A follow-up of Beagle dogs intradermally infected with Leishmania chagasi in the presence or absence of sand fly saliva.
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2003 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/4158 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. |
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Silva, Moacir ParanhosOliveira, Geraldo Gileno de SáReis, Eliana Almeida GomesMenezes, Rejane Marcia Chaves deFernandes, OctavioSherlock, Ítalo Rodrigues de AraújoGomes, Regis Bernardo BrandimPontes-de-Carvalho, Lain CarlosdosSantos, Washington Luis Conrado2012-07-09T20:33:37Z2012-07-09T20:33:37Z2003SILVA, Moacir Paranhos et al. A follow-up of Beagle dogs intradermally infected with Leishmania chagasi in the presence or absence of sand fly saliva. Veterinary Parasitology, v. 114, n. 2, p. 97-111, May 2003.https://www.arca.fiocruz.br/handle/icict/4158engA follow-up of Beagle dogs intradermally infected with Leishmania chagasi in the presence or absence of sand fly saliva.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2003Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo MonizSalvadorFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.In this study, we compare the development of infection and/or disease in Beagle dogs intradermally infected with Leishmania chagasi, in the presence or absence of Lutzomyia longipalpis saliva, with those of intravenously infected animals. Spleen samples of all the animals inoculated with parasites had positive polymerase chain reaction tests for Leishmania DNA. Positive spleen cultures for Leishmania were detected earlier (P < or = 0.018) and were more frequent (five out of the five animals) in intravenously infected animals than in the intradermally infected animals, in presence (two out of the six animals) or absence (three out of the five animals) of salivary gland lysate of L. longipalpis. Significant increase in serum antibodies against Leishmania was observed only in the intravenously infected group (P = 0.004). In addition, dogs with infection confirmed by isolation of amastigotes or detection of parasite DNA were, nevertheless, negative for anti-Leishmania antibodies up to 5 months or more after infection. Only animals of the intravenously infected group developed progressive decreases in hematocrit (Pearson r = -0.8076, P = -0.0026) and hemoglobin (Pearson r = -0.8403, P = 0.0012) during the infection period. No significant difference in the course of infection was observed between groups of intradermally infected animals. The data presented herein confirms that the intradermal inoculation of dogs with Leishmania produces an asymptomatic form of infection. It also fails to show an advantage in using L. longipalpis saliva as an infection-enhancing agent in experimental canine leishmaniasis.Leishmania chagasiLeishmaniasisDogExperimentalSalivaDoenças do Cão/parasitologiaInsetos Vetores/químicaLeishmania/fisiologiaLeishmaniose Visceral/veterináriaPsychodidae/químicaAnticorpos Antiprotozoários/sangueDNA de Protozoário/análiseModelos Animais de DoençasLeishmania/genéticaLeishmaniose Visceral/parasitologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALParanhos-Silva M A follow up of beagle....pdfParanhos-Silva M A follow up of beagle....pdfapplication/pdf133995https://www.arca.fiocruz.br/bitstream/icict/4158/1/Paranhos-Silva%20M%20A%20follow%20up%20of%20beagle....pdf749e5ebaef4ee847f7e1c096815b6170MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81990https://www.arca.fiocruz.br/bitstream/icict/4158/2/license.txtb6ead4607e393dee1190c21ba08397beMD52TEXTParanhos-Silva M A follow up of beagle....pdf.txtParanhos-Silva M A follow up of beagle....pdf.txtExtracted texttext/plain48627https://www.arca.fiocruz.br/bitstream/icict/4158/5/Paranhos-Silva%20M%20A%20follow%20up%20of%20beagle....pdf.txt294ecb6b30f2faf7839ef007228ee15dMD55THUMBNAILParanhos-Silva M A follow up of beagle....pdf.jpgParanhos-Silva M A follow up of beagle....pdf.jpgGenerated Thumbnailimage/jpeg1382https://www.arca.fiocruz.br/bitstream/icict/4158/4/Paranhos-Silva%20M%20A%20follow%20up%20of%20beagle....pdf.jpg41095a0e8451030f63621882c202b9dbMD54icict/41582023-09-14 15:46:44.774oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-14T18:46:44Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
