Trypanosoma cruzi recognition by macrophages and muscle cells: perspectives after a 15-year study

Detalhes bibliográficos
Autor(a) principal: Araujo-Jorge, Tania C.
Data de Publicação: 1992
Outros Autores: Barbosa, Helene S., Meirelles, Maria Nazareth L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36083
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil.
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spelling Araujo-Jorge, Tania C.Barbosa, Helene S.Meirelles, Maria Nazareth L.2019-10-02T14:25:52Z2019-10-02T14:25:52Z1992ARAUJO-JORGE, Tania C. de; BARBOSA, Helene S.; MEIRELLES, Maria Nazareth L. Trypanosoma cruzi recognition by macrophages and muscle cells: perspectives after a 15-year study. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 87, Suppl. V, p. 43-56, 1992.0074-0276https://www.arca.fiocruz.br/handle/icict/3608310.1590/S0074-027619920009000061678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Trypanosoma cruziMacrófagosUltraestruturaMiócitos CardíacosLectinasEndocitoseProteasesTrypanosoma cruziMacrophageHeart muscle cellLectinsLigand-receptor interactionUltrastructureEndocytosisProteinasesAlpha-2-macroglobulinMiócitos Cardíacosalfa-MacroglobulinasTrypanosoma cruzi recognition by macrophages and muscle cells: perspectives after a 15-year studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil.Macrophages and muscle cells are the main targets for invasion of Trypanosoma cruzi. Ultrastructural studies of this phenomenon in vitro showed that invasion occurs by endocytosis, with attachment and internalization being mediated by different components capable of recognizing epi-or trypomastigotes (TRY). A parasitophorus vacuole was formed in both cell types, thereafter fusing with lysosomes. Then, the mechanism of T. cruzi invasion of host cells (HC) is essentially similar (during a primary infection in the abscence of a specific immune response), regardless of wether the target cell is a professional or a non-professional phagocytic cell. Using sugars, lectins, glycosidases, proteinases and proteinase inhibitors, we observed that the relative balance between exposed sialic acid and galactose/N-acetyl galactosamine (GAL) residues on the TRY surface, determines the parasite's capacity to invade HC, and that lectin-mediated phagocytosis with GAL specificity is important for internalization of T. cruzi into macrophages. On the other hand, GAL on the surface to heart muscle cells participate on TRY adhesion. TRY need to process proteolytically both the HC and their own surface, to expose the necessary ligands and receptors that allow binding to, and internalization in the host cell. The diverse range of molecular mechanisms which the parasite could use to invade the host cell may correspond to differences in the available "receptors"on the surface of each specific cell type. Acute phase components, with lectin or proteinase inhibitory activities (a-macroglobulins), may also be involved in T. cruzi-host cell interaction.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/36083/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALTaniaAJOrge_HeleneSBarbosa_etal_IOC_1992.pdfTaniaAJOrge_HeleneSBarbosa_etal_IOC_1992.pdfapplication/pdf859020https://www.arca.fiocruz.br/bitstream/icict/36083/2/TaniaAJOrge_HeleneSBarbosa_etal_IOC_1992.pdf6b925d50467cc34c49a14f9f3d8e63b8MD52TEXTTaniaAJOrge_HeleneSBarbosa_etal_IOC_1992.pdf.txtTaniaAJOrge_HeleneSBarbosa_etal_IOC_1992.pdf.txtExtracted texttext/plain14https://www.arca.fiocruz.br/bitstream/icict/36083/3/TaniaAJOrge_HeleneSBarbosa_etal_IOC_1992.pdf.txt06b7e51e8fc077b8c75076712e4dd2b3MD53icict/360832022-06-24 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dc.title.pt_BR.fl_str_mv Trypanosoma cruzi recognition by macrophages and muscle cells: perspectives after a 15-year study
title Trypanosoma cruzi recognition by macrophages and muscle cells: perspectives after a 15-year study
spellingShingle Trypanosoma cruzi recognition by macrophages and muscle cells: perspectives after a 15-year study
Araujo-Jorge, Tania C.
Trypanosoma cruzi
Macrófagos
Ultraestrutura
Miócitos Cardíacos
Lectinas
Endocitose
Proteases
Trypanosoma cruzi
Macrophage
Heart muscle cell
Lectins
Ligand-receptor interaction
Ultrastructure
Endocytosis
Proteinases
Alpha-2-macroglobulin
Miócitos Cardíacos
alfa-Macroglobulinas
title_short Trypanosoma cruzi recognition by macrophages and muscle cells: perspectives after a 15-year study
title_full Trypanosoma cruzi recognition by macrophages and muscle cells: perspectives after a 15-year study
title_fullStr Trypanosoma cruzi recognition by macrophages and muscle cells: perspectives after a 15-year study
title_full_unstemmed Trypanosoma cruzi recognition by macrophages and muscle cells: perspectives after a 15-year study
title_sort Trypanosoma cruzi recognition by macrophages and muscle cells: perspectives after a 15-year study
author Araujo-Jorge, Tania C.
author_facet Araujo-Jorge, Tania C.
Barbosa, Helene S.
Meirelles, Maria Nazareth L.
author_role author
author2 Barbosa, Helene S.
Meirelles, Maria Nazareth L.
author2_role author
author
dc.contributor.author.fl_str_mv Araujo-Jorge, Tania C.
Barbosa, Helene S.
Meirelles, Maria Nazareth L.
dc.subject.other.pt_BR.fl_str_mv Trypanosoma cruzi
Macrófagos
Ultraestrutura
Miócitos Cardíacos
Lectinas
Endocitose
Proteases
topic Trypanosoma cruzi
Macrófagos
Ultraestrutura
Miócitos Cardíacos
Lectinas
Endocitose
Proteases
Trypanosoma cruzi
Macrophage
Heart muscle cell
Lectins
Ligand-receptor interaction
Ultrastructure
Endocytosis
Proteinases
Alpha-2-macroglobulin
Miócitos Cardíacos
alfa-Macroglobulinas
dc.subject.en.pt_BR.fl_str_mv Trypanosoma cruzi
Macrophage
Heart muscle cell
Lectins
Ligand-receptor interaction
Ultrastructure
Endocytosis
Proteinases
Alpha-2-macroglobulin
dc.subject.decs.pt_BR.fl_str_mv Miócitos Cardíacos
alfa-Macroglobulinas
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil.
publishDate 1992
dc.date.issued.fl_str_mv 1992
dc.date.accessioned.fl_str_mv 2019-10-02T14:25:52Z
dc.date.available.fl_str_mv 2019-10-02T14:25:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ARAUJO-JORGE, Tania C. de; BARBOSA, Helene S.; MEIRELLES, Maria Nazareth L. Trypanosoma cruzi recognition by macrophages and muscle cells: perspectives after a 15-year study. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 87, Suppl. V, p. 43-56, 1992.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36083
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02761992000900006
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv ARAUJO-JORGE, Tania C. de; BARBOSA, Helene S.; MEIRELLES, Maria Nazareth L. Trypanosoma cruzi recognition by macrophages and muscle cells: perspectives after a 15-year study. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 87, Suppl. V, p. 43-56, 1992.
0074-0276
10.1590/S0074-02761992000900006
1678-8060
url https://www.arca.fiocruz.br/handle/icict/36083
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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