Reorganization of metabolism during cardiomyogenesis implies time-specific signaling pathway regulation

Detalhes bibliográficos
Autor(a) principal: Barisón, María Julia
Data de Publicação: 2021
Outros Autores: Pereira, Isabela Tiemy, Robert, Anny Waloski, Dallagiovanna, Bruno
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/46362
https://doi.org/10.3390/ ijms22031330
Resumo: Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.
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spelling Barisón, María JuliaPereira, Isabela TiemyRobert, Anny WaloskiDallagiovanna, Bruno2021-03-15T15:18:04Z2021-03-15T15:18:04Z2021Barisón, Maria Julia et al. Reorganization of metabolism during cardiomyogenesis implies time-specific signaling pathway regulation. Int. J. Mol. Sci., v. 22, n.1330, p. 1-27, 2021.Barisón, Maria Julia et al. Reorganization of metabolism during cardiomyogenesis implies time-specific signaling pathway regulation. Int. J. Mol. Sci., v. 22, n.1330, p. 1-27, 2021.1422-0067https://www.arca.fiocruz.br/handle/icict/46362https://doi.org/10.3390/ ijms22031330porMDPIReorganization of metabolism during cardiomyogenesis implies time-specific signaling pathway regulationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.Understanding the cell differentiation process involves the characterization of signaling and regulatory pathways. The coordinated action involved in multilevel regulation determines the commitment of stem cells and their differentiation into a specific cell lineage. Cellular metabolism plays a relevant role in modulating the expression of genes, which act as sensors of the extra-and intracellular environment. In this work, we analyzed mRNAs associated with polysomes by focusing on the expression profile of metabolism-related genes during the cardiac differentiation of human embryonic stem cells (hESCs). We compared different time points during cardiac differentiation (pluripotency, embryoid body aggregation, cardiac mesoderm, cardiac progenitor and cardiomyocyte) and showed the immature cell profile of energy metabolism. Highly regulated canonical pathways are thoroughly discussed, such as those involved in metabolic signaling and lipid homeostasis. We reveal the critical relevance of retinoic X receptor (RXR) heterodimers in upstream retinoic acid metabolism and their relationship with thyroid hormone signaling. Additionally, we highlight the importance of lipid homeostasis and extracellular matrix component biosynthesis during cardiomyogenesis, providing new insights into how hESCs reorganize their metabolism during in vitro cardiac differentiation.Cell DifferentiationMyocytes, CardiacMetabolismHomeostasisHuman Embryonic Stem CellsDiferenciación CelularMiocitos CardíacosCélulas Madre Embrionarias HumanasDifférenciation cellulaireMyocytes cardiaquesMétabolismeHoméostasieCellules souches embryonnaires humainesDiferenciação CelularMiócitos CardíacosMetabolismoHomeostaseCélulas-Tronco Embrionárias Humanasinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Reorganization of metabolism during cardiomyogenesis implies time-specific signaling pathway regulation
title Reorganization of metabolism during cardiomyogenesis implies time-specific signaling pathway regulation
spellingShingle Reorganization of metabolism during cardiomyogenesis implies time-specific signaling pathway regulation
Barisón, María Julia
Cell Differentiation
Myocytes, Cardiac
Metabolism
Homeostasis
Human Embryonic Stem Cells
Diferenciación Celular
Miocitos Cardíacos
Células Madre Embrionarias Humanas
Différenciation cellulaire
Myocytes cardiaques
Métabolisme
Homéostasie
Cellules souches embryonnaires humaines
Diferenciação Celular
Miócitos Cardíacos
Metabolismo
Homeostase
Células-Tronco Embrionárias Humanas
title_short Reorganization of metabolism during cardiomyogenesis implies time-specific signaling pathway regulation
title_full Reorganization of metabolism during cardiomyogenesis implies time-specific signaling pathway regulation
title_fullStr Reorganization of metabolism during cardiomyogenesis implies time-specific signaling pathway regulation
title_full_unstemmed Reorganization of metabolism during cardiomyogenesis implies time-specific signaling pathway regulation
title_sort Reorganization of metabolism during cardiomyogenesis implies time-specific signaling pathway regulation
author Barisón, María Julia
author_facet Barisón, María Julia
Pereira, Isabela Tiemy
Robert, Anny Waloski
Dallagiovanna, Bruno
author_role author
author2 Pereira, Isabela Tiemy
Robert, Anny Waloski
Dallagiovanna, Bruno
author2_role author
author
author
dc.contributor.author.fl_str_mv Barisón, María Julia
Pereira, Isabela Tiemy
Robert, Anny Waloski
Dallagiovanna, Bruno
dc.subject.en.pt_BR.fl_str_mv Cell Differentiation
Myocytes, Cardiac
Metabolism
Homeostasis
Human Embryonic Stem Cells
topic Cell Differentiation
Myocytes, Cardiac
Metabolism
Homeostasis
Human Embryonic Stem Cells
Diferenciación Celular
Miocitos Cardíacos
Células Madre Embrionarias Humanas
Différenciation cellulaire
Myocytes cardiaques
Métabolisme
Homéostasie
Cellules souches embryonnaires humaines
Diferenciação Celular
Miócitos Cardíacos
Metabolismo
Homeostase
Células-Tronco Embrionárias Humanas
dc.subject.es.pt_BR.fl_str_mv Diferenciación Celular
Miocitos Cardíacos
Células Madre Embrionarias Humanas
dc.subject.fr.pt_BR.fl_str_mv Différenciation cellulaire
Myocytes cardiaques
Métabolisme
Homéostasie
Cellules souches embryonnaires humaines
dc.subject.decs.pt_BR.fl_str_mv Diferenciação Celular
Miócitos Cardíacos
Metabolismo
Homeostase
Células-Tronco Embrionárias Humanas
description Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-03-15T15:18:04Z
dc.date.available.fl_str_mv 2021-03-15T15:18:04Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Barisón, Maria Julia et al. Reorganization of metabolism during cardiomyogenesis implies time-specific signaling pathway regulation. Int. J. Mol. Sci., v. 22, n.1330, p. 1-27, 2021.Barisón, Maria Julia et al. Reorganization of metabolism during cardiomyogenesis implies time-specific signaling pathway regulation. Int. J. Mol. Sci., v. 22, n.1330, p. 1-27, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/46362
dc.identifier.issn.pt_BR.fl_str_mv 1422-0067
dc.identifier.doi.none.fl_str_mv https://doi.org/10.3390/ ijms22031330
identifier_str_mv Barisón, Maria Julia et al. Reorganization of metabolism during cardiomyogenesis implies time-specific signaling pathway regulation. Int. J. Mol. Sci., v. 22, n.1330, p. 1-27, 2021.Barisón, Maria Julia et al. Reorganization of metabolism during cardiomyogenesis implies time-specific signaling pathway regulation. Int. J. Mol. Sci., v. 22, n.1330, p. 1-27, 2021.
1422-0067
url https://www.arca.fiocruz.br/handle/icict/46362
https://doi.org/10.3390/ ijms22031330
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/46362/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/46362/2/ijms-22-01ok.pdf
https://www.arca.fiocruz.br/bitstream/icict/46362/3/ijms-22-01ok.pdf.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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