Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children

Detalhes bibliográficos
Autor(a) principal: Ziqi, Zhao
Data de Publicação: 2020
Outros Autores: Ziwei, Shang, Vasconcelos, Zilton Farias Meira de, Chunfeng, Li, Yisheng, Jiang, Shulong, Zu, Jingyi, Zhang, Fengchao, Wang, Li, Yao, Jung, Jae U., Brasil, Patricia, Moreira, Maria Elisabeth Lopes, Cheng-Feng, Qin, Kerin, Tara, Nielsen-Saines,  Karin, Genhong, Cheng, Xiaohui, Zhang, Zhiheng, Xu
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/44240
Resumo: R01 AI069120/AI/NIAID NIH HHS/United States / R01 AI140718/AI/NIAID / NIH HHS/United States / P30 AI028697/AI/NIAID NIH HHS/United States / R21 AI129534/AI/NIAID NIH HHS/United States / R21 EY028318/EY/NEI / NIH HHS/United States / R56 AI078389/AI/NIAID NIH HHS/United States / R01 AI078389/AI/NIAID NIH HHS/United States
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spelling Ziqi, ZhaoZiwei, ShangVasconcelos, Zilton Farias Meira deChunfeng, LiYisheng, JiangShulong, ZuJingyi, ZhangFengchao, WangLi, YaoJung, Jae U.Brasil, PatriciaMoreira, Maria Elisabeth LopesCheng-Feng, QinKerin, TaraNielsen-Saines,  KarinGenhong, ChengXiaohui, ZhangZhiheng, Xu2020-10-27T19:49:15Z2020-10-27T19:49:15Z2020ZIQI, Zhao et al. Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children. Advanced Science, v. 7, p. 1-10, Aug. 2020.2198-3844https://www.arca.fiocruz.br/handle/icict/4424010.1002/advs.201901996R01 AI069120/AI/NIAID NIH HHS/United States / R01 AI140718/AI/NIAID / NIH HHS/United States / P30 AI028697/AI/NIAID NIH HHS/United States / R21 AI129534/AI/NIAID NIH HHS/United States / R21 EY028318/EY/NEI / NIH HHS/United States / R56 AI078389/AI/NIAID NIH HHS/United States / R01 AI078389/AI/NIAID NIH HHS/United StatesChinese Academy of Sciences.Technology School of Future Technology Institute of Genetics and Developmental Biology Beijing. ChinaBeijing Normal University. Beijing. China.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Stanford University Stanford. Institute for Immunity Transplantation, and Infection. CA. USA.Chinese Academy of Sciences.Technology School of Future Technology Institute of Genetics and Developmental Biology. Beijing. China.Chinese Academy of Medical Sciences & Peking Union Medical College. Beijing. China. / Suzhou Institute of Systems Medicine. Suzhou Jiangsu. China.Beijing Normal University. Beijing. China.Beijing Normal University. Beijing. China.Beijing Normal University. Beijing. China.University of Southern California. Zilkha Neurogenetic Institute Los Angeles CA. USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Beijing Institute of Microbiology and Epidemiology. Department of Virology State Key Laboratory of Pathogen and Biosecurity. Beijing. China.University of California. David Geffen School of Medicine. Division of Pediatric Infectious Diseases . Mattel Children's Hospital. Los Angeles, CA. USA.University of California. David Geffen School of Medicine. Division of Pediatric Infectious Diseases . Mattel Children's Hospital. Los Angeles, CA. USA.Chinese Academy of Medical Sciences & Peking Union Medical College. Beijing. China / Suzhou Institute of Systems Medicine. Suzhou Jiangsu. China / University of California. Department of Microbiology Immunology and Molecular Genetics. Los Angeles, CA USA.Beijing Normal University. Beijing. China.Chinese Academy of Sciences.Technology School of Future Technology Institute of Genetics and Developmental Biology Beijing. China / Beijing Institute for Brain Disorders. Parkinson's Disease Center. Beijing. China.Zika virus (ZIKV) has evolved into a global health threat because of its causal link to congenital Zika syndrome. ZIKV infection of pregnant women may cause a spectrum of abnormalities in children. In the studies in Brazil, a large cohort of children with perinatal exposure to ZIKV is followed, and a spectrum of neurodevelopmental abnormalities is identified. In parallel, it is demonstrated that infection of the mouse neonatal brain by a contemporary ZIKV strain instead of an Asian ancestral strain can cause microcephaly and various abnormal neurological functions. These include defects in social interaction and depression, impaired learning and memory, in addition to severe motor defects, which are present in adult mice as well as in the prospective cohort of