Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression

Detalhes bibliográficos
Autor(a) principal: Luz, Nívea Farias
Data de Publicação: 2018
Outros Autores: Cunha, Antonio Ricardo Khouri, Van Weyenbergh, Johan, Zanette, Dalila Lucíola, Fiuza, Paloma Peixoto dos Santos, Noronha, Almerio, Barral, Aldina Maria Prado, Boaventura, Viviane Sampaio, Prates, Deboraci Brito, Chan, Francis Ka-Ming, Andrade, Bruno de Bezerril, Borges, Valeria de Matos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/30423
Resumo: Fundação de Amparo a Pesquisa do Estado da Bahia (FAPESB) (JCB0047/2013 to DP and 5760/2015 to VMB); The Research Foundation Flanders-FWO (G0D6817N to JVW). FC was supported by a grant from the National Institutes of Health (NIH) AI119030. NL received funding from CAPES – Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Grants 88887.142000/2017-00 and 88887.137958/2017-00). VMB and AB are senior investigators of CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico).
id CRUZ_d9cc66ea84aabfd768f51ae8b66a54c2
oai_identifier_str oai:www.arca.fiocruz.br:icict/30423
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Luz, Nívea FariasCunha, Antonio Ricardo KhouriVan Weyenbergh, JohanZanette, Dalila LucíolaFiuza, Paloma Peixoto dos SantosNoronha, AlmerioBarral, Aldina Maria PradoBoaventura, Viviane SampaioPrates, Deboraci BritoChan, Francis Ka-MingAndrade, Bruno de BezerrilBorges, Valeria de Matos2018-12-07T16:54:31Z2018-12-07T16:54:31Z2018LUZ, Nívea Farias et al. Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression. Frontiers in Microbiology, v. 9, p. 1-6, 2018.1664-302Xhttps://www.arca.fiocruz.br/handle/icict/3042310.3389/fmicb.2018.02283Fundação de Amparo a Pesquisa do Estado da Bahia (FAPESB) (JCB0047/2013 to DP and 5760/2015 to VMB); The Research Foundation Flanders-FWO (G0D6817N to JVW). FC was supported by a grant from the National Institutes of Health (NIH) AI119030. NL received funding from CAPES – Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Grants 88887.142000/2017-00 and 88887.137958/2017-00). VMB and AB are senior investigators of CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Rega Institute for Medical Research. KU Leuven. Department of Microbiology and Immunology. Leuven, Belgium.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biomorfologia. Salvador, BA, Brasil.Duke University Medical Center. Department of Immunology. Durham, NC, United States.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Leishmania braziliensis infection causes skin ulcers, typically found in localized cutaneous leishmaniasis (LCL). This tissue pathology associates with different modalities of cell necrosis, which are subverted by the parasite as a survival strategy. Herein we examined the participation of necroptosis, a specific form of programmed necrosis, in LCL lesions and found reduced RIPK3 and PGAM5 gene expression compared to normal skin. Assays using infected macrophages demonstrated that the parasite deactivates both RIPK3 and MLKL expression and that these molecules are important to control the intracellular L. braziliensis replication. Thus, LCL-related necroptosis may be targeted to control infection and disease immunopathology.engFrontiers MediaRIPK3MLKLMacrófagoNecroptoseLeishmania braziliensisRIPK3MLKLMacrophageNecroptosisLeishmania braziliensisLeishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expressioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/30423/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLuz NF. Leishimania Brasiliensis... 2018.pdfLuz NF. Leishimania Brasiliensis... 2018.pdfapplication/pdf1416218https://www.arca.fiocruz.br/bitstream/icict/30423/2/Luz%20NF.%20Leishimania%20Brasiliensis...%202018.pdfe8c3ff29f884d38354b401951f805bbbMD52TEXTLuz NF. Leishimania Brasiliensis... 2018.pdf.txtLuz NF. Leishimania Brasiliensis... 2018.pdf.txtExtracted texttext/plain32892https://www.arca.fiocruz.br/bitstream/icict/30423/3/Luz%20NF.%20Leishimania%20Brasiliensis...%202018.pdf.txt55eb5c0f9920a58659121724f9cd6acaMD53icict/304232023-03-15 14:34:15.428oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:15Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression
title Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression
spellingShingle Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression
Luz, Nívea Farias
RIPK3
MLKL
Macrófago
Necroptose
Leishmania braziliensis
RIPK3
MLKL
Macrophage
Necroptosis
Leishmania braziliensis
title_short Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression
title_full Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression
title_fullStr Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression
title_full_unstemmed Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression
title_sort Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression
author Luz, Nívea Farias
author_facet Luz, Nívea Farias
Cunha, Antonio Ricardo Khouri
Van Weyenbergh, Johan
Zanette, Dalila Lucíola
Fiuza, Paloma Peixoto dos Santos
Noronha, Almerio
Barral, Aldina Maria Prado
Boaventura, Viviane Sampaio
Prates, Deboraci Brito
Chan, Francis Ka-Ming
Andrade, Bruno de Bezerril
Borges, Valeria de Matos
author_role author
author2 Cunha, Antonio Ricardo Khouri
Van Weyenbergh, Johan
Zanette, Dalila Lucíola
Fiuza, Paloma Peixoto dos Santos
Noronha, Almerio
Barral, Aldina Maria Prado
Boaventura, Viviane Sampaio
Prates, Deboraci Brito
Chan, Francis Ka-Ming
Andrade, Bruno de Bezerril
Borges, Valeria de Matos
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Luz, Nívea Farias
Cunha, Antonio Ricardo Khouri
Van Weyenbergh, Johan
Zanette, Dalila Lucíola
Fiuza, Paloma Peixoto dos Santos
Noronha, Almerio
Barral, Aldina Maria Prado
Boaventura, Viviane Sampaio
Prates, Deboraci Brito
Chan, Francis Ka-Ming
Andrade, Bruno de Bezerril
Borges, Valeria de Matos
dc.subject.other.pt_BR.fl_str_mv RIPK3
MLKL
Macrófago
Necroptose
Leishmania braziliensis
topic RIPK3
MLKL
Macrófago
Necroptose
Leishmania braziliensis
RIPK3
MLKL
Macrophage
Necroptosis
Leishmania braziliensis
dc.subject.en.pt_BR.fl_str_mv RIPK3
MLKL
Macrophage
Necroptosis
Leishmania braziliensis
description Fundação de Amparo a Pesquisa do Estado da Bahia (FAPESB) (JCB0047/2013 to DP and 5760/2015 to VMB); The Research Foundation Flanders-FWO (G0D6817N to JVW). FC was supported by a grant from the National Institutes of Health (NIH) AI119030. NL received funding from CAPES – Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Grants 88887.142000/2017-00 and 88887.137958/2017-00). VMB and AB are senior investigators of CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico).
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-12-07T16:54:31Z
dc.date.available.fl_str_mv 2018-12-07T16:54:31Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LUZ, Nívea Farias et al. Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression. Frontiers in Microbiology, v. 9, p. 1-6, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/30423
dc.identifier.issn.pt_BR.fl_str_mv 1664-302X
dc.identifier.doi.none.fl_str_mv 10.3389/fmicb.2018.02283
identifier_str_mv LUZ, Nívea Farias et al. Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression. Frontiers in Microbiology, v. 9, p. 1-6, 2018.
1664-302X
10.3389/fmicb.2018.02283
url https://www.arca.fiocruz.br/handle/icict/30423
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/30423/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/30423/2/Luz%20NF.%20Leishimania%20Brasiliensis...%202018.pdf
https://www.arca.fiocruz.br/bitstream/icict/30423/3/Luz%20NF.%20Leishimania%20Brasiliensis...%202018.pdf.txt
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
e8c3ff29f884d38354b401951f805bbb
55eb5c0f9920a58659121724f9cd6aca
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813009181651763200