Gene-environment interaction in molar incisor hypomineralizatio
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/49057 |
Resumo: | Department of Oral Biology, University of Pittsburgh, Pittsburgh, Pennsylvania. USA. |
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Bezamat, MarianaSouza, Juliana F.Silva, Fernanda M. F.Corrêa, Emilly G.Fatturi, Aluhe L.Brancher, João A.Carvalho, Flávia M.Cavallari, TaylaBertolazo, LaísSouza, Cleber MachadoKoruyucu, MineBayram, MerveRacic, AndreaHarrison, Benjamin M.Sweat, Yan Y.Letra, AriadneStuden-Pavlovich, DeborahSeymen, FigenAmendt, BradWerneck, Rebata I.Costa, Marcelo C.Modesto, AdrianaVieira, Alexandre R.2021-09-12T18:20:26Z2021-09-12T18:20:26Z2021BENZAMAT, Mariana et al. Gene-environment interaction in molar incisor hypomineralization. Plos One, v. 16, n. 1, e0241898, 16 p, Jan. 2021.1932-6203https://www.arca.fiocruz.br/handle/icict/4905710.1371/journal.pone.0241898engPublic Library of ScienceInteração gene-ambientehipomineralização molarincisorGene-environment interactionHypomineralizationMolar incisorGene-environment interaction in molar incisor hypomineralizatioinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDepartment of Oral Biology, University of Pittsburgh, Pittsburgh, Pennsylvania. USA.Universidade Federal do Paraná. Departamento de Estomatologia. Curitiba, PR, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Odontologia Pediátrica e Ortodontia. Rio de Janeiro, RJ, Brasil.Pontifícia Universidade Católica do Paraná. Programa de Pós-Graduação em Odontologia. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Estomatologia. Curitiba, PR, Brasil.Universidade Positivo. Programa de Pós-Graduação em Odontologia. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Genética. Rio de Janeiro, RJ, Brasil.Pontifícia Universidade Católica do Paraná. Programa de Pós-Graduação em Odontologia. Curitiba, PR, Brasil.Pontifícia Universidade Católica do Paraná. Programa de Pós-Graduação em Odontologia. Curitiba, PR, Brasil.Colégio Pequeno Príncipe. Programa de Pós-Graduação de Biotecnologia Aplicada à Saúde da Criança e do Adolescente. Curitiba, PR, Brasil.Department of Pedodontics. Istanbul University, Istanbul. Turkey.Department of Pedodontics. Medipol Istanbul University. Istanbul, Turkey.Department of Oral Biology, University of Pittsburgh, Pittsburgh, Pennsylvania. USA.Department of Oral Biology, University of Pittsburgh, Pittsburgh, Pennsylvania. USA.Craniofacial Anomalies Research Center and Department of Orthodontics, College of Dentistry, The University of Iowa. Iowa City, Iowa, USA.Department of Diagnostic and Biomedical Sciences, and Center for Craniofacial Research,. UTHealth School of Dentistry at Houston. Houston, Texas, USA.Department of Pediatric Dentistry, University of Pittsburgh. Pittsburgh, Pennsylvania, USA,Department of Pedodontics, Istanbul University. Istanbul, Turkey.Craniofacial Anomalies Research Center and Department of Orthodontics, College of Dentistry, The University of Iowa. Iowa City, Iowa, USA.Pontifícia Universidade Católica do Paraná. Programa de Pós-Graduação em Odontologia. Curitiba, PR, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Odontologia Pediátrica e Ortodontia. Rio de Janeiro, RJ, Brasil.Department of Pediatric Dentistry, University of Pittsburgh. Pittsburgh, Pennsylvania.Department of Oral Biology, University of Pittsburgh, Pittsburgh, Pennsylvania. USA.Molar incisor hypomineralization (MIH) is an enamel condition characterized by lesions ranging in color from white to brown which present rapid caries progression, and mainly affects permanent first molars and incisors. These enamel defects usually occur when there are disturbances during the mineralization or maturation stage of amelogenesis. Both genetic and environmental factors have been suggested to play roles in MIH’s development, but no conclusive risk factors have shown the source of the disease. During head and neck development, the interferon regulatory factor 6 (IRF6) gene is involved in the structure for mation of the oral and maxillofacial regions, and the transforming growth factor alpha (TGFA) is an essential cell regulator, acting during proliferation, differentiation, migration and apoptosis. In this present study, it was hypothesized that these genes interact and con tribute to predisposition of MIH. Environmental factors affecting children that were 3 years of age or older were also hypothesized to play a role in the disease etiology. Those factors included respiratory issues, malnutrition, food intolerance, infection of any sort and medica tion intake. A total of 1,065 salivary samples from four different cohorts were obtained, and DNA was extracted from each sample and genotyped for nine different single nucleotide polymorphisms. Association tests and logistic regression implemented in PLINK were used for analyses. A potential interaction between TGFA rs930655 with all markers tested in the cohort from Turkey was identified. These interactions were not identified in the remaining cohorts. Associations (p<0.05) between the use of medication after three years of age and MIH were also found, suggesting that conditions acquired at the age children start to social ize might contribute to the development of MIH.