Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/17753 |
Resumo: | The National Counsel of Technological and Scientific Development (CNPq), São Paulo Research Foundation (FAPESP); and by Research Support of the University of Sao Paulo, CISBi-NAP/USP. |
id |
CRUZ_63c91609e6cf3f7adf651d0ceb37997f |
---|---|
oai_identifier_str |
oai:www.arca.fiocruz.br:icict/17753 |
network_acronym_str |
CRUZ |
network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
repository_id_str |
2135 |
spelling |
Muys, Bruna RodriguesLorenzi, Júlio Cesar CetruloZanette, Dalila LucíolaBueno, Rafaela de Barros Lima eAraújo, Luíza Ferreira deSantos, Anemari Ramos DinarteAlves, Cleidson de PáduaRamão, AnelisaMolfetta, Greice Andreotti deVidal, Daniel OnofreSilva, Wilson Araújo2017-02-08T19:30:24Z2017-02-08T19:30:24Z2016MUYS, B. R. et al. Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line. Plos One, v. 11, n. 3, p. 1-17, 2016.1932-6203https://www.arca.fiocruz.br/handle/icict/1775310.1371/journal.pone.0151560The National Counsel of Technological and Scientific Development (CNPq), São Paulo Research Foundation (FAPESP); and by Research Support of the University of Sao Paulo, CISBi-NAP/USP.University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / National institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Regional Blood Center of Ribeirão Preto. Riberão Preto, SP, Brazil / Center for Integrative Systems Biology. Center for Medical Genomics. Ribeirão Preto, SP, Brazil.University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / National institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Regional Blood Center of Ribeirão Preto. Riberão Preto, SP, Brazil / Center for Integrative Systems Biology. Center for Medical Genomics. Ribeirão Preto, SP, Brazil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / National institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Regional Blood Center of Ribeirão Preto. Riberão Preto, SP, Brazil / Center for Integrative Systems Biology. Center for Medical Genomics. Ribeirão Preto, SP, Brazil.University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / National institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Regional Blood Center of Ribeirão Preto. Riberão Preto, SP, Brazil / Center for Integrative Systems Biology. Center for Medical Genomics. Ribeirão Preto, SP, Brazil.National institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Regional Blood Center of Ribeirão Preto. Riberão Preto, SP, Brazil / Center for Integrative Systems Biology. Center for Medical Genomics. Ribeirão Preto, SP, Brazil.University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / National institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Regional Blood Center of Ribeirão Preto. Riberão Preto, SP, Brazil / Center for Integrative Systems Biology. Center for Medical Genomics. Ribeirão Preto, SP, Brazil.University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / National institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Regional Blood Center of Ribeirão Preto. Riberão Preto, SP, Brazil / Center for Integrative Systems Biology. Center for Medical Genomics. Ribeirão Preto, SP, Brazil.University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / National institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Regional Blood Center of Ribeirão Preto. Riberão Preto, SP, Brazil / Center for Integrative Systems Biology. Center for Medical Genomics. Ribeirão Preto, SP, Brazil.Molecular Oncology Research Center. Barretos Cancer Hospital. Barretos, SP, Brazil.University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / National institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Regional Blood Center of Ribeirão Preto. Riberão Preto, SP, Brazil / Center for Integrative Systems Biology. Center for Medical Genomics. Ribeirão Preto, SP, Brazil.LINC00629 and MIR503HG are long intergenic non-coding RNAs (lincRNAs) mapped on chromosome X (Xq26), a region enriched for genes associated with human reproduction. Genes highly expressed in normal reproductive tissues and cancers (CT genes) are well known as potential tumor biomarkers. This study aimed to characterize the structure, expression, function and regulation mechanism of MIR503HG and LINC00629 lincRNAs. According to our data, MIR503HG expression was almost exclusive to placenta and LINC00629 was highly expressed in placenta and other reproductive tissues. Further analysis, using a cancer cell lines panel, showed that MIR503HG and LINC00629 were expressed in 50% and 100% of the cancer cell lines, respectively. MIR503HG was expressed predominantly in the nucleus of JEG-3 choriocarcinoma cells. We observed a positively correlated expression between MIR503HG and LINC00629, and between the lincRNAs and neighboring miRNAs. Also, both LINC00629 and MIR503GH could be negatively regulated by DNA methylation in an indirect way. Additionally, we identified new transcripts for MIR503HG and LINC00629 that are relatively conserved when compared to other primates. Furthermore, we found that overexpression of MIR503HG2 and the three-exon LINC00629 new isoforms decreased invasion and migration potential of JEG-3 tumor cell line. In conclusion, our results suggest that lincRNAs MIR503HG and LINC00629 impaired migration