A NEW SECO-LIMONOID FROM THE INFLORESCENCES OF Dictyoloma vandellianum

Detalhes bibliográficos
Autor(a) principal: Pereira,Laiane Caline Oliveira
Data de Publicação: 2020
Outros Autores: Abreu,Lucas Silva, Silveira,Mayra Bitencourt, Nascimento,Yuri Mangueira do, Souza,Thalisson Amorim de, Hyaric,Mireille Le, Lisboa,Thaís Mangeon Honorato, Sobral,Marianna Vieira, Velozo,Eudes da Silva, Tavares,Josean Fechine, Silva,Marcelo Sobral da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000500568
Resumo: Phytochemical investigation of the inflorescences of Dictyoloma vandellianum A. Juss. (Rutaceae) has led to the isolation of a new A-seco-limonoid, named dictyolomol (1), along with a known quinolone alkaloid, casimiroine (2), previously isolated from the same species. The structures were established by spectroscopic analysis such as one- and two-dimensional NMR, IR, high-resolution mass spectrometry and chemical transformations. The isolated compounds (1 and 2) and O-acetyl derivative (1a) were evaluated for their cytotoxicity against MCF-7 and HeLa cancer cell lines. The results indicated that 1, 1a and 2 showed no significant cytotoxicity.
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spelling A NEW SECO-LIMONOID FROM THE INFLORESCENCES OF Dictyoloma vandellianumA-seco-limonoidalkaloidDictyoloma vandellianumRutaceaecytotoxicityPhytochemical investigation of the inflorescences of Dictyoloma vandellianum A. Juss. (Rutaceae) has led to the isolation of a new A-seco-limonoid, named dictyolomol (1), along with a known quinolone alkaloid, casimiroine (2), previously isolated from the same species. The structures were established by spectroscopic analysis such as one- and two-dimensional NMR, IR, high-resolution mass spectrometry and chemical transformations. The isolated compounds (1 and 2) and O-acetyl derivative (1a) were evaluated for their cytotoxicity against MCF-7 and HeLa cancer cell lines. The results indicated that 1, 1a and 2 showed no significant cytotoxicity.Sociedade Brasileira de Química2020-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000500568Química Nova v.43 n.5 2020reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0100-4042.20170515info:eu-repo/semantics/openAccessPereira,Laiane Caline OliveiraAbreu,Lucas SilvaSilveira,Mayra BitencourtNascimento,Yuri Mangueira doSouza,Thalisson Amorim deHyaric,Mireille LeLisboa,Thaís Mangeon HonoratoSobral,Marianna VieiraVelozo,Eudes da SilvaTavares,Josean FechineSilva,Marcelo Sobral daeng2020-06-25T00:00:00Zoai:scielo:S0100-40422020000500568Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2020-06-25T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv A NEW SECO-LIMONOID FROM THE INFLORESCENCES OF Dictyoloma vandellianum
title A NEW SECO-LIMONOID FROM THE INFLORESCENCES OF Dictyoloma vandellianum
spellingShingle A NEW SECO-LIMONOID FROM THE INFLORESCENCES OF Dictyoloma vandellianum
Pereira,Laiane Caline Oliveira
A-seco-limonoid
alkaloid
Dictyoloma vandellianum
Rutaceae
cytotoxicity
title_short A NEW SECO-LIMONOID FROM THE INFLORESCENCES OF Dictyoloma vandellianum
title_full A NEW SECO-LIMONOID FROM THE INFLORESCENCES OF Dictyoloma vandellianum
title_fullStr A NEW SECO-LIMONOID FROM THE INFLORESCENCES OF Dictyoloma vandellianum
title_full_unstemmed A NEW SECO-LIMONOID FROM THE INFLORESCENCES OF Dictyoloma vandellianum
title_sort A NEW SECO-LIMONOID FROM THE INFLORESCENCES OF Dictyoloma vandellianum
author Pereira,Laiane Caline Oliveira
author_facet Pereira,Laiane Caline Oliveira
Abreu,Lucas Silva
Silveira,Mayra Bitencourt
Nascimento,Yuri Mangueira do
Souza,Thalisson Amorim de
Hyaric,Mireille Le
Lisboa,Thaís Mangeon Honorato
Sobral,Marianna Vieira
Velozo,Eudes da Silva
Tavares,Josean Fechine
Silva,Marcelo Sobral da
author_role author
author2 Abreu,Lucas Silva
Silveira,Mayra Bitencourt
Nascimento,Yuri Mangueira do
Souza,Thalisson Amorim de
Hyaric,Mireille Le
Lisboa,Thaís Mangeon Honorato
Sobral,Marianna Vieira
Velozo,Eudes da Silva
Tavares,Josean Fechine
Silva,Marcelo Sobral da
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pereira,Laiane Caline Oliveira
Abreu,Lucas Silva
Silveira,Mayra Bitencourt
Nascimento,Yuri Mangueira do
Souza,Thalisson Amorim de
Hyaric,Mireille Le
Lisboa,Thaís Mangeon Honorato
Sobral,Marianna Vieira
Velozo,Eudes da Silva
Tavares,Josean Fechine
Silva,Marcelo Sobral da
dc.subject.por.fl_str_mv A-seco-limonoid
alkaloid
Dictyoloma vandellianum
Rutaceae
cytotoxicity
topic A-seco-limonoid
alkaloid
Dictyoloma vandellianum
Rutaceae
cytotoxicity
description Phytochemical investigation of the inflorescences of Dictyoloma vandellianum A. Juss. (Rutaceae) has led to the isolation of a new A-seco-limonoid, named dictyolomol (1), along with a known quinolone alkaloid, casimiroine (2), previously isolated from the same species. The structures were established by spectroscopic analysis such as one- and two-dimensional NMR, IR, high-resolution mass spectrometry and chemical transformations. The isolated compounds (1 and 2) and O-acetyl derivative (1a) were evaluated for their cytotoxicity against MCF-7 and HeLa cancer cell lines. The results indicated that 1, 1a and 2 showed no significant cytotoxicity.
publishDate 2020
dc.date.none.fl_str_mv 2020-05-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000500568
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000500568
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.21577/0100-4042.20170515
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.43 n.5 2020
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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