Zika Virus Infection and Differential Diagnosis in A Cohort of HIV-Infected Patients
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/28907 |
Resumo: | 2019-12-04 |
| id |
CRUZ_65b070a9425f9c4433bc2d3c98578730 |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/28907 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Calvet, Guilherme AmaralBrasil, PatriciaSiqueira, Andre MachadoZogbi, Heruza EinsfeldGonçalves, Bianca de SantisSantos, Aline da SilvaLupi, OtiliaSouza, Rogerio VallsRodrigues, Cintia Damasceno dos SantosBressan, Clarisse da SilveiraWakimoto, Mauymi DuarteAraújo, Eliane SaraivaSantos, Ingrid CardosoGeorg, IngebourgNogueira, Rita Maria RibeiroVeloso, Valdiléa G.Filippis, Ana Maria Bispo2018-09-19T17:32:01Z2018-09-19T17:32:01Z2018CALVET, Guilherme Amaral et al. Zika Virus Infection and Differential Diagnosis in a Cohort of HIV-Infected Patients. Journal of Acquired Immune Deficiency Syndromes: JAIDS, v. 79, n. 2, p. 237-243, 2018.1525-4135https://www.arca.fiocruz.br/handle/icict/2890710.1097/QAI.0000000000001777engZika Virus Infection and Differential Diagnosis in A Cohort of HIV-Infected Patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2019-12-04Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Acute Febrile Illnesses Laboratory. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Acute Febrile Illnesses Laboratory. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Acute Febrile Illnesses Laboratory. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Acute Febrile Illnesses Laboratory. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Flavivirus Laboratory. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Flavivirus Laboratory. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Acute Febrile Illnesses Laboratory, Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Acute Febrile Illnesses Laboratory, Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Acute Febrile Illnesses Laboratory, Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Acute Febrile Illnesses Laboratory, Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Flavivirus Laboratory. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Acute Febrile Illnesses Laboratory, Rio de Janeiro, RJ, Brazil.Immunodiagnostic Section, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, BrazilOswaldo Cruz Foundation. Oswaldo Cruz Institute. Flavivirus Laboratory. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, BrasilOswaldo Cruz Foundation. Oswaldo Cruz Institute. Flavivirus Laboratory. Rio de Janeiro, RJ, Brazil.Background: Zika virus (ZIKV) emergence in South America revealed the lack of knowledge regarding clinical manifestations in HIV-infected individuals. Objectives: We described the clinical characteristics, laboratory manifestations, differential diagnosis, and