GATA-3 expression and its correlation with prognostic factors and survival in canine mammary tumors
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/60829 |
Resumo: | Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). |
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Gonçalves, Gabriel Saraiva DinizHielm-Björkman, AnnaSilva, Vanessa Bonfim daRibeiro, Lorena Gabriela RochaVieira Filho, Carlos Humberto da CostaSilva, Laís PereiraMelo, Stella Maria BarrouinCassali, Geovanni DantasDamasceno, Karine AraújoLima, Alessandra Estrela2023-10-18T14:23:59Z2023-10-18T14:23:59Z2023GONÇALVES, Gabriel Saraiva Diniz et al. GATA-3 expression and its correlation with prognostic factors and survival in canine mammary tumors. Frontiers in Veterinary Science, v. 10, p. 1-12, 2023.2297-1769https://www.arca.fiocruz.br/handle/icict/6082910.3389/fvets.2023.1179808Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).Universidade Federal da Bahia. Centro de Pesquisa em Oncologia Mamária NPqOM/HOSPMEV. Salvador, BA, Brasil.DogRisk Research Group. Department of Equine and Small Animal Medicine. Faculty of Veterinary Medicine. University of Helsinki. Helsinki, Finland.Universidade Federal da Bahia. Centro de Pesquisa em Oncologia Mamária NPqOM/HOSPMEV. Salvador, BA, Brasil.Universidade Federal de Sergipe. Departamento de Medicina Veterinária. Laboratório de Patologia Animal. São Cristóvão, SE, Brasil.Universidade Federal da Bahia. Centro de Pesquisa em Oncologia Mamária NPqOM/HOSPMEV. Salvador, BA, Brasil.Universidade Federal da Bahia. Centro de Pesquisa em Oncologia Mamária NPqOM/HOSPMEV. Salvador, BA, Brasil.DogRisk Research Group. Department of Equine and Small Animal Medicine. Faculty of Veterinary Medicine. University of Helsinki. Helsinki, Finland / Universidade Federal da Bahia. Faculdade de Medicina Veterinária e Zootecnia. Departamento de Anatomia, Patologia e Clínica Veterinária. Salvador, BA, Brasil.Universidade Federal de Minas Gerais. Departamento de Patologia Geral. Laboratório de Patologia Comparada. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil.Universidade Federal da Bahia. Centro de Pesquisa em Oncologia Mamária NPqOM/HOSPMEV. Salvador, BA, Brasil / DogRisk Research Group. Department of Equine and Small Animal Medicine. Faculty of Veterinary Medicine. University of Helsinki. Helsinki, Finland / Universidade Federal da Bahia. Faculdade de Medicina Veterinária e Zootecnia. Departamento de Anatomia, Patologia e Clínica Veterinária. Salvador, BA, Brasil.Introduction: The transcription factor GATA-3 plays a significant role in mammary gland development and differentiation. Recent studies on human oncology have demonstrated its association with favorable pathologic factors in breast cancer. Canine mammary tumours, proposed as comparative and translational study models, have epidemiological, clinical, biological, and genetic characteristics similar to those of human breast cancers. Methods: Here, we evaluated the frequency of GATA-3 expression in mammary tumors of dogs and its relationship with prognostic factors and survival. Tumor samples were obtained from 40 female dogs and grouped according to histological type into benign tumors (n = 10), carcinoma in mixed tumors (CMTs) (n = 20), and aggressive tumors (n = 10). CMTs were further separated according to histological grade, and data on clinical staging and diagnosis, histopathological grading, and survival rate were collected. Results: GATA-3 and estrogen receptor (ER) expression were higher in benign and well-differentiated carcinomas than in aggressive tumors, which showed greater Ki-67 expression. The expression rate of ER in the studied groups was equivalent to that of GATA-3. We identified a strong positive correlation between GATA-3 and ER expression frequencies and a negative correlation between those of GATA-3 and Ki-67. There were associations between GATA-3 (p < 0.001), Ki-67 (p = 0.003), tumor size (p < 0.001), clinical stage (p = 0.002), lymph node metastasis (p < 0.001), and histological grade (p < 0.001) by univariate survival analysis. The parameters ER (p = 0.015) and GATA-3 (p = 0.005) also influenced survival in a multifactorial manner. Discussion: Kaplan–Meier analysis of survival curves validated our previous findings that dogs with GATA-3 expression in ≥79.4% of cells had significantly higher survival rates (p < 0.001). The performance analysis showed that the expression of GATA-3 in ≥79.4% of cells effectively predicted survival or death in dogs with mammary tumors. Collectively, these results suggest that GATA-3 can be a relevant marker in the study of mammary tumor progression and has potential as a prognosis marker for predicting outcomes in canine mammary tumors.engFrontiers MediaCâncer de mamaFator de transcriçãoBiomarcador prognósticoProgressão tumoralSobrevivênciaTumores mamários caninosBreast cancerTranscription factorPrognostic biomarkerTumor progressionSurvivalCanine mammary tumorsNeoplasias da MamaBiomarcadoresSobrevivênciaCãesGATA-3 expression and its correlation with prognostic factors and survival in canine mammary tumorsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/60829/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALGonçalves, Gabriel S. D. - GATA-3 expression and its correlation with prognostic factors and survival in canine mammary tumors.pdfGonçalves, Gabriel S. D. - GATA-3 expression and its correlation with prognostic factors and survival in canine mammary tumors.pdfapplication/pdf2191708https://www.arca.fiocruz.br/bitstream/icict/60829/2/Gon%c3%a7alves%2c%20Gabriel%20S.