Serotyping of 467 Cryptococcus neoformans isolates from clinical and environmental sources in Brazil: analysys of host and regional patterns

Detalhes bibliográficos
Autor(a) principal: Nishikawa, M. M.
Data de Publicação: 2003
Outros Autores: Lazéra, M. S., Barbosa, G. G., Trilles, L., Balassiano, B. R., Macêdo, R. C., Bezerra, C. C., Perez, M. A., Leite, P., Wanke, B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33629
Resumo: 2019-12-24
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spelling Nishikawa, M. M.Lazéra, M. S.Barbosa, G. G.Trilles, L.Balassiano, B. R.Macêdo, R. C.Bezerra, C. C.Perez, M. A.Leite, P.Wanke, B.2019-06-24T12:58:59Z2019-06-24T12:58:59Z2003NISHIKAWA, Marília M. et al. Serotyping of 467 Cryptococcus neoformans isolates from clinical and environmental sources in Brazil: analysys of host and regional patterns. Journal of Clinical Microbiology, v. 41, n. 1, p. 73-77, 2003.0095-1137https://www.arca.fiocruz.br/handle/icict/3362910.1128/jcm.41.1.73-77.20031098-660XengAmerican Society for MicrobiologySerotyping of 467 Cryptococcus neoformans isolates from clinical and environmental sources in Brazil: analysys of host and regional patternsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2019-12-24Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Micologia. Rio de Janeiro, RJ, Brasil.Federal University of Rio de Janeiro. Center of Community Health Studies. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Micologia. Rio de Janeiro, RJ, Brasil.Cryptococcus neoformans is an important zoopathogen, and it is one of the most prevalent lethal mycotic agents. Its polysaccharide capsule, synthesized in vivo and in vitro, is a virulence factor, contains predominantly glucuronoxylomannan, and is responsible for the antigenic differentiation of serotypes A, B, C, D, and AD. A total of 467 isolates of C. neoformans obtained from clinical and environmental sources from Brazilian regions were studied serologically by using the Crypto Check Iatron RM 304-K kit. Serotyping of the clinical isolates showed the following prevalences of the serotypes: A (77.95%), followed by B (18.2%), AD (1.3%), D (0.4%), C (0.2%), and untypeable (1.93%). The epidemiology of serotype A in the Brazilian southern and southeastern regions reproduces the picture observed worldwide. In contrast, serotype B was the most frequent agent of cryptococcosis in the northeastern region, occurring nearly equally in male and female healthy hosts. Among the isolates from environmental sources, serotypes A and B were found to occur in the hollows of tropical trees of the genera Cassia, Ficus, and Moquillea. The few isolates from Eucalyptus camaldulensis debris were serotypes A and B and untypeable. Overall, no association with a specific host tree was identified for these serotypes, denoting a distinct ecoepidemiological regional pattern. The one serotype C isolate was recovered from a human immunodeficiency virus-negative host. Serotype AD predominated over serotype D among both clinical and environmental isolates.Cryptococcus neoformansSerotypingBrazilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/33629/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Nishikawa_Marília_etal_INI_2003.pdfve_Nishikawa_Marília_etal_INI_2003.pdfapplication/pdf80164https://www.arca.fiocruz.br/bitstream/icict/33629/2/ve_Nishikawa_Mar%c3%adlia_etal_INI_2003.pdf3b40ec0cae1d4c290fdb16b95fd45db5MD52TEXTve_Nishikawa_Marília_etal_INI_2003.pdf.txtve_Nishikawa_Marília_etal_INI_2003.pdf.txtExtracted texttext/plain28309https://www.arca.fiocruz.br/bitstream/icict/33629/3/ve_Nishikawa_Mar%c3%adlia_etal_INI_2003.pdf.txt0cfc49ed2b738b13cd86e0cb35b80e7fMD53icict/336292021-03-24 16:32:25.904oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:25Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Serotyping of 467 Cryptococcus neoformans isolates from clinical and environmental sources in Brazil: analysys of host and regional patterns
title Serotyping of 467 Cryptococcus neoformans isolates from clinical and environmental sources in Brazil: analysys of host and regional patterns
spellingShingle Serotyping of 467 Cryptococcus neoformans isolates from clinical and environmental sources in Brazil: analysys of host and regional patterns
Nishikawa, M. M.
Cryptococcus neoformans
Serotyping
Brazil
title_short Serotyping of 467 Cryptococcus neoformans isolates from clinical and environmental sources in Brazil: analysys of host and regional patterns
title_full Serotyping of 467 Cryptococcus neoformans isolates from clinical and environmental sources in Brazil: analysys of host and regional patterns
title_fullStr Serotyping of 467 Cryptococcus neoformans isolates from clinical and environmental sources in Brazil: analysys of host and regional patterns
title_full_unstemmed Serotyping of 467 Cryptococcus neoformans isolates from clinical and environmental sources in Brazil: analysys of host and regional patterns
title_sort Serotyping of 467 Cryptococcus neoformans isolates from clinical and environmental sources in Brazil: analysys of host and regional patterns
author Nishikawa, M. M.
author_facet Nishikawa, M. M.
Lazéra, M. S.
Barbosa, G. G.
Trilles, L.
Balassiano, B. R.
Macêdo, R. C.
Bezerra, C. C.
Perez, M. A.
Leite, P.
Wanke, B.
author_role author
author2 Lazéra, M. S.
Barbosa, G. G.
Trilles, L.
Balassiano, B. R.
Macêdo, R. C.
Bezerra, C. C.
Perez, M. A.
Leite, P.
Wanke, B.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nishikawa, M. M.
Lazéra, M. S.
Barbosa, G. G.
Trilles, L.
Balassiano, B. R.
Macêdo, R. C.
Bezerra, C. C.
Perez, M. A.
Leite, P.
Wanke, B.
dc.subject.en.pt_BR.fl_str_mv Cryptococcus neoformans
Serotyping
Brazil
topic Cryptococcus neoformans
Serotyping
Brazil
description 2019-12-24
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2019-06-24T12:58:59Z
dc.date.available.fl_str_mv 2019-06-24T12:58:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv NISHIKAWA, Marília M. et al. Serotyping of 467 Cryptococcus neoformans isolates from clinical and environmental sources in Brazil: analysys of host and regional patterns. Journal of Clinical Microbiology, v. 41, n. 1, p. 73-77, 2003.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33629
dc.identifier.issn.pt_BR.fl_str_mv 0095-1137
dc.identifier.doi.none.fl_str_mv 10.1128/jcm.41.1.73-77.2003
dc.identifier.eissn.none.fl_str_mv 1098-660X
identifier_str_mv NISHIKAWA, Marília M. et al. Serotyping of 467 Cryptococcus neoformans isolates from clinical and environmental sources in Brazil: analysys of host and regional patterns. Journal of Clinical Microbiology, v. 41, n. 1, p. 73-77, 2003.
0095-1137
10.1128/jcm.41.1.73-77.2003
1098-660X
url https://www.arca.fiocruz.br/handle/icict/33629
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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