestor
Parkhill, Julia
van Tonder, J.
dc.subject.other.pt_BR.fl_str_mv Mycobacterium bovis
Análises genômicas
Análises temporais
Sul do Brasil
topic Mycobacterium bovis
Análises genômicas
Análises temporais
Sul do Brasil
Mycobacterium bovis
Temporal analyses
Genomic analyses
Southern Brazil
dc.subject.en.pt_BR.fl_str_mv Mycobacterium bovis
Temporal analyses
Genomic analyses
Southern Brazil
description Universidade Federal do Mato Grosso do Sul. Faculdade de Medicina Veterinária e Zootecnia. Programa de Pós-Graduação em Ciência Veterinária. Campo Grande, MS, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-07-08T14:37:06Z
dc.date.available.fl_str_mv 2021-07-08T14:37:06Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RODRIGUES, Rudielle de Arruda et al. Genomic and temporal analyses of Mycobacterium bovis in southern Brazil. Microbial Genomics, v. 7, 000569, 13 p, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/48067
dc.identifier.issn.pt_BR.fl_str_mv 2057-5858
dc.identifier.doi.none.fl_str_mv 10.1099/mgen.0.000569
identifier_str_mv RODRIGUES, Rudielle de Arruda et al. Genomic and temporal analyses of Mycobacterium bovis in southern Brazil. Microbial Genomics, v. 7, 000569, 13 p, 2021.
2057-5858
10.1099/mgen.0.000569
url https://www.arca.fiocruz.br/handle/icict/48067
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Microbiology Society
publisher.none.fl_str_mv Microbiology Society
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/48067/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/48067/2/AlbertoMartinR_Davila_etal_IOC_2021.pdf
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