Metastatic niches and the modulatory contribution of mesenchymal stem cells and its exosomes

Detalhes bibliográficos
Autor(a) principal: Valenzuela Alvarez, Matias
Data de Publicação: 2019
Outros Autores: Gutierrez, Luciana M., Dominguez, Alejandro Correa, Lazarowski, Alberto, Bolontrade, Marcela F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33550
Resumo: Instituto de Medicina Traslacional e Ingeniería Biomédica. Remodelative Processes and Cellular Niches Laboratory. Buenos Aires, Argentina.
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spelling Valenzuela Alvarez, MatiasGutierrez, Luciana M.Dominguez, Alejandro CorreaLazarowski, AlbertoBolontrade, Marcela F.2019-06-18T15:59:03Z2019-06-18T15:59:03Z2019VALENZUELA ALVES, Matias et al. Metastatic niches and the modulatory contribution of mesenchymal stem cells and Its exosomes. Int. J. Mol. Sci, v. 20, n. 1946, p. 1-17, 2019.1661-6596https://www.arca.fiocruz.br/handle/icict/3355010.3390/ijms200819461422-0067engMDPINicho Pré-MetastáticoMesenchymal Stromal CellsExosomesNeoplasm MetastasisCélulas del Estroma MesenquimatosoExosomasMetástasis de la NeoplasiaCélulas Mesenquimais EstromaisExossomosMetástase NeoplásicaMetastatic niches and the modulatory contribution of mesenchymal stem cells and its exosomesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto de Medicina Traslacional e Ingeniería Biomédica. Remodelative Processes and Cellular Niches Laboratory. Buenos Aires, Argentina.Instituto de Medicina Traslacional e Ingeniería Biomédica. Remodelative Processes and Cellular Niches Laboratory. Buenos Aires, Argentina.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.University of Buenos Aires. School of Pharmacy and Biochemistry. Clinical Biochemistry Department. Buenos Aires, Argentina.Instituto de Medicina Traslacional e Ingeniería Biomédica. Remodelative Processes and Cellular Niches Laboratory. Buenos Aires, Argentina.Mesenchymal stem cells (MSCs) represent an interesting population due to their capacity to release a variety of cytokines, chemokines, and growth factors, and due to their motile nature and homing ability. MSCs can be isolated from different sources, like adipose tissue or bone marrow, and have the capacity to differentiate, both in vivo and in vitro, into adipocytes, chondrocytes, and osteoblasts, making them even more interesting in the regenerative medicine field. Tumor associated stroma has been recognized as a key element in tumor progression, necessary for the biological success of the tumor, and MSCs represent a functionally fundamental part of this associated stroma. Exosomes represent one of the dominant signaling pathways within the tumor microenvironment. Their biology raises high interest, with implications in different biological processes involved in cancer progression, such as the formation of the pre-metastatic niche. This is critical during the metastatic cascade, given that it is the formation of a permissive context that would allow metastatic tumor cells survival within the new environment. In this context, we explored the role of exosomes, particularly MSCs-derived exosomes as direct or indirect modulators. All this points out a possible new tool useful for designing better treatment and detection strategies for metastatic progression, including the management of chemoresistance.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/33550/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALijms-20-0194.pdfijms-20-0194.pdfapplication/pdf755498https://www.arca.fiocruz.br/bitstream/icict/33550/2/ijms-20-0194.pdf25f29748d0753e01eb89f5c4ca903b70MD52TEXTijms-20-0194.pdf.txtijms-20-0194.pdf.txtExtracted texttext/plain76904https://www.arca.fiocruz.br/bitstream/icict/33550/3/ijms-20-0194.pdf.txt895b21d9442315b3e26f1e75337cd57dMD53icict/335502019-10-31 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dc.title.pt_BR.fl_str_mv Metastatic niches and the modulatory contribution of mesenchymal stem cells and its exosomes
title Metastatic niches and the modulatory contribution of mesenchymal stem cells and its exosomes
spellingShingle Metastatic niches and the modulatory contribution of mesenchymal stem cells and its exosomes
Valenzuela Alvarez, Matias
Nicho Pré-Metastático
Mesenchymal Stromal Cells
Exosomes
Neoplasm Metastasis
Células del Estroma Mesenquimatoso
Exosomas
Metástasis de la Neoplasia
Células Mesenquimais Estromais
Exossomos
Metástase Neoplásica
title_short Metastatic niches and the modulatory contribution of mesenchymal stem cells and its exosomes
title_full Metastatic niches and the modulatory contribution of mesenchymal stem cells and its exosomes
title_fullStr Metastatic niches and the modulatory contribution of mesenchymal stem cells and its exosomes
title_full_unstemmed Metastatic niches and the modulatory contribution of mesenchymal stem cells and its exosomes
title_sort Metastatic niches and the modulatory contribution of mesenchymal stem cells and its exosomes
author Valenzuela Alvarez, Matias
author_facet Valenzuela Alvarez, Matias
Gutierrez, Luciana M.
Dominguez, Alejandro Correa
Lazarowski, Alberto
Bolontrade, Marcela F.
author_role author
author2 Gutierrez, Luciana M.
Dominguez, Alejandro Correa
Lazarowski, Alberto
Bolontrade, Marcela F.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Valenzuela Alvarez, Matias
Gutierrez, Luciana M.
Dominguez, Alejandro Correa
Lazarowski, Alberto
Bolontrade, Marcela F.
dc.subject.other.pt_BR.fl_str_mv Nicho Pré-Metastático
topic Nicho Pré-Metastático
Mesenchymal Stromal Cells
Exosomes
Neoplasm Metastasis
Células del Estroma Mesenquimatoso
Exosomas
Metástasis de la Neoplasia
Células Mesenquimais Estromais
Exossomos
Metástase Neoplásica
dc.subject.en.pt_BR.fl_str_mv Mesenchymal Stromal Cells
Exosomes
Neoplasm Metastasis
dc.subject.es.pt_BR.fl_str_mv Células del Estroma Mesenquimatoso
Exosomas
Metástasis de la Neoplasia
dc.subject.decs.pt_BR.fl_str_mv Células Mesenquimais Estromais
Exossomos
Metástase Neoplásica
description Instituto de Medicina Traslacional e Ingeniería Biomédica. Remodelative Processes and Cellular Niches Laboratory. Buenos Aires, Argentina.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-06-18T15:59:03Z
dc.date.available.fl_str_mv 2019-06-18T15:59:03Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv VALENZUELA ALVES, Matias et al. Metastatic niches and the modulatory contribution of mesenchymal stem cells and Its exosomes. Int. J. Mol. Sci, v. 20, n. 1946, p. 1-17, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33550
dc.identifier.issn.pt_BR.fl_str_mv 1661-6596
dc.identifier.doi.pt_BR.fl_str_mv 10.3390/ijms20081946
dc.identifier.eissn.none.fl_str_mv 1422-0067
identifier_str_mv VALENZUELA ALVES, Matias et al. Metastatic niches and the modulatory contribution of mesenchymal stem cells and Its exosomes. Int. J. Mol. Sci, v. 20, n. 1946, p. 1-17, 2019.
1661-6596
10.3390/ijms20081946
1422-0067
url https://www.arca.fiocruz.br/handle/icict/33550
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/33550/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/33550/2/ijms-20-0194.pdf
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