Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line

Detalhes bibliográficos
Autor(a) principal: Muys, Bruna Rodrigues
Data de Publicação: 2016
Outros Autores: Lorenzi, Júlio Cesar Cetrulo, Zanette, Dalila Lucíola, Bueno, Rafaela de Barros Lima e, Araújo, Luíza Ferreira de, Santos, Anemari Ramos Dinarte, Alves, Cleidson de Pádua, Ramão, Anelisa, Molfetta, Greice Andreotti de, Vidal, Daniel Onofre, Silva, Wilson Araújo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/17753
Resumo: The National Counsel of Technological and Scientific Development (CNPq), São Paulo Research Foundation (FAPESP); and by Research Support of the University of Sao Paulo, CISBi-NAP/USP.
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spelling Muys, Bruna RodriguesLorenzi, Júlio Cesar CetruloZanette, Dalila LucíolaBueno, Rafaela de Barros Lima eAraújo, Luíza Ferreira deSantos, Anemari Ramos DinarteAlves, Cleidson de PáduaRamão, AnelisaMolfetta, Greice Andreotti deVidal, Daniel OnofreSilva, Wilson Araújo2017-02-08T19:30:24Z2017-02-08T19:30:24Z2016MUYS, B. R. et al. Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line. Plos One, v. 11, n. 3, p. 1-17, 2016.1932-6203https://www.arca.fiocruz.br/handle/icict/1775310.1371/journal.pone.0151560The National Counsel of Technological and Scientific Development (CNPq), São Paulo Research Foundation (FAPESP); and by Research Support of the University of Sao Paulo, CISBi-NAP/USP.University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / National institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Regional Blood Center of Ribeirão Preto. Riberão Preto, SP, Brazil / Center for Integrative Systems Biology. Center for Medical Genomics. Ribeirão Preto, SP, Brazil.University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / National institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Regional Blood Center of Ribeirão Preto. Riberão Preto, SP, Brazil / Center for Integrative Systems Biology. Center for Medical Genomics. Ribeirão Preto, SP, Brazil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / National institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Regional Blood Center of Ribeirão Preto. Riberão Preto, SP, Brazil / Center for Integrative Systems Biology. Center for Medical Genomics. Ribeirão Preto, SP, Brazil.University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / National institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Regional Blood Center of Ribeirão Preto. Riberão Preto, SP, Brazil / Center for Integrative Systems Biology. Center for Medical Genomics. Ribeirão Preto, SP, Brazil.National institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Regional Blood Center of Ribeirão Preto. Riberão Preto, SP, Brazil / Center for Integrative Systems Biology. Center for Medical Genomics. Ribeirão Preto, SP, Brazil.University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / National institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Regional Blood Center of Ribeirão Preto. Riberão Preto, SP, Brazil / Center for Integrative Systems Biology. Center for Medical Genomics. Ribeirão Preto, SP, Brazil.University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / National institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Regional Blood Center of Ribeirão Preto. Riberão Preto, SP, Brazil / Center for Integrative Systems Biology. Center for Medical Genomics. Ribeirão Preto, SP, Brazil.University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / National institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Regional Blood Center of Ribeirão Preto. Riberão Preto, SP, Brazil / Center for Integrative Systems Biology. Center for Medical Genomics. Ribeirão Preto, SP, Brazil.Molecular Oncology Research Center. Barretos Cancer Hospital. Barretos, SP, Brazil.University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / National institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Regional Blood Center of Ribeirão Preto. Riberão Preto, SP, Brazil / Center for Integrative Systems Biology. Center for Medical Genomics. Ribeirão Preto, SP, Brazil.LINC00629 and MIR503HG are long intergenic non-coding RNAs (lincRNAs) mapped on chromosome X (Xq26), a region enriched for genes associated with human reproduction. Genes highly expressed in normal reproductive tissues and cancers (CT genes) are well known as potential tumor biomarkers. This study aimed to characterize the structure, expression, function and regulation mechanism of MIR503HG and LINC00629 lincRNAs. According to our data, MIR503HG expression was almost exclusive to placenta and LINC00629 was highly expressed in placenta and other reproductive tissues. Further analysis, using a cancer cell lines panel, showed that MIR503HG and LINC00629 were expressed in 50% and 100% of the cancer cell lines, respectively. MIR503HG was expressed predominantly in the nucleus of