Spectrum of Morphologic Changes of Lymph Nodes in HIV Infection

Detalhes bibliográficos
Autor(a) principal: Paiva, D. D.
Data de Publicação: 1996
Outros Autores: Morais, J. C., Pilotto, José H. P., Veloso, Valdiléa G., Duarte, F., Lenzi, H. L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31647
Resumo: FIRST BRAZILIAN SYMPOSIUM ON BASIC RESEARCH IN HIV/ AIDS
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spelling Paiva, D. D.Morais, J. C.Pilotto, José H. P.Veloso, Valdiléa G.Duarte, F.Lenzi, H. L.2019-02-14T15:23:33Z2019-02-14T15:23:33Z1996PAIVA, D. D. et al. Spectrum of Morphologic Changes of Lymph Nodes in HIV Infection. Memórias do Instituto Oswaldo Cruz, v. 91, n. 3, p. 371-379, 1996.1678-8060https://www.arca.fiocruz.br/handle/icict/3164710.1590/S0074-02761996000300023FIRST BRAZILIAN SYMPOSIUM ON BASIC RESEARCH IN HIV/ AIDSUniversidade do Estado do Rio de Janeiro. Faculdade de Medicina. Departamento de Patologia e Laboratórios. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Departamento de Patologia. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Serviço de Doenças Infecciosas e Parasitárias. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS./ Hospital Carlos Chagas. Rio de Janeiro, RJ, Brasil.Departamento de Patologia. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Cervical lymph nodes biopsies from 31 HIV positive patients (with or without AIDS) were studied by histologic methods and immunohistochemistry (StreptABC staining of paraffin sections) to identify cellular and extracellular matrix components. The results were the following: (1) the biopsies were included in the stages of follicular hyperplasia without fragmentation FH-FF (4 cases); follicular hyperplasia with follicular fragmentation FH + FF (16 cases); follicular involution FI (6 cases) and diffuse pattern DP (5 cases); (2) the most important alteration was the germinal centers disruption due to follicle lysis, which began in the light zone; (3) there was coincidence between intrafollicular hemorrhages and segmental hyaline mycroangiopathy; (4) during the progression of the disease occurred; (a) an increase in the number of mast cells, CD68+ and Mac 387+ macrophages; (b) a diffuse augment of collagen III, elastic fibers, laminin, fibronectin and proteoglycans; (c) maintenance of Factor VIII-related antigens in the vascular endothelial cells, with decrease in the expression of Ulex-Europeus I lectin. Follicular hyperplasia (FH - FF or FH + FF) was the most common histologic pattern recognized in the lymph nodes of patients without AIDS and follicular involution and difuse pattern were seen in those who had AIDS. The results indicate that the lymph node biopsies may provide important information about the evolutive stage of the disease and its prognosis.engInstituto Oswaldo CruzSpectrum of Morphologic Changes of Lymph Nodes in HIV Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLymph nodeHIVAIDSExtracellular matrixMast cellsMycroangiopathyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Spectrum of Morphologic Changes of Lymph Nodes in HIV Infection
title Spectrum of Morphologic Changes of Lymph Nodes in HIV Infection
spellingShingle Spectrum of Morphologic Changes of Lymph Nodes in HIV Infection
Paiva, D. D.
Lymph node
HIV
AIDS
Extracellular matrix
Mast cells
Mycroangiopathy
title_short Spectrum of Morphologic Changes of Lymph Nodes in HIV Infection
title_full Spectrum of Morphologic Changes of Lymph Nodes in HIV Infection
title_fullStr Spectrum of Morphologic Changes of Lymph Nodes in HIV Infection
title_full_unstemmed Spectrum of Morphologic Changes of Lymph Nodes in HIV Infection
title_sort Spectrum of Morphologic Changes of Lymph Nodes in HIV Infection
author Paiva, D. D.
author_facet Paiva, D. D.
Morais, J. C.
Pilotto, José H. P.
Veloso, Valdiléa G.
Duarte, F.
Lenzi, H. L.
author_role author
author2 Morais, J. C.
Pilotto, José H. P.
Veloso, Valdiléa G.
Duarte, F.
Lenzi, H. L.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Paiva, D. D.
Morais, J. C.
Pilotto, José H. P.
Veloso, Valdiléa G.
Duarte, F.
Lenzi, H. L.
dc.subject.en.pt_BR.fl_str_mv Lymph node
HIV
AIDS
Extracellular matrix
Mast cells
Mycroangiopathy
topic Lymph node
HIV
AIDS
Extracellular matrix
Mast cells
Mycroangiopathy
description FIRST BRAZILIAN SYMPOSIUM ON BASIC RESEARCH IN HIV/ AIDS
publishDate 1996
dc.date.issued.fl_str_mv 1996
dc.date.accessioned.fl_str_mv 2019-02-14T15:23:33Z
dc.date.available.fl_str_mv 2019-02-14T15:23:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PAIVA, D. D. et al. Spectrum of Morphologic Changes of Lymph Nodes in HIV Infection. Memórias do Instituto Oswaldo Cruz, v. 91, n. 3, p. 371-379, 1996.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31647
dc.identifier.issn.pt_BR.fl_str_mv 1678-8060
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02761996000300023
identifier_str_mv PAIVA, D. D. et al. Spectrum of Morphologic Changes of Lymph Nodes in HIV Infection. Memórias do Instituto Oswaldo Cruz, v. 91, n. 3, p. 371-379, 1996.
1678-8060
10.1590/S0074-02761996000300023
url https://www.arca.fiocruz.br/handle/icict/31647
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz
publisher.none.fl_str_mv Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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