outcome of ZIKV infection in a large, single-center cohort of HIV-infected patients. Methods: HIV-infected patients aged 18 years and older with clinical suspected arboviral disease from an ongoing cohort were followed from February 2015 through December 2015. Acute serum samples were tested for ZIKV, dengue virus (DENV), and chikungunya virus by real-time reverse transcriptase polymerase chain reaction, anti-DENV immunoglobulin (Ig)M/IgG, and syphilis assays; convalescent samples were tested for anti-DENV IgM/IgG; and urine samples were tested for ZIKV by real-time reverse transcriptase polymerase chain reaction. ZIKV disease was defined according to the Pan American Health Organization (PAHO) guidelines. Results: Of 101 patients, ZIKV was confirmed in 43 cases and suspected in 34, and another diagnosis was assumed for 24 patients (dengue, secondary/latent syphilis, respiratory infections, human parvovirus B19, adverse drug reaction, musculoskeletal disorders, and acute gastroenteritis). ZIKV-confirmed and ZIKV-suspected patients reported similar signs and symptoms. Pruritic rash was the most common symptom, followed by myalgia, nonpurulent conjunctivitis, arthralgia, prostration, and headache. In the short-term follow-up [median 67.5 days (interquartile range: 32-104.5)], CD4 cell count (Z = -0.831, P = 0.406) and HIV viral load (Z = -0.447, P = 0.655) did not change significantly after ZIKV infection. There were no hospitalizations, complications, or deaths. Conclusions: Among HIV-infected patients with suspected arboviral disease, 42.6% were ZIKV-infected. CD4 cell counts and HIV viral load were not different after ZIKV infection. Differential diagnosis with other diseases and adverse drug reaction should be evaluated.Zika, ZIKV, arboviruses, HIV, BrazilZikaZIKVArbovirusesHIVBrazilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/28907/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALZika Virus Infection and Differential Diagnosis in A Cohort of HIV_Valdilea_Veloso_INI_Lapclin-AIDS_2018.pdfZika Virus Infection and Differential Diagnosis in A Cohort of HIV_Valdilea_Veloso_INI_Lapclin-AIDS_2018.pdfapplication/pdf724782https://www.arca.fiocruz.br/bitstream/icict/28907/2/Zika%20Virus%20Infection%20and%20Differential%20Diagnosis%20in%20A%20Cohort%20of%20HIV_Valdilea_Veloso_INI_Lapclin-AIDS_2018.pdf2df3818ab5c9206cd2ec54bf9082b8ccMD52TEXTZika Virus Infection and Differential Diagnosis in A Cohort of HIV_Valdilea_Veloso_INI_Lapclin-AIDS_2018.pdf.txtZika Virus Infection and Differential Diagnosis in A Cohort of HIV_Valdilea_Veloso_INI_Lapclin-AIDS_2018.pdf.txtExtracted texttext/plain40962https://www.arca.fiocruz.br/bitstream/icict/28907/3/Zika%20Virus%20Infection%20and%20Differential%20Diagnosis%20in%20A%20Cohort%20of%20HIV_Valdilea_Veloso_INI_Lapclin-AIDS_2018.pdf.txt501b9cb5aa9a01970206dd7bf5e3c41bMD53icict/289072023-03-30 