Neuroimaging assessment of pediatric cerebral changes associated with SARS-CoV-2 infection during pregnancy

Araujo Junior, David Alves de; Motta, Felipe; Fernandes, Geraldo Magela; Castro, Maria Eduarda Canellas De; Sasaki, Lizandra Moura Paravidine; Luna, Licia Pacheco; Rodrigues, Thalys Sampaio; Kurizky, Patricia Shu; Soares, Alexandre Anderson De Sousa Munhoz; Nobrega, Otavio de Toledo; Espindola, Laila Salmen; Zaconeta, Alberto Moreno; Gomes, Ciro Martins; Martins Filho, Olindo Assis; Albuquerque, Cleandro Pires de; Mota, Licia Maria Henrique da

Neuroimaging assessment of pediatric cerebral changes associated with SARS-CoV-2 infection during pregnancy

Detalhes bibliográficos
Autor(a) principal:	Araujo Junior, David Alves de
Data de Publicação:	2023
Outros Autores:	Motta, Felipe, Fernandes, Geraldo Magela, Castro, Maria Eduarda Canellas De, Sasaki, Lizandra Moura Paravidine, Luna, Licia Pacheco, Rodrigues, Thalys Sampaio, Kurizky, Patricia Shu, Soares, Alexandre Anderson De Sousa Munhoz, Nobrega, Otavio de Toledo, Espindola, Laila Salmen, Zaconeta, Alberto Moreno, Gomes, Ciro Martins, Martins Filho, Olindo Assis, Albuquerque, Cleandro Pires de, Mota, Licia Maria Henrique da
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/59570
Resumo:	Department of Medicine. University of Brasilia. Brasilia, DF, Brazil/Hospital Universitario de Brasília. Brasilia, DF, Brazil/Medical Sciences. University of Brasilia. Brasilia, DF, Brazil/Department of Medicine. Austin Health. University of Melbourne. Melbourne, VIC, Australia.

