Comparative Analysis of Circulating Levels of SARS-CoV-2 Antibodies and Inflammatory Mediators in HealthcareWorkers and COVID-19 Patients
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.3390/v14030455 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/56423 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. |
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Pinto, Luzia Maria de OliveiraSolórzano, Victor Edgar FiestasMartins, Maria de LourdesSantos, Caroline FernandesDamasco, Paula HesselbergSiqueira, Marilda Agudo Mendonça Teixeira deDias, Helver GonçalvesPauvolid-Corrêa, AlexDamasco, Paulo VieiraAzeredo, Elzinandes Leal de2023-01-10T17:33:09Z2023-01-10T17:33:09Z2022PINTO, Luzia Maria de Oliveira et al. Comparative Analysis of Circulating Levels of SARS-CoV-2 Antibodies and Inflammatory Mediators in Healthcare Workers and COVID-19 Patients. Viruses, v. 14, 455, p. 1 - 19, Feb. 2022.1999-4915https://www.arca.fiocruz.br/handle/icict/5642310.3390/v14030455engMDPISARS-CoV-2COVID-19Profissionais de saúdeAnticorposCitocinaQuimiocinasPacientesBrasilSARS-CoV-2COVID-19Healthcare workersAntibodiesCytokinesChemokinesBrazilPatientsComparative Analysis of Circulating Levels of SARS-CoV-2 Antibodies and Inflammatory Mediators in HealthcareWorkers and COVID-19 Patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Rede Casa Hospital Rio Laranjeiras e Rio Botafogo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense (UFF). Departamento de Clínica Médica. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratório e Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratório e Sarampo. Rio de Janeiro, RJ, Brasil / Department of Veterinary Integrative Biosciences, Texas A&M University, College Station. Texas, USA,Rede Casa Hospital Rio Laranjeiras e Rio Botafogo. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Advances in knowledge of the pathophysiology of COVID-19 have been acquired; however, the host factors that could explain the mild and severe forms of the disease are not fully understood. Thus, we proposed to evaluate anti-SARS-CoV-2 antibodies and the inflammatory response of different groups of individuals, including healthcare workers (HCW), sick and dead COVID-19 patients and also recovered patients to contribute to this knowledge gap. Our objective is to relate the clinical evolution of these individuals with the level of detection and functionality of specific antibodies and with the production of inflammatory mediators. As main findings, IgA and IgG anti-SARS-CoV-2 were detected in asymptomatic HCW. IFN- and TNF- levels were higher in symptomatic HCWs than patients with COVID-19 and those who died. Patients who died had higher levels of IL-6, IL-10, and CCL2/MCP-1. We found an imbalance between antiviral and pro-inflammatory mediators in the groups, in which IFN- and TNF- seem to be more associated with protection and IL-6 and CCL2/MCP-1 with pathology. Our work is pioneering the Brazilian population and corroborates data from people from other countries.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56423/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLuziaPinto_AlexCorrea_etal_IOC_2022.pdfLuziaPinto_AlexCorrea_etal_IOC_2022.pdfapplication/pdf1932789https://www.arca.fiocruz.br/bitstream/icict/56423/2/LuziaPinto_AlexCorrea_etal_IOC_2022.pdfc0938d3de6aa54a012207f05d31e884dMD52icict/564232023-09-04 11:10:51.824oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-04T14:10:51Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Comparative Analysis of Circulating Levels of SARS-CoV-2 Antibodies and Inflammatory Mediators in HealthcareWorkers and COVID-19 Patients |
| title |
Comparative Analysis of Circulating Levels of SARS-CoV-2 Antibodies and Inflammatory Mediators in HealthcareWorkers and COVID-19 Patients |
