Electrocardiographic ventricular repolarization parameters in chronic Chagas' disease as predictors of asymptomatic left ventricular systolic dysfunction

Detalhes bibliográficos
Autor(a) principal: Salles, Gil F.
Data de Publicação: 2003
Outros Autores: Cardoso, Claudia R. L., Xavier, Sergio S., Sousa, Andrea S., Hasslocher-Moreno, Alejandro Marcel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33627
Resumo: 2020-06-24
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spelling Salles, Gil F.Cardoso, Claudia R. L.Xavier, Sergio S.Sousa, Andrea S.Hasslocher-Moreno, Alejandro Marcel2019-06-24T12:06:05Z2019-06-24T12:06:05Z2003SALLES, Gil F. et al. Electrocardiographic ventricular repolarization parameters in chronic Chagas' disease as predictors of asymptomatic left ventricular systolic dysfunction. Pacing Clinical Electrophysiology, v. 26, n. 6, p. 1326-1335, June 2003.0147-8389https://www.arca.fiocruz.br/handle/icict/3362710.1046/j.1460-9592.2003.t01-1-00190.x1540-8159engWileyElectrocardiographic ventricular repolarization parameters in chronic Chagas' disease as predictors of asymptomatic left ventricular systolic dysfunctioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-06-24Federal University of Rio de Janeiro. Clementino Fraga Filho University Hospital. Department of Internal Medicine. Rio de Janeiro, RJ, Brazil.Federal University of Rio de Janeiro. Clementino Fraga Filho University Hospital. Department of Internal Medicine. Rio de Janeiro, RJ, Brazil.Federal University of Rio de Janeiro. Clementino Fraga Filho University Hospital. Department of Internal Medicine. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Hospital Evandro Chagas. Rio de Janeiro, RJ, Brasil.Federal University of Rio de Janeiro. Clementino Fraga Filho University Hospital. Department of Internal Medicine. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Hospital Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Hospital Evandro Chagas. Rio de Janeiro, RJ, Brasil.Electrocardiographic re-polarization parameters are potential markers of arrhythmogenic risk and have not been evaluated inChagas’ disease. The aim of this report was to investigate their associations with LV systolic function as-sessed by two-dimensional echocardiography. In a cross-sectional study involving 738 adult outpatientsin the chronic phase of Chagas’ disease, maximal QTc and T wave peak-to-end (TpTe) intervals, and QT,QTapex (QTa), JT and TpTe interval dispersions, and variation coefficients were measured and calculatedfrom 12-lead standard ECGs. Clinical, radiological, ECG, and echocardiographic data were recorded. Inbivariate statistical analysis, all repolarization parameters were significantly increased in patients withmoderate or severe LV systolic dysfunction, and these patients showed more clinical, radiologic, and ECGabnormalities. Receiver operating characteristic curve analysis demonstrated that isolatedly QTd had thebest predictive performance for LV dysfunction, with an 80% specificity and 67% sensitivity for values>60 ms in the subgroup of chagasic patients with abnormal ECGs and no heart failure. Multivariate lo-gistic regression selected, as the best predictive model for LV dysfunction in this subgroup of patients, thepresence of cardiomegaly on chest X ray (OR 14.06, 95% CI, 5.54–35.71), QTd>60 ms (OR 9.35, 95% CI,4.01–21.81), male gender (OR 7.70, 95% CI, 2.98–19.91) and the presence of frequent premature ventric-ular contractions (PVCs) on ECG (OR 4.06, 95% CI, 1.65–9.97). This model showed 90% specificity and71% sensitivity. In conclusion, QTd was associated to LV systolic function and could be used to predictasymptomatic dysfunction in chronic Chagas’ disease. The presence of cardiomegaly, frequent PVCs, andmale sex refined LV function stratification in these patients.Chagas’ diseaseQT intervalsQT dispersionSystolic dysfunctionVentricular repolarizationElectrocardiologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/33627/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Salles_G_etal_INI_2003.pdfve_Salles_G_etal_INI_2003.pdfapplication/pdf315439https://www.arca.fiocruz.br/bitstream/icict/33627/2/ve_Salles_G_etal_INI_2003.pdf87c1198c69b6785717d08a3d0e2597ceMD52TEXTve_Salles_G_etal_INI_2003.pdf.txtve_Salles_G_etal_INI_2003.pdf.txtExtracted texttext/plain40045https://www.arca.fiocruz.br/bitstream/icict/33627/3/ve_Salles_G_etal_INI_2003.pdf.txt150df656a211a66b4085c2c20f008ee2MD53icict/336272023-06-12 22:29:56.419oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-06-13T01:29:56Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Electrocardiographic ventricular repolarization parameters in chronic Chagas' disease as predictors of asymptomatic left ventricular systolic dysfunction
title Electrocardiographic ventricular repolarization parameters in chronic Chagas' disease as predictors of asymptomatic left ventricular systolic dysfunction
spellingShingle Electrocardiographic ventricular repolarization parameters in chronic Chagas' disease as predictors of asymptomatic left ventricular systolic dysfunction
Salles, Gil F.
