Comparative microsatellite typing of new world leishmania infantum reveals low heterogeneity among populations and its recent old world origin
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/16205 |
Resumo: | Charité Universitá¨tsmedizin Berlin. Institut für Mikrobiologie und Hygiene. Berlin, Germany. |
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Kuhls, KatrinAlam, Mohammad ZahangirCupolillo, ElisaFerreira, Gabriel Eduardo M.Mauricio, Isabel L.Oddone, RolandoFeliciangeli, M. DoraWirth, ThierryMiles, Michael A.Schönian, Gabriele2016-10-13T11:19:59Z2016-10-13T11:19:59Z2011KUHLS, Katrin; et al. Comparative Microsatellite Typing of New World Leishmania infantum Reveals Low Heterogeneity among Populations and Its Recent Old World Origin. PLoS Negl Trop Dis., v.5, n.6, e1155, June 2011.1935-2727https://www.arca.fiocruz.br/handle/icict/1620510.1371/journal.pntd.0001155engPublic Library of ScienceLeishmaniose visceralAméricasLeishmania infantumLeishmania infantumvisceral leishmaniasisNew WorldComparative microsatellite typing of new world leishmania infantum reveals low heterogeneity among populations and its recent old world origininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCharité Universitá¨tsmedizin Berlin. Institut für Mikrobiologie und Hygiene. Berlin, Germany.Charité Universitá¨tsmedizin Berlin. Institut für Mikrobiologie und Hygiene. Berlin, Germany.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Insetos. Rio de Janeiro, RJ, Brasil.London School of Hygiene and Tropical Medicine. Faculty of Infectious and Tropical Diseases. Department of Pathogen Molecular Biology. London, United Kingdom.Universidad Nacional de Asuncion. Instituto de Investigaciones en Ciencias de la Salud. Asunción, Paraguay.Universidad de Carabobo. BIOMED-Centro Nacional de Referencia de Flebotomos de Venezuela. UCBIOMED- CNRFV. Maracay, Venezuela.Muséum National d’Histoire Naturelle. Ecole Pratique des Hautes Etudes. Département de Systématique et Évolution. Paris, France.London School of Hygiene and Tropical Medicine. Faculty of Infectious and Tropical Diseases. Department of Pathogen Molecular Biology. London, United Kingdom.Charité Universitá¨tsmedizin Berlin. Institut für Mikrobiologie und Hygiene. Berlin, Germany.Leishmania infantum (syn. L. chagasi) is the causative agent of visceral leishmaniasis (VL) in the New World (NW) with endemic regions extending from southern USA to northern Argentina. The two hypotheses about the origin of VL in the NW suggest (1) recent importation of L. infantum from the Old World (OW), or (2) an indigenous origin and a distinct taxonomic rank for the NW parasite. Multilocus microsatellite typing was applied in a survey of 98 L. infantum isolates from different NW foci. The microsatellite profiles obtained were compared to those of 308 L. infantum and 20 L. donovani strains from OW countries previously assigned to well-defined populations. Two main populations were identified for both NW and OW L. infantum. Most of the NW strains belonged to population 1, which corresponded to the OW MON-1 population. However, the NW population was much more homogeneous. A second, more heterogeneous, population comprised most Caribbean strains and corresponded to the OW non-MON-1 population. All Brazilian L. infantum strains belonged to population 1, although they represented 61% of the sample and originated from 9 states. Population analysis including the OW L. infantum populations indicated that the NW strains were more similar to MON-1 and non-MON-1 sub-populations of L. infantum from southwest Europe, than to any other OW sub-population. Moreover, similarity between NW and Southwest European L. infantum was higher than between OW L. infantum from distinct parts of the Mediterranean region, Middle East and Central Asia. No correlation was found between NW L. infantum genotypes and clinical picture or host background. This study represents the first continent-wide analysis of NW L. infantum population structure. It confirmed that the agent of VL in the NW is L. infantum and that the parasite has been recently imported multiple times to the NW from southwest Europe.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16205/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALgabriel_ferreira_etal_IOC_2011.pdfgabriel_ferreira_etal_IOC_2011.pdfapplication/pdf862838https://www.arca.fiocruz.br/bitstream/icict/16205/2/gabriel_ferreira_etal_IOC_2011.pdf926cd686d5c6d0985598c2aa24b8c120MD52TEXTgabriel_ferreira_etal_IOC_2011.pdf.txtgabriel_ferreira_etal_IOC_2011.pdf.txtExtracted texttext/plain81745https://www.arca.fiocruz.br/bitstream/icict/16205/3/gabriel_ferreira_etal_IOC_2011.pdf.txt7cb0d09da8afb8b9cc08ee5faa90940eMD53icict/162052018-04-02 07:58:38.559oai:www.arca.fiocruz.br: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ório 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| dc.title.pt_BR.fl_str_mv |