Metadados do item

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spelling	Araujo Junior, David Alves deMotta, FelipeFernandes, Geraldo MagelaCastro, Maria Eduarda Canellas DeSasaki, Lizandra Moura ParavidineLuna, Licia PachecoRodrigues, Thalys SampaioKurizky, Patricia ShuSoares, Alexandre Anderson De Sousa MunhozNobrega, Otavio de ToledoEspindola, Laila SalmenZaconeta, Alberto MorenoGomes, Ciro MartinsMartins Filho, Olindo AssisAlbuquerque, Cleandro Pires deMota, Licia Maria Henrique da2023-07-13T17:50:23Z2023-07-13T17:50:23Z2023ARAUJO JUNIOR, David Alves de et al. Neuroimaging assessment of pediatric cerebral changes associated with SARS-CoV-2 infection during pregnancy. Frontiers in Pediatrics, v. 11, 2023. doi.org/10.3389/fped.2023.1194114.2296-2360https://www.arca.fiocruz.br/handle/icict/59570engFrontiers Media SACOVIDSARS-CoV-2COVIDSARS-CoV-2elastographyneonatologyneuroimagingpregnancyultrasoundNeuroimaging assessment of pediatric cerebral changes associated with SARS-CoV-2 infection during pregnancyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDepartment of Medicine. University of Brasilia. Brasilia, DF, Brazil/Hospital Universitario de Brasília. Brasilia, DF, Brazil/Medical Sciences. University of Brasilia. Brasilia, DF, Brazil/Department of Medicine. Austin Health. University of Melbourne. Melbourne, VIC, Australia.Department of Medicine. University of Brasilia. Brasilia, DF, Brazil/Hospital Universitario de Brasília. Brasilia, DF, Brazil/Medical Sciences. University of Brasilia. Brasilia, DF, BrazilDepartment of Medicine. University of Brasilia. Brasilia, DF, Brazil/Hospital Universitario de Brasília. Brasilia, DF, Brazil/Medical Sciences. University of Brasilia. Brasilia, DF, BrazilDepartment of Medicine. University of Brasilia. Brasilia, DF, Brazil/Hospital Universitario de Brasília. Brasilia, DF, Brazil/Medical Sciences. University of Brasilia. Brasilia, DF, BrazilDepartment of Medicine. University of Brasilia. Brasilia, DF, Brazil/Hospital Universitario de Brasília. Brasilia, DF, Brazil/Medical Sciences. University of Brasilia. Brasilia, DF, BrazilRussell H. Morgan Department of Radiology and Radiological Science. Johns Hopkins University School of Medicine. Baltimore, MD, United States.Department of Medicine. Austin Health. University of Melbourne. Melbourne, VIC, Australia.Department of Medicine. University of Brasilia. Brasilia, DF, Brazil/Hospital Universitario de Brasília. Brasilia, DF, Brazil/Medical Sciences. University of Brasilia. Brasilia, DF, BrazilMedical Sciences. University of Brasilia. Brasilia, DF, Brazil.Medical Sciences. University of Brasilia. Brasilia, DF, Brazil.Medical Sciences. University of Brasilia. Brasilia, DF, Brazil.Medical Sciences. University of Brasilia. Brasilia, DF, Brazil.Department of Medicine. University of Brasilia. Brasilia, DF, Brazil/Hospital Universitario de Brasília. Brasilia, DF, Brazil/Medical Sciences. University of Brasilia. Brasilia, DF, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Department of Medicine. University of Brasilia. Brasilia, DF, Brazil/Hospital Universitario de Brasília. Brasilia, DF, Brazil/Medical Sciences. University of Brasilia. Brasilia, DF, BrazilDepartment of Medicine. University of Brasilia. Brasilia, DF, Brazil/Hospital Universitario de Brasília. Brasilia, DF, Brazil/Medical Sciences. University of Brasilia. Brasilia, DF, BrazilBackground: SARS-CoV-2 infection and perinatal neurologic outcomes are still not fully understood. However, there is recent evidence of white matter disease and impaired neurodevelopment in newborns following maternal SARS-CoV-2 infection. These appear to occur as a consequence of both direct viral effects and a systemic inflammatory response, with glial cell/myelin involvement and regional hypoxia/microvascular dysfunction. We sought to characterize the consequences of maternal and fetal inflammatory states in the central nervous system of newborns following maternal SARS-CoV-2 infection. Methods: We conducted a longitudinal prospective cohort study from June 2020 to December 2021, with follow-up of newborns born to mothers exposed or not exposed to SARS-CoV-2 infection during pregnancy. Brain analysis included data from cranial ultrasound scans (CUS) with grayscale, Doppler studies (color and spectral), and ultrasound-based brain elastography (shear-wave mode) in specific regions of interest (ROIs): deep white matter, superficial white matter, corpus callosum, basal ganglia, and cortical gray matter. Brain elastography was used to estimate brain parenchymal stiffness, which is an indirect quantifier of cerebral myelin tissue content. Results: A total of 219 single-pregnancy children were enrolled, including 201 born to mothers exposed to SARS-CoV-2 infection and 18 from unexposed controls. A neuroimaging evaluation was performed at 6 months of adjusted chronological age and revealed 18 grayscale and 21 Doppler abnormalities. Predominant findings were hyperechogenicity of deep brain white matter and basal ganglia (caudate nuclei/thalamus) and a reduction in the resistance and pulsatility indices of intracranial arterial flow. The anterior brain circulation (middle cerebral and pericallosal arteries) displayed a wider range of flow variation than the posterior circulation (basilar artery). Shear-wave US elastography analysis showed a reduction in stiffness values in the SARS-CoV-2 exposed group in all analyzed regions of interest, especially in the deep white matter elasticity coefficients (3.98 ± 0.62) compared to the control group (7.76 ± 0.77); p-value < 0.001. Conclusion: This study further characterizes pediatric structural encephalic changes associated with SARS-CoV-2 infection during pregnancy. The maternal infection has been shown to be related to cerebral deep white matter predominant involvement, with regional hyperechogenicity and reduction of elasticity coefficients, suggesting zonal impairment of myelin content. Morphologic findings may be subtle, and functional studies such as Doppler and elastography may be valuable tools to more accurately identify infants at risk of neurologic damage.