Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil

Detalhes bibliográficos
Autor(a) principal: Gesto, João Silveira Moledo
Data de Publicação: 2021
Outros Autores: Ribeiro, Gabriel Sylvestre, Rocha, Marcele Neves, Dias, Fernando Braga Stehling, Peixoto, Julia, Carvalho, Fabiano Duarte, Pereira, Thiago Nunes, Moreira, Luciano Andrade
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51824
Resumo: Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno Vetor. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. World Mosquito Program. Rio de Janeiro, RJ, Brazil.
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spelling Gesto, João Silveira MoledoRibeiro, Gabriel SylvestreRocha, Marcele NevesDias, Fernando Braga StehlingPeixoto, JuliaCarvalho, Fabiano DuartePereira, Thiago NunesMoreira, Luciano Andrade2022-03-22T18:42:26Z2022-03-22T18:42:26Z2021GESTO, João Silveira Moledo et al. Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil. Sci Rep., vol 11, n. 1, 10039, 2021. doi: 10.1038/s41598-021-89409-8.2045-2322https://www.arca.fiocruz.br/handle/icict/5182410.1038/s41598-021-89409-8engNature Publishing GroupReduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto René Rachou. Grupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno Vetor. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. World Mosquito Program. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno Vetor. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. World Mosquito Program. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno Vetor. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. World Mosquito Program. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. World Mosquito Program. Rio de Janeiro, RJ, Brazil/Fundação Oswaldo Cruz. Fortaleza, CE, Brazil.Fundação Oswaldo Cruz. World Mosquito Program. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno Vetor. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno Vetor. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno Vetor. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. World Mosquito Program. Rio de Janeiro, RJ, Brazil.Field release of Wolbachia-infected Aedes aegypti has emerged as a promising solution to manage the transmission of dengue, Zika and chikungunya in endemic areas across the globe. Through an efficient self-dispersing mechanism, and the ability to induce virus-blocking properties, Wolbachia offers an unmatched potential to gradually modify wild Ae. aegypti populations turning them unsuitable disease vectors. Here we describe a proof-of-concept field trial carried out in a small community of Niterói, greater Rio de Janeiro, Brazil. Following the release of Wolbachia-infected eggs, we report here a successful invasion and long-term establishment of the bacterium across the territory, as denoted by stable high-infection indexes (> 80%). We have also demonstrated that refractoriness to dengue and Zika viruses, either thorough oral-feeding or intra-thoracic saliva challenging assays, was maintained over the adaptation to the natural environment of Southeastern Brazil. These findings further support Wolbachia's ability to invade local Ae. aegypti populations and impair disease transmission, and will pave the way for future epidemiological and economic impact assessments.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/51824/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALReduced competence.pdfReduced competence.pdfapplication/pdf7803426https://www.arca.fiocruz.br/bitstream/icict/51824/2/Reduced%20competence.pdfd9f65e716ae9406a5d25d19b8ef3f383MD52icict/518242022-03-22 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dc.title.pt_BR.fl_str_mv Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil
title Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil
spellingShingle Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil
Gesto, João Silveira Moledo
title_short Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil
title_full Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil
title_fullStr Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil
title_full_unstemmed Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil
title_sort Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil
author Gesto, João Silveira Moledo
author_facet Gesto, João Silveira Moledo
Ribeiro, Gabriel Sylvestre
Rocha, Marcele Neves
Dias, Fernando Braga Stehling
Peixoto, Julia
Carvalho, Fabiano Duarte
Pereira, Thiago Nunes
Moreira, Luciano Andrade
author_role author
author2 Ribeiro, Gabriel Sylvestre
Rocha, Marcele Neves
Dias, Fernando Braga Stehling
Peixoto, Julia
Carvalho, Fabiano Duarte
Pereira, Thiago Nunes
Moreira, Luciano Andrade
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gesto, João Silveira Moledo
Ribeiro, Gabriel Sylvestre
Rocha, Marcele Neves
Dias, Fernando Braga Stehling
Peixoto, Julia
Carvalho, Fabiano Duarte
Pereira, Thiago Nunes
Moreira, Luciano Andrade
description Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno Vetor. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. World Mosquito Program. Rio de Janeiro, RJ, Brazil.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-03-22T18:42:26Z
dc.date.available.fl_str_mv 2022-03-22T18:42:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GESTO, João Silveira Moledo et al. Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil. Sci Rep., vol 11, n. 1, 10039, 2021. doi: 10.1038/s41598-021-89409-8.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51824
dc.identifier.issn.pt_BR.fl_str_mv 2045-2322
dc.identifier.doi.none.fl_str_mv 10.1038/s41598-021-89409-8
identifier_str_mv GESTO, João Silveira Moledo et al. Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil. Sci Rep., vol 11, n. 1, 10039, 2021. doi: 10.1038/s41598-021-89409-8.
2045-2322
10.1038/s41598-021-89409-8
url https://www.arca.fiocruz.br/handle/icict/51824
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/51824/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/51824/2/Reduced%20competence.pdf
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