Polymorphisms in DENND1B gene are associated with asthma and atopy phenotypes in Brazilian children
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/25004 |
Resumo: | CNPq − National Research Council - Brazil and FAPESB − State of Bahia, Brazil Research Council |
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Fiuza, Bianca Sampaio DottoSilva, Milca de JesusNeves, Neuza Maria AlcântaraBarreto, Maurício LimaCosta, Ryan dos SantosFigueiredo, Camila Alexandrina Viana de2018-02-28T19:25:21Z2018-02-28T19:25:21Z2017FIUZA, B. S. D. et al. Polymorphisms in DENND1B gene are associated with asthma and atopy phenotypes in Brazilian children. Molecular Immunology, v. 90, p. 33–41, 2017.0161-5890https://www.arca.fiocruz.br/handle/icict/2500410.1016/j.molimm.2017.06.030CNPq − National Research Council - Brazil and FAPESB − State of Bahia, Brazil Research CouncilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Laboratório de Imunofarmacologia e Biologia Molecular. Departamento de Biorregulação. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Laboratório de Imunofarmacologia e Biologia Molecular. Departamento de Biorregulação. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Laboratório de Imunofarmacologia e Biologia Molecular. Departamento de Biorregulação. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Laboratório de Imunofarmacologia e Biologia Molecular. Departamento de Biorregulação. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Laboratório de Imunofarmacologia e Biologia Molecular. Departamento de Biorregulação. Salvador, BA, BrasilAsthma is a heterogeneous disease associated with a complex basis involving environmental factors and individual variabilities. The DENN Domain Containing 1B (DENND1B) gene has an important role on T cell receptor (TCR) down-regulation on Th2 cells and studies have shown that mutations or loss of this factor can be associated with increased Th2 responses and asthma. The aim of this work is to evaluate the association of polymorphisms in the DENND1B with asthma and allergy markers phenotypes in Brazilian children. Genotyping was performed using a commercial panel from Illumina (2.5 Human Omni bead chip) in 1309 participants of SCAALA (Social Change, Asthma, Allergy in Latin American) program. Logistic regressions for asthma and atopy markers were performed using PLINK software 1.9. The analyzes were adjusted for sex, age, helminth infections and ancestry markers. The DENND1B gene was associated with different phenotypes such as severe asthma and atopic markers (specific IgE production, skin prick test and IL-13 production). Among the 166 SNPs analyzed, 72 were associated with asthma and/or allergy markers. In conclusion, polymorphisms in the DENND1B are significantly associated with development of asthma and atopy and these polymorphisms can influence DENND1B expression and consequently, asthma.engElsevierAsmaAtopiaPolimorfismoAsthmaAtopyPolymorphismDENND1BPolymorphisms in DENND1B gene are associated with asthma and atopy phenotypes in Brazilian childreninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25004/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFiuza BS Polymorphisms in DENND1B gene are associated....pdfFiuza BS Polymorphisms in DENND1B gene are associated....pdfapplication/pdf785468https://www.arca.fiocruz.br/bitstream/icict/25004/2/Fiuza%20BS%20Polymorphisms%20in%20DENND1B%20gene%20are%20associated....pdf752a3a4da4f9e5c39c215f56d208c14bMD52TEXTFiuza BS Polymorphisms in DENND1B gene are associated....pdf.txtFiuza BS Polymorphisms in DENND1B gene are associated....pdf.txtExtracted texttext/plain51802https://www.arca.fiocruz.br/bitstream/icict/25004/3/Fiuza%20BS%20Polymorphisms%20in%20DENND1B%20gene%20are%20associated....pdf.txtafd3c121dea81c940a26a87fed9e7a71MD53icict/250042023-03-15 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| dc.title.pt_BR.fl_str_mv |
Polymorphisms in DENND1B gene are associated with asthma and atopy phenotypes in Brazilian children |
| title |
Polymorphisms in DENND1B gene are associated with asthma and atopy phenotypes in Brazilian children |
| spellingShingle |
Polymorphisms in DENND1B gene are associated with asthma and atopy phenotypes in Brazilian children Fiuza, Bianca Sampaio Dotto Asma Atopia Polimorfismo Asthma Atopy Polymorphism DENND1B |
| title_short |
Polymorphisms in DENND1B gene are associated with asthma and atopy phenotypes in Brazilian children |
| title_full |
Polymorphisms in DENND1B gene are associated with asthma and atopy phenotypes in Brazilian children |
| title_fullStr |
Polymorphisms in DENND1B gene are associated with asthma and atopy phenotypes in Brazilian children |
| title_full_unstemmed |
Polymorphisms in DENND1B gene are associated with asthma and atopy phenotypes in Brazilian children |
| title_sort |
Polymorphisms in DENND1B gene are associated with asthma and atopy phenotypes in Brazilian children |
| author |
Fiuza, Bianca Sampaio Dotto |
| author_facet |
Fiuza, Bianca Sampaio Dotto Silva, Milca de Jesus Neves, Neuza Maria Alcântara Barreto, Maurício Lima Costa, Ryan dos Santos Figueiredo, Camila Alexandrina Viana de |
| author_role |
author |
| author2 |
Silva, Milca de Jesus Neves, Neuza Maria Alcântara Barreto, Maurício Lima Costa, Ryan dos Santos Figueiredo, Camila Alexandrina Viana de |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Fiuza, Bianca Sampaio Dotto Silva, Milca de Jesus Neves, Neuza Maria Alcântara Barreto, Maurício Lima Costa, Ryan dos Santos Figueiredo, Camila Alexandrina Viana de |
| dc.subject.other.pt_BR.fl_str_mv |
Asma Atopia Polimorfismo |
| topic |
Asma Atopia Polimorfismo Asthma Atopy Polymorphism DENND1B |
| dc.subject.en.pt_BR.fl_str_mv |
Asthma Atopy Polymorphism DENND1B |
| description |
CNPq − National Research Council - Brazil and FAPESB − State of Bahia, Brazil Research Council |
| publishDate |
2017 |
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2017 |
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2018-02-28T19:25:21Z |
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2018-02-28T19:25:21Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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FIUZA, B. S. D. et al. Polymorphisms in DENND1B gene are associated with asthma and atopy phenotypes in Brazilian children. Molecular Immunology, v. 90, p. 33–41, 2017. |
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https://www.arca.fiocruz.br/handle/icict/25004 |
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0161-5890 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.molimm.2017.06.030 |
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FIUZA, B. S. D. et al. Polymorphisms in DENND1B gene are associated with asthma and atopy phenotypes in Brazilian children. Molecular Immunology, v. 90, p. 33–41, 2017. 0161-5890 10.1016/j.molimm.2017.06.030 |
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Elsevier |
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