Fat, fight, and beyond: the multiple roles of lipid droplets in infections and inflammation

Detalhes bibliográficos
Autor(a) principal: Dutra, Filipe Santos Pereira
Data de Publicação: 2019
Outros Autores: Teixeira, Livia, Costa, Maria Fernanda de Souza, Bozza, Patrícia T.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/40929
Resumo: Acesso aberto em 23/04/2020 - https://www.ncbi.nlm.nih.gov/pubmed/31121077
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spelling Dutra, Filipe Santos PereiraTeixeira, LiviaCosta, Maria Fernanda de SouzaBozza, Patrícia T.2020-04-23T13:15:06Z2020-04-23T13:15:06Z2019DUTRA, Filipe Santos Pereira et al. Fat, fight, and beyond: the multiple roles of lipid droplets in infections and inflammation. Journal of Leukocite Biology, v. 106, n. 3, p. 563-580, 23 May 2019.0741-5400https://www.arca.fiocruz.br/handle/icict/4092910.1002/JLB.4MR0119-035R1938-3673Acesso aberto em 23/04/2020 - https://www.ncbi.nlm.nih.gov/pubmed/31121077Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Increased accumulation of cytoplasmic lipid droplets (LDs) in host nonadipose cells is commonly observed in response to numerous infectious diseases, including bacterial, parasite, and fungal infections. LDs are lipid-enriched, dynamic organelles composed of a core of neutral lipids surrounded by a monolayer of phospholipids associated with a diverse array of proteins that are cell and stimulus regulated. Far beyond being simply a deposit of neutral lipids, LDs have come to be seen as an essential platform for various cellular processes, including metabolic regulation, cell signaling, and the immune response. LD participation in the immune response occurs as sites for compartmentalization of several immunometabolic signaling pathways, production of inflammatory lipid mediators, and regulation of antigen presentation. Infection-driven LD biogenesis is a complexly regulated process that involves innate immune receptors, transcriptional and posttranscriptional regulation, increased lipid uptake, and new lipid synthesis. Accumulating evidence demonstrates that intracellular pathogens are able to exploit LDs as an energy source, a replication site, and/or a mechanism of immune response evasion. Nevertheless, LDs can also act in favor of the host as part of the immune and inflammatory response to pathogens. Here, we review recent findings that explored the new roles of LDs in the context of host-pathogen interactions.engWileyInfecçãoInflamaçãoGotas lipidicasMetabolismoInfectionInflammationLipid dropletsMetabolismFat, fight, and beyond: the multiple roles of lipid droplets in infections and inflammationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Fat, fight, and beyond: the multiple roles of lipid droplets in infections and inflammation
title Fat, fight, and beyond: the multiple roles of lipid droplets in infections and inflammation
spellingShingle Fat, fight, and beyond: the multiple roles of lipid droplets in infections and inflammation
Dutra, Filipe Santos Pereira
Infecção
Inflamação
Gotas lipidicas
Metabolismo
Infection
Inflammation
Lipid droplets
Metabolism
title_short Fat, fight, and beyond: the multiple roles of lipid droplets in infections and inflammation
title_full Fat, fight, and beyond: the multiple roles of lipid droplets in infections and inflammation
title_fullStr Fat, fight, and beyond: the multiple roles of lipid droplets in infections and inflammation
title_full_unstemmed Fat, fight, and beyond: the multiple roles of lipid droplets in infections and inflammation
title_sort Fat, fight, and beyond: the multiple roles of lipid droplets in infections and inflammation
author Dutra, Filipe Santos Pereira
author_facet Dutra, Filipe Santos Pereira
Teixeira, Livia
Costa, Maria Fernanda de Souza
Bozza, Patrícia T.
author_role author
author2 Teixeira, Livia
Costa, Maria Fernanda de Souza
Bozza, Patrícia T.
author2_role author
author
author
dc.contributor.author.fl_str_mv Dutra, Filipe Santos Pereira
Teixeira, Livia
Costa, Maria Fernanda de Souza
Bozza, Patrícia T.
dc.subject.other.pt_BR.fl_str_mv Infecção
Inflamação
Gotas lipidicas
Metabolismo
topic Infecção
Inflamação
Gotas lipidicas
Metabolismo
Infection
Inflammation
Lipid droplets
Metabolism
dc.subject.en.en.fl_str_mv Infection
Inflammation
Lipid droplets
Metabolism
description Acesso aberto em 23/04/2020 - https://www.ncbi.nlm.nih.gov/pubmed/31121077
publishDate 2019
dc.date.issued.fl_str_mv 2019
dc.date.accessioned.fl_str_mv 2020-04-23T13:15:06Z
dc.date.available.fl_str_mv 2020-04-23T13:15:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv DUTRA, Filipe Santos Pereira et al. Fat, fight, and beyond: the multiple roles of lipid droplets in infections and inflammation. Journal of Leukocite Biology, v. 106, n. 3, p. 563-580, 23 May 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/40929
dc.identifier.issn.pt_BR.fl_str_mv 0741-5400
dc.identifier.doi.pt_BR.fl_str_mv 10.1002/JLB.4MR0119-035R
dc.identifier.eissn.pt_BR.fl_str_mv 1938-3673
identifier_str_mv DUTRA, Filipe Santos Pereira et al. Fat, fight, and beyond: the multiple roles of lipid droplets in infections and inflammation. Journal of Leukocite Biology, v. 106, n. 3, p. 563-580, 23 May 2019.
0741-5400
10.1002/JLB.4MR0119-035R
1938-3673
url https://www.arca.fiocruz.br/handle/icict/40929
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/40929/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/40929/2/PatriciaBozz_LiviaTexeira_etal_IOC_2019.pdf
https://www.arca.fiocruz.br/bitstream/icict/40929/3/PatriciaBozz_LiviaTexeira_etal_IOC_2019.pdf.txt
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