Comparative microsatellite typing of new world leishmania infantum reveals low heterogeneity among populations and its recent old world origin |
| title |
Comparative microsatellite typing of new world leishmania infantum reveals low heterogeneity among populations and its recent old world origin |
| spellingShingle |
Comparative microsatellite typing of new world leishmania infantum reveals low heterogeneity among populations and its recent old world origin Kuhls, Katrin Leishmaniose visceral Américas Leishmania infantum Leishmania infantum visceral leishmaniasis New World |
| title_short |
Comparative microsatellite typing of new world leishmania infantum reveals low heterogeneity among populations and its recent old world origin |
| title_full |
Comparative microsatellite typing of new world leishmania infantum reveals low heterogeneity among populations and its recent old world origin |
| title_fullStr |
Comparative microsatellite typing of new world leishmania infantum reveals low heterogeneity among populations and its recent old world origin |
| title_full_unstemmed |
Comparative microsatellite typing of new world leishmania infantum reveals low heterogeneity among populations and its recent old world origin |
| title_sort |
Comparative microsatellite typing of new world leishmania infantum reveals low heterogeneity among populations and its recent old world origin |
| author |
Kuhls, Katrin |
| author_facet |
Kuhls, Katrin Alam, Mohammad Zahangir Cupolillo, Elisa Ferreira, Gabriel Eduardo M. Mauricio, Isabel L. Oddone, Rolando Feliciangeli, M. Dora Wirth, Thierry Miles, Michael A. Schönian, Gabriele |
| author_role |
author |
| author2 |
Alam, Mohammad Zahangir Cupolillo, Elisa Ferreira, Gabriel Eduardo M. Mauricio, Isabel L. Oddone, Rolando Feliciangeli, M. Dora Wirth, Thierry Miles, Michael A. Schönian, Gabriele |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Kuhls, Katrin Alam, Mohammad Zahangir Cupolillo, Elisa Ferreira, Gabriel Eduardo M. Mauricio, Isabel L. Oddone, Rolando Feliciangeli, M. Dora Wirth, Thierry Miles, Michael A. Schönian, Gabriele |
| dc.subject.other.pt_BR.fl_str_mv |
Leishmaniose visceral Américas Leishmania infantum |
| topic |
Leishmaniose visceral Américas Leishmania infantum Leishmania infantum visceral leishmaniasis New World |
| dc.subject.en.pt_BR.fl_str_mv |
Leishmania infantum visceral leishmaniasis New World |
| description |
Charité Universitá¨tsmedizin Berlin. Institut für Mikrobiologie und Hygiene. Berlin, Germany. |
| publishDate |
2011 |
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2011 |
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2016-10-13T11:19:59Z |
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2016-10-13T11:19:59Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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KUHLS, Katrin; et al. Comparative Microsatellite Typing of New World Leishmania infantum Reveals Low Heterogeneity among Populations and Its Recent Old World Origin. PLoS Negl Trop Dis., v.5, n.6, e1155, June 2011. |
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https://www.arca.fiocruz.br/handle/icict/16205 |
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1935-2727 |
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10.1371/journal.pntd.0001155 |
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KUHLS, Katrin; et al. Comparative Microsatellite Typing of New World Leishmania infantum Reveals Low Heterogeneity among Populations and Its Recent Old World Origin. PLoS Negl Trop Dis., v.5, n.6, e1155, June 2011. 1935-2727 10.1371/journal.pntd.0001155 |
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