22:23:21.863oai:www.arca.fiocruz.br:icict/28907Q0VTU8ODTyBOw4NPIEVYQ0xVU0lWQSBERSBESVJFSVRPUyBBVVRPUkFJUw0KDQpGw6FiaW8gTWFycXVlcywgQ1BGOiAxMTMuMTg3Ljg1Ny00MCwgdmluY3VsYWRvIGEgSU5JIC0gSW5zdGl0dXRvIE5hY2lvbmFsIGRlIEluZmVjdG9sb2dpYSBFdmFuZHJvIENoYWdhcwoKQW8gYWNlaXRhciBvcyBURVJNT1MgZSBDT05EScOHw5VFUyBkZXN0YSBDRVNTw4NPLCBvIEFVVE9SIGUvb3UgVElUVUxBUiBkZSBkaXJlaXRvcwphdXRvcmFpcyBzb2JyZSBhIE9CUkEgZGUgcXVlIHRyYXRhIGVzdGUgZG9jdW1lbnRvOgoKKDEpIENFREUgZSBUUkFOU0ZFUkUsIHRvdGFsIGUgZ3JhdHVpdGFtZW50ZSwgw6AgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaLCBlbQpjYXLDoXRlciBwZXJtYW5lbnRlLCBpcnJldm9nw6F2ZWwgZSBOw4NPIEVYQ0xVU0lWTywgdG9kb3Mgb3MgZGlyZWl0b3MgcGF0cmltb25pYWlzIE7Dg08KQ09NRVJDSUFJUyBkZSB1dGlsaXphw6fDo28gZGEgT0JSQSBhcnTDrXN0aWNhIGUvb3UgY2llbnTDrWZpY2EgaW5kaWNhZGEgYWNpbWEsIGluY2x1c2l2ZSBvcyBkaXJlaXRvcwpkZSB2b3ogZSBpbWFnZW0gdmluY3VsYWRvcyDDoCBPQlJBLCBkdXJhbnRlIHRvZG8gbyBwcmF6byBkZSBkdXJhw6fDo28gZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCBlbQpxdWFscXVlciBpZGlvbWEgZSBlbSB0b2RvcyBvcyBwYcOtc2VzOwoKKDIpIEFDRUlUQSBxdWUgYSBjZXNzw6NvIHRvdGFsIG7Do28gZXhjbHVzaXZhLCBwZXJtYW5lbnRlIGUgaXJyZXZvZ8OhdmVsIGRvcyBkaXJlaXRvcyBhdXRvcmFpcwpwYXRyaW1vbmlhaXMgbsOjbyBjb21lcmNpYWlzIGRlIHV0aWxpemHDp8OjbyBkZSBxdWUgdHJhdGEgZXN0ZSBkb2N1bWVudG8gaW5jbHVpLCBleGVtcGxpZmljYXRpdmFtZW50ZSwKb3MgZGlyZWl0b3MgZGUgZGlzcG9uaWJpbGl6YcOnw6NvIGUgY29tdW5pY2HDp8OjbyBww7pibGljYSBkYSBPQlJBLCBlbSBxdWFscXVlciBtZWlvIG91IHZlw61jdWxvLAppbmNsdXNpdmUgZW0gUmVwb3NpdMOzcmlvcyBEaWdpdGFpcywgYmVtIGNvbW8gb3MgZGlyZWl0b3MgZGUgcmVwcm9kdcOnw6NvLCBleGliacOnw6NvLCBleGVjdcOnw6NvLApkZWNsYW1hw6fDo28sIHJlY2l0YcOnw6NvLCBleHBvc2nDp8OjbywgYXJxdWl2YW1lbnRvLCBpbmNsdXPDo28gZW0gYmFuY28gZGUgZGFkb3MsIHByZXNlcnZhw6fDo28sIGRpZnVzw6NvLApkaXN0cmlidWnDp8OjbywgZGl2dWxnYcOnw6NvLCBlbXByw6lzdGltbywgdHJhZHXDp8OjbywgZHVibGFnZW0sIGxlZ2VuZGFnZW0sIGluY2x1c8OjbyBlbSBub3ZhcyBvYnJhcyBvdQpjb2xldMOibmVhcywgcmV1dGlsaXphw6fDo28sIGVkacOnw6NvLCBwcm9kdcOnw6NvIGRlIG1hdGVyaWFsIGRpZMOhdGljbyBlIGN1cnNvcyBvdSBxdWFscXVlciBmb3JtYSBkZQp1dGlsaXphw6fDo28gbsOjbyBjb21lcmNpYWw7CgooMykgUkVDT05IRUNFIHF1ZSBhIGNlc3PDo28gYXF1aSBlc3BlY2lmaWNhZGEgY29uY2VkZSDDoCBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPCkNSVVogbyBkaXJlaXRvIGRlIGF1dG9yaXphciBxdWFscXVlciBwZXNzb2Eg4oCTIGbDrXNpY2Egb3UganVyw61kaWNhLCBww7pibGljYSBvdSBwcml2YWRhLCBuYWNpb25hbCBvdQplc3RyYW5nZWlyYSDigJMgYSBhY2Vzc2FyIGUgdXRpbGl6YXIgYW1wbGFtZW50ZSBhIE9CUkEsIHNlbSBleGNsdXNpdmlkYWRlLCBwYXJhIHF1YWlzcXVlcgpmaW5hbGlkYWRlcyBuw6NvIGNvbWVyY2lhaXM7CgooNCkgREVDTEFSQSBxdWUgYSBvYnJhIMOpIGNyaWHDp8OjbyBvcmlnaW5hbCBlIHF1ZSDDqSBvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGFxdWkgY2VkaWRvcyBlIGF1dG9yaXphZG9zLApyZXNwb25zYWJpbGl6YW5kby1zZSBpbnRlZ3JhbG1lbnRlIHBlbG8gY29udGXDumRvIGUgb3V0cm9zIGVsZW1lbnRvcyBxdWUgZmF6ZW0gcGFydGUgZGEgT0JSQSwKaW5jbHVzaXZlIG9zIGRpcmVpdG9zIGRlIHZveiBlIGltYWdlbSB2aW5jdWxhZG9zIMOgIE9CUkEsIG9icmlnYW5kby1zZSBhIGluZGVuaXphciB0ZXJjZWlyb3MgcG9yCmRhbm9zLCBiZW0gY29tbyBpbmRlbml6YXIgZSByZXNzYXJjaXIgYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVogZGUKZXZlbnR1YWlzIGRlc3Blc2FzIHF1ZSB2aWVyZW0gYSBzdXBvcnRhciwgZW0gcmF6w6NvIGRlIHF1YWxxdWVyIG9mZW5zYSBhIGRpcmVpdG9zIGF1dG9yYWlzIG91CmRpcmVpdG9zIGRlIHZveiBvdSBpbWFnZW0sIHByaW5jaXBhbG1lbnRlIG5vIHF1ZSBkaXogcmVzcGVpdG8gYSBwbMOhZ2lvIGUgdmlvbGHDp8O1ZXMgZGUgZGlyZWl0b3M7CgooNSkgQUZJUk1BIHF1ZSBjb25oZWNlIGEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTwpPU1dBTERPIENSVVogZSBhcyBkaXJldHJpemVzIHBhcmEgbyBmdW5jaW9uYW1lbnRvIGRvIHJlcG9zaXTDs3JpbyBpbnN0aXR1Y2lvbmFsIEFSQ0EuCgpBIFBvbMOtdGljYSBJbnN0aXR1Y2lvbmFsIGRlIEFjZXNzbyBBYmVydG8gZGEgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaIHJlc2VydmEKZXhjbHVzaXZhbWVudGUgYW8gQVVUT1Igb3MgZGlyZWl0b3MgbW9yYWlzIGUgb3MgdXNvcyBjb21lcmNpYWlzIHNvYnJlIGFzIG9icmFzIGRlIHN1YSBhdXRvcmlhCmUvb3UgdGl0dWxhcmlkYWRlLCBzZW5kbyBvcyB0ZXJjZWlyb3MgdXN1w6FyaW9zIHJlc3BvbnPDoXZlaXMgcGVsYSBhdHJpYnVpw6fDo28gZGUgYXV0b3JpYSBlIG1hbnV0ZW7Dp8OjbwpkYSBpbnRlZ3JpZGFkZSBkYSBPQlJBIGVtIHF1YWxxdWVyIHV0aWxpemHDp8Ojby4KCkEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVoKcmVzcGVpdGEgb3MgY29udHJhdG9zIGUgYWNvcmRvcyBwcmVleGlzdGVudGVzIGRvcyBBdXRvcmVzIGNvbSB0ZXJjZWlyb3MsIGNhYmVuZG8gYW9zIEF1dG9yZXMKaW5mb3JtYXIgw6AgSW5zdGl0dWnDp8OjbyBhcyBjb25kacOnw7VlcyBlIG91dHJhcyByZXN0cmnDp8O1ZXMgaW1wb3N0YXMgcG9yIGVzdGVzIGluc3RydW1lbnRvcy4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-31T01:23:21Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Zika Virus Infection and Differential Diagnosis in A Cohort of HIV-Infected Patients |
| title |
Zika Virus Infection and Differential Diagnosis in A Cohort of HIV-Infected Patients |
| spellingShingle |
Zika Virus Infection and Differential Diagnosis in A Cohort of HIV-Infected Patients Calvet, Guilherme Amaral Zika, ZIKV, arboviruses, HIV, Brazil Zika ZIKV Arboviruses HIV Brazil |
| title_short |
Zika Virus Infection and Differential Diagnosis in A Cohort of HIV-Infected Patients |
| title_full |
Zika Virus Infection and Differential Diagnosis in A Cohort of HIV-Infected Patients |
| title_fullStr |
Zika Virus Infection and Differential Diagnosis in A Cohort of HIV-Infected Patients |
| title_full_unstemmed |
Zika Virus Infection and Differential Diagnosis in A Cohort of HIV-Infected Patients |
| title_sort |
Zika Virus Infection and Differential Diagnosis in A Cohort of HIV-Infected Patients |
| author |
Calvet, Guilherme Amaral |
| author_facet |
Calvet, Guilherme Amaral Brasil, Patricia Siqueira, Andre Machado Zogbi, Heruza Einsfeld Gonçalves, Bianca de Santis Santos, Aline da Silva Lupi, Otilia Souza, Rogerio Valls Rodrigues, Cintia Damasceno dos Santos Bressan, Clarisse da Silveira Wakimoto, Mauymi Duarte Araújo, Eliane Saraiva Santos, Ingrid Cardoso Georg, Ingebourg Nogueira, Rita Maria Ribeiro Veloso, Valdiléa G. Filippis, Ana Maria Bispo |
