Congenital Zika Syndrome: a nationwide cohort study in Brazil, 2015-2018
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/52606 |
Resumo: | Secretaria de Vigilância em Saúde do Ministério da Saúde do Brasil. Wellcome Trust. Departamento de Desenvolvimento Internacional do Reino Unido. British Council Newton Fund. programa de Pesquisa e Inovação Horizon 2020 da União Europeia sob ZikaPLAN |
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Paixao, Enny S.Cardim, Luciana L.Costa, Maria da Conceição N.Brickley, Elizabeth B.Sauer, Rita de Cassia Oliveira de CarvalhoCarmo, Eduardo H.Andrade, Roberto F. S.Rodrigues, Moreno S.Veiga, Rafael V.Costa, Larissa C.Moore, Cynthia A.França, Giovanny V. A.Smeeth, LiamRodrigues, Laura C.Barreto, Mauricio L.Teixeira, Maria Gloria2022-05-11T14:03:43Z2022-05-11T14:03:43Z2022PAIXÃO, Enny S. et al. Congenital Zika Syndrome: a nationwide cohort Study in Brazil, 2015-2018. The New England Journal of Medicine, v. 386, n. 8, p. 1-17, 2022.1533-4406https://www.arca.fiocruz.br/handle/icict/5260610.1056/NEJMoa2101195Secretaria de Vigilância em Saúde do Ministério da Saúde do Brasil. Wellcome Trust. Departamento de Desenvolvimento Internacional do Reino Unido. British Council Newton Fund. programa de Pesquisa e Inovação Horizon 2020 da União Europeia sob ZikaPLANLondon School of Hygiene and Tropical Medicine. London, UK. / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.London School of Hygiene and Tropical Medicine. London, UK.Núcleo Regional de Saúde Leste da Secretaria Estadual de Saúde da Bahia. Santo Antonio de Jesus, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil.Division of Birth Defects and Infant Disorders. National Center on Birth Defects and Developmental Disabilities. Centers for Disease Control and Prevention. Atlanta, GA.Ministério da Saúde. Secretaria de Vigilância em Saúde. Brasília, DF, Brasil.London School of Hygiene and Tropical Medicine. London, UK.London School of Hygiene and Tropical Medicine. London, UK / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Background: Prenatal exposure to ZIKV has potential teratogenic effects with a wide spectrum of clinical presentation called congenital Zika syndrome (CZS). There are limited data on survival of children with CZS, we estimated mortality comparing live births with and without CZS. Methods: A population-based cohort study using linked routinely collected data in Brazil, from January 2015 to December 2018. Kaplan-Meier and survival analyses were performed adjusted for confounding and stratified by gestational age, birth weight and small for gestational age. Results: We followed 11,737,554 live births for up to 36 months. The mortality rate among live births with CZS was 52.6 (95% confidence interval [CI] 47.6-58.0) and among those without CZS it was 5.6 (5.6-5.7) per 1000 person-years. The mortality rate ratio was 11.3 (95%CI 10.2-12.4) times higher among live births with CZS than those without CZS up to the age of 36 months. For infants born before 32 weeks' gestation or with birth weight less than 1500g, the risk of death was similar regardless of CZS. Infants with CZS born at term (mortality rate with and without CZS—38.4 vs 2.7) or with birth weight greater than 2499g (mortality rate with and without CZS—32.6 vs 2.5) were 14.3 (95%CI 12.4-16.4) and 12.9 (95%CI 10.9-15.3) times more likely to die than those without CZS. The burden of congenital anomalies, diseases of the nervous system and infectious diseases, as recorded causes of deaths, were higher among the CZS group. Conclusion: There is a higher mortality risk in live births with CZS than live births without CZS that persists throughout the first three years of life.engMassachusetts Medical SocietyZika virusInfecção por Zika virusMortalidade infantilZika virusZika virus infectionInfant mortalityVirus ZikaInfección por el virus ZikaMortalidad infantilVirus ZikaInfection par le virus ZikaMortalité infantileCongenital Zika Syndrome: a nationwide cohort study in Brazil, 2015-2018info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/52606/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPaixao Enny - Congenital Zika Syndrome.pdfPaixao Enny - Congenital Zika Syndrome.pdfapplication/pdf915296https://www.arca.fiocruz.br/bitstream/icict/52606/2/Paixao%20Enny%20-%20Congenital%20Zika%20Syndrome.pdf209636a2f437a57f537de42273adbfd1MD52icict/526062023-03-15 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| dc.title.pt_BR.fl_str_mv |
