Programmed necrosis in the cross talk of cell death and inflammation

Detalhes bibliográficos
Autor(a) principal: Chan, Francis Ka-Ming
Data de Publicação: 2014
Outros Autores: Luz, Nívea Farias, Moriwaki, Kenta
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10571
Resumo: University of Massachusetts Medical School. Department of Pathology, Immunology and Microbiology Program. Worcester, Massachusetts
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spelling Chan, Francis Ka-MingLuz, Nívea FariasMoriwaki, Kenta2015-05-27T16:41:58Z2015-05-27T16:41:58Z2014CHAN, F. K.-M.; LUZ, N. F.; MORIWAKI, K. Programmed necrosis in the cross talk of cell death and inflammation. Annual Review Immunology, v. 33, p. 79-106, 2015.1545-3278https://www.arca.fiocruz.br/handle/icict/1057110.1146/annurev-immunol-032414-112248engAnnual ReviewsProgrammed necrosis in the cross talk of cell death and inflammationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of Massachusetts Medical School. Department of Pathology, Immunology and Microbiology Program. Worcester, MassachusettsUniversity of Massachusetts Medical School. Department of Pathology, Immunology and Microbiology Program. Worcester, Massachusetts / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversity of Massachusetts Medical School. Department of Pathology, Immunology and Microbiology Program. Worcester, MassachusettsCell proliferation and cell death are integral elements in maintaining homeostatic balance in metazoans. Disease pathologies ensue when these processes are disturbed. A plethora of evidence indicates that malfunction of cell death can lead to inflammation, autoimmunity, or immunodeficiency. Programmed necrosis or necroptosis is a form of nonapoptotic cell death driven by the receptor interacting protein kinase 3 (RIPK3) and its substrate, mixed lineage kinase domain-like (MLKL). RIPK3 partners with its upstream adaptors RIPK1, TRIF, or DAI to signal for necroptosis in response to death receptor or Toll-like receptor stimulation, pathogen infection, or sterile cell injury. Necroptosis promotes inflammation through leakage of cellular contents from damaged plasma membranes. Intriguingly, many of the signal adaptors of necroptosis have dual functions in innate immune signaling. This unique signature illustrates the cooperative nature of necroptosis and innate inflammatory signaling pathways in managing cell and organismal stresses from pathogen infection and sterile tissue injury.NecroptosisRIPK1RIPK3MLKLTNFInflammationTRIFDAI,MCMVVaccinia virusinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/10571/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALChan FKM Programmed....pdfChan FKM Programmed....pdfapplication/pdf1513332https://www.arca.fiocruz.br/bitstream/icict/10571/2/Chan%20FKM%20Programmed....pdf357651763eff241bde315ead53b8b817MD52TEXTChan FKM Programmed....pdf.txtChan FKM Programmed....pdf.txtExtracted texttext/plain123254https://www.arca.fiocruz.br/bitstream/icict/10571/3/Chan%20FKM%20Programmed....pdf.txt6c6b10c3b0ee8eec13de1ad9c79e2209MD53icict/105712023-03-15 14:33:25.634oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:25Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Programmed necrosis in the cross talk of cell death and inflammation
title Programmed necrosis in the cross talk of cell death and inflammation
spellingShingle Programmed necrosis in the cross talk of cell death and inflammation
Chan, Francis Ka-Ming
Necroptosis
RIPK1
RIPK3
MLKL
TNF
Inflammation
TRIF
DAI,
MCMV
Vaccinia virus
title_short Programmed necrosis in the cross talk of cell death and inflammation
title_full Programmed necrosis in the cross talk of cell death and inflammation
title_fullStr Programmed necrosis in the cross talk of cell death and inflammation
title_full_unstemmed Programmed necrosis in the cross talk of cell death and inflammation
title_sort Programmed necrosis in the cross talk of cell death and inflammation
author Chan, Francis Ka-Ming
author_facet Chan, Francis Ka-Ming
Luz, Nívea Farias
Moriwaki, Kenta
author_role author
author2 Luz, Nívea Farias
Moriwaki, Kenta
author2_role author
author
dc.contributor.author.fl_str_mv Chan, Francis Ka-Ming
Luz, Nívea Farias
Moriwaki, Kenta
dc.subject.en.pt_BR.fl_str_mv Necroptosis
RIPK1
RIPK3
MLKL
TNF
Inflammation
TRIF
DAI,
MCMV
Vaccinia virus
topic Necroptosis
RIPK1
RIPK3
MLKL
TNF
Inflammation
TRIF
DAI,
MCMV
Vaccinia virus
description University of Massachusetts Medical School. Department of Pathology, Immunology and Microbiology Program. Worcester, Massachusetts
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-05-27T16:41:58Z
dc.date.available.fl_str_mv 2015-05-27T16:41:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CHAN, F. K.-M.; LUZ, N. F.; MORIWAKI, K. Programmed necrosis in the cross talk of cell death and inflammation. Annual Review Immunology, v. 33, p. 79-106, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10571
dc.identifier.issn.none.fl_str_mv 1545-3278
dc.identifier.doi.none.fl_str_mv 10.1146/annurev-immunol-032414-112248
identifier_str_mv CHAN, F. K.-M.; LUZ, N. F.; MORIWAKI, K. Programmed necrosis in the cross talk of cell death and inflammation. Annual Review Immunology, v. 33, p. 79-106, 2015.
1545-3278
10.1146/annurev-immunol-032414-112248
url https://www.arca.fiocruz.br/handle/icict/10571
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Annual Reviews
publisher.none.fl_str_mv Annual Reviews
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