| author_role |
author |
| author2 |
Brasil, Patricia Siqueira, Andre Machado Zogbi, Heruza Einsfeld Gonçalves, Bianca de Santis Santos, Aline da Silva Lupi, Otilia Souza, Rogerio Valls Rodrigues, Cintia Damasceno dos Santos Bressan, Clarisse da Silveira Wakimoto, Mauymi Duarte Araújo, Eliane Saraiva Santos, Ingrid Cardoso Georg, Ingebourg Nogueira, Rita Maria Ribeiro Veloso, Valdiléa G. Filippis, Ana Maria Bispo |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Calvet, Guilherme Amaral Brasil, Patricia Siqueira, Andre Machado Zogbi, Heruza Einsfeld Gonçalves, Bianca de Santis Santos, Aline da Silva Lupi, Otilia Souza, Rogerio Valls Rodrigues, Cintia Damasceno dos Santos Bressan, Clarisse da Silveira Wakimoto, Mauymi Duarte Araújo, Eliane Saraiva Santos, Ingrid Cardoso Georg, Ingebourg Nogueira, Rita Maria Ribeiro Veloso, Valdiléa G. Filippis, Ana Maria Bispo |
| dc.subject.en.pt_BR.fl_str_mv |
Zika, ZIKV, arboviruses, HIV, Brazil |
| topic |
Zika, ZIKV, arboviruses, HIV, Brazil Zika ZIKV Arboviruses HIV Brazil |
| dc.subject.en.none.fl_str_mv |
Zika ZIKV Arboviruses HIV Brazil |
| description |
2019-12-04 |
| publishDate |
2018 |
| dc.date.accessioned.fl_str_mv |
2018-09-19T17:32:01Z |
| dc.date.available.fl_str_mv |
2018-09-19T17:32:01Z |
| dc.date.issued.fl_str_mv |
2018 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
CALVET, Guilherme Amaral et al. Zika Virus Infection and Differential Diagnosis in a Cohort of HIV-Infected Patients. Journal of Acquired Immune Deficiency Syndromes: JAIDS, v. 79, n. 2, p. 237-243, 2018. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/28907 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1525-4135 |
| dc.identifier.doi.none.fl_str_mv |
10.1097/QAI.0000000000001777 |
| identifier_str_mv |
CALVET, Guilherme Amaral et al. Zika Virus Infection and Differential Diagnosis in a Cohort of HIV-Infected Patients. Journal of Acquired Immune Deficiency Syndromes: JAIDS, v. 79, n. 2, p. 237-243, 2018. 1525-4135 10.1097/QAI.0000000000001777 |
| url |
https://www.arca.fiocruz.br/handle/icict/28907 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/28907/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/28907/2/Zika%20Virus%20Infection%20and%20Differential%20Diagnosis%20in%20A%20Cohort%20of%20HIV_Valdilea_Veloso_INI_Lapclin-AIDS_2018.pdf https://www.arca.fiocruz.br/bitstream/icict/28907/3/Zika%20Virus%20Infection%20and%20Differential%20Diagnosis%20in%20A%20Cohort%20of%20HIV_Valdilea_Veloso_INI_Lapclin-AIDS_2018.pdf.txt |
| bitstream.checksum.fl_str_mv |
586c046dcfeef936e32f0323bb9a47c0 2df3818ab5c9206cd2ec54bf9082b8cc 501b9cb5aa9a01970206dd7bf5e3c41b |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1813009309756293120 |