Chagas’ disease
QT intervals
QT dispersion
Systolic dysfunction
Ventricular repolarization
Electrocardiology
title_short Electrocardiographic ventricular repolarization parameters in chronic Chagas' disease as predictors of asymptomatic left ventricular systolic dysfunction
title_full Electrocardiographic ventricular repolarization parameters in chronic Chagas' disease as predictors of asymptomatic left ventricular systolic dysfunction
title_fullStr Electrocardiographic ventricular repolarization parameters in chronic Chagas' disease as predictors of asymptomatic left ventricular systolic dysfunction
title_full_unstemmed Electrocardiographic ventricular repolarization parameters in chronic Chagas' disease as predictors of asymptomatic left ventricular systolic dysfunction
title_sort Electrocardiographic ventricular repolarization parameters in chronic Chagas' disease as predictors of asymptomatic left ventricular systolic dysfunction
author Salles, Gil F.
author_facet Salles, Gil F.
Cardoso, Claudia R. L.
Xavier, Sergio S.
Sousa, Andrea S.
Hasslocher-Moreno, Alejandro Marcel
author_role author
author2 Cardoso, Claudia R. L.
Xavier, Sergio S.
Sousa, Andrea S.
Hasslocher-Moreno, Alejandro Marcel
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Salles, Gil F.
Cardoso, Claudia R. L.
Xavier, Sergio S.
Sousa, Andrea S.
Hasslocher-Moreno, Alejandro Marcel
dc.subject.en.pt_BR.fl_str_mv Chagas’ disease
QT intervals
QT dispersion
Systolic dysfunction
Ventricular repolarization
Electrocardiology
topic Chagas’ disease
QT intervals
QT dispersion
Systolic dysfunction
Ventricular repolarization
Electrocardiology
description 2020-06-24
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2019-06-24T12:06:05Z
dc.date.available.fl_str_mv 2019-06-24T12:06:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SALLES, Gil F. et al. Electrocardiographic ventricular repolarization parameters in chronic Chagas' disease as predictors of asymptomatic left ventricular systolic dysfunction. Pacing Clinical Electrophysiology, v. 26, n. 6, p. 1326-1335, June 2003.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33627
dc.identifier.issn.pt_BR.fl_str_mv 0147-8389
dc.identifier.doi.none.fl_str_mv 10.1046/j.1460-9592.2003.t01-1-00190.x
dc.identifier.eissn.none.fl_str_mv 1540-8159
identifier_str_mv SALLES, Gil F. et al. Electrocardiographic ventricular repolarization parameters in chronic Chagas' disease as predictors of asymptomatic left ventricular systolic dysfunction. Pacing Clinical Electrophysiology, v. 26, n. 6, p. 1326-1335, June 2003.
0147-8389
10.1046/j.1460-9592.2003.t01-1-00190.x
1540-8159
url https://www.arca.fiocruz.br/handle/icict/33627
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
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