%20D.%20-%20GATA-3%20expression%20and%20its%20correlation%20with%20prognostic%20factors%20and%20survival%20in%20canine%20mammary%20tumors.pdf3c0b8f10623a38d2fa618f6e48cc9ff9MD52icict/608292023-10-18 11:24:00.036oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-10-18T14:24Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
GATA-3 expression and its correlation with prognostic factors and survival in canine mammary tumors |
| title |
GATA-3 expression and its correlation with prognostic factors and survival in canine mammary tumors |
| spellingShingle |
GATA-3 expression and its correlation with prognostic factors and survival in canine mammary tumors Gonçalves, Gabriel Saraiva Diniz Câncer de mama Fator de transcrição Biomarcador prognóstico Progressão tumoral Sobrevivência Tumores mamários caninos Breast cancer Transcription factor Prognostic biomarker Tumor progression Survival Canine mammary tumors Neoplasias da Mama Biomarcadores Sobrevivência Cães |
| title_short |
GATA-3 expression and its correlation with prognostic factors and survival in canine mammary tumors |
| title_full |
GATA-3 expression and its correlation with prognostic factors and survival in canine mammary tumors |
| title_fullStr |
GATA-3 expression and its correlation with prognostic factors and survival in canine mammary tumors |
| title_full_unstemmed |
GATA-3 expression and its correlation with prognostic factors and survival in canine mammary tumors |
| title_sort |
GATA-3 expression and its correlation with prognostic factors and survival in canine mammary tumors |
| author |
Gonçalves, Gabriel Saraiva Diniz |
| author_facet |
Gonçalves, Gabriel Saraiva Diniz Hielm-Björkman, Anna Silva, Vanessa Bonfim da Ribeiro, Lorena Gabriela Rocha Vieira Filho, Carlos Humberto da Costa Silva, Laís Pereira Melo, Stella Maria Barrouin Cassali, Geovanni Dantas Damasceno, Karine Araújo Lima, Alessandra Estrela |
| author_role |
author |
| author2 |
Hielm-Björkman, Anna Silva, Vanessa Bonfim da Ribeiro, Lorena Gabriela Rocha Vieira Filho, Carlos Humberto da Costa Silva, Laís Pereira Melo, Stella Maria Barrouin Cassali, Geovanni Dantas Damasceno, Karine Araújo Lima, Alessandra Estrela |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Gonçalves, Gabriel Saraiva Diniz Hielm-Björkman, Anna Silva, Vanessa Bonfim da Ribeiro, Lorena Gabriela Rocha Vieira Filho, Carlos Humberto da Costa Silva, Laís Pereira Melo, Stella Maria Barrouin Cassali, Geovanni Dantas Damasceno, Karine Araújo Lima, Alessandra Estrela |
| dc.subject.other.en_US.fl_str_mv |
Câncer de mama Fator de transcrição Biomarcador prognóstico Progressão tumoral Sobrevivência Tumores mamários caninos |
| topic |
Câncer de mama Fator de transcrição Biomarcador prognóstico Progressão tumoral Sobrevivência Tumores mamários caninos Breast cancer Transcription factor Prognostic biomarker Tumor progression Survival Canine mammary tumors Neoplasias da Mama Biomarcadores Sobrevivência Cães |
| dc.subject.en.en_US.fl_str_mv |
Breast cancer Transcription factor Prognostic biomarker Tumor progression Survival Canine mammary tumors |
| dc.subject.decs.en_US.fl_str_mv |
Neoplasias da Mama Biomarcadores Sobrevivência Cães |
| description |
Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). |
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2023 |
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2023-10-18T14:23:59Z |
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2023-10-18T14:23:59Z |
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2023 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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GONÇALVES, Gabriel Saraiva Diniz et al. GATA-3 expression and its correlation with prognostic factors and survival in canine mammary tumors. Frontiers in Veterinary Science, v. 10, p. 1-12, 2023. |
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https://www.arca.fiocruz.br/handle/icict/60829 |
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2297-1769 |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fvets.2023.1179808 |
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GONÇALVES, Gabriel Saraiva Diniz et al. GATA-3 expression and its correlation with prognostic factors and survival in canine mammary tumors. Frontiers in Veterinary Science, v. 10, p. 1-12, 2023. 2297-1769 10.3389/fvets.2023.1179808 |
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Frontiers Media |
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Frontiers Media |
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