Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2001 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/5526 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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Gonçalves, Marilda de SouzaQueiroz, I. LCardoso, Silvia AndradeZanette, Angela Maria DiasStrapazoni, A. CAdorno, Elisângela VitóriaAlbuquerque, Alessandra B. LimaSant'Ana, AReis, Mitermayer Galvão dosBarral, Aldina Maria PradoBarral Netto, Manoel2012-09-18T21:17:54Z2012-09-18T21:17:54Z2001GONÇALVES, M.S. et al. Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease. Brazilian Journal of Medical and Biological Research, v. 34, n. 10, p. 1309-13, oct. 2001.0100-879Xhttps://www.arca.fiocruz.br/handle/icict/5526engInterleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Hemocentro da Bahia. Secretaria de Saúde do Estado da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Hemocentro da Bahia. Secretaria de Saúde do Estado da Bahia. Salvador, BA, BrasilFundação Hemocentro da Bahia. Secretaria de Saúde do Estado da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Hemocentro da Bahia. Secretaria de Saúde do Estado da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilSickle cell disease has a worldwide distribution and is a public health problem in Brazil. Although vaso-occlusive crisis (VOC) is one of the most important clinical features of the disease, there are still several steps of its pathogenesis which are unknown. The increase of the chemotactic factor interleukin 8 (IL-8) has been reported to be involved in sickle cell disease crisis, but this has not been demonstrated conclusively. In the present study we analyzed serum IL-8 levels by ELISA and hematological parameters and hemoglobin patterns by standard techniques in 23 (21 SS and 2 SC) Brazilian patients with sickle cell syndromes during VOC caused by different inducing factors, 22 (21 SS and 1 SC) sickle cell patients out of crisis, and 11 healthy controls. Increased IL-8 levels were observed in 19 of 23 VOC patients (79.2%), 3 of them with more than 1,000 pg/ml. Seventeen of 22 (77.3%) non-crisis patients showed low IL-8 levels (less than 15 pg/ml). Healthy controls had low IL-8 levels. A significant difference in serum IL-8 levels was observed between crisis and non-crisis sickle cell patients (P<0.0001). There was no correlation between IL-8 levels and hematological data or hemoglobin patterns. High serum IL-8 levels were observed in VOC patients independently of the crisis-inducing factor. We conclude that in the studied population, IL-8 concentration may be a useful VOC marker, although the mechanism of the pathogenic process of sickle cell VOC syndromes remains unclear.Interleukin 8Sickle cell syndromesVaso-occlusive crisisAnemia Falciforme/sangueArteriopatias Oclusivas/sangueInterleucina-8/sangueAnemia Falciforme/fisiopatologiaAdolescenteAdultoArteriopatias Oclusivas/etiologiaMarcadores Biológicos/sangueBrasilCriançaPré-EscolarFemininoHemoglobina Falciforme/análiseHemoglobinas/análiseHumanosLactenteMeia-IdadeFatores de RiscoSindromeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALGoncalves MS Interleukin 8 as a vaso-occlusive....pdfGoncalves MS Interleukin 8 as a vaso-occlusive....pdfapplication/pdf152416https://www.arca.fiocruz.br/bitstream/icict/5526/1/Goncalves%20MS%20Interleukin%208%20as%20a%20vaso-occlusive....pdf512aa64419dd6e1503998984ac84211dMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5526/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTGoncalves MS Interleukin 8 as a vaso-occlusive....pdf.txtGoncalves MS Interleukin 8 as a vaso-occlusive....pdf.txtExtracted texttext/plain21040https://www.arca.fiocruz.br/bitstream/icict/5526/5/Goncalves%20MS%20Interleukin%208%20as%20a%20vaso-occlusive....pdf.txted11dafde727c4ba2371c7017aa4cca7MD55THUMBNAILGoncalves MS Interleukin 8 as a vaso-occlusive....pdf.jpgGoncalves MS Interleukin 8 as a vaso-occlusive....pdf.jpgGenerated Thumbnailimage/jpeg2228https://www.arca.fiocruz.br/bitstream/icict/5526/4/Goncalves%20MS%20Interleukin%208%20as%20a%20vaso-occlusive....pdf.jpg63228bf046a0b5bc59880bd282c7facdMD54icict/55262023-09-14 15:53:40.975oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-14T18:53:40Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease |
| title |
Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease |
| spellingShingle |
Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease Gonçalves, Marilda de Souza Interleukin 8 Sickle cell syndromes Vaso-occlusive crisis Anemia Falciforme/sangue Arteriopatias Oclusivas/sangue Interleucina-8/sangue Anemia Falciforme/fisiopatologia Adolescente Adulto Arteriopatias Oclusivas/etiologia Marcadores Biológicos/sangue Brasil Criança Pré-Escolar Feminino Hemoglobina Falciforme/análise Hemoglobinas/análise Humanos Lactente Meia-Idade Fatores de Risco Sindrome |
| title_short |
Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease |
| title_full |
Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease |
| title_fullStr |
Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease |
| title_full_unstemmed |
Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease |
| title_sort |
Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease |
| author |
Gonçalves, Marilda de Souza |
| author_facet |
Gonçalves, Marilda de Souza Queiroz, I. L Cardoso, Silvia Andrade Zanette, Angela Maria Dias Strapazoni, A. C Adorno, Elisângela Vitória Albuquerque, Alessandra B. Lima Sant'Ana, A Reis, Mitermayer Galvão dos Barral, Aldina Maria Prado Barral Netto, Manoel |
| author_role |
author |
| author2 |
Queiroz, I. L Cardoso, Silvia Andrade Zanette, Angela Maria Dias Strapazoni, A. C Adorno, Elisângela Vitória Albuquerque, Alessandra B. Lima Sant'Ana, A Reis, Mitermayer Galvão dos Barral, Aldina Maria Prado Barral Netto, Manoel |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Gonçalves, Marilda de Souza Queiroz, I. L Cardoso, Silvia Andrade Zanette, Angela Maria Dias Strapazoni, A. C Adorno, Elisângela Vitória Albuquerque, Alessandra B. Lima Sant'Ana, A Reis, Mitermayer Galvão dos Barral, Aldina Maria Prado Barral Netto, Manoel |
| dc.subject.en.pt_BR.fl_str_mv |
Interleukin 8 Sickle cell syndromes Vaso-occlusive crisis |
| topic |
Interleukin 8 Sickle cell syndromes Vaso-occlusive crisis Anemia Falciforme/sangue Arteriopatias Oclusivas/sangue Interleucina-8/sangue Anemia Falciforme/fisiopatologia Adolescente Adulto Arteriopatias Oclusivas/etiologia Marcadores Biológicos/sangue Brasil Criança Pré-Escolar Feminino Hemoglobina Falciforme/análise Hemoglobinas/análise Humanos Lactente Meia-Idade Fatores de Risco Sindrome |
| dc.subject.decs.pt_BR.fl_str_mv |
Anemia Falciforme/sangue Arteriopatias Oclusivas/sangue Interleucina-8/sangue Anemia Falciforme/fisiopatologia Adolescente Adulto Arteriopatias Oclusivas/etiologia Marcadores Biológicos/sangue Brasil Criança Pré-Escolar Feminino Hemoglobina Falciforme/análise Hemoglobinas/análise Humanos Lactente Meia-Idade Fatores de Risco Sindrome |
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Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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2001 |
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2001 |
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2012-09-18T21:17:54Z |
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2012-09-18T21:17:54Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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GONÇALVES, M.S. et al. Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease. Brazilian Journal of Medical and Biological Research, v. 34, n. 10, p. 1309-13, oct. 2001. |
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https://www.arca.fiocruz.br/handle/icict/5526 |
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0100-879X |
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GONÇALVES, M.S. et al. Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease. Brazilian Journal of Medical and Biological Research, v. 34, n. 10, p. 1309-13, oct. 2001. 0100-879X |
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