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/59570/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALNeuroimaging assessment of pediatric cerebral changes associated with SARS-CoV-2 infection during pregnancy.pdfNeuroimaging assessment of pediatric cerebral changes associated with SARS-CoV-2 infection during pregnancy.pdfapplication/pdf273762https://www.arca.fiocruz.br/bitstream/icict/59570/2/Neuroimaging%20assessment%20of%20pediatric%20cerebral%20changes%20associated%20with%20SARS-CoV-2%20infection%20during%20pregnancy.pdff3855566e86dc4e36413cd50df129ed6MD52Neuroimaging assessment of pediatric cerebral changes associated with SARS-CoV-2 infection during pregnancy.pdfNeuroimaging assessment of pediatric cerebral changes associated with SARS-CoV-2 infection during pregnancy.pdfapplication/pdf273762https://www.arca.fiocruz.br/bitstream/icict/59570/3/Neuroimaging%20assessment%20of%20pediatric%20cerebral%20changes%20associated%20with%20SARS-CoV-2%20infection%20during%20pregnancy.pdff3855566e86dc4e36413cd50df129ed6MD53icict/595702023-07-13 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dc.title.en_US.fl_str_mv	Neuroimaging assessment of pediatric cerebral changes associated with SARS-CoV-2 infection during pregnancy
title	Neuroimaging assessment of pediatric cerebral changes associated with SARS-CoV-2 infection during pregnancy
spellingShingle	Neuroimaging assessment of pediatric cerebral changes associated with SARS-CoV-2 infection during pregnancy Araujo Junior, David Alves de COVID SARS-CoV-2 COVID SARS-CoV-2 elastography neonatology neuroimaging pregnancy ultrasound
title_short	Neuroimaging assessment of pediatric cerebral changes associated with SARS-CoV-2 infection during pregnancy
title_full	Neuroimaging assessment of pediatric cerebral changes associated with SARS-CoV-2 infection during pregnancy
title_fullStr	Neuroimaging assessment of pediatric cerebral changes associated with SARS-CoV-2 infection during pregnancy
title_full_unstemmed	Neuroimaging assessment of pediatric cerebral changes associated with SARS-CoV-2 infection during pregnancy
title_sort	Neuroimaging assessment of pediatric cerebral changes associated with SARS-CoV-2 infection during pregnancy
author	Araujo Junior, David Alves de
author_facet	Araujo Junior, David Alves de Motta, Felipe Fernandes, Geraldo Magela Castro, Maria Eduarda Canellas De Sasaki, Lizandra Moura Paravidine Luna, Licia Pacheco Rodrigues, Thalys Sampaio Kurizky, Patricia Shu Soares, Alexandre Anderson De Sousa Munhoz Nobrega, Otavio de Toledo Espindola, Laila Salmen Zaconeta, Alberto Moreno Gomes, Ciro Martins Martins Filho, Olindo Assis Albuquerque, Cleandro Pires de Mota, Licia Maria Henrique da
author_role	author
author2	Motta, Felipe Fernandes, Geraldo Magela Castro, Maria Eduarda Canellas De Sasaki, Lizandra Moura Paravidine Luna, Licia Pacheco Rodrigues, Thalys Sampaio Kurizky, Patricia Shu Soares, Alexandre Anderson De Sousa Munhoz Nobrega, Otavio de Toledo Espindola, Laila Salmen Zaconeta, Alberto Moreno Gomes, Ciro Martins Martins Filho, Olindo Assis Albuquerque, Cleandro Pires de Mota, Licia Maria Henrique da
author2_role	author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Araujo Junior, David Alves de Motta, Felipe Fernandes, Geraldo Magela Castro, Maria Eduarda Canellas De Sasaki, Lizandra Moura Paravidine Luna, Licia Pacheco Rodrigues, Thalys Sampaio Kurizky, Patricia Shu Soares, Alexandre Anderson De Sousa Munhoz Nobrega, Otavio de Toledo Espindola, Laila Salmen Zaconeta, Alberto Moreno Gomes, Ciro Martins Martins Filho, Olindo Assis Albuquerque, Cleandro Pires de Mota, Licia Maria Henrique da
dc.subject.other.en_US.fl_str_mv	COVID SARS-CoV-2
topic	COVID SARS-CoV-2 COVID SARS-CoV-2 elastography neonatology neuroimaging pregnancy ultrasound
dc.subject.en.en_US.fl_str_mv	COVID SARS-CoV-2 elastography neonatology neuroimaging pregnancy ultrasound
description	Department of Medicine. University of Brasilia. Brasilia, DF, Brazil/Hospital Universitario de Brasília. Brasilia, DF, Brazil/Medical Sciences. University of Brasilia. Brasilia, DF, Brazil/Department of Medicine. Austin Health. University of Melbourne. Melbourne, VIC, Australia.
publishDate	2023
dc.date.accessioned.fl_str_mv	2023-07-13T17:50:23Z
dc.date.available.fl_str_mv	2023-07-13T17:50:23Z
dc.date.issued.fl_str_mv	2023
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	ARAUJO JUNIOR, David Alves de et al. Neuroimaging assessment of pediatric cerebral changes associated with SARS-CoV-2 infection during pregnancy. Frontiers in Pediatrics, v. 11, 2023. doi.org/10.3389/fped.2023.1194114.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/59570
dc.identifier.issn.en_US.fl_str_mv	2296-2360
identifier_str_mv	ARAUJO JUNIOR, David Alves de et al. Neuroimaging assessment of pediatric cerebral changes associated with SARS-CoV-2 infection during pregnancy. Frontiers in Pediatrics, v. 11, 2023. doi.org/10.3389/fped.2023.1194114. 2296-2360
url	https://www.arca.fiocruz.br/handle/icict/59570
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Frontiers Media SA
publisher.none.fl_str_mv	Frontiers Media SA
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/59570/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/59570/2/Neuroimaging%20assessment%20of%20pediatric%20cerebral%20changes%20associated%20with%20SARS-CoV-2%20infection%20during%20pregnancy.pdf https://www.arca.fiocruz.br/bitstream/icict/59570/3/Neuroimaging%20assessment%20of%20pediatric%20cerebral%20changes%20associated%20with%20SARS-CoV-2%20infection%20during%20pregnancy.pdf
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repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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Neuroimaging assessment of pediatric cerebral changes associated with SARS-CoV-2 infection during pregnancy

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