Hyperresistinemia in obese female dogs with mammary carcinoma in benign-mixed tumors and its correlation with tumor aggressiveness and survival

Detalhes bibliográficos
Autor(a) principal: Nicchio, Bianca Oliveira
Data de Publicação: 2020
Outros Autores: Melo, Stella Maria Barrouin, Machado, Marilia Carneiro, Vieira Filho, Carlos Humberto, Santos, Ferlando Lima, Martins Filho, Emanoel Ferreira, Barbosa, Vivian Fernanda, Barral, Thiago Doria, Portela, Ricardo Wagner, Damasceno, Karine Araújo, Lima, Alessandra Estrela
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/44011
Resumo: Bahia Research Foundation (FAPESB), 023/2014 PROINTER. BN was a M.Sc. fellow the Coordination for the Improvement of Higher Education Personnel (CAPES - Proc. 1803306). EM-F was a postdoctoral fellow from CAPES (Proc. 88887.310811/2018-00). AE-L (Proc. 305938/2018-5), FS (Proc. 305938/2018-5), and SB-M (Proc. 307813/2018-5) are Research fellows from the National Council for Scientific and Technological Development (CNPq). RP is a Technological Development fellow from CNPq (Proc. 313350/2019-1).
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spelling Nicchio, Bianca OliveiraMelo, Stella Maria BarrouinMachado, Marilia CarneiroVieira Filho, Carlos HumbertoSantos, Ferlando LimaMartins Filho, Emanoel FerreiraBarbosa, Vivian FernandaBarral, Thiago DoriaPortela, Ricardo WagnerDamasceno, Karine AraújoLima, Alessandra Estrela2020-10-16T17:40:14Z2020-10-16T17:40:14Z2020NICCHIO, Bianca Oliveira et al. Hyperresistinemia in obese female dogs with mammary carcinoma in benign-mixed tumors and its correlation with tumor aggressiveness and survival. Frontiers in Veterinary Science, v. 7, n. 509, p. 1-14, 13 Aug. 2020.2297-1769https://www.arca.fiocruz.br/handle/icict/4401110.3389/fvets.2020.00509Bahia Research Foundation (FAPESB), 023/2014 PROINTER. BN was a M.Sc. fellow the Coordination for the Improvement of Higher Education Personnel (CAPES - Proc. 1803306). EM-F was a postdoctoral fellow from CAPES (Proc. 88887.310811/2018-00). AE-L (Proc. 305938/2018-5), FS (Proc. 305938/2018-5), and SB-M (Proc. 307813/2018-5) are Research fellows from the National Council for Scientific and Technological Development (CNPq). RP is a Technological Development fellow from CNPq (Proc. 313350/2019-1).Federal University of Bahia. School of Veterinary Medicine. Salvador, BA, Brazil / Federal University of Bahia. Research Center on Mammary Oncology. Salvador, BA, Brazil.Federal University of Bahia. School of Veterinary Medicine. Salvador, BA, Brazil.Federal University of Bahia. School of Veterinary Medicine. Salvador, BA, Brazil / Federal University of Bahia. Research Center on Mammary Oncology. Salvador, BA, Brazil.Federal University of Bahia. School of Veterinary Medicine. Salvador, BA, Brazil / Federal University of Bahia. Research Center on Mammary Oncology. Salvador, BA, Brazil.Federal University of the Recôncavo of Bahia. Health Science Center. Santo Antônio de Jesus, BA, Brazil.Federal University of Bahia. School of Veterinary Medicine. Salvador, BA, Brazil / Federal University of Bahia. Research Center on Mammary Oncology. Salvador, BA, Brazil.Federal University of Bahia. School of Veterinary Medicine. Salvador, BA, Brazil.Federal University of Bahia. Institute of Health Sciences. Laboratory of Immunology and Molecular Biology. Salvador, BA, Brazil.Federal University of Bahia. Research Center on Mammary Oncology. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil.Federal University of Bahia. School of Veterinary Medicine. Salvador, BA, Brazil / Federal University of Bahia. Research Center on Mammary Oncology. Salvador, BA, Brazil.Resistin is associated with metabolic, inflammatory, and neoplastic disorders, and is also considered a prognostic marker in human oncology. Canine mammary tumors have epidemiological, clinical, biological, and genetic characteristics similar to those of women and are proposed as a comparative study model. Here, we evaluate the serum levels of resistin in female dogs with or without mammary carcinoma in mixed tumors (CBMT) and its correlation with the proliferative potential of the tumor, obesity, and survival. Eighty dogs grouped according to the presence (50) or absence (30) of CBMT, reproductive status and body condition were assessed for weight, fat percentage, and canine body mass index. The characteristic of the proliferative potential of the tumor (Ki-67) was evaluated. Ki-67 levels (p = 0.024), staging (p = 0.004), and grade (p = 0.016) influenced the survival of the female dogs. Through a multifactorial analysis, it could be seen that the parameters proliferation index (Ki-67) (p = 0.044) and staging (p = 0.036) influenced the survival of the animals. Neutered and overweight dogs from the control and CBMT groups showed hyperresistinemia. Ki-67 expression and resistin levels in dogs with CBMT were higher in overweight dogs than in dogs with normal weight (p = 0.0001). The survival rate of dogs with CBMT, obese and with high levels of resistin (8,400 µg L−1) was lower when compared to those with lower levels of resistin. These results showed an important relationship between hyperresistinemia, tumor proliferative potential and excessive body fat, suggesting that resistin levels may act as an interesting prognostic marker in patients with CBMT.engFrontiers MediaCitocinasKi-67Câncer mamárioSobrevivênciaObesidadeAdipocytokinesKi-67Mammary cancerSurvivalObesityPrognostic markerHyperresistinemia in obese female dogs with mammary carcinoma in benign-mixed tumors and its correlation with tumor aggressiveness and survivalinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/44011/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALNicchio, Bianca Oliveira. Hyperresistinemia....pdfNicchio, Bianca Oliveira. Hyperresistinemia....pdfapplication/pdf2013045https://www.arca.fiocruz.br/bitstream/icict/44011/2/Nicchio%2c%20Bianca%20Oliveira.