Liquid Biopsies in the Clinical Management of Germ Cell Tumor Patients: State-of-the-Art and Future Directions
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/104755 https://doi.org/10.3390/ijms22052654 |
Resumo: | Liquid biopsies constitute a minimally invasive means of managing cancer patients, entailing early diagnosis, follow-up and prediction of response to therapy. Their use in the germ cell tumor field is invaluable since diagnostic tissue biopsies (which are invasive) are often not performed, and therefore only a presumptive diagnosis can be made, confirmed upon examination of the surgical specimen. Herein, we provide an overall review of the current liquid biopsy-based biomarkers of this disease, including the classical, routinely used serum tumor markers-the promising microRNAs rapidly approaching the introduction into clinical practice-but also cell-free DNA markers (including DNA methylation) and circulating tumor cells. Finally, and importantly, we also explore novel strategies and challenges for liquid biopsy markers and methodologies, providing a critical view of the future directions for liquid biopsy tests in this field, highlighting gaps and unanswered questions. |
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Liquid Biopsies in the Clinical Management of Germ Cell Tumor Patients: State-of-the-Art and Future Directionsgerm cell tumorsliquid biopsiesmicroRNAsDNA methylationcirculating tumor cellsbiomarkersdiagnosisfollow-upserum tumor markersBiomarkers, TumorCritical PathwaysDNA, NeoplasmDisease ManagementFemaleHumansMaleMicroRNAsNeoplasm ProteinsNeoplasms, Germ Cell and EmbryonalNeoplastic Cells, CirculatingOvarian NeoplasmsRNA, NeoplasmTesticular NeoplasmsLiquid BiopsyLiquid biopsies constitute a minimally invasive means of managing cancer patients, entailing early diagnosis, follow-up and prediction of response to therapy. Their use in the germ cell tumor field is invaluable since diagnostic tissue biopsies (which are invasive) are often not performed, and therefore only a presumptive diagnosis can be made, confirmed upon examination of the surgical specimen. Herein, we provide an overall review of the current liquid biopsy-based biomarkers of this disease, including the classical, routinely used serum tumor markers-the promising microRNAs rapidly approaching the introduction into clinical practice-but also cell-free DNA markers (including DNA methylation) and circulating tumor cells. Finally, and importantly, we also explore novel strategies and challenges for liquid biopsy markers and methodologies, providing a critical view of the future directions for liquid biopsy tests in this field, highlighting gaps and unanswered questions.MDPI AG2021-03-06info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/104755http://hdl.handle.net/10316/104755https://doi.org/10.3390/ijms22052654eng1422-0067Lobo, JoãoLeão, RicardoJerónimo, CarmenHenriques, Rui T.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-01-24T22:04:14Zoai:estudogeral.uc.pt:10316/104755Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:21:24.678740Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Liquid Biopsies in the Clinical Management of Germ Cell Tumor Patients: State-of-the-Art and Future Directions |
title |
Liquid Biopsies in the Clinical Management of Germ Cell Tumor Patients: State-of-the-Art and Future Directions |
spellingShingle |
Liquid Biopsies in the Clinical Management of Germ Cell Tumor Patients: State-of-the-Art and Future Directions Lobo, João germ cell tumors liquid biopsies microRNAs DNA methylation circulating tumor cells biomarkers diagnosis follow-up serum tumor markers Biomarkers, Tumor Critical Pathways DNA, Neoplasm Disease Management Female Humans Male MicroRNAs Neoplasm Proteins Neoplasms, Germ Cell and Embryonal Neoplastic Cells, Circulating Ovarian Neoplasms RNA, Neoplasm Testicular Neoplasms Liquid Biopsy |
title_short |
Liquid Biopsies in the Clinical Management of Germ Cell Tumor Patients: State-of-the-Art and Future Directions |
title_full |
Liquid Biopsies in the Clinical Management of Germ Cell Tumor Patients: State-of-the-Art and Future Directions |
title_fullStr |
Liquid Biopsies in the Clinical Management of Germ Cell Tumor Patients: State-of-the-Art and Future Directions |
title_full_unstemmed |
Liquid Biopsies in the Clinical Management of Germ Cell Tumor Patients: State-of-the-Art and Future Directions |
title_sort |
Liquid Biopsies in the Clinical Management of Germ Cell Tumor Patients: State-of-the-Art and Future Directions |
author |
Lobo, João |
author_facet |
Lobo, João Leão, Ricardo Jerónimo, Carmen Henriques, Rui T. |
author_role |
author |
author2 |
Leão, Ricardo Jerónimo, Carmen Henriques, Rui T. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Lobo, João Leão, Ricardo Jerónimo, Carmen Henriques, Rui T. |
dc.subject.por.fl_str_mv |
germ cell tumors liquid biopsies microRNAs DNA methylation circulating tumor cells biomarkers diagnosis follow-up serum tumor markers Biomarkers, Tumor Critical Pathways DNA, Neoplasm Disease Management Female Humans Male MicroRNAs Neoplasm Proteins Neoplasms, Germ Cell and Embryonal Neoplastic Cells, Circulating Ovarian Neoplasms RNA, Neoplasm Testicular Neoplasms Liquid Biopsy |
topic |
germ cell tumors liquid biopsies microRNAs DNA methylation circulating tumor cells biomarkers diagnosis follow-up serum tumor markers Biomarkers, Tumor Critical Pathways DNA, Neoplasm Disease Management Female Humans Male MicroRNAs Neoplasm Proteins Neoplasms, Germ Cell and Embryonal Neoplastic Cells, Circulating Ovarian Neoplasms RNA, Neoplasm Testicular Neoplasms Liquid Biopsy |
description |
Liquid biopsies constitute a minimally invasive means of managing cancer patients, entailing early diagnosis, follow-up and prediction of response to therapy. Their use in the germ cell tumor field is invaluable since diagnostic tissue biopsies (which are invasive) are often not performed, and therefore only a presumptive diagnosis can be made, confirmed upon examination of the surgical specimen. Herein, we provide an overall review of the current liquid biopsy-based biomarkers of this disease, including the classical, routinely used serum tumor markers-the promising microRNAs rapidly approaching the introduction into clinical practice-but also cell-free DNA markers (including DNA methylation) and circulating tumor cells. Finally, and importantly, we also explore novel strategies and challenges for liquid biopsy markers and methodologies, providing a critical view of the future directions for liquid biopsy tests in this field, highlighting gaps and unanswered questions. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-03-06 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/104755 http://hdl.handle.net/10316/104755 https://doi.org/10.3390/ijms22052654 |
url |
http://hdl.handle.net/10316/104755 https://doi.org/10.3390/ijms22052654 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1422-0067 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
MDPI AG |
publisher.none.fl_str_mv |
MDPI AG |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
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1799134105035603968 |