Solid lipid nanoparticles as a novel formulation approach for tanespimycin (17-AAG) against leishmania infections: Preparation, characterization and macrophage uptake
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/42999 |
Resumo: | Programa de Excelência Acadêmica – Proex (PgPat/UFBA/FIOCRUZ), INCT-MCTI/CNPq/CAPES/FAPs N° 16/2014 and grants from the Fundação de Amparo à Pesquisa do Estado da Bahia – FAPESB and the Conselho Nacional de Pesquisa e Desenvolvimento Científico – CNPq. PSTV holds a grant from CNPq for productivity in research (307832/2015–5). In addition, this study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001. The authors also acknowledge support from the Serviço de Microscopia Eletrônica (SME) – FIOCRUZ/BA for TEM analysis and CIENAM/UFBA for size and zeta potential measurements |
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Pires, Vinícius CoutoMagalhães, Carla PiresFerrante, MarcosRebouças, Juliana de SouzaNguewa, PaulSeverino, PatríciaBarral, Aldina Maria PradoVeras, Patrícia Sampaio TavaresFormiga, Fabio Rocha2020-08-26T16:51:39Z2020-08-26T16:51:39Z2020PIRES, Vinícius Couto et al. Solid lipid nanoparticles as a novel formulation approach for tanespimycin (17-AAG) against leishmania infections: Preparation, characterization and macrophage uptake. Acta Tropica, p. 1-5, 16 Mar. 2020.0001-706Xhttps://www.arca.fiocruz.br/handle/icict/4299910.1016/j.actatropica.2020.105595Programa de Excelência Acadêmica – Proex (PgPat/UFBA/FIOCRUZ), INCT-MCTI/CNPq/CAPES/FAPs N° 16/2014 and grants from the Fundação de Amparo à Pesquisa do Estado da Bahia – FAPESB and the Conselho Nacional de Pesquisa e Desenvolvimento Científico – CNPq. PSTV holds a grant from CNPq for productivity in research (307832/2015–5). In addition, this study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001. The authors also acknowledge support from the Serviço de Microscopia Eletrônica (SME) – FIOCRUZ/BA for TEM analysis and CIENAM/UFBA for size and zeta potential measurementsFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal de Lavras. Departamento de Medicina Veterinária. Lavras, MG, Brasil.Universidade de Pernambuco. Instituto de Ciências Biológicas. Recife, PE, Brasil.University of Navarra. Irunlarrea. Instituto de Salud Tropical. Pamplona, Spain.Laboratório de Universidade Tiradentes. Instituto de Tecnologia e Pesquisa. Nanotecnologia e Nanomedicina. Aracaju, SE, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade de Pernambuco. Programa de Pós-Graduação em Biologia Celular e Molecular Aplicada. Recife, PE, Brasil / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.17-N-allylamino-17-demethoxygeldanamycin (17-AAG, tanespimycin) is an inhibitor of heat shock protein 90 (Hsp90), which has been studied in the treatment of cancer such as leukemia or solid tumors. Alternatively, 17-AAG may represent a promising therapeutic agent against leishmaniasis. However, the delivery of 17-AAG is difficult due to its poor aqueous solubility. For exploring the therapeutic value of 17-AAG, we developed solid lipid nanoparticles (SLN) by double emulsion method. SLN exhibited ~100 nm, PDI < 0.2 and zeta potential ~20 mV. In addition, SLN were morphologically spherical with negligible aggregation. The entrapment efficiency of 17-AAG into the lipid matrix reached at nearly 80%. In a separate set of experiments, fluorescent SLN (FITC-labeled) showed a remarkable macrophage uptake, peaking within 2 h of incubation by confocal microscopy. Regarding the drug internalization as critical step for elimination of intracellular Leishmania, this finding demonstrates an important feature of the developed SLN. Collectively, these data indicate the feasibility of developing SLN as potential delivery systems for 17-AAG in leishmaniasis chemotherapy.engElsevierNanopartículasLipidiosIn vitroMacrófagosLeishmaniose17-n-allylamino-17-demethoxygeldanamycin (17-aag)Solid lipid nanoparticles (sln)In vitro uptakeMacrophagesLeishmaniasisSolid lipid nanoparticles as a novel formulation approach for tanespimycin (17-AAG) against leishmania infections: Preparation, characterization and macrophage uptakeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/42999/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPires, Vinicius Couto. Solid lipid....pdfPires, Vinicius Couto. 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dc.title.pt_BR.fl_str_mv |
Solid lipid nanoparticles as a novel formulation approach for tanespimycin (17-AAG) against leishmania infections: Preparation, characterization and macrophage uptake |
title |
