Immune reconstitution syndrome in patients treated for HIV and tuberculosis in Rio de Janeiro

Detalhes bibliográficos
Autor(a) principal: Serra, Fabiana C.
Data de Publicação: 2007
Outros Autores: Hadad, David, Orofino, Renata L., Marinho, Flavia, Lourenço, Cristina, Morgado, Mariza, Rolla, Valeria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/57113
Resumo: Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
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spelling Serra, Fabiana C.Hadad, DavidOrofino, Renata L.Marinho, FlaviaLourenço, CristinaMorgado, MarizaRolla, Valeria2023-02-24T19:00:28Z2023-02-24T19:00:28Z2007SERRA, Fabiana C. et al. Immune reconstitution syndrome in patients treated for HIV and tuberculosis in Rio de Janeiro. The Brazilian Journal of Infectious Diseases, v. 11, n. 5, p. 458-461, Oct. 2007.1413-8670https://www.arca.fiocruz.br/handle/icict/5711310.1590/S1413-867020070005000041678-4391engBrazilian Society of Infectious DiseasesImmune reconstitution syndrome in patients treated for HIV and tuberculosis in Rio de Janeiroinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Espírito Santo. Center of Infectious Diseases. Vitória, ES, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratory of Immunology in HIV/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.We made a retrospective longitudinal study from January 2000 to January 2003 to examine cases of immune reconstitution syndrome (IRS) and its incidence rate in tuberculosis (TB)-human immunodeficiency virus (HIV) co-infected patients. The incidence rate (IR) was calculated using a Poisson regression. The confidence interval (CI) that was stipulated was 95%. IRS occurred in 10/84 HIV and TB-positive patients; nine of them were on highly active anti-retroviral therapy (HAART) during a mean of 61.7 (±59) days following the introduction of antiretrovirals. Lymph-node enlargement was the sole clinical manifestation. CD4 counts were <100 cells/mm³in 50% of the patients, at the time of TB diagnosis. All but two patients were treated with prednisone, and recovered from TB within a mean of 91 days (±30 days). One relapse of TB was observed, but there were no IRS-related deaths. The incidence rate was higher (IR=11.18; CI, 1.41-88.76) in patients that had superficial lymph node enlargement at the moment of TB diagnosis (not associated with TB), extrapulmonary TB (IR=1.97; CI, 0.44-8.79), were antiretroviral naive (IR=1.85; CI, 0.48-7.16), and CD4 counts <100 cells/mm³ (IR=1.50; CI, 0.40-5.59), although with a wide CI. IRS was frequent in our sample, occurred more frequently in HIV-naive patients with lymph-node enlargement and extrapulmonary TB. No cases of new pulmonary lesions or worsening of pulmonary infiltrates were observed.AIDSImmune reconstitution syndromeTuberculosisHAARTLymph node enlargementParadoxical reactioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALve_Serra_Fabiana_etal_INI_IOC_2007.pdfve_Serra_Fabiana_etal_INI_IOC_2007.pdfapplication/pdf34365https://www.arca.fiocruz.br/bitstream/icict/57113/2/ve_Serra_Fabiana_etal_INI_IOC_2007.pdfd2762bb439e64a651dbab2980683c8ccMD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/57113/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/571132023-09-04 11:30:22.444oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-04T14:30:22Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Immune reconstitution syndrome in patients treated for HIV and tuberculosis in Rio de Janeiro
title Immune reconstitution syndrome in patients treated for HIV and tuberculosis in Rio de Janeiro
spellingShingle Immune reconstitution syndrome in patients treated for HIV and tuberculosis in Rio de Janeiro
Serra, Fabiana C.
AIDS
Immune reconstitution syndrome
Tuberculosis
HAART
Lymph node enlargement
Paradoxical reaction
title_short Immune reconstitution syndrome in patients treated for HIV and tuberculosis in Rio de Janeiro
title_full Immune reconstitution syndrome in patients treated for HIV and tuberculosis in Rio de Janeiro
title_fullStr Immune reconstitution syndrome in patients treated for HIV and tuberculosis in Rio de Janeiro
title_full_unstemmed Immune reconstitution syndrome in patients treated for HIV and tuberculosis in Rio de Janeiro
title_sort Immune reconstitution syndrome in patients treated for HIV and tuberculosis in Rio de Janeiro
author Serra, Fabiana C.
author_facet Serra, Fabiana C.
Hadad, David
Orofino, Renata L.
Marinho, Flavia
Lourenço, Cristina
Morgado, Mariza
Rolla, Valeria
author_role author
author2 Hadad, David
Orofino, Renata L.
Marinho, Flavia
Lourenço, Cristina
Morgado, Mariza
Rolla, Valeria
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Serra, Fabiana C.
Hadad, David
Orofino, Renata L.
Marinho, Flavia
Lourenço, Cristina
Morgado, Mariza
Rolla, Valeria
dc.subject.en.en_US.fl_str_mv AIDS
Immune reconstitution syndrome
Tuberculosis
HAART
Lymph node enlargement
Paradoxical reaction
topic AIDS
Immune reconstitution syndrome
Tuberculosis
HAART
Lymph node enlargement
Paradoxical reaction
description Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2023-02-24T19:00:28Z
dc.date.available.fl_str_mv 2023-02-24T19:00:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SERRA, Fabiana C. et al. Immune reconstitution syndrome in patients treated for HIV and tuberculosis in Rio de Janeiro. The Brazilian Journal of Infectious Diseases, v. 11, n. 5, p. 458-461, Oct. 2007.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/57113
dc.identifier.issn.en_US.fl_str_mv 1413-8670
dc.identifier.doi.none.fl_str_mv 10.1590/S1413-86702007000500004
dc.identifier.eissn.none.fl_str_mv 1678-4391
identifier_str_mv SERRA, Fabiana C. et al. Immune reconstitution syndrome in patients treated for HIV and tuberculosis in Rio de Janeiro. The Brazilian Journal of Infectious Diseases, v. 11, n. 5, p. 458-461, Oct. 2007.
1413-8670
10.1590/S1413-86702007000500004
1678-4391
url https://www.arca.fiocruz.br/handle/icict/57113
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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