Bothrops erythromelas snake venom induces a proinflammatory response in mice splenocytes

Detalhes bibliográficos
Autor(a) principal: Luna, Karla Patrícia de Oliveira
Data de Publicação: 2011
Outros Autores: Melo, Cristiane ML, Pascoal, Vanessa Peruhype Magalhães, Martins Filho, Olindo Assis, Pereira, Valéria Rêgo Alves
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8798
Resumo: Fundação Oswaldo Cruz. Instituto Aggeu Magalhães Departamento de Imunologia. Pernambuco, Brazil/Universidade Estadual da Paraíba. Campina Grande, Brazil;
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spelling Luna, Karla Patrícia de OliveiraMelo, Cristiane MLPascoal, Vanessa Peruhype MagalhãesMartins Filho, Olindo AssisPereira, Valéria Rêgo Alves2014-11-12T12:19:19Z2014-11-12T12:19:19Z2011LUNA, Karla Patrícia de Oliveira et al. Bothrops erythromelas snake venom induces a proinflammatory response in mice splenocytes. International Journal of Interferon, cytokine and mediator research, volume 3 p. 9-18, 2011.1179-139Xhttps://www.arca.fiocruz.br/handle/icict/879810.2147/IJICMR.S14331engUniversidade de São PauloBothrops erythromelas snake venom induces a proinflammatory response in mice splenocytesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Aggeu Magalhães Departamento de Imunologia. Pernambuco, Brazil/Universidade Estadual da Paraíba. Campina Grande, Brazil;Fundação Oswaldo Cruz. Instituto Aggeu Magalhães Departamento de Imunologia. Pernambuco, Brazil;Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto Aggeu Magalhães Departamento de Imunologia. Pernambuco, Brazil;Snake venom is a complex biological mixture used for immobilization and killing of prey for alimentation. Many effects are inflicted by this venom, such as coagulation, necrosis, bleeding, inflammation, and shock. This study aimed to evaluate the inflammatory activity promoted by Bothrops erythromelas and Crotalus durissus cascavella snake venom. It was observed that both B. erythromelas and C. d. cascavella venom induced higher interferon-gamma and interleukin-6 production. Nitric oxide (NO) was significantly produced only by B.erythromelas venom, which also showed a higher rate of cell death induction when compared with C. d. cascavella. Results showed that B. erythromelas and C. d. cascavella venom induced distinct response in vitro through cytokines and NO production. However, B. erythromelasinduces a proinflammatory response and a higher rate of cell death in relation to C. d. cascavella venom.snake venomBothropsnitric oxidenecrosisCrotalusinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8798/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALBothrops erythromelas snake venom induces a proinflammatory response in mice splenocytes.pdfBothrops erythromelas snake venom induces a proinflammatory response in mice splenocytes.pdfapplication/pdf345490https://www.arca.fiocruz.br/bitstream/icict/8798/2/Bothrops%20erythromelas%20snake%20venom%20induces%20a%20proinflammatory%20response%20in%20mice%20splenocytes.pdff76d0d934776525562cdec7f12fbb45dMD52TEXTBothrops erythromelas snake venom induces a proinflammatory response in mice splenocytes.pdf.txtBothrops erythromelas snake venom induces a proinflammatory response in mice splenocytes.pdf.txtExtracted texttext/plain47035https://www.arca.fiocruz.br/bitstream/icict/8798/3/Bothrops%20erythromelas%20snake%20venom%20induces%20a%20proinflammatory%20response%20in%20mice%20splenocytes.pdf.txt691c567310f0297e70ff5cb1bf0589d5MD53icict/87982019-06-19 10:12:21.435oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-06-19T13:12:21Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Bothrops erythromelas snake venom induces a proinflammatory response in mice splenocytes
title Bothrops erythromelas snake venom induces a proinflammatory response in mice splenocytes
spellingShingle Bothrops erythromelas snake venom induces a proinflammatory response in mice splenocytes
Luna, Karla Patrícia de Oliveira
snake venom
Bothrops
nitric oxide
necrosis
Crotalus
title_short Bothrops erythromelas snake venom induces a proinflammatory response in mice splenocytes
title_full Bothrops erythromelas snake venom induces a proinflammatory response in mice splenocytes
title_fullStr Bothrops erythromelas snake venom induces a proinflammatory response in mice splenocytes
title_full_unstemmed Bothrops erythromelas snake venom induces a proinflammatory response in mice splenocytes
title_sort Bothrops erythromelas snake venom induces a proinflammatory response in mice splenocytes
author Luna, Karla Patrícia de Oliveira
author_facet Luna, Karla Patrícia de Oliveira
Melo, Cristiane ML
Pascoal, Vanessa Peruhype Magalhães
Martins Filho, Olindo Assis
Pereira, Valéria Rêgo Alves
author_role author
author2 Melo, Cristiane ML
Pascoal, Vanessa Peruhype Magalhães
Martins Filho, Olindo Assis
Pereira, Valéria Rêgo Alves
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Luna, Karla Patrícia de Oliveira
Melo, Cristiane ML
Pascoal, Vanessa Peruhype Magalhães
Martins Filho, Olindo Assis
Pereira, Valéria Rêgo Alves
dc.subject.en.pt_BR.fl_str_mv snake venom
Bothrops
nitric oxide
necrosis
Crotalus
topic snake venom
Bothrops
nitric oxide
necrosis
Crotalus
description Fundação Oswaldo Cruz. Instituto Aggeu Magalhães Departamento de Imunologia. Pernambuco, Brazil/Universidade Estadual da Paraíba. Campina Grande, Brazil;
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2014-11-12T12:19:19Z
dc.date.available.fl_str_mv 2014-11-12T12:19:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LUNA, Karla Patrícia de Oliveira et al. Bothrops erythromelas snake venom induces a proinflammatory response in mice splenocytes. International Journal of Interferon, cytokine and mediator research, volume 3 p. 9-18, 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8798
dc.identifier.issn.none.fl_str_mv 1179-139X
dc.identifier.doi.none.fl_str_mv 10.2147/IJICMR.S14331
identifier_str_mv LUNA, Karla Patrícia de Oliveira et al. Bothrops erythromelas snake venom induces a proinflammatory response in mice splenocytes. International Journal of Interferon, cytokine and mediator research, volume 3 p. 9-18, 2011.
1179-139X
10.2147/IJICMR.S14331
url https://www.arca.fiocruz.br/handle/icict/8798
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/8798/1/license.txt
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