children. Importantly, although mouse brains infected later after birth do not have apparent abnormal brain structure, those mice still show significant impairments of visual cortical functions, circuit organization, and experience-dependent plasticity. Thus, the study suggests that special attention should be paid to all children born to ZIKV infected mothers for screening of abnormal behaviors and sensory function during childhood.engWiley Open AccessZika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Childreninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleVisual cortical functionsNeurological functionsMicrocephalyAbnormal behaviorsZika virusinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/44240/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALzhao_ziqi_et_all.pdfapplication/pdf13651516https://www.arca.fiocruz.br/bitstream/icict/44240/2/zhao_ziqi_et_all.pdf81bffac5c4d58e778eaa140d088aa5afMD52TEXTzhao_ziqi_et_all.pdf.txtzhao_ziqi_et_all.pdf.txtExtracted texttext/plain37088https://www.arca.fiocruz.br/bitstream/icict/44240/3/zhao_ziqi_et_all.pdf.txt097cb1d34bcacd22e67190f90054864fMD53icict/442402020-12-02 22:33:15.011oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352020-12-03T01:33:15Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children
title Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children
spellingShingle Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children
Ziqi, Zhao
Visual cortical functions
Neurological functions
Microcephaly
Abnormal behaviors
Zika virus
title_short Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children
title_full Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children
title_fullStr Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children
title_full_unstemmed Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children
title_sort Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children
author Ziqi, Zhao
author_facet Ziqi, Zhao
Ziwei, Shang
Vasconcelos, Zilton Farias Meira de
Chunfeng, Li
Yisheng, Jiang
Shulong, Zu
Jingyi, Zhang
Fengchao, Wang
Li, Yao
Jung, Jae U.
Brasil, Patricia
Moreira, Maria Elisabeth Lopes
Cheng-Feng, Qin
Kerin, Tara
Nielsen-Saines,  Karin
Genhong, Cheng
Xiaohui, Zhang
Zhiheng, Xu
author_role author
author2 Ziwei, Shang
Vasconcelos, Zilton Farias Meira de
Chunfeng, Li
Yisheng, Jiang
Shulong, Zu
Jingyi, Zhang
Fengchao, Wang
Li, Yao
Jung, Jae U.
Brasil, Patricia
Moreira, Maria Elisabeth Lopes
Cheng-Feng, Qin
Kerin, Tara
Nielsen-Saines,  Karin
Genhong, Cheng
Xiaohui, Zhang
Zhiheng, Xu
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ziqi, Zhao
Ziwei, Shang
Vasconcelos, Zilton Farias Meira de
Chunfeng, Li
Yisheng, Jiang
Shulong, Zu
Jingyi, Zhang
Fengchao, Wang
Li, Yao
Jung, Jae U.
Brasil, Patricia
Moreira, Maria Elisabeth Lopes
Cheng-Feng, Qin
Kerin, Tara
Nielsen-Saines,  Karin
Genhong, Cheng
Xiaohui, Zhang
Zhiheng, Xu
dc.subject.en.pt_BR.fl_str_mv Visual cortical functions
Neurological functions
Microcephaly
Abnormal behaviors
Zika virus
topic Visual cortical functions
Neurological functions
Microcephaly
Abnormal behaviors
Zika virus
description R01 AI069120/AI/NIAID NIH HHS/United States / R01 AI140718/AI/NIAID / NIH HHS/United States / P30 AI028697/AI/NIAID NIH HHS/United States / R21 AI129534/AI/NIAID NIH HHS/United States / R21 EY028318/EY/NEI / NIH HHS/United States / R56 AI078389/AI/NIAID NIH HHS/United States / R01 AI078389/AI/NIAID NIH HHS/United States
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-10-27T19:49:15Z
dc.date.available.fl_str_mv 2020-10-27T19:49:15Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ZIQI, Zhao et al. Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children. Advanced Science, v. 7, p. 1-10, Aug. 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/44240
dc.identifier.issn.pt_BR.fl_str_mv 2198-3844
dc.identifier.doi.none.fl_str_mv 10.1002/advs.201901996
identifier_str_mv ZIQI, Zhao et al. Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children. Advanced Science, v. 7, p. 1-10, Aug. 2020.
2198-3844
10.1002/advs.201901996
url https://www.arca.fiocruz.br/handle/icict/44240
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley Open Access
publisher.none.fl_str_mv Wiley Open Access
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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