H1N1pdm influenza infection in hospitalized cancer patients: clinical evolution and viral analysis
| Main Author: | |
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| Publication Date: | 2010 |
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| Format: | Article |
| Language: | eng |
| Source: | Repositório Institucional da FIOCRUZ (ARCA) |
| Download full: | https://www.arca.fiocruz.br/handle/icict/25292 |
Summary: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil. |
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Souza, Thiago Moreno L.Salluh, Jorge I. F.Bozza, Fernando A.Mesquita, MileneSoares, MárcioMotta, Fernando C.Pitrowsky, Melissa TassanoOliveira, Maria de LourdesMishin, Vasiliy P.Gubareva, Larissa V.Whitney, AnneRocco, Sandra AmaralGonçalves, Vânia Maria C.Marques, Venceslaine PradoVelasco, EduardoSiqueira, Marilda Agudo Mendonça Teixeira de2018-03-13T17:30:33Z2018-03-13T17:30:33Z2010SOUZA, Thiago Moreno L. et al. H1N1pdm Influenza Infection in Hospitalized Cancer Patients: Clinical Evolution and Viral Analysis. PLoS ONE, v. 5, n. 11, p.1-10, Nov. 2010.1932-6203https://www.arca.fiocruz.br/handle/icict/2529210.1371/journal.pone.0014158engPublic Library of SciencePacientes com câncerHospitalizadosAnálise viralEvolução clínicaVírus pandêmico da gripe ACancer PatientsHospitalizedInfluenza A pandemic virusClinical EvolutionViral AnalysisH1N1pdm influenza infection in hospitalized cancer patients: clinical evolution and viral analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil.Hospital de Câncer. Unidade de Cuidados Intensivos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisas Evandro Chagas. Unidade de Cuidados Intensivos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil.Hospital de Câncer. Unidade de Cuidados Intensivos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil.Hospital de Câncer. Unidade de Cuidados Intensivos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil.Centers for Disease Control. National Center for Immunization and Respiratory Diseases. Influenza Division. Atlanta, Georgia, USA.Centers for Disease Control. National Center for Immunization and Respiratory Diseases. Influenza Division. Atlanta, Georgia, USA.Centers for Disease Control. National Center for Immunization and Respiratory Diseases. Influenza Division. Atlanta, Georgia, USA.Hospital de Câncer. Unidade de Cuidados Intensivos Pediátricos. Rio de Janeiro, RJ, Brasil.Hospital de Câncer. Departamento de Doenças Infecciosas. Comitê de Controle de Infecções. Rio de Janeiro, RJ, BrasilHospital de Câncer. Departamento de Doenças Infecciosas. Comitê de Controle de Infecções. Rio de Janeiro, RJ, BrasilHospital de Câncer. Departamento de Doenças Infecciosas. Comitê de Controle de Infecções. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil.Background: The novel influenza A pandemic virus (H1N1pdm) caused considerable morbidity and mortality worldwide in 2009. The aim of the present study was to evaluate the clinical course, duration of viral shedding, H1N1pdm evolution and emergence of antiviral resistance in hospitalized cancer patients with severe H1N1pdm infections during the winter of 2009 in Brazil. Methods: We performed a prospective single-center cohort study in a cancer center in Rio de Janeiro, Brazil. Hospitalized patients with cancer and a confirmed diagnosis of influenza A H1N1pdm were evaluated. The main outcome measures in this study were in-hospital mortality, duration of viral shedding, viral persistence and both functional and molecular analyses of H1N1pdm susceptibility to oseltamivir. Results: A total of 44 hospitalized patients with suspected influenza-like illness were screened. A total of 24 had diagnosed H1N1pdm infections. The overall hospital mortality in our cohort was 21%. Thirteen (54%) patients required intensive care. The median age of the studied cohort was 14.5 years (3–69 years). Eighteen (75%) patients had received chemotherapy in the previous month, and 14 were neutropenic at the onset of influenza. A total of 10 patients were evaluated for their duration of viral shedding, and 5 (50%) displayed prolonged viral shedding (median 23, range = 11–63 days); however, this was not associated with the emergence of a resistant H1N1pdm virus. Viral evolution was observed in sequentially collected samples. Conclusions: Prolonged influenza A H1N1pdm shedding was observed in cancer patients. However, oseltamivir resistance was not detected. Taken together, our data suggest that severely ill cancer patients may constitute a pandemic virus reservoir with major implications for viral propagation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25292/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmilene_mesquita_etal_IOC_2010.pdfmilene_mesquita_etal_IOC_2010.pdfapplication/pdf582231https://www.arca.fiocruz.br/bitstream/icict/25292/2/milene_mesquita_etal_IOC_2010.pdfe60564217bd7de984ce2aba3c8669050MD52TEXTmilene_mesquita_etal_IOC_2010.pdf.txtmilene_mesquita_etal_IOC_2010.pdf.txtExtracted texttext/plain48060https://www.arca.fiocruz.br/bitstream/icict/25292/3/milene_mesquita_etal_IOC_2010.pdf.txt3968becaef3f5d70206374c3579f92d1MD53icict/252922022-03-23 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| dc.title.pt_BR.fl_str_mv |
