Identification of εPKC targets during cardiac ischemic injury
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/18706 |
Resumo: | Stanford University School of Medicine. Department of Chemical and Systems Biology. São Paulo, SP, Brasil. |
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Budas, GrantCosta Junior, Helio MirandaFerreira, Julio Cesar BatistaFerreira, André Teixeira da SilvaPerales, JonasKrieger, José EduardoMochly-Rosen, DariaSchechtman, Deborah2017-05-02T12:56:37Z2017-05-02T12:56:37Z2012BUDAS, Grant; et al. Identification of εPKC targets during cardiac ischemic injury. Circ J., v. 76, n.6, p.1476–1485, 2012.1346-9843https://www.arca.fiocruz.br/handle/icict/187061347-4820engNational Institute of HealthMitocôndriasProteína Quinase CIsquemiaFosforilaçãoεPKCischemiaphosphorylationmitochondriaMitocôndriasProteína Quinase CIsquemiaFosforilaçãoIdentification of εPKC targets during cardiac ischemic injuryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleStanford University School of Medicine. Department of Chemical and Systems Biology. São Paulo, SP, Brasil.Instituto do Coração. São Paulo, SP, Brasil.Stanford University School of Medicine. Department of Chemical and Systems Biology. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Instituto do Coração. São Paulo, SP, Brasil.tanford University School of Medicine. Department of Chemical and Systems Biology. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Química. Departamento de Bioquímica. São Paulo, SP, Brasil.Background—Activation of ε protein kinase C (εPKC) protects hearts from ischemic injury. However, some of the mechanism(s) of εPKC mediated cardioprotection are still unclear. Identification of εPKC targets may aid to elucidate εPKC–mediated cardioprotective mechanisms. Previous studies, using a combination of εPKC transgenic mice and difference in gel electrophoresis (DIGE), identified a number of proteins involved in glucose metabolism, whose expression was modified by εPKC. These studies, were accompanied by metabolomic analysis, and suggested that increased glucose oxidation may be responsible for the cardioprotective effect of εPKC. However, whether these εPKC-mediated alterations were due to differences in protein expression or phosphorylation was not determined.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18706/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALandre_teixeira_etal_IOC_2012.pdfandre_teixeira_etal_IOC_2012.pdfapplication/pdf1862111https://www.arca.fiocruz.br/bitstream/icict/18706/2/andre_teixeira_etal_IOC_2012.pdfa1e9d15c61bac74b6d078f3163f11e37MD52TEXTandre_teixeira_etal_IOC_2012.pdf.txtandre_teixeira_etal_IOC_2012.pdf.txtExtracted texttext/plain59929https://www.arca.fiocruz.br/bitstream/icict/18706/3/andre_teixeira_etal_IOC_2012.pdf.txte06ffa86aeb6bbfadc7f058cfc22152fMD53icict/187062023-09-14 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| dc.title.pt_BR.fl_str_mv |
Identification of εPKC targets during cardiac ischemic injury |
| title |
Identification of εPKC targets during cardiac ischemic injury |
| spellingShingle |
Identification of εPKC targets during cardiac ischemic injury Budas, Grant Mitocôndrias Proteína Quinase C Isquemia Fosforilação εPKC ischemia phosphorylation mitochondria Mitocôndrias Proteína Quinase C Isquemia Fosforilação |
| title_short |
Identification of εPKC targets during cardiac ischemic injury |
| title_full |
Identification of εPKC targets during cardiac ischemic injury |
| title_fullStr |
Identification of εPKC targets during cardiac ischemic injury |
| title_full_unstemmed |
Identification of εPKC targets during cardiac ischemic injury |
| title_sort |
Identification of εPKC targets during cardiac ischemic injury |
| author |
Budas, Grant |
| author_facet |
Budas, Grant Costa Junior, Helio Miranda Ferreira, Julio Cesar Batista Ferreira, André Teixeira da Silva Perales, Jonas Krieger, José Eduardo Mochly-Rosen, Daria Schechtman, Deborah |
| author_role |
author |
| author2 |
Costa Junior, Helio Miranda Ferreira, Julio Cesar Batista Ferreira, André Teixeira da Silva Perales, Jonas Krieger, José Eduardo Mochly-Rosen, Daria Schechtman, Deborah |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Budas, Grant Costa Junior, Helio Miranda Ferreira, Julio Cesar Batista Ferreira, André Teixeira da Silva Perales, Jonas Krieger, José Eduardo Mochly-Rosen, Daria Schechtman, Deborah |
| dc.subject.other.pt_BR.fl_str_mv |
Mitocôndrias Proteína Quinase C Isquemia Fosforilação |
| topic |
Mitocôndrias Proteína Quinase C Isquemia Fosforilação εPKC ischemia phosphorylation mitochondria Mitocôndrias Proteína Quinase C Isquemia Fosforilação |
| dc.subject.en.pt_BR.fl_str_mv |
εPKC ischemia phosphorylation mitochondria |
| dc.subject.decs.pt_BR.fl_str_mv |
Mitocôndrias Proteína Quinase C Isquemia Fosforilação |
| description |
Stanford University School of Medicine. Department of Chemical and Systems Biology. São Paulo, SP, Brasil. |
| publishDate |
2012 |
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2012 |
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2017-05-02T12:56:37Z |
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2017-05-02T12:56:37Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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BUDAS, Grant; et al. Identification of εPKC targets during cardiac ischemic injury. Circ J., v. 76, n.6, p.1476–1485, 2012. |
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https://www.arca.fiocruz.br/handle/icict/18706 |
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1346-9843 |
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1347-4820 |
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BUDAS, Grant; et al. Identification of εPKC targets during cardiac ischemic injury. Circ J., v. 76, n.6, p.1476–1485, 2012. 1346-9843 1347-4820 |
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National Institute of Health |
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National Institute of Health |
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