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/49057/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCleberMachado_Souza_etal_IOC_2021.pdfCleberMachado_Souza_etal_IOC_2021.pdfapplication/pdf1143394https://www.arca.fiocruz.br/bitstream/icict/49057/2/CleberMachado_Souza_etal_IOC_2021.pdf56fbb7acc7512b7de97f112df9d0fe98MD52TEXTCleberMachado_Souza_etal_IOC_2021.pdf.txtCleberMachado_Souza_etal_IOC_2021.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Gene-environment interaction in molar incisor hypomineralizatio |
| title |
Gene-environment interaction in molar incisor hypomineralizatio |
| spellingShingle |
Gene-environment interaction in molar incisor hypomineralizatio Bezamat, Mariana Interação gene-ambiente hipomineralização molarincisor Gene-environment interaction Hypomineralization Molar incisor |
| title_short |
Gene-environment interaction in molar incisor hypomineralizatio |
| title_full |
Gene-environment interaction in molar incisor hypomineralizatio |
| title_fullStr |
Gene-environment interaction in molar incisor hypomineralizatio |
| title_full_unstemmed |
Gene-environment interaction in molar incisor hypomineralizatio |
| title_sort |
Gene-environment interaction in molar incisor hypomineralizatio |
| author |
Bezamat, Mariana |
| author_facet |
Bezamat, Mariana Souza, Juliana F. Silva, Fernanda M. F. Corrêa, Emilly G. Fatturi, Aluhe L. Brancher, João A. Carvalho, Flávia M. Cavallari, Tayla Bertolazo, Laís Souza, Cleber Machado Koruyucu, Mine Bayram, Merve Racic, Andrea Harrison, Benjamin M. Sweat, Yan Y. Letra, Ariadne Studen-Pavlovich, Deborah Seymen, Figen Amendt, Brad Werneck, Rebata I. Costa, Marcelo C. Modesto, Adriana Vieira, Alexandre R. |
| author_role |
author |
| author2 |
Souza, Juliana F. Silva, Fernanda M. F. Corrêa, Emilly G. Fatturi, Aluhe L. Brancher, João A. Carvalho, Flávia M. Cavallari, Tayla Bertolazo, Laís Souza, Cleber Machado Koruyucu, Mine Bayram, Merve Racic, Andrea Harrison, Benjamin M. Sweat, Yan Y. Letra, Ariadne Studen-Pavlovich, Deborah Seymen, Figen Amendt, Brad Werneck, Rebata I. Costa, Marcelo C. Modesto, Adriana Vieira, Alexandre R. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Bezamat, Mariana Souza, Juliana F. Silva, Fernanda M. F. Corrêa, Emilly G. Fatturi, Aluhe L. Brancher, João A. Carvalho, Flávia M. Cavallari, Tayla Bertolazo, Laís Souza, Cleber Machado Koruyucu, Mine Bayram, Merve Racic, Andrea Harrison, Benjamin M. Sweat, Yan Y. Letra, Ariadne Studen-Pavlovich, Deborah Seymen, Figen Amendt, Brad Werneck, Rebata I. Costa, Marcelo C. Modesto, Adriana Vieira, Alexandre R. |
| dc.subject.other.pt_BR.fl_str_mv |
Interação gene-ambiente hipomineralização molarincisor |
| topic |
Interação gene-ambiente hipomineralização molarincisor Gene-environment interaction Hypomineralization Molar incisor |
| dc.subject.en.pt_BR.fl_str_mv |
Gene-environment interaction Hypomineralization Molar incisor |
| description |
Department of Oral Biology, University of Pittsburgh, Pittsburgh, Pennsylvania. USA. |
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2021 |
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2021-09-12T18:20:26Z |
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2021-09-12T18:20:26Z |
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2021 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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BENZAMAT, Mariana et al. Gene-environment interaction in molar incisor hypomineralization. Plos One, v. 16, n. 1, e0241898, 16 p, Jan. 2021. |
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https://www.arca.fiocruz.br/handle/icict/49057 |
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1932-6203 |
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10.1371/journal.pone.0241898 |
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BENZAMAT, Mariana et al. Gene-environment interaction in molar incisor hypomineralization. Plos One, v. 16, n. 1, e0241898, 16 p, Jan. 2021. 1932-6203 10.1371/journal.pone.0241898 |
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