Dynamics of Lymphocyte Populations during Trypanosoma cruzi Infection: From Thymocyte Depletion to Differential Cell Expansion/Contraction in Peripheral Lymphoid Organs

Detalhes bibliográficos
Autor(a) principal: Morrot, Alexandre
Data de Publicação: 2012
Outros Autores: Albuquerque, Juliana Barreto de, Berbert, Luiz Ricardo, Pinto, Carla Eponina de Carvalho, Meis, Juliana de, Savino, Wilson
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/18601
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.
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spelling Morrot, AlexandreAlbuquerque, Juliana Barreto deBerbert, Luiz RicardoPinto, Carla Eponina de CarvalhoMeis, Juliana deSavino, Wilson2017-04-20T16:53:40Z2017-04-20T16:53:40Z2012MORROT, Alexandre; et al. Dynamics of Lymphocyte Populations during Trypanosoma cruzi Infection: From Thymocyte Depletion to Differential Cell Expansion/Contraction in Peripheral Lymphoid Organs. Journal of Tropical Medicine, Volume 2012, Article ID 747185, 7p, 2012.1687-9686https://www.arca.fiocruz.br/handle/icict/1860110.1155/2012/7471851687-9694engHindawi Publishing CorporationPopulações de Linfócitosinfecção por Trypanosoma cruziTimócitosCélula DiferencialÓrgãos Linfóides PeriféricosDoença de Chagasexperimental acute infectionTrypanosoma cruziPeripheral Lymphoid OrgansThymocyte DepletionLymphocyte PopulationsChagas DiseaseDynamics of Lymphocyte Populations during Trypanosoma cruzi Infection: From Thymocyte Depletion to Differential Cell Expansion/Contraction in Peripheral Lymphoid Organsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / Universidade Federal Fluminense. Instituto de Biologia. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil .Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil.The comprehension of the immune responses in infectious diseases is crucial for developing novel therapeutic strategies. Here, we review current findings on the dynamics of lymphocyte subpopulations following experimental acute infection by Trypanosoma cruzi, the causative agent of Chagas disease. In the thymus, although the negative selection process of the T-cell repertoire remains operational, there is a massive thymocyte depletion and abnormal release of immature CD4(+)CD8(+) cells to peripheral lymphoid organs, where they acquire an activated phenotype similar to activated effector or memory T cells. These cells apparently bypassed the negative selection process, and some of them are potentially autoimmune. In infected animals, an atrophy of mesenteric lymph nodes is also observed, in contrast with the lymphocyte expansion in spleen and subcutaneous lymph nodes, illustrating a complex and organ specific dynamics of lymphocyte subpopulations. Accordingly, T- and B-cell activation is seen in subcutaneous lymph nodes and spleen, but not in mesenteric lymph nodes. Lastly, although the function of peripheral CD4(+)CD8(+) T-cell population remains to be defined in vivo, their presence may contribute to the immunopathological events found in both murine and human Chagas disease.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18601/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALalexandre_morrot_etal_IOC_2012.pdfalexandre_morrot_etal_IOC_2012.pdfapplication/pdf2552317https://www.arca.fiocruz.br/bitstream/icict/18601/2/alexandre_morrot_etal_IOC_2012.pdfe878059fbbcd18fa14c62d29eae1e85cMD52TEXTalexandre_morrot_etal_IOC_2012.pdf.txtalexandre_morrot_etal_IOC_2012.pdf.txtExtracted texttext/plain38554https://www.arca.fiocruz.br/bitstream/icict/18601/3/alexandre_morrot_etal_IOC_2012.pdf.txte5ed97ccc144b3ac569dc15fd8bf18f7MD53icict/186012023-09-14 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dc.title.pt_BR.fl_str_mv Dynamics of Lymphocyte Populations during Trypanosoma cruzi Infection: From Thymocyte Depletion to Differential Cell Expansion/Contraction in Peripheral Lymphoid Organs
