Genetics of cognitive trajectory in Brazilians: 15 years of follow-up from the Bambuí-Epigen Cohort Study of Aging
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/57514 https://doi.org/10.1038/s41598-019-53988-4 |
Resumo: | EUROPEAN UNION |
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Gouveia, Mateus HenriqueCésar, Cibele CominiSantolalla, Meddly LeslyeSant Anna, Hanaisa de Pla eScliar, Marília de OliveiraLeal, Thiago P.Araujo, Natalia Motta deSouza, Giordano Bruno SoaresMagalhães, Wagner C. S.Mata, Ignacio F.Ferri, Cleusa PinheiroCosta, Erico de CastroMbulaiteye, Sam M.Tishkoff, Sarah A.Shriner, DanielRotimi, Charles N.Santos, Eduardo TarazonaCosta, Maria Fernanda Furtado Lima2023-03-23T12:59:36Z2023-03-23T12:59:36Z2019GOUVEIA, Mateus Henrique et al. Genetics of cognitive trajectory in Brazilians: 15 years of follow-up from the Bambuí-Epigen Cohort Study of Aging. Sci Rep., v. 9, n. 1, 18085, 2019. doi: 10.1038/s41598-019-53988-4.2045-2322https://www.arca.fiocruz.br/handle/icict/57514https://doi.org/10.1038/s41598-019-53988-4EUROPEAN UNIONFundação Oswaldo Cruz. Instituto de Pesquisas René Rachou. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, Brazil/Center for Research on Genomics and Global Health. National Human Genome Research Institute, National Institutes of Health. Bethesda, MA, United States of AmericaUniversidade Federal de Minas Gerais. Faculdade de Ciências Econômicas. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, Brazil/Melbourne Integrative Genomics. The University of Melbourne. Melbourne, VIC 3052 AustraliaUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo HorizonteUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo HorizonteFundação Oswaldo Cruz. Instituto de Pesquisas René Rachou. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo HorizonteUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, Brazil/Instituto Mário Penna. Núcleo de Ensino e Pesquisa. Belo Horizonte, MG, BrazilLerner Research Institute. Genomic Medicine. Cleveland Clinic Foundation. Cleveland, OH, USAUniversidade Federal de São Paulo. Department of Psychiatry. São Paulo, SP, BrazilFundação Oswaldo Cruz. Instituto de Pesquisas René Rachou. Belo Horizonte, MG, BrazilDivision of Cancer Epidemiology and Genetics. National Cancer Institute. National Institutes of Health.Bethesda, MaA, United States of AmericaDepartment of Genetics. University of Pennsylvania. Philadelphia, PA,United States of AmericaCenter for Research on Genomics and Global Health. National Human Genome Research Institute, National Institutes of Health. Bethesda, MA, United States of AmericaCenter for Research on Genomics and Global Health. National Human Genome Research Institute, National Institutes of Health. Bethesda, MA, United States of AmericaUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto de Pesquisas René Rachou. Belo Horizonte, MG, BrazilThe human genetic diversity of the Americas has been affected by several events of gene flow that have continued since the colonial era and the Atlantic slave trade. Moreover, multiple waves of migration followed by local admixture occurred in the last two centuries, the impact of which has been largely unexplored. Here, we compiled a genome-wide dataset of similar to 12,000 individuals from twelve American countries and similar to 6,000 individuals from worldwide populations and applied haplotype-based methods to investigate how historical movements from outside the New World affected (1) the genetic structure, (2) the admixture profile, (3) the demographic history, and (4) sex-biased gene-flow dynamics of the Americas. We revealed a high degree of complexity underlying the genetic contribution of European and African populations in North and South America, from both geographic and temporal perspectives, identifying previously unreported sources related to Italy, the Middle East, and to specific regions of Africa.engNature Publishing GroupGenetics of cognitive trajectory in Brazilians: 15 years of follow-up from the Bambuí-Epigen Cohort Study of Aginginfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALGenetics of cognitive trajectory in Brazilians.pdfGenetics of cognitive trajectory in Brazilians.pdfapplication/pdf659164https://www.arca.fiocruz.br/bitstream/icict/57514/2/Genetics%20of%20cognitive%20trajectory%20in%20Brazilians.pdfd22657f0037da942991bad3d6052166fMD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/57514/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/575142023-03-23 09:59:36.832oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-23T12:59:36Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Genetics of cognitive trajectory in Brazilians: 15 years of follow-up from the Bambuí-Epigen Cohort Study of Aging |
