Polymorphisms in DENND1B gene are associated with asthma and atopy phenotypes in Brazilian children

Bibliographic Details
Main Author: Fiuza, Bianca Sampaio Dotto
Publication Date: 2017
Other Authors: Silva, Milca de Jesus, Neves, Neuza Maria Alcântara, Barreto, Maurício Lima, Costa, Ryan dos Santos, Figueiredo, Camila Alexandrina Viana de
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
Download full: https://www.arca.fiocruz.br/handle/icict/25004
Summary: CNPq − National Research Council - Brazil and FAPESB − State of Bahia, Brazil Research Council
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spelling Fiuza, Bianca Sampaio DottoSilva, Milca de JesusNeves, Neuza Maria AlcântaraBarreto, Maurício LimaCosta, Ryan dos SantosFigueiredo, Camila Alexandrina Viana de2018-02-28T19:25:21Z2018-02-28T19:25:21Z2017FIUZA, B. S. D. et al. Polymorphisms in DENND1B gene are associated with asthma and atopy phenotypes in Brazilian children. Molecular Immunology, v. 90, p. 33–41, 2017.0161-5890https://www.arca.fiocruz.br/handle/icict/2500410.1016/j.molimm.2017.06.030CNPq − National Research Council - Brazil and FAPESB − State of Bahia, Brazil Research CouncilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Laboratório de Imunofarmacologia e Biologia Molecular. Departamento de Biorregulação. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Laboratório de Imunofarmacologia e Biologia Molecular. Departamento de Biorregulação. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Laboratório de Imunofarmacologia e Biologia Molecular. Departamento de Biorregulação. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Laboratório de Imunofarmacologia e Biologia Molecular. Departamento de Biorregulação. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Laboratório de Imunofarmacologia e Biologia Molecular. Departamento de Biorregulação. Salvador, BA, BrasilAsthma is a heterogeneous disease associated with a complex basis involving environmental factors and individual variabilities. The DENN Domain Containing 1B (DENND1B) gene has an important role on T cell receptor (TCR) down-regulation on Th2 cells and studies have shown that mutations or loss of this factor can be associated with increased Th2 responses and asthma. The aim of this work is to evaluate the association of polymorphisms in the DENND1B with asthma and allergy markers phenotypes in Brazilian children. Genotyping was performed using a commercial panel from Illumina (2.5 Human Omni bead chip) in 1309 participants of SCAALA (Social Change, Asthma, Allergy in Latin American) program. Logistic regressions for asthma and atopy markers were performed using PLINK software 1.9. The analyzes were adjusted for sex, age, helminth infections and ancestry markers. The DENND1B gene was associated with different phenotypes such as severe asthma and atopic markers (specific IgE production, skin prick test and IL-13 production). Among the 166 SNPs analyzed, 72 were associated with asthma and/or allergy markers. In conclusion, polymorphisms in the DENND1B are significantly associated with development of asthma and atopy and these polymorphisms can influence DENND1B expression and consequently, asthma.engElsevierAsmaAtopiaPolimorfismoAsthmaAtopyPolymorphismDENND1BPolymorphisms in DENND1B gene are associated with asthma and atopy phenotypes in Brazilian childreninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25004/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFiuza BS Polymorphisms in DENND1B gene are associated....pdfFiuza BS Polymorphisms in DENND1B gene are 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dc.title.pt_BR.fl_str_mv Polymorphisms in DENND1B gene are associated with asthma and atopy phenotypes in Brazilian children
title Polymorphisms in DENND1B gene are associated with asthma and atopy phenotypes in Brazilian children
spellingShingle Polymorphisms in DENND1B gene are associated with asthma and atopy phenotypes in Brazilian children
Fiuza, Bianca Sampaio Dotto
Asma
Atopia
Polimorfismo
Asthma
Atopy
Polymorphism
DENND1B
title_short Polymorphisms in DENND1B gene are associated with asthma and atopy phenotypes in Brazilian children
title_full Polymorphisms in DENND1B gene are associated with asthma and atopy phenotypes in Brazilian children
title_fullStr Polymorphisms in DENND1B gene are associated with asthma and atopy phenotypes in Brazilian children
title_full_unstemmed Polymorphisms in DENND1B gene are associated with asthma and atopy phenotypes in Brazilian children
title_sort Polymorphisms in DENND1B gene are associated with asthma and atopy phenotypes in Brazilian children
author Fiuza, Bianca Sampaio Dotto
author_facet Fiuza, Bianca Sampaio Dotto
Silva, Milca de Jesus
Neves, Neuza Maria Alcântara
Barreto, Maurício Lima
Costa, Ryan dos Santos
Figueiredo, Camila Alexandrina Viana de
author_role author
author2 Silva, Milca de Jesus
Neves, Neuza Maria Alcântara
Barreto, Maurício Lima
Costa, Ryan dos Santos
Figueiredo, Camila Alexandrina Viana de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Fiuza, Bianca Sampaio Dotto
Silva, Milca de Jesus
Neves, Neuza Maria Alcântara
Barreto, Maurício Lima
Costa, Ryan dos Santos
Figueiredo, Camila Alexandrina Viana de
dc.subject.other.pt_BR.fl_str_mv Asma
Atopia
Polimorfismo
topic Asma
Atopia
Polimorfismo
Asthma
Atopy
Polymorphism
DENND1B
dc.subject.en.pt_BR.fl_str_mv Asthma
Atopy
Polymorphism
DENND1B
description CNPq − National Research Council - Brazil and FAPESB − State of Bahia, Brazil Research Council
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-02-28T19:25:21Z
dc.date.available.fl_str_mv 2018-02-28T19:25:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FIUZA, B. S. D. et al. Polymorphisms in DENND1B gene are associated with asthma and atopy phenotypes in Brazilian children. Molecular Immunology, v. 90, p. 33–41, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/25004
dc.identifier.issn.pt_BR.fl_str_mv 0161-5890
dc.identifier.doi.none.fl_str_mv 10.1016/j.molimm.2017.06.030
identifier_str_mv FIUZA, B. S. D. et al. Polymorphisms in DENND1B gene are associated with asthma and atopy phenotypes in Brazilian children. Molecular Immunology, v. 90, p. 33–41, 2017.
0161-5890
10.1016/j.molimm.2017.06.030
url https://www.arca.fiocruz.br/handle/icict/25004
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/25004/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/25004/2/Fiuza%20BS%20Polymorphisms%20in%20DENND1B%20gene%20are%20associated....pdf
https://www.arca.fiocruz.br/bitstream/icict/25004/3/Fiuza%20BS%20Polymorphisms%20in%20DENND1B%20gene%20are%20associated....pdf.txt
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