The biological in vitro effect and selectivity of aromatic dicationic compounds on Trypanosoma cruzi

Detalhes bibliográficos
Autor(a) principal: Silva, Cristiane França da
Data de Publicação: 2010
Outros Autores: Silva, Patrícia Bernadino da, Batista, Marcos Meuser, Daliry, Anissa, Tidwell, Richard R., Soeiro, Maria de Nazaré Correia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/30316
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
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spelling Silva, Cristiane França daSilva, Patrícia Bernadino daBatista, Marcos MeuserDaliry, AnissaTidwell, Richard R.Soeiro, Maria de Nazaré Correia2018-11-29T14:04:31Z2018-11-29T14:04:31Z2010SILVA, Cristiana França da; et al. The biological in vitro effect and selectivity of aromatic dicationic compounds on Trypanosoma cruzi. Mem Inst Oswaldo Cruz, v.105, n.3, p.239-245, May 2010.0074-0276https://www.arca.fiocruz.br/handle/icict/303161678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzDoença de ChagasQuimioterapiaTrypanosoma cruzicompostos aromáticosaromatic compoundsTrypanosoma cruzichemotherapyChagas diseaseThe biological in vitro effect and selectivity of aromatic dicationic compounds on Trypanosoma cruziinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.University of North Carolina at Chapel Hill. Department of Pathology and Laboratory Medicine. Chapell Hill, NC, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.Trypanosoma cruzi is a parasite that causes Chagas disease, which affects millions of individuals in endemic areas of Latin America. One hundred years after the discovery of Chagas disease, it is still considered a neglected illness because the available drugs are unsatisfactory. Aromatic compounds represent an important class of DNA minor groove-binding ligands that exhibit potent antimicrobial activity. This study focused on the in vitro activity of 10 aromatic dicationic compounds against bloodstream trypomastigotes and intracellular forms of T. cruzi. Our data demonstrated that these compounds display trypanocidal effects against both forms of the parasite and that seven out of the 10 compounds presented higher anti-parasitic activity against intracellular parasites compared with the bloodstream forms. Additional assays to determine the potential toxicity to mammalian cells showed that the majority of the dicationic compounds did not considerably decrease cellular viability. Fluorescent microscopy analysis demonstrated that although all compounds were localised to a greater extent within the kinetoplast than the nucleus, no correlation could be found between compound activity and kDNA accumulation. The present results stimulate further investigations of this class of compounds for the rational design of new chemotherapeutic agents for Chagas disease.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/30316/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALpatriciap_silva_etal_IOC_2010.pdfpatriciap_silva_etal_IOC_2010.pdfapplication/pdf1034869https://www.arca.fiocruz.br/bitstream/icict/30316/2/patriciap_silva_etal_IOC_2010.pdfc644a3178c415cec63d104ddcd857555MD52TEXTpatriciap_silva_etal_IOC_2010.pdf.txtpatriciap_silva_etal_IOC_2010.pdf.txtExtracted texttext/plain25759https://www.arca.fiocruz.br/bitstream/icict/30316/3/patriciap_silva_etal_IOC_2010.pdf.txtaa3122c28624d174751175e17b31d726MD53icict/303162018-11-30 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dc.title.pt_BR.fl_str_mv The biological in vitro effect and selectivity of aromatic dicationic compounds on Trypanosoma cruzi
title The biological in vitro effect and selectivity of aromatic dicationic compounds on Trypanosoma cruzi
spellingShingle The biological in vitro effect and selectivity of aromatic dicationic compounds on Trypanosoma cruzi
Silva, Cristiane França da
Doença de Chagas
Quimioterapia
Trypanosoma cruzi
compostos aromáticos
aromatic compounds
Trypanosoma cruzi
chemotherapy
Chagas disease
title_short The biological in vitro effect and selectivity of aromatic dicationic compounds on Trypanosoma cruzi
title_full The biological in vitro effect and selectivity of aromatic dicationic compounds on Trypanosoma cruzi
title_fullStr The biological in vitro effect and selectivity of aromatic dicationic compounds on Trypanosoma cruzi
title_full_unstemmed The biological in vitro effect and selectivity of aromatic dicationic compounds on Trypanosoma cruzi
title_sort The biological in vitro effect and selectivity of aromatic dicationic compounds on Trypanosoma cruzi
author Silva, Cristiane França da
author_facet Silva, Cristiane França da
Silva, Patrícia Bernadino da
Batista, Marcos Meuser
Daliry, Anissa
Tidwell, Richard R.
Soeiro, Maria de Nazaré Correia
author_role author
author2 Silva, Patrícia Bernadino da
Batista, Marcos Meuser
Daliry, Anissa
Tidwell, Richard R.
Soeiro, Maria de Nazaré Correia
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Cristiane França da
Silva, Patrícia Bernadino da
Batista, Marcos Meuser
Daliry, Anissa
Tidwell, Richard R.
Soeiro, Maria de Nazaré Correia
dc.subject.other.pt_BR.fl_str_mv Doença de Chagas
Quimioterapia
Trypanosoma cruzi
compostos aromáticos
topic Doença de Chagas
Quimioterapia
Trypanosoma cruzi
compostos aromáticos
aromatic compounds
Trypanosoma cruzi
chemotherapy
Chagas disease
dc.subject.en.pt_BR.fl_str_mv aromatic compounds
Trypanosoma cruzi
chemotherapy
Chagas disease
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2018-11-29T14:04:31Z
dc.date.available.fl_str_mv 2018-11-29T14:04:31Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Cristiana França da; et al. The biological in vitro effect and selectivity of aromatic dicationic compounds on Trypanosoma cruzi. Mem Inst Oswaldo Cruz, v.105, n.3, p.239-245, May 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/30316
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv SILVA, Cristiana França da; et al. The biological in vitro effect and selectivity of aromatic dicationic compounds on Trypanosoma cruzi. Mem Inst Oswaldo Cruz, v.105, n.3, p.239-245, May 2010.
0074-0276
1678-8060
url https://www.arca.fiocruz.br/handle/icict/30316
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/30316/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/30316/2/patriciap_silva_etal_IOC_2010.pdf
https://www.arca.fiocruz.br/bitstream/icict/30316/3/patriciap_silva_etal_IOC_2010.pdf.txt
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