%20Hyperresistinemia....pdf92280cfc93bdbb01d27d13cbb00f601eMD52TEXTNicchio, Bianca Oliveira. Hyperresistinemia....pdf.txtNicchio, Bianca Oliveira. Hyperresistinemia....pdf.txtExtracted texttext/plain62887https://www.arca.fiocruz.br/bitstream/icict/44011/3/Nicchio%2c%20Bianca%20Oliveira.%20Hyperresistinemia....pdf.txt491414e60186fa6a264bf4321cd1d37cMD53icict/440112023-03-15 14:34:25.864oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:25Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en.fl_str_mv Hyperresistinemia in obese female dogs with mammary carcinoma in benign-mixed tumors and its correlation with tumor aggressiveness and survival
title Hyperresistinemia in obese female dogs with mammary carcinoma in benign-mixed tumors and its correlation with tumor aggressiveness and survival
spellingShingle Hyperresistinemia in obese female dogs with mammary carcinoma in benign-mixed tumors and its correlation with tumor aggressiveness and survival
Nicchio, Bianca Oliveira
Citocinas
Ki-67
Câncer mamário
Sobrevivência
Obesidade
Adipocytokines
Ki-67
Mammary cancer
Survival
Obesity
Prognostic marker
title_short Hyperresistinemia in obese female dogs with mammary carcinoma in benign-mixed tumors and its correlation with tumor aggressiveness and survival
title_full Hyperresistinemia in obese female dogs with mammary carcinoma in benign-mixed tumors and its correlation with tumor aggressiveness and survival
title_fullStr Hyperresistinemia in obese female dogs with mammary carcinoma in benign-mixed tumors and its correlation with tumor aggressiveness and survival
title_full_unstemmed Hyperresistinemia in obese female dogs with mammary carcinoma in benign-mixed tumors and its correlation with tumor aggressiveness and survival
title_sort Hyperresistinemia in obese female dogs with mammary carcinoma in benign-mixed tumors and its correlation with tumor aggressiveness and survival
author Nicchio, Bianca Oliveira
author_facet Nicchio, Bianca Oliveira
Melo, Stella Maria Barrouin
Machado, Marilia Carneiro
Vieira Filho, Carlos Humberto
Santos, Ferlando Lima
Martins Filho, Emanoel Ferreira
Barbosa, Vivian Fernanda
Barral, Thiago Doria
Portela, Ricardo Wagner
Damasceno, Karine Araújo
Lima, Alessandra Estrela
author_role author
author2 Melo, Stella Maria Barrouin
Machado, Marilia Carneiro
Vieira Filho, Carlos Humberto
Santos, Ferlando Lima
Martins Filho, Emanoel Ferreira
Barbosa, Vivian Fernanda
Barral, Thiago Doria
Portela, Ricardo Wagner
Damasceno, Karine Araújo
Lima, Alessandra Estrela
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nicchio, Bianca Oliveira
Melo, Stella Maria Barrouin
Machado, Marilia Carneiro
Vieira Filho, Carlos Humberto
Santos, Ferlando Lima
Martins Filho, Emanoel Ferreira
Barbosa, Vivian Fernanda
Barral, Thiago Doria
Portela, Ricardo Wagner
Damasceno, Karine Araújo
Lima, Alessandra Estrela
dc.subject.other.pt_BR.fl_str_mv Citocinas
Ki-67
Câncer mamário
Sobrevivência
Obesidade
topic Citocinas
Ki-67
Câncer mamário
Sobrevivência
Obesidade
Adipocytokines
Ki-67
Mammary cancer
Survival
Obesity
Prognostic marker
dc.subject.en.pt_BR.fl_str_mv Adipocytokines
Ki-67
Mammary cancer
Survival
Obesity
Prognostic marker
description Bahia Research Foundation (FAPESB), 023/2014 PROINTER. BN was a M.Sc. fellow the Coordination for the Improvement of Higher Education Personnel (CAPES - Proc. 1803306). EM-F was a postdoctoral fellow from CAPES (Proc. 88887.310811/2018-00). AE-L (Proc. 305938/2018-5), FS (Proc. 305938/2018-5), and SB-M (Proc. 307813/2018-5) are Research fellows from the National Council for Scientific and Technological Development (CNPq). RP is a Technological Development fellow from CNPq (Proc. 313350/2019-1).
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-10-16T17:40:14Z
dc.date.available.fl_str_mv 2020-10-16T17:40:14Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv NICCHIO, Bianca Oliveira et al. Hyperresistinemia in obese female dogs with mammary carcinoma in benign-mixed tumors and its correlation with tumor aggressiveness and survival. Frontiers in Veterinary Science, v. 7, n. 509, p. 1-14, 13 Aug. 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/44011
dc.identifier.issn.pt_BR.fl_str_mv 2297-1769
dc.identifier.doi.pt_BR.fl_str_mv 10.3389/fvets.2020.00509
identifier_str_mv NICCHIO, Bianca Oliveira et al. Hyperresistinemia in obese female dogs with mammary carcinoma in benign-mixed tumors and its correlation with tumor aggressiveness and survival. Frontiers in Veterinary Science, v. 7, n. 509, p. 1-14, 13 Aug. 2020.
2297-1769
10.3389/fvets.2020.00509
url https://www.arca.fiocruz.br/handle/icict/44011
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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