JEG-3 choriocarcinoma cells. We observed a positively correlated expression between MIR503HG and LINC00629, and between the lincRNAs and neighboring miRNAs. Also, both LINC00629 and MIR503GH could be negatively regulated by DNA methylation in an indirect way. Additionally, we identified new transcripts for MIR503HG and LINC00629 that are relatively conserved when compared to other primates. Furthermore, we found that overexpression of MIR503HG2 and the three-exon LINC00629 new isoforms decreased invasion and migration potential of JEG-3 tumor cell line. In conclusion, our results suggest that lincRNAs MIR503HG and LINC00629 impaired migration and invasion capacities in a choriocarcinoma in vitro model, indicating a potential role in human reproduction and tumorigenesis. Moreover, the MIR503HG expression pattern found here could indicate a putative new tumor biomarker.engPublic Library of ScienceLinha celular, TumorMetilação DNARegulação da Expressão GenéticaMicro-RNAsHumanosNeoplasmaPlacentaGravidezProteinaRNAReproduçãoCell Line, TumorDNA MethylationGene Expression Regulation, NeoplasticMicroRNAsHumansNeoplasmPlacentaPregnancyProteinRNAReproductionPlacenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Lineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/17753/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMuys BR Placenta enriched....pdfMuys BR Placenta 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dc.title.pt_BR.fl_str_mv Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line
title Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line
spellingShingle Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line
Muys, Bruna Rodrigues
Linha celular, Tumor
Metilação DNA
Regulação da Expressão Genética
Micro-RNAs
Humanos
Neoplasma
Placenta
Gravidez
Proteina
RNA
Reprodução
Cell Line, Tumor
DNA Methylation
Gene Expression Regulation, Neoplastic
MicroRNAs
Humans
Neoplasm
Placenta
Pregnancy
Protein
RNA
Reproduction
title_short Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line
title_full Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line
title_fullStr Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line
title_full_unstemmed Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line
title_sort Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line
author Muys, Bruna Rodrigues
author_facet Muys, Bruna Rodrigues
Lorenzi, Júlio Cesar Cetrulo
Zanette, Dalila Lucíola
Bueno, Rafaela de Barros Lima e
Araújo, Luíza Ferreira de
Santos, Anemari Ramos Dinarte
Alves, Cleidson de Pádua
Ramão, Anelisa
Molfetta, Greice Andreotti de
Vidal, Daniel Onofre
Silva, Wilson Araújo
author_role author
author2 Lorenzi, Júlio Cesar Cetrulo
Zanette, Dalila Lucíola
Bueno, Rafaela de Barros Lima e
Araújo, Luíza Ferreira de
Santos, Anemari Ramos Dinarte
Alves, Cleidson de Pádua
Ramão, Anelisa
Molfetta, Greice Andreotti de
Vidal, Daniel Onofre
Silva, Wilson Araújo
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Muys, Bruna Rodrigues
Lorenzi, Júlio Cesar Cetrulo
Zanette, Dalila Lucíola
Bueno, Rafaela de Barros Lima e
Araújo, Luíza Ferreira de
Santos, Anemari Ramos Dinarte
Alves, Cleidson de Pádua
Ramão, Anelisa
Molfetta, Greice Andreotti de
Vidal, Daniel Onofre
Silva, Wilson Araújo
dc.subject.other.pt_BR.fl_str_mv Linha celular, Tumor
Metilação DNA
Regulação da Expressão Genética
Micro-RNAs
Humanos
Neoplasma
Placenta
Gravidez
Proteina
RNA
Reprodução
topic Linha celular, Tumor
Metilação DNA
Regulação da Expressão Genética
Micro-RNAs
Humanos
Neoplasma
Placenta
Gravidez
Proteina
RNA
Reprodução
Cell Line, Tumor
DNA Methylation
Gene Expression Regulation, Neoplastic
MicroRNAs
Humans
Neoplasm
Placenta
Pregnancy
Protein
RNA
Reproduction
dc.subject.en.pt_BR.fl_str_mv Cell Line, Tumor
DNA Methylation
Gene Expression Regulation, Neoplastic
MicroRNAs
Humans
Neoplasm
Placenta
Pregnancy
Protein
RNA
Reproduction
description The National Counsel of Technological and Scientific Development (CNPq), São Paulo Research Foundation (FAPESP); and by Research Support of the University of Sao Paulo, CISBi-NAP/USP.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-02-08T19:30:24Z
dc.date.available.fl_str_mv 2017-02-08T19:30:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv MUYS, B. R. et al. Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line. Plos One, v. 11, n. 3, p. 1-17, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/17753
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0151560
identifier_str_mv MUYS, B. R. et al. Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line. Plos One, v. 11, n. 3, p. 1-17, 2016.
1932-6203
10.1371/journal.pone.0151560
url https://www.arca.fiocruz.br/handle/icict/17753
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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collection Repositório Institucional da FIOCRUZ (ARCA)
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