Pyranochromones from Dictyoloma vandellianum A. Juss and Their Cytotoxic Evaluation
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/24897 |
Resumo: | CAPES and CNPq |
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Alves, Iura MunizAbreu, Lucas SilvaCosta, Cinara Oliveira D' SouzaLe Hyaric, MireilleGuedes, Maria Lenise SilvaSoares, Milena Botelho PereiraBezerra, Daniel PereiraVelozo, Eudes da Silva2018-02-21T13:10:07Z2018-02-21T13:10:07Z2017ALVES, I. M. et al. Pyranochromones from Dictyoloma vandellianum A. Juss and Their Cytotoxic Evaluation. Chemistry & Biodiversity, v. 14, e1600276, 2017.1612-1872https://www.arca.fiocruz.br/handle/icict/2489710.1002/cbdv.201600276CAPES and CNPqFederal University of Bahia. Institute of Chemistry. Salvador, BA, BrazilFederal University of Bahia. College of Pharmacy. Salvador, BA, BrazilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFederal University of Juiz de Fora. Department of Chemistry. Juiz de Fora, MG, BrazilFederal University of Bahia. Institute of Biology. Salvador, BA, BrazilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFederal University of Bahia. Institute of Chemistry. Salvador, BA, Brazil / Federal University of Bahia. College of Pharmacy. Salvador, BA, BrazilOne new chromone 3,3-dimethylallylspatheliachromene methyl ether (1), as well as five known chromones, 6-(3-methylbut-2-enyl) allopteroxylin methyl ether (2), 6-(3-methylbut-2-enyl) allopteroxylin (3), 3,3-dimethylallylspatheliachromene (4), 5-O-methylcneorumchromone K (5) and spatheliabischromene (6), two alkaloids, 8-methoxy-N-methylflindersine (7) and 8-methoxyflindersine (8), and two limonoids, limonin diosphenol (9) and rutaevin (10), were isolated from Dictyoloma vandellianum A. Juss (Rutaceae). Cytotoxic activities towards tumor cell lines B16-F10, HepG2, K562 and HL60 and non-tumor cells PBMC were evaluated for compounds 1 - 6. Compound 1 was the most active showing IC50values ranging from 6.26 to 14.82 μg/ml in B16-F10 and K562 cell lines, respectively, and presented IC50value of 11.65 μg/ml in PBMC cell line.engWileyChromonesLimonoidsAlcalóidesSubstâncias citotóxicasDictyolomaRutaceaeChromonesLimonoidsAlkaloidsCytotoxic activitiesDictyolomaRutaceaePyranochromones from Dictyoloma vandellianum A. Juss and Their Cytotoxic Evaluationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/24897/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAlves MI Pyranochromones from Dictyoloma ....pdfAlves MI Pyranochromones from Dictyoloma ....pdfapplication/pdf205022https://www.arca.fiocruz.br/bitstream/icict/24897/2/Alves%20MI%20Pyranochromones%20from%20Dictyoloma%20....pdff93a791ebdf1e5e9ed9ed8df1fd3f84dMD52TEXTAlves MI Pyranochromones from Dictyoloma ....pdf.txtAlves MI Pyranochromones from Dictyoloma ....pdf.txtExtracted texttext/plain20585https://www.arca.fiocruz.br/bitstream/icict/24897/3/Alves%20MI%20Pyranochromones%20from%20Dictyoloma%20....pdf.txt5060022cdd9d3eb1cc42bcbeaf924bc1MD53icict/248972023-03-15 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| dc.title.pt_BR.fl_str_mv |
Pyranochromones from Dictyoloma vandellianum A. Juss and Their Cytotoxic Evaluation |
| title |
Pyranochromones from Dictyoloma vandellianum A. Juss and Their Cytotoxic Evaluation |
| spellingShingle |
Pyranochromones from Dictyoloma vandellianum A. Juss and Their Cytotoxic Evaluation Alves, Iura Muniz Chromones Limonoids Alcalóides Substâncias citotóxicas Dictyoloma Rutaceae Chromones Limonoids Alkaloids Cytotoxic activities Dictyoloma Rutaceae |
| title_short |
Pyranochromones from Dictyoloma vandellianum A. Juss and Their Cytotoxic Evaluation |
| title_full |
Pyranochromones from Dictyoloma vandellianum A. Juss and Their Cytotoxic Evaluation |
| title_fullStr |
Pyranochromones from Dictyoloma vandellianum A. Juss and Their Cytotoxic Evaluation |
| title_full_unstemmed |
Pyranochromones from Dictyoloma vandellianum A. Juss and Their Cytotoxic Evaluation |
| title_sort |
Pyranochromones from Dictyoloma vandellianum A. Juss and Their Cytotoxic Evaluation |
| author |
Alves, Iura Muniz |
| author_facet |
Alves, Iura Muniz Abreu, Lucas Silva Costa, Cinara Oliveira D' Souza Le Hyaric, Mireille Guedes, Maria Lenise Silva Soares, Milena Botelho Pereira Bezerra, Daniel Pereira Velozo, Eudes da Silva |
| author_role |
author |
| author2 |
Abreu, Lucas Silva Costa, Cinara Oliveira D' Souza Le Hyaric, Mireille Guedes, Maria Lenise Silva Soares, Milena Botelho Pereira Bezerra, Daniel Pereira Velozo, Eudes da Silva |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Alves, Iura Muniz Abreu, Lucas Silva Costa, Cinara Oliveira D' Souza Le Hyaric, Mireille Guedes, Maria Lenise Silva Soares, Milena Botelho Pereira Bezerra, Daniel Pereira Velozo, Eudes da Silva |
| dc.subject.other.pt_BR.fl_str_mv |
Chromones Limonoids Alcalóides Substâncias citotóxicas Dictyoloma Rutaceae |
| topic |
Chromones Limonoids Alcalóides Substâncias citotóxicas Dictyoloma Rutaceae Chromones Limonoids Alkaloids Cytotoxic activities Dictyoloma Rutaceae |
| dc.subject.en.pt_BR.fl_str_mv |
Chromones Limonoids Alkaloids Cytotoxic activities Dictyoloma Rutaceae |
| description |
CAPES and CNPq |
| publishDate |
2017 |
| dc.date.issued.fl_str_mv |
2017 |
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2018-02-21T13:10:07Z |
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2018-02-21T13:10:07Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
ALVES, I. M. et al. Pyranochromones from Dictyoloma vandellianum A. Juss and Their Cytotoxic Evaluation. Chemistry & Biodiversity, v. 14, e1600276, 2017. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/24897 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1612-1872 |
| dc.identifier.doi.none.fl_str_mv |
10.1002/cbdv.201600276 |
| identifier_str_mv |
ALVES, I. M. et al. Pyranochromones from Dictyoloma vandellianum A. Juss and Their Cytotoxic Evaluation. Chemistry & Biodiversity, v. 14, e1600276, 2017. 1612-1872 10.1002/cbdv.201600276 |
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https://www.arca.fiocruz.br/handle/icict/24897 |
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eng |
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eng |
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openAccess |
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Wiley |
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Wiley |
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