Association between high titers of glutamic acid decarboxylase antibody and epilepsy in patients with type 1 diabetes mellitus: a cross-sectional study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/36071 |
Resumo: | Marco Antonio Lima. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. |
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Aguiar, Tiago S.Dantas, Joana R.Cabral, Débora B.Rêgo, Cláudia Cecília S.Zajdenverg, LenitaSalles, Gil FernandoAlves-Leon, Soniza V.Rodacki, MelanieLima, Marco Antonio2019-10-02T13:51:42Z2019-10-02T13:51:42Z2019AGUIAR, Tiago S. et al. Association between high titers of glutamic acid decarboxylase antibody and epilepsy in patients with type 1 diabetes mellitus: a cross-sectional study. Seizure: European Journal of Epilepsy, v. 71, p. 318-321, 2019.1059-1311https://www.arca.fiocruz.br/handle/icict/3607110.1016/j.seizure.2019.09.0031532-2688Marco Antonio Lima. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.2020-10-02Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Departamento de Neurologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Departamento de Nutrologia e Diabetes. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Departamento de Nutrologia e Diabetes. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Departamento de Neurologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro. Departamento de Neurologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Departamento de Nutrologia e Diabetes. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Departamento de e Clínica Médica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Departamento de Neurologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro. Departamento de Neurologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Departamento de Nutrologia e Diabetes. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Departamento de Neurologia. Rio de Janeiro, RJ, Brasil.Purpose: Individuals with type 1 diabetes mellitus (T1D) are at higher risk of epilepsy. T1D is a progressive immune-mediated disease and the etiology of epilepsy remains unknown in most. Glutamic acid decarboxylase (GAD) catalyzes GABA formation. GABA-secreting neurons and pancreatic beta cells are the major cells expressing GAD. Methods: Cross-sectional study. Patients with T1D from a multiethnic population underwent GADA measurement to investigate possible association between T1D and epilepsy of unknown etiology. Results: T1D patients were analyzed (n = 375). Overall frequency of epilepsy was 5.9% (n = 22). Frequency of epilepsy of unknown etiology was 3.2% (n = 12). Of these, 8 (2.1%) had idiopathic generalized epilepsy (IGE) and 4 (1.1%) MRI-negative temporal lobe epilepsy (TLE). Patients with T1D and epilepsy of unknown etiology did not show differences in GADA frequency (83.3% vs 50%; p = 0.076); however, their titers were higher (106.9 ± 136.5 IU/mL; median 7; IQR 1.65–256 vs 10.2 ± 14.5 IU/ml; median 4.3; IQR 1.9–8.9; p = 0.019) compared to patients without epilepsy. Moreover, epilepsy of unknown etiology was associated with GADA titers ≥ 100 UI/mL [odds ratio (OR) 4.42, 95% CI 2.36–8.66]. Conclusion: Epilepsy frequency was elevated in patients with T1D and multiethnic background. Presence of epilepsy of unknown etiology was associated with high titers of GADA in this population with long-standing T1D, which has different ethnic and genetic background compared to previous studies. Further prospective studies are required to identify if GADA presence or its persistence are directly responsible for epilepsy in individuals with T1D.engElsevierAssociation between high titers of glutamic acid decarboxylase antibody and epilepsy in patients with type 1 diabetes mellitus: a cross-sectional studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAutoimmune epilepsyAnti-GADAntibodiesType 1 diabetes mellitusAutoimmunitySeizureinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Association between high titers of glutamic acid decarboxylase antibody and epilepsy in patients with type 1 diabetes mellitus: a cross-sectional study |
| title |
Association between high titers of glutamic acid decarboxylase antibody and epilepsy in patients with type 1 diabetes mellitus: a cross-sectional study |
| spellingShingle |
Association between high titers of glutamic acid decarboxylase antibody and epilepsy in patients with type 1 diabetes mellitus: a cross-sectional study Aguiar, Tiago S. Autoimmune epilepsy Anti-GAD Antibodies Type 1 diabetes mellitus Autoimmunity Seizure |
| title_short |
Association between high titers of glutamic acid decarboxylase antibody and epilepsy in patients with type 1 diabetes mellitus: a cross-sectional study |
| title_full |
Association between high titers of glutamic acid decarboxylase antibody and epilepsy in patients with type 1 diabetes mellitus: a cross-sectional study |
| title_fullStr |
Association between high titers of glutamic acid decarboxylase antibody and epilepsy in patients with type 1 diabetes mellitus: a cross-sectional study |
| title_full_unstemmed |
Association between high titers of glutamic acid decarboxylase antibody and epilepsy in patients with type 1 diabetes mellitus: a cross-sectional study |
| title_sort |
Association between high titers of glutamic acid decarboxylase antibody and epilepsy in patients with type 1 diabetes mellitus: a cross-sectional study |
| author |
Aguiar, Tiago S. |
| author_facet |
Aguiar, Tiago S. Dantas, Joana R. Cabral, Débora B. Rêgo, Cláudia Cecília S. Zajdenverg, Lenita Salles, Gil Fernando Alves-Leon, Soniza V. Rodacki, Melanie Lima, Marco Antonio |
| author_role |
author |
| author2 |
Dantas, Joana R. Cabral, Débora B. Rêgo, Cláudia Cecília S. Zajdenverg, Lenita Salles, Gil Fernando Alves-Leon, Soniza V. Rodacki, Melanie Lima, Marco Antonio |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Aguiar, Tiago S. Dantas, Joana R. Cabral, Débora B. Rêgo, Cláudia Cecília S. Zajdenverg, Lenita Salles, Gil Fernando Alves-Leon, Soniza V. Rodacki, Melanie Lima, Marco Antonio |
| dc.subject.en.pt_BR.fl_str_mv |
Autoimmune epilepsy Anti-GAD Antibodies Type 1 diabetes mellitus Autoimmunity Seizure |
| topic |
Autoimmune epilepsy Anti-GAD Antibodies Type 1 diabetes mellitus Autoimmunity Seizure |
| description |
Marco Antonio Lima. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. |
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2019 |
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2019-10-02T13:51:42Z |
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2019-10-02T13:51:42Z |
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2019 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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AGUIAR, Tiago S. et al. Association between high titers of glutamic acid decarboxylase antibody and epilepsy in patients with type 1 diabetes mellitus: a cross-sectional study. Seizure: European Journal of Epilepsy, v. 71, p. 318-321, 2019. |
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https://www.arca.fiocruz.br/handle/icict/36071 |
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1059-1311 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.seizure.2019.09.003 |
| dc.identifier.eissn.none.fl_str_mv |
1532-2688 |
| identifier_str_mv |
AGUIAR, Tiago S. et al. Association between high titers of glutamic acid decarboxylase antibody and epilepsy in patients with type 1 diabetes mellitus: a cross-sectional study. Seizure: European Journal of Epilepsy, v. 71, p. 318-321, 2019. 1059-1311 10.1016/j.seizure.2019.09.003 1532-2688 |
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Elsevier |
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Elsevier |
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