| spellingShingle |
Comparative Analysis of Circulating Levels of SARS-CoV-2 Antibodies and Inflammatory Mediators in HealthcareWorkers and COVID-19 Patients Pinto, Luzia Maria de Oliveira SARS-CoV-2 COVID-19 Profissionais de saúde Anticorpos Citocina Quimiocinas Pacientes Brasil SARS-CoV-2 COVID-19 Healthcare workers Antibodies Cytokines Chemokines Brazil Patients |
| title_short |
Comparative Analysis of Circulating Levels of SARS-CoV-2 Antibodies and Inflammatory Mediators in HealthcareWorkers and COVID-19 Patients |
| title_full |
Comparative Analysis of Circulating Levels of SARS-CoV-2 Antibodies and Inflammatory Mediators in HealthcareWorkers and COVID-19 Patients |
| title_fullStr |
Comparative Analysis of Circulating Levels of SARS-CoV-2 Antibodies and Inflammatory Mediators in HealthcareWorkers and COVID-19 Patients |
| title_full_unstemmed |
Comparative Analysis of Circulating Levels of SARS-CoV-2 Antibodies and Inflammatory Mediators in HealthcareWorkers and COVID-19 Patients |
| title_sort |
Comparative Analysis of Circulating Levels of SARS-CoV-2 Antibodies and Inflammatory Mediators in HealthcareWorkers and COVID-19 Patients |
| author |
Pinto, Luzia Maria de Oliveira |
| author_facet |
Pinto, Luzia Maria de Oliveira Solórzano, Victor Edgar Fiestas Martins, Maria de Lourdes Santos, Caroline Fernandes Damasco, Paula Hesselberg Siqueira, Marilda Agudo Mendonça Teixeira de Dias, Helver Gonçalves Pauvolid-Corrêa, Alex Damasco, Paulo Vieira Azeredo, Elzinandes Leal de |
| author_role |
author |
| author2 |
Solórzano, Victor Edgar Fiestas Martins, Maria de Lourdes Santos, Caroline Fernandes Damasco, Paula Hesselberg Siqueira, Marilda Agudo Mendonça Teixeira de Dias, Helver Gonçalves Pauvolid-Corrêa, Alex Damasco, Paulo Vieira Azeredo, Elzinandes Leal de |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Pinto, Luzia Maria de Oliveira Solórzano, Victor Edgar Fiestas Martins, Maria de Lourdes Santos, Caroline Fernandes Damasco, Paula Hesselberg Siqueira, Marilda Agudo Mendonça Teixeira de Dias, Helver Gonçalves Pauvolid-Corrêa, Alex Damasco, Paulo Vieira Azeredo, Elzinandes Leal de |
| dc.subject.other.en_US.fl_str_mv |
SARS-CoV-2 COVID-19 Profissionais de saúde Anticorpos Citocina Quimiocinas Pacientes Brasil |
| topic |
SARS-CoV-2 COVID-19 Profissionais de saúde Anticorpos Citocina Quimiocinas Pacientes Brasil SARS-CoV-2 COVID-19 Healthcare workers Antibodies Cytokines Chemokines Brazil Patients |
| dc.subject.en.en_US.fl_str_mv |
SARS-CoV-2 COVID-19 Healthcare workers Antibodies Cytokines Chemokines Brazil Patients |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. |
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2022 |
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2022 |
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2023-01-10T17:33:09Z |
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2023-01-10T17:33:09Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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PINTO, Luzia Maria de Oliveira et al. Comparative Analysis of Circulating Levels of SARS-CoV-2 Antibodies and Inflammatory Mediators in Healthcare Workers and COVID-19 Patients. Viruses, v. 14, 455, p. 1 - 19, Feb. 2022. |
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https://www.arca.fiocruz.br/handle/icict/56423 |
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1999-4915 |
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10.3390/v14030455 |
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PINTO, Luzia Maria de Oliveira et al. Comparative Analysis of Circulating Levels of SARS-CoV-2 Antibodies and Inflammatory Mediators in Healthcare Workers and COVID-19 Patients. Viruses, v. 14, 455, p. 1 - 19, Feb. 2022. 1999-4915 10.3390/v14030455 |
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