Prevalence of Mycobacterium leprae in armadillos in Brazil: A systematic review and meta-analysis

Detalhes bibliográficos
Autor(a) principal: Deps, Patrícia
Data de Publicação: 2020
Outros Autores: Antunes, João Marcelo, Santos, Adalberto Rezende, Collin, Simon M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/41263
Resumo: Universidade Federal do Espírito Santo. Departamento de Medicina Social. Vitória, ES, Brasil / Universidade Federal do Espírito Santo. Postgraduate Programme in Infectious Diseases. Vitória, ES, Brasil.
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spelling Deps, PatríciaAntunes, João MarceloSantos, Adalberto RezendeCollin, Simon M.2020-05-16T22:37:58Z2020-05-16T22:37:58Z2020DEPS, Patrícia et al. Prevalence of Mycobacterium leprae in armadillos in Brazil: a systematic review and meta-analysis. PLOS Neglected Tropical Diseases, p. 1-16, Mar. 23, 2020.1935-2727https://www.arca.fiocruz.br/handle/icict/4126310.1371/journal.pntd.0008127engPublic Library of ScienceMycobacterium lepraeRevisão sistemáticaBrasilMycobacterium lepraeSystematic reviewBrazilPrevalence of Mycobacterium leprae in armadillos in Brazil: A systematic review and meta-analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Espírito Santo. Departamento de Medicina Social. Vitória, ES, Brasil / Universidade Federal do Espírito Santo. Postgraduate Programme in Infectious Diseases. Vitória, ES, Brasil.Universidade Federal Rural do Semi-Árido. Hospital Veterinário Jerônimo Dix-Huit Rosado Maia. Mossoró, RN, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactérias. Rio de Janeiro, RJ, Brasil.National Infection Service. Public Health England. London, United Kingdom.Understanding the prevalence of M. leprae infection in armadillos is important because of evidence from Brazil and other countries of an association between contact with armadillos and the development of Hansen’s Disease (leprosy). Our aim was to characterize studies which have investigated natural M. leprae infection in wild armadillos in Brazil, and to quantify and explore variability in the reported prevalence of infection. We conducted a systematic review (PROSPERO CRD42019155277) of publications in MEDLINE, EMBASE, Global Health, Scopus, LILACS, Biblioteca Digital Brasileira de Teses e Dissertações, Catálogo de Teses e Dissertações de CAPES, and Biblioteca Virtual em Saúde up to 10/2019 using Mesh and text search terms (in English, Portuguese, Spanish, and French). The 10 included studies represented a total sample of 302 armadillos comprising 207 (69%) Dasypus novemcinctus, 67 (22%) Euphractus sexcinctus, 16 (5%) Priodontes maximus, 10 (3%) Cabassous unicinctus, and 2 (1%) Cabassous tatouay from 7 different states. Methods used included histopathology (4 studies), PGL-1 and LID-1 antigen detection (4 studies) and examination for clinical signs of disease (4 studies). Eight studies used PCR of which 7 targeted the RLEP repetitive element and 3 tested for inhibitory substances. M. leprae prevalence by PCR ranged from 0% (in 3 studies) to 100% in one study, with a summary estimate of 9.4% (95% CI 0.4% to 73.1%) and a predictive interval of 0–100%. The average prevalence is equivalent to 1 in 10 armadillos in Brazil being infected with M. leprae, but wide variation in sample estimates means that the prevalence in any similar study would be entirely unpredictable. We propose instead that future studies aim to investigate transmission and persistence of M. leprae within and between armadillo populations, meanwhile adopting the precautionary principle to protect human health and an endangered species in Brazil.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83134https://www.arca.fiocruz.br/bitstream/icict/41263/1/license.txt0ab46789d568c4ba27c7b5d29a9fe9c4MD51ORIGINALDeps_Patrícia_etal_IOC_2020.pdfDeps_Patrícia_etal_IOC_2020.pdfapplication/pdf1467527https://www.arca.fiocruz.br/bitstream/icict/41263/2/Deps_Patr%c3%adcia_etal_IOC_2020.pdfef8f62d4fc63c82ab7fd67dd605c87b1MD52TEXTDeps_Patrícia_etal_IOC_2020.pdf.txtDeps_Patrícia_etal_IOC_2020.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Prevalence of Mycobacterium leprae in armadillos in Brazil: A systematic review and meta-analysis
title Prevalence of Mycobacterium leprae in armadillos in Brazil: A systematic review and meta-analysis
spellingShingle Prevalence of Mycobacterium leprae in armadillos in Brazil: A systematic review and meta-analysis
Deps, Patrícia
Mycobacterium leprae
Revisão sistemática
Brasil
Mycobacterium leprae
Systematic review
Brazil
title_short Prevalence of Mycobacterium leprae in armadillos in Brazil: A systematic review and meta-analysis
title_full Prevalence of Mycobacterium leprae in armadillos in Brazil: A systematic review and meta-analysis
title_fullStr Prevalence of Mycobacterium leprae in armadillos in Brazil: A systematic review and meta-analysis
title_full_unstemmed Prevalence of Mycobacterium leprae in armadillos in Brazil: A systematic review and meta-analysis
title_sort Prevalence of Mycobacterium leprae in armadillos in Brazil: A systematic review and meta-analysis
author Deps, Patrícia
author_facet Deps, Patrícia
Antunes, João Marcelo
Santos, Adalberto Rezende
Collin, Simon M.
author_role author
author2 Antunes, João Marcelo
Santos, Adalberto Rezende
Collin, Simon M.
author2_role author
author
author
dc.contributor.author.fl_str_mv Deps, Patrícia
Antunes, João Marcelo
Santos, Adalberto Rezende
Collin, Simon M.
dc.subject.other.pt_BR.fl_str_mv Mycobacterium leprae
Revisão sistemática
Brasil
topic Mycobacterium leprae
Revisão sistemática
Brasil
Mycobacterium leprae
Systematic review
Brazil
dc.subject.en.pt_BR.fl_str_mv Mycobacterium leprae
Systematic review
Brazil
description Universidade Federal do Espírito Santo. Departamento de Medicina Social. Vitória, ES, Brasil / Universidade Federal do Espírito Santo. Postgraduate Programme in Infectious Diseases. Vitória, ES, Brasil.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-05-16T22:37:58Z
dc.date.available.fl_str_mv 2020-05-16T22:37:58Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv DEPS, Patrícia et al. Prevalence of Mycobacterium leprae in armadillos in Brazil: a systematic review and meta-analysis. PLOS Neglected Tropical Diseases, p. 1-16, Mar. 23, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/41263
dc.identifier.issn.pt_BR.fl_str_mv 1935-2727
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0008127
identifier_str_mv DEPS, Patrícia et al. Prevalence of Mycobacterium leprae in armadillos in Brazil: a systematic review and meta-analysis. PLOS Neglected Tropical Diseases, p. 1-16, Mar. 23, 2020.
1935-2727
10.1371/journal.pntd.0008127
url https://www.arca.fiocruz.br/handle/icict/41263
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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