Congenital Zika Syndrome: a nationwide cohort study in Brazil, 2015-2018 |
| title |
Congenital Zika Syndrome: a nationwide cohort study in Brazil, 2015-2018 |
| spellingShingle |
Congenital Zika Syndrome: a nationwide cohort study in Brazil, 2015-2018 Paixao, Enny S. Zika virus Infecção por Zika virus Mortalidade infantil Zika virus Zika virus infection Infant mortality Virus Zika Infección por el virus Zika Mortalidad infantil Virus Zika Infection par le virus Zika Mortalité infantile |
| title_short |
Congenital Zika Syndrome: a nationwide cohort study in Brazil, 2015-2018 |
| title_full |
Congenital Zika Syndrome: a nationwide cohort study in Brazil, 2015-2018 |
| title_fullStr |
Congenital Zika Syndrome: a nationwide cohort study in Brazil, 2015-2018 |
| title_full_unstemmed |
Congenital Zika Syndrome: a nationwide cohort study in Brazil, 2015-2018 |
| title_sort |
Congenital Zika Syndrome: a nationwide cohort study in Brazil, 2015-2018 |
| author |
Paixao, Enny S. |
| author_facet |
Paixao, Enny S. Cardim, Luciana L. Costa, Maria da Conceição N. Brickley, Elizabeth B. Sauer, Rita de Cassia Oliveira de Carvalho Carmo, Eduardo H. Andrade, Roberto F. S. Rodrigues, Moreno S. Veiga, Rafael V. Costa, Larissa C. Moore, Cynthia A. França, Giovanny V. A. Smeeth, Liam Rodrigues, Laura C. Barreto, Mauricio L. Teixeira, Maria Gloria |
| author_role |
author |
| author2 |
Cardim, Luciana L. Costa, Maria da Conceição N. Brickley, Elizabeth B. Sauer, Rita de Cassia Oliveira de Carvalho Carmo, Eduardo H. Andrade, Roberto F. S. Rodrigues, Moreno S. Veiga, Rafael V. Costa, Larissa C. Moore, Cynthia A. França, Giovanny V. A. Smeeth, Liam Rodrigues, Laura C. Barreto, Mauricio L. Teixeira, Maria Gloria |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Paixao, Enny S. Cardim, Luciana L. Costa, Maria da Conceição N. Brickley, Elizabeth B. Sauer, Rita de Cassia Oliveira de Carvalho Carmo, Eduardo H. Andrade, Roberto F. S. Rodrigues, Moreno S. Veiga, Rafael V. Costa, Larissa C. Moore, Cynthia A. França, Giovanny V. A. Smeeth, Liam Rodrigues, Laura C. Barreto, Mauricio L. Teixeira, Maria Gloria |
| dc.subject.other.pt_BR.fl_str_mv |
Zika virus Infecção por Zika virus Mortalidade infantil |
| topic |
Zika virus Infecção por Zika virus Mortalidade infantil Zika virus Zika virus infection Infant mortality Virus Zika Infección por el virus Zika Mortalidad infantil Virus Zika Infection par le virus Zika Mortalité infantile |
| dc.subject.en.pt_BR.fl_str_mv |
Zika virus Zika virus infection Infant mortality |
| dc.subject.es.pt_BR.fl_str_mv |
Virus Zika Infección por el virus Zika Mortalidad infantil |
| dc.subject.fr.pt_BR.fl_str_mv |
Virus Zika Infection par le virus Zika Mortalité infantile |
| description |
Secretaria de Vigilância em Saúde do Ministério da Saúde do Brasil. Wellcome Trust. Departamento de Desenvolvimento Internacional do Reino Unido. British Council Newton Fund. programa de Pesquisa e Inovação Horizon 2020 da União Europeia sob ZikaPLAN |
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2022 |
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2022-05-11T14:03:43Z |
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2022-05-11T14:03:43Z |
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2022 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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PAIXÃO, Enny S. et al. Congenital Zika Syndrome: a nationwide cohort Study in Brazil, 2015-2018. The New England Journal of Medicine, v. 386, n. 8, p. 1-17, 2022. |
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https://www.arca.fiocruz.br/handle/icict/52606 |
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1533-4406 |
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10.1056/NEJMoa2101195 |
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PAIXÃO, Enny S. et al. Congenital Zika Syndrome: a nationwide cohort Study in Brazil, 2015-2018. The New England Journal of Medicine, v. 386, n. 8, p. 1-17, 2022. 1533-4406 10.1056/NEJMoa2101195 |
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Massachusetts Medical Society |
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Massachusetts Medical Society |
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