A follow-up of Beagle dogs intradermally infected with Leishmania chagasi in the presence or absence of sand fly saliva. |
| title |
A follow-up of Beagle dogs intradermally infected with Leishmania chagasi in the presence or absence of sand fly saliva. |
| spellingShingle |
A follow-up of Beagle dogs intradermally infected with Leishmania chagasi in the presence or absence of sand fly saliva. Silva, Moacir Paranhos Leishmania chagasi Leishmaniasis Dog Experimental Saliva Doenças do Cão/parasitologia Insetos Vetores/química Leishmania/fisiologia Leishmaniose Visceral/veterinária Psychodidae/química Anticorpos Antiprotozoários/sangue DNA de Protozoário/análise Modelos Animais de Doenças Leishmania/genética Leishmaniose Visceral/parasitologia |
| title_short |
A follow-up of Beagle dogs intradermally infected with Leishmania chagasi in the presence or absence of sand fly saliva. |
| title_full |
A follow-up of Beagle dogs intradermally infected with Leishmania chagasi in the presence or absence of sand fly saliva. |
| title_fullStr |
A follow-up of Beagle dogs intradermally infected with Leishmania chagasi in the presence or absence of sand fly saliva. |
| title_full_unstemmed |
A follow-up of Beagle dogs intradermally infected with Leishmania chagasi in the presence or absence of sand fly saliva. |
| title_sort |
A follow-up of Beagle dogs intradermally infected with Leishmania chagasi in the presence or absence of sand fly saliva. |
| author |
Silva, Moacir Paranhos |
| author_facet |
Silva, Moacir Paranhos Oliveira, Geraldo Gileno de Sá Reis, Eliana Almeida Gomes Menezes, Rejane Marcia Chaves de Fernandes, Octavio Sherlock, Ítalo Rodrigues de Araújo Gomes, Regis Bernardo Brandim Pontes-de-Carvalho, Lain Carlos dosSantos, Washington Luis Conrado |
| author_role |
author |
| author2 |
Oliveira, Geraldo Gileno de Sá Reis, Eliana Almeida Gomes Menezes, Rejane Marcia Chaves de Fernandes, Octavio Sherlock, Ítalo Rodrigues de Araújo Gomes, Regis Bernardo Brandim Pontes-de-Carvalho, Lain Carlos dosSantos, Washington Luis Conrado |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Moacir Paranhos Oliveira, Geraldo Gileno de Sá Reis, Eliana Almeida Gomes Menezes, Rejane Marcia Chaves de Fernandes, Octavio Sherlock, Ítalo Rodrigues de Araújo Gomes, Regis Bernardo Brandim Pontes-de-Carvalho, Lain Carlos dosSantos, Washington Luis Conrado |
| dc.subject.en.pt_BR.fl_str_mv |
Leishmania chagasi Leishmaniasis Dog Experimental Saliva |
| topic |
Leishmania chagasi Leishmaniasis Dog Experimental Saliva Doenças do Cão/parasitologia Insetos Vetores/química Leishmania/fisiologia Leishmaniose Visceral/veterinária Psychodidae/química Anticorpos Antiprotozoários/sangue DNA de Protozoário/análise Modelos Animais de Doenças Leishmania/genética Leishmaniose Visceral/parasitologia |
| dc.subject.decs.pt_BR.fl_str_mv |
Doenças do Cão/parasitologia Insetos Vetores/química Leishmania/fisiologia Leishmaniose Visceral/veterinária Psychodidae/química Anticorpos Antiprotozoários/sangue DNA de Protozoário/análise Modelos Animais de Doenças Leishmania/genética Leishmaniose Visceral/parasitologia |
| description |
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. |
| publishDate |
2003 |
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2003 |
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2012-07-09T20:33:37Z |
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2012-07-09T20:33:37Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
SILVA, Moacir Paranhos et al. A follow-up of Beagle dogs intradermally infected with Leishmania chagasi in the presence or absence of sand fly saliva. Veterinary Parasitology, v. 114, n. 2, p. 97-111, May 2003. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/4158 |
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SILVA, Moacir Paranhos et al. A follow-up of Beagle dogs intradermally infected with Leishmania chagasi in the presence or absence of sand fly saliva. Veterinary Parasitology, v. 114, n. 2, p. 97-111, May 2003. |
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eng |
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