Miniemulsion RAFT Copolymerization of MMA with Acrylic Acid and Methacrylic Acid and Bioconjugation with BSA

Detalhes bibliográficos
Autor(a) principal: Way, Débora Vieira
Data de Publicação: 2019
Outros Autores: Braido, Rayany Stôcco, Reis, Sabrina Alves dos, Lara, Flávio Alves, Pinto, José Carlos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/35350
Resumo: Universidade Federal do Rio de Janeiro. COPPE. Programa de Engenharia Química. Rio de Janeiro, RJ, Brasil.
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spelling Way, Débora VieiraBraido, Rayany StôccoReis, Sabrina Alves dosLara, Flávio AlvesPinto, José Carlos2019-09-05T13:00:02Z2019-09-05T13:00:02Z2019WAY, Débora Vieira et al. Miniemulsion RAFT Copolymerization of MMA with Acrylic Acid and Methacrylic Acid and Bioconjugation with BSA. Nanomaterials, v. 9, n. 828, p. 1-16, 2019.2079-4991https://www.arca.fiocruz.br/handle/icict/3535010.3390/nano90608282079-4991engMDPICopolímeroBioconjungaçãoTransferência de cadeia de adição-fragmentação reversívelRAFTCopolymersBioconjugationMaleimide-PEG-NHSMiniemulsion RAFT Copolymerization of MMA with Acrylic Acid and Methacrylic Acid and Bioconjugation with BSAinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. COPPE. Programa de Engenharia Química. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. COPPE. Programa de Engenharia Química. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. Brasil.Universidade Federal do Rio de Janeiro. COPPE. Programa de Engenharia Química. Rio de Janeiro, RJ, Brasil.Polymerization through reversible addition-fragmentation chain-transfer (RAFT) polymerization has been extensively employed for the production of polymers with controlled molar mass, complex architectures and copolymer composition distributions intended for biomedical and pharmaceutical applications. In the present work, RAFT miniemulsion copolymerizations of methyl methacrylate with acrylic acid and methacrylic acid were conducted to prepare hydrophilic polymer nanoparticles and compare cell uptake results after bioconjugation with bovine serum albumin (BSA), used as a model biomolecule. Obtained results indicate that the RAFT agent 2-cyano-propyl-dithiobenzoate allowed for successful free radical controlled methyl methacrylate copolymerizations and performed better when methacrylic acid was used as comonomer. Results also indicate that poly(methyl methacrylate-co-methacrylic acid) nanoparticles prepared by RAFT copolymerization and bioconjugated with BSA were exceptionally well accepted by cells, when compared to the other produced polymer nanoparticles because cellular uptake levels were much higher for particles prepared in presence of methacrylic acid, which can probably be associated to its high hydrophilicity.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Miniemulsion RAFT Copolymerization of MMA with Acrylic Acid and Methacrylic Acid and Bioconjugation with BSA
title Miniemulsion RAFT Copolymerization of MMA with Acrylic Acid and Methacrylic Acid and Bioconjugation with BSA
spellingShingle Miniemulsion RAFT Copolymerization of MMA with Acrylic Acid and Methacrylic Acid and Bioconjugation with BSA
Way, Débora Vieira
Copolímero
Bioconjungação
Transferência de cadeia de adição-fragmentação reversível
RAFT
Copolymers
Bioconjugation
Maleimide-PEG-NHS
title_short Miniemulsion RAFT Copolymerization of MMA with Acrylic Acid and Methacrylic Acid and Bioconjugation with BSA
title_full Miniemulsion RAFT Copolymerization of MMA with Acrylic Acid and Methacrylic Acid and Bioconjugation with BSA
title_fullStr Miniemulsion RAFT Copolymerization of MMA with Acrylic Acid and Methacrylic Acid and Bioconjugation with BSA
title_full_unstemmed Miniemulsion RAFT Copolymerization of MMA with Acrylic Acid and Methacrylic Acid and Bioconjugation with BSA
title_sort Miniemulsion RAFT Copolymerization of MMA with Acrylic Acid and Methacrylic Acid and Bioconjugation with BSA
author Way, Débora Vieira
author_facet Way, Débora Vieira
Braido, Rayany Stôcco
Reis, Sabrina Alves dos
Lara, Flávio Alves
Pinto, José Carlos
author_role author
author2 Braido, Rayany Stôcco
Reis, Sabrina Alves dos
Lara, Flávio Alves
Pinto, José Carlos
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Way, Débora Vieira
Braido, Rayany Stôcco
Reis, Sabrina Alves dos
Lara, Flávio Alves
Pinto, José Carlos
dc.subject.other.pt_BR.fl_str_mv Copolímero
Bioconjungação
Transferência de cadeia de adição-fragmentação reversível
topic Copolímero
Bioconjungação
Transferência de cadeia de adição-fragmentação reversível
RAFT
Copolymers
Bioconjugation
Maleimide-PEG-NHS
dc.subject.en.pt_BR.fl_str_mv RAFT
Copolymers
Bioconjugation
Maleimide-PEG-NHS
description Universidade Federal do Rio de Janeiro. COPPE. Programa de Engenharia Química. Rio de Janeiro, RJ, Brasil.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-09-05T13:00:02Z
dc.date.available.fl_str_mv 2019-09-05T13:00:02Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv WAY, Débora Vieira et al. Miniemulsion RAFT Copolymerization of MMA with Acrylic Acid and Methacrylic Acid and Bioconjugation with BSA. Nanomaterials, v. 9, n. 828, p. 1-16, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/35350
dc.identifier.issn.pt_BR.fl_str_mv 2079-4991
dc.identifier.doi.none.fl_str_mv 10.3390/nano9060828
dc.identifier.eissn.none.fl_str_mv 2079-4991
identifier_str_mv WAY, Débora Vieira et al. Miniemulsion RAFT Copolymerization of MMA with Acrylic Acid and Methacrylic Acid and Bioconjugation with BSA. Nanomaterials, v. 9, n. 828, p. 1-16, 2019.
2079-4991
10.3390/nano9060828
url https://www.arca.fiocruz.br/handle/icict/35350
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/35350/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/35350/2/FlavioLara_SabrinaReis_etal_IOC_2019.pdf
https://www.arca.fiocruz.br/bitstream/icict/35350/3/FlavioLara_SabrinaReis_etal_IOC_2019.pdf.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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