H1N1pdm influenza infection in hospitalized cancer patients: clinical evolution and viral analysis |
| title |
H1N1pdm influenza infection in hospitalized cancer patients: clinical evolution and viral analysis |
| spellingShingle |
H1N1pdm influenza infection in hospitalized cancer patients: clinical evolution and viral analysis Souza, Thiago Moreno L. Pacientes com câncer Hospitalizados Análise viral Evolução clínica Vírus pandêmico da gripe A Cancer Patients Hospitalized Influenza A pandemic virus Clinical Evolution Viral Analysis |
| title_short |
H1N1pdm influenza infection in hospitalized cancer patients: clinical evolution and viral analysis |
| title_full |
H1N1pdm influenza infection in hospitalized cancer patients: clinical evolution and viral analysis |
| title_fullStr |
H1N1pdm influenza infection in hospitalized cancer patients: clinical evolution and viral analysis |
| title_full_unstemmed |
H1N1pdm influenza infection in hospitalized cancer patients: clinical evolution and viral analysis |
| title_sort |
H1N1pdm influenza infection in hospitalized cancer patients: clinical evolution and viral analysis |
| author |
Souza, Thiago Moreno L. |
| author_facet |
Souza, Thiago Moreno L. Salluh, Jorge I. F. Bozza, Fernando A. Mesquita, Milene Soares, Márcio Motta, Fernando C. Pitrowsky, Melissa Tassano Oliveira, Maria de Lourdes Mishin, Vasiliy P. Gubareva, Larissa V. Whitney, Anne Rocco, Sandra Amaral Gonçalves, Vânia Maria C. Marques, Venceslaine Prado Velasco, Eduardo Siqueira, Marilda Agudo Mendonça Teixeira de |
| author_role |
author |
| author2 |
Salluh, Jorge I. F. Bozza, Fernando A. Mesquita, Milene Soares, Márcio Motta, Fernando C. Pitrowsky, Melissa Tassano Oliveira, Maria de Lourdes Mishin, Vasiliy P. Gubareva, Larissa V. Whitney, Anne Rocco, Sandra Amaral Gonçalves, Vânia Maria C. Marques, Venceslaine Prado Velasco, Eduardo Siqueira, Marilda Agudo Mendonça Teixeira de |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Souza, Thiago Moreno L. Salluh, Jorge I. F. Bozza, Fernando A. Mesquita, Milene Soares, Márcio Motta, Fernando C. Pitrowsky, Melissa Tassano Oliveira, Maria de Lourdes Mishin, Vasiliy P. Gubareva, Larissa V. Whitney, Anne Rocco, Sandra Amaral Gonçalves, Vânia Maria C. Marques, Venceslaine Prado Velasco, Eduardo Siqueira, Marilda Agudo Mendonça Teixeira de |
| dc.subject.other.pt_BR.fl_str_mv |
Pacientes com câncer Hospitalizados Análise viral Evolução clínica Vírus pandêmico da gripe A |
| topic |
Pacientes com câncer Hospitalizados Análise viral Evolução clínica Vírus pandêmico da gripe A Cancer Patients Hospitalized Influenza A pandemic virus Clinical Evolution Viral Analysis |
| dc.subject.en.pt_BR.fl_str_mv |
Cancer Patients Hospitalized Influenza A pandemic virus Clinical Evolution Viral Analysis |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil. |
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2010 |
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2010 |
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2018-03-13T17:30:33Z |
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2018-03-13T17:30:33Z |
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info:eu-repo/semantics/article |
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SOUZA, Thiago Moreno L. et al. H1N1pdm Influenza Infection in Hospitalized Cancer Patients: Clinical Evolution and Viral Analysis. PLoS ONE, v. 5, n. 11, p.1-10, Nov. 2010. |
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https://www.arca.fiocruz.br/handle/icict/25292 |
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1932-6203 |
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10.1371/journal.pone.0014158 |
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SOUZA, Thiago Moreno L. et al. H1N1pdm Influenza Infection in Hospitalized Cancer Patients: Clinical Evolution and Viral Analysis. PLoS ONE, v. 5, n. 11, p.1-10, Nov. 2010. 1932-6203 10.1371/journal.pone.0014158 |
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