title Dynamics of Lymphocyte Populations during Trypanosoma cruzi Infection: From Thymocyte Depletion to Differential Cell Expansion/Contraction in Peripheral Lymphoid Organs
spellingShingle Dynamics of Lymphocyte Populations during Trypanosoma cruzi Infection: From Thymocyte Depletion to Differential Cell Expansion/Contraction in Peripheral Lymphoid Organs
Morrot, Alexandre
Populações de Linfócitos
infecção por Trypanosoma cruzi
Timócitos
Célula Diferencial
Órgãos Linfóides Periféricos
Doença de Chagas
experimental acute infection
Trypanosoma cruzi
Peripheral Lymphoid Organs
Thymocyte Depletion
Lymphocyte Populations
Chagas Disease
title_short Dynamics of Lymphocyte Populations during Trypanosoma cruzi Infection: From Thymocyte Depletion to Differential Cell Expansion/Contraction in Peripheral Lymphoid Organs
title_full Dynamics of Lymphocyte Populations during Trypanosoma cruzi Infection: From Thymocyte Depletion to Differential Cell Expansion/Contraction in Peripheral Lymphoid Organs
title_fullStr Dynamics of Lymphocyte Populations during Trypanosoma cruzi Infection: From Thymocyte Depletion to Differential Cell Expansion/Contraction in Peripheral Lymphoid Organs
title_full_unstemmed Dynamics of Lymphocyte Populations during Trypanosoma cruzi Infection: From Thymocyte Depletion to Differential Cell Expansion/Contraction in Peripheral Lymphoid Organs
title_sort Dynamics of Lymphocyte Populations during Trypanosoma cruzi Infection: From Thymocyte Depletion to Differential Cell Expansion/Contraction in Peripheral Lymphoid Organs
author Morrot, Alexandre
author_facet Morrot, Alexandre
Albuquerque, Juliana Barreto de
Berbert, Luiz Ricardo
Pinto, Carla Eponina de Carvalho
Meis, Juliana de
Savino, Wilson
author_role author
author2 Albuquerque, Juliana Barreto de
Berbert, Luiz Ricardo
Pinto, Carla Eponina de Carvalho
Meis, Juliana de
Savino, Wilson
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Morrot, Alexandre
Albuquerque, Juliana Barreto de
Berbert, Luiz Ricardo
Pinto, Carla Eponina de Carvalho
Meis, Juliana de
Savino, Wilson
dc.subject.other.pt_BR.fl_str_mv Populações de Linfócitos
infecção por Trypanosoma cruzi
Timócitos
Célula Diferencial
Órgãos Linfóides Periféricos
Doença de Chagas
topic Populações de Linfócitos
infecção por Trypanosoma cruzi
Timócitos
Célula Diferencial
Órgãos Linfóides Periféricos
Doença de Chagas
experimental acute infection
Trypanosoma cruzi
Peripheral Lymphoid Organs
Thymocyte Depletion
Lymphocyte Populations
Chagas Disease
dc.subject.en.pt_BR.fl_str_mv experimental acute infection
Trypanosoma cruzi
Peripheral Lymphoid Organs
Thymocyte Depletion
Lymphocyte Populations
Chagas Disease
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2017-04-20T16:53:40Z
dc.date.available.fl_str_mv 2017-04-20T16:53:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MORROT, Alexandre; et al. Dynamics of Lymphocyte Populations during Trypanosoma cruzi Infection: From Thymocyte Depletion to Differential Cell Expansion/Contraction in Peripheral Lymphoid Organs. Journal of Tropical Medicine, Volume 2012, Article ID 747185, 7p, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/18601
dc.identifier.issn.pt_BR.fl_str_mv 1687-9686
dc.identifier.doi.none.fl_str_mv 10.1155/2012/747185
dc.identifier.eissn.none.fl_str_mv 1687-9694
identifier_str_mv MORROT, Alexandre; et al. Dynamics of Lymphocyte Populations during Trypanosoma cruzi Infection: From Thymocyte Depletion to Differential Cell Expansion/Contraction in Peripheral Lymphoid Organs. Journal of Tropical Medicine, Volume 2012, Article ID 747185, 7p, 2012.
1687-9686
10.1155/2012/747185
1687-9694
url https://www.arca.fiocruz.br/handle/icict/18601
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/18601/2/alexandre_morrot_etal_IOC_2012.pdf
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