Zika virus-associated neurological disorders: a review

Detalhes bibliográficos
Autor(a) principal: Araujo, Abelardo Q. C.
Data de Publicação: 2016
Outros Autores: Silva, Marcus Tulius T., Araujo, Alexandra P. Q. C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/15190
Resumo: We are grateful to Professor William W. Hall, MD, PhD (CRID, University College Dublin, Ireland) for his useful suggestions. We thank Dr. Lara Brandão, MD (Clinica Radiologica Felipe Mattoso, Rio de Janeiro, Brazil), for the MRI report of the microcephaly case.
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spelling Araujo, Abelardo Q. C.Silva, Marcus Tulius T.Araujo, Alexandra P. Q. C.2016-08-03T13:08:57Z2016-08-03T13:08:57Z2016ARAUJO, Abelardo Q. C.; SILVA, Marcus Tulius T.; ARAUJO, Alexandra P. Q. C. Zika virus-associated neurological disorders: a review. Brain a Journal of Neurology, p.1-9, 2016.0006-8950https://www.arca.fiocruz.br/handle/icict/1519010.1093/brain/aww1581460-2156We are grateful to Professor William W. Hall, MD, PhD (CRID, University College Dublin, Ireland) for his useful suggestions. We thank Dr. Lara Brandão, MD (Clinica Radiologica Felipe Mattoso, Rio de Janeiro, Brazil), for the MRI report of the microcephaly case.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Neurologia Deolindo Couto. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Puericultura e Pediatria Martagão Gesteira. Rio de Janeiro, RJ, Brasil.Zika virus, an arbovirus transmitted by mosquitoes of the Aedes species, is now rapidly disseminating throughout the Americas and the ongoing Brazilian outbreak is the largest Zika virus epidemic so far described. In addition to being associated with a non-specific acute febrile illness, a number of neurological manifestations, mainly microcephaly and Guillain-Barré syndrome, have been associated with infection. These with other rarer neurological conditions suggest that Zika virus, similar to other flaviviruses, is neuropathogenic. The surge of Zika virus-related microcephaly cases in Brazil has received much attention and the role of the virus in this and in other neurological manifestations is growing. Zika virus has been shown to be transmitted perinatally and the virus can be detected in amniotic fluid, placenta and foetus brain tissue. A significant increase in Guillain-Barré syndrome incidence has also been reported during this, as well as in previous outbreaks. More recently, meningoencephalitis and myelitis have also been reported following Zika virus infection. In summary, while preliminary studies have suggested a clear relationship between Zika virus infection and certain neurological conditions, only longitudinal studies in this epidemic, as well as experimental studies either in animal models or in vitro, will help to better understand the role of the virus and the pathogenesis of these disorders.engOxford University PressZika virus-associated neurological disorders: a reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleZika virusArbovirusMicrocephalyGuillain-Barré syndromeNeurological complicationsZIKVinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15190/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALINI - Zika virus-associated neurological disorders - a review.pdfINI - Zika virus-associated neurological disorders - 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dc.title.pt_BR.fl_str_mv Zika virus-associated neurological disorders: a review
title Zika virus-associated neurological disorders: a review
spellingShingle Zika virus-associated neurological disorders: a review
Araujo, Abelardo Q. C.
Zika virus
Arbovirus
Microcephaly
Guillain-Barré syndrome
Neurological complications
ZIKV
title_short Zika virus-associated neurological disorders: a review
title_full Zika virus-associated neurological disorders: a review
title_fullStr Zika virus-associated neurological disorders: a review
title_full_unstemmed Zika virus-associated neurological disorders: a review
title_sort Zika virus-associated neurological disorders: a review
author Araujo, Abelardo Q. C.
author_facet Araujo, Abelardo Q. C.
Silva, Marcus Tulius T.
Araujo, Alexandra P. Q. C.
author_role author
author2 Silva, Marcus Tulius T.
Araujo, Alexandra P. Q. C.
author2_role author
author
dc.contributor.author.fl_str_mv Araujo, Abelardo Q. C.
Silva, Marcus Tulius T.
Araujo, Alexandra P. Q. C.
dc.subject.en.pt_BR.fl_str_mv Zika virus
Arbovirus
Microcephaly
Guillain-Barré syndrome
Neurological complications
ZIKV
topic Zika virus
Arbovirus
Microcephaly
Guillain-Barré syndrome
Neurological complications
ZIKV
description We are grateful to Professor William W. Hall, MD, PhD (CRID, University College Dublin, Ireland) for his useful suggestions. We thank Dr. Lara Brandão, MD (Clinica Radiologica Felipe Mattoso, Rio de Janeiro, Brazil), for the MRI report of the microcephaly case.
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-08-03T13:08:57Z
dc.date.available.fl_str_mv 2016-08-03T13:08:57Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv ARAUJO, Abelardo Q. C.; SILVA, Marcus Tulius T.; ARAUJO, Alexandra P. Q. C. Zika virus-associated neurological disorders: a review. Brain a Journal of Neurology, p.1-9, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/15190
dc.identifier.issn.pt_BR.fl_str_mv 0006-8950
dc.identifier.doi.none.fl_str_mv 10.1093/brain/aww158
dc.identifier.eissn.none.fl_str_mv 1460-2156
identifier_str_mv ARAUJO, Abelardo Q. C.; SILVA, Marcus Tulius T.; ARAUJO, Alexandra P. Q. C. Zika virus-associated neurological disorders: a review. Brain a Journal of Neurology, p.1-9, 2016.
0006-8950
10.1093/brain/aww158
1460-2156
url https://www.arca.fiocruz.br/handle/icict/15190
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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