Solid lipid nanoparticles as a novel formulation approach for tanespimycin (17-AAG) against leishmania infections: Preparation, characterization and macrophage uptake |
spellingShingle |
Solid lipid nanoparticles as a novel formulation approach for tanespimycin (17-AAG) against leishmania infections: Preparation, characterization and macrophage uptake Pires, Vinícius Couto Nanopartículas Lipidios In vitro Macrófagos Leishmaniose 17-n-allylamino-17-demethoxygeldanamycin (17-aag) Solid lipid nanoparticles (sln) In vitro uptake Macrophages Leishmaniasis |
title_short |
Solid lipid nanoparticles as a novel formulation approach for tanespimycin (17-AAG) against leishmania infections: Preparation, characterization and macrophage uptake |
title_full |
Solid lipid nanoparticles as a novel formulation approach for tanespimycin (17-AAG) against leishmania infections: Preparation, characterization and macrophage uptake |
title_fullStr |
Solid lipid nanoparticles as a novel formulation approach for tanespimycin (17-AAG) against leishmania infections: Preparation, characterization and macrophage uptake |
title_full_unstemmed |
Solid lipid nanoparticles as a novel formulation approach for tanespimycin (17-AAG) against leishmania infections: Preparation, characterization and macrophage uptake |
title_sort |
Solid lipid nanoparticles as a novel formulation approach for tanespimycin (17-AAG) against leishmania infections: Preparation, characterization and macrophage uptake |
author |
Pires, Vinícius Couto |
author_facet |
Pires, Vinícius Couto Magalhães, Carla Pires Ferrante, Marcos Rebouças, Juliana de Souza Nguewa, Paul Severino, Patrícia Barral, Aldina Maria Prado Veras, Patrícia Sampaio Tavares Formiga, Fabio Rocha |
author_role |
author |
author2 |
Magalhães, Carla Pires Ferrante, Marcos Rebouças, Juliana de Souza Nguewa, Paul Severino, Patrícia Barral, Aldina Maria Prado Veras, Patrícia Sampaio Tavares Formiga, Fabio Rocha |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Pires, Vinícius Couto Magalhães, Carla Pires Ferrante, Marcos Rebouças, Juliana de Souza Nguewa, Paul Severino, Patrícia Barral, Aldina Maria Prado Veras, Patrícia Sampaio Tavares Formiga, Fabio Rocha |
dc.subject.other.pt_BR.fl_str_mv |
Nanopartículas Lipidios In vitro Macrófagos Leishmaniose |
topic |
Nanopartículas Lipidios In vitro Macrófagos Leishmaniose 17-n-allylamino-17-demethoxygeldanamycin (17-aag) Solid lipid nanoparticles (sln) In vitro uptake Macrophages Leishmaniasis |
dc.subject.en.pt_BR.fl_str_mv |
17-n-allylamino-17-demethoxygeldanamycin (17-aag) Solid lipid nanoparticles (sln) In vitro uptake Macrophages Leishmaniasis |
description |
Programa de Excelência Acadêmica – Proex (PgPat/UFBA/FIOCRUZ), INCT-MCTI/CNPq/CAPES/FAPs N° 16/2014 and grants from the Fundação de Amparo à Pesquisa do Estado da Bahia – FAPESB and the Conselho Nacional de Pesquisa e Desenvolvimento Científico – CNPq. PSTV holds a grant from CNPq for productivity in research (307832/2015–5). In addition, this study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001. The authors also acknowledge support from the Serviço de Microscopia Eletrônica (SME) – FIOCRUZ/BA for TEM analysis and CIENAM/UFBA for size and zeta potential measurements |
publishDate |
2020 |
dc.date.accessioned.fl_str_mv |
2020-08-26T16:51:39Z |
dc.date.available.fl_str_mv |
2020-08-26T16:51:39Z |
dc.date.issued.fl_str_mv |
2020 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
PIRES, Vinícius Couto et al. Solid lipid nanoparticles as a novel formulation approach for tanespimycin (17-AAG) against leishmania infections: Preparation, characterization and macrophage uptake. Acta Tropica, p. 1-5, 16 Mar. 2020. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/42999 |
dc.identifier.issn.pt_BR.fl_str_mv |
0001-706X |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.actatropica.2020.105595 |
identifier_str_mv |
PIRES, Vinícius Couto et al. Solid lipid nanoparticles as a novel formulation approach for tanespimycin (17-AAG) against leishmania infections: Preparation, characterization and macrophage uptake. Acta Tropica, p. 1-5, 16 Mar. 2020. 0001-706X 10.1016/j.actatropica.2020.105595 |
url |
https://www.arca.fiocruz.br/handle/icict/42999 |
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eng |
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eng |
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openAccess |
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Elsevier |
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Elsevier |
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