and invasion capacities in a choriocarcinoma in vitro model, indicating a potential role in human reproduction and tumorigenesis. Moreover, the MIR503HG expression pattern found here could indicate a putative new tumor biomarker.engPublic Library of ScienceLinha celular, TumorMetilação DNARegulação da Expressão GenéticaMicro-RNAsHumanosNeoplasmaPlacentaGravidezProteinaRNAReproduçãoCell Line, TumorDNA MethylationGene Expression Regulation, NeoplasticMicroRNAsHumansNeoplasmPlacentaPregnancyProteinRNAReproductionPlacenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Lineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/17753/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMuys BR Placenta enriched....pdfMuys BR Placenta enriched....pdfapplication/pdf3902919https://www.arca.fiocruz.br/bitstream/icict/17753/2/Muys%20BR%20Placenta%20enriched....pdf85d84fb7ebfa1af7eeed10bd86032a93MD52TEXTMuys BR Placenta enriched....pdf.txtMuys BR Placenta enriched....pdf.txtExtracted texttext/plain44694https://www.arca.fiocruz.br/bitstream/icict/17753/3/Muys%20BR%20Placenta%20enriched....pdf.txt7634c47e3a7d7b9784414ad0d2b8205dMD53icict/177532023-03-15 14:32:57.767oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:57Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line |
title |
Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line |
spellingShingle |
Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line Muys, Bruna Rodrigues Linha celular, Tumor Metilação DNA Regulação da Expressão Genética Micro-RNAs Humanos Neoplasma Placenta Gravidez Proteina RNA Reprodução Cell Line, Tumor DNA Methylation Gene Expression Regulation, Neoplastic MicroRNAs Humans Neoplasm Placenta Pregnancy Protein RNA Reproduction |
title_short |
Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line |
title_full |
Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line |
title_fullStr |
Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line |
title_full_unstemmed |
Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line |
title_sort |
Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line |
author |
Muys, Bruna Rodrigues |
author_facet |
Muys, Bruna Rodrigues Lorenzi, Júlio Cesar Cetrulo Zanette, Dalila Lucíola Bueno, Rafaela de Barros Lima e Araújo, Luíza Ferreira de Santos, Anemari Ramos Dinarte Alves, Cleidson de Pádua Ramão, Anelisa Molfetta, Greice Andreotti de Vidal, Daniel Onofre Silva, Wilson Araújo |
author_role |
author |
author2 |
Lorenzi, Júlio Cesar Cetrulo Zanette, Dalila Lucíola Bueno, Rafaela de Barros Lima e Araújo, Luíza Ferreira de Santos, Anemari Ramos Dinarte Alves, Cleidson de Pádua Ramão, Anelisa Molfetta, Greice Andreotti de Vidal, Daniel Onofre Silva, Wilson Araújo |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Muys, Bruna Rodrigues Lorenzi, Júlio Cesar Cetrulo Zanette, Dalila Lucíola Bueno, Rafaela de Barros Lima e Araújo, Luíza Ferreira de Santos, Anemari Ramos Dinarte Alves, Cleidson de Pádua Ramão, Anelisa Molfetta, Greice Andreotti de Vidal, Daniel Onofre Silva, Wilson Araújo |
dc.subject.other.pt_BR.fl_str_mv |
Linha celular, Tumor Metilação DNA Regulação da Expressão Genética Micro-RNAs Humanos Neoplasma Placenta Gravidez Proteina RNA Reprodução |
topic |
Linha celular, Tumor Metilação DNA Regulação da Expressão Genética Micro-RNAs Humanos Neoplasma Placenta Gravidez Proteina RNA Reprodução Cell Line, Tumor DNA Methylation Gene Expression Regulation, Neoplastic MicroRNAs Humans Neoplasm Placenta Pregnancy Protein RNA Reproduction |
dc.subject.en.pt_BR.fl_str_mv |
Cell Line, Tumor DNA Methylation Gene Expression Regulation, Neoplastic MicroRNAs Humans Neoplasm Placenta Pregnancy Protein RNA Reproduction |
description |
The National Counsel of Technological and Scientific Development (CNPq), São Paulo Research Foundation (FAPESP); and by Research Support of the University of Sao Paulo, CISBi-NAP/USP. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2017-02-08T19:30:24Z |
dc.date.available.fl_str_mv |
2017-02-08T19:30:24Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MUYS, B. R. et al. Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line. Plos One, v. 11, n. 3, p. 1-17, 2016. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/17753 |
dc.identifier.issn.pt_BR.fl_str_mv |
1932-6203 |
dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pone.0151560 |
identifier_str_mv |
MUYS, B. R. et al. Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line. Plos One, v. 11, n. 3, p. 1-17, 2016. 1932-6203 10.1371/journal.pone.0151560 |
url |
https://www.arca.fiocruz.br/handle/icict/17753 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Public Library of Science |
publisher.none.fl_str_mv |
Public Library of Science |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
collection |
Repositório Institucional da FIOCRUZ (ARCA) |
bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/17753/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/17753/2/Muys%20BR%20Placenta%20enriched....pdf https://www.arca.fiocruz.br/bitstream/icict/17753/3/Muys%20BR%20Placenta%20enriched....pdf.txt |
bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 85d84fb7ebfa1af7eeed10bd86032a93 7634c47e3a7d7b9784414ad0d2b8205d |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
_version_ |
1813009225185492992 |