| title |
Genetics of cognitive trajectory in Brazilians: 15 years of follow-up from the Bambuí-Epigen Cohort Study of Aging |
| spellingShingle |
Genetics of cognitive trajectory in Brazilians: 15 years of follow-up from the Bambuí-Epigen Cohort Study of Aging Gouveia, Mateus Henrique |
| title_short |
Genetics of cognitive trajectory in Brazilians: 15 years of follow-up from the Bambuí-Epigen Cohort Study of Aging |
| title_full |
Genetics of cognitive trajectory in Brazilians: 15 years of follow-up from the Bambuí-Epigen Cohort Study of Aging |
| title_fullStr |
Genetics of cognitive trajectory in Brazilians: 15 years of follow-up from the Bambuí-Epigen Cohort Study of Aging |
| title_full_unstemmed |
Genetics of cognitive trajectory in Brazilians: 15 years of follow-up from the Bambuí-Epigen Cohort Study of Aging |
| title_sort |
Genetics of cognitive trajectory in Brazilians: 15 years of follow-up from the Bambuí-Epigen Cohort Study of Aging |
| author |
Gouveia, Mateus Henrique |
| author_facet |
Gouveia, Mateus Henrique César, Cibele Comini Santolalla, Meddly Leslye Sant Anna, Hanaisa de Pla e Scliar, Marília de Oliveira Leal, Thiago P. Araujo, Natalia Motta de Souza, Giordano Bruno Soares Magalhães, Wagner C. S. Mata, Ignacio F. Ferri, Cleusa Pinheiro Costa, Erico de Castro Mbulaiteye, Sam M. Tishkoff, Sarah A. Shriner, Daniel Rotimi, Charles N. Santos, Eduardo Tarazona Costa, Maria Fernanda Furtado Lima |
| author_role |
author |
| author2 |
César, Cibele Comini Santolalla, Meddly Leslye Sant Anna, Hanaisa de Pla e Scliar, Marília de Oliveira Leal, Thiago P. Araujo, Natalia Motta de Souza, Giordano Bruno Soares Magalhães, Wagner C. S. Mata, Ignacio F. Ferri, Cleusa Pinheiro Costa, Erico de Castro Mbulaiteye, Sam M. Tishkoff, Sarah A. Shriner, Daniel Rotimi, Charles N. Santos, Eduardo Tarazona Costa, Maria Fernanda Furtado Lima |
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author author author author author author author author author author author author author author author author author |
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Gouveia, Mateus Henrique César, Cibele Comini Santolalla, Meddly Leslye Sant Anna, Hanaisa de Pla e Scliar, Marília de Oliveira Leal, Thiago P. Araujo, Natalia Motta de Souza, Giordano Bruno Soares Magalhães, Wagner C. S. Mata, Ignacio F. Ferri, Cleusa Pinheiro Costa, Erico de Castro Mbulaiteye, Sam M. Tishkoff, Sarah A. Shriner, Daniel Rotimi, Charles N. Santos, Eduardo Tarazona Costa, Maria Fernanda Furtado Lima |
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EUROPEAN UNION |
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2019 |
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2019 |
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2023-03-23T12:59:36Z |
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2023-03-23T12:59:36Z |
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GOUVEIA, Mateus Henrique et al. Genetics of cognitive trajectory in Brazilians: 15 years of follow-up from the Bambuí-Epigen Cohort Study of Aging. Sci Rep., v. 9, n. 1, 18085, 2019. doi: 10.1038/s41598-019-53988-4. |
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2045-2322 |
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https://doi.org/10.1038/s41598-019-53988-4 |
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GOUVEIA, Mateus Henrique et al. Genetics of cognitive trajectory in Brazilians: 15 years of follow-up from the Bambuí-Epigen Cohort Study of Aging. Sci Rep., v. 9, n. 1, 18085, 2019. doi: 10.1038/s41598-019-53988-4. 2045-2322 |
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