Chromoblastomycosis: a Clinical and Molecular Study of 18 Cases in Rio de Janeiro, Brazil

Detalhes bibliográficos
Autor(a) principal: Mouchalouat, Marcelle de F.
Data de Publicação: 2011
Outros Autores: Galhardo, Maria Clara Gutierrez, Zancopé-Oliveira, Rosely Maria, Fialho, Paulo Cezar Monteiro, Coelho, Janice Mery C. de Oliveira, Tavares, Patrícia Morais Silva, Valle, Antonio Carlos Francesconi do
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/37030
Resumo: 2020-11-13
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spelling Mouchalouat, Marcelle de F.Galhardo, Maria Clara GutierrezZancopé-Oliveira, Rosely MariaFialho, Paulo Cezar MonteiroCoelho, Janice Mery C. de OliveiraTavares, Patrícia Morais SilvaValle, Antonio Carlos Francesconi do2019-11-13T14:25:39Z2019-11-13T14:25:39Z2011MOUCHALOUAT, Marcelle de F. de el al. Chromoblastomycosis: a clinical and molecular study of 18 cases in Rio de Janeiro, Brazil. International Journal of Dermatology, v. 50, p. 981-986, 2011.0011-9059https://www.arca.fiocruz.br/handle/icict/3703010.1111/j.1365-4632.2010.04729.x1365-4632engWileyChromoblastomycosis: a Clinical and Molecular Study of 18 Cases in Rio de Janeiro, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-11-13Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Dermatologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Dermatologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Dermatologia. Rio de Janeiro, RJ, Brasil.Background: Chromoblastomycosis (CBM) is a chronic subcutaneous mycosis caused by dematiaceous fungi. Methods: We described epidemiological data, clinical presentation, and treatment of 18 cases of CBM diagnosed in Rio de Janeiro, Brazil. Diagnosis was obtained by mycological, histopathological findings demonstrating typical muriform cells with confirmation of isolated by DNA sequencing of the ribosomal internal transcribed spacer. Results: The majority of patients were male (72.2%) ranging from 39 to 83 years old, farm laborers and construction workers. The duration of disease varied from four months to 32 years. The most common presentations were verrucous form in ten (55.6%) patients, followed by tumoral in three (16.7%) patients, primarily of moderate (55.6%) and severe (38.9%) intensity. Lower (44.4%) and upper limbs (33.3%) were the most affected sites. Fonsecaea pedrosoi isolated from 14 (77.8%), and Cladophialophora carrionii isolated from one case (5.6%). Fifteen patients (83.3%) were treated. Six patients (40%) received oral itraconazole 200–400 mg/day, five patients (33.3%) received oral itraconazole 200–400 mg/day combined with fluconazole 200 mg/day, and four (26.7%) patients were submitted to surgery. The duration of therapy varied from 12 to 48 months. Cure rate was 80% (12/15). No relapse was observed after two years of follow-up. Conclusions: Success was due to attending a center with specialized clinical care, laboratory support, and pharmaceutical care.ChromoblastomycosisRio de JaneiroBrazilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/37030/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Mouchalouat_Marcelle_etal_INI_2011.pdfve_Mouchalouat_Marcelle_etal_INI_2011.pdfapplication/pdf158694https://www.arca.fiocruz.br/bitstream/icict/37030/2/ve_Mouchalouat_Marcelle_etal_INI_2011.pdfb8f35f114dce66337f1b670df21c3f9aMD52TEXTve_Mouchalouat_Marcelle_etal_INI_2011.pdf.txtve_Mouchalouat_Marcelle_etal_INI_2011.pdf.txtExtracted texttext/plain25229https://www.arca.fiocruz.br/bitstream/icict/37030/3/ve_Mouchalouat_Marcelle_etal_INI_2011.pdf.txtd803549659f0f0ea73df127ca6291095MD53icict/370302021-03-24 16:32:38.816oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:38Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Chromoblastomycosis: a Clinical and Molecular Study of 18 Cases in Rio de Janeiro, Brazil
title Chromoblastomycosis: a Clinical and Molecular Study of 18 Cases in Rio de Janeiro, Brazil
spellingShingle Chromoblastomycosis: a Clinical and Molecular Study of 18 Cases in Rio de Janeiro, Brazil
Mouchalouat, Marcelle de F.
Chromoblastomycosis
Rio de Janeiro
Brazil
title_short Chromoblastomycosis: a Clinical and Molecular Study of 18 Cases in Rio de Janeiro, Brazil
title_full Chromoblastomycosis: a Clinical and Molecular Study of 18 Cases in Rio de Janeiro, Brazil
title_fullStr Chromoblastomycosis: a Clinical and Molecular Study of 18 Cases in Rio de Janeiro, Brazil
title_full_unstemmed Chromoblastomycosis: a Clinical and Molecular Study of 18 Cases in Rio de Janeiro, Brazil
title_sort Chromoblastomycosis: a Clinical and Molecular Study of 18 Cases in Rio de Janeiro, Brazil
author Mouchalouat, Marcelle de F.
author_facet Mouchalouat, Marcelle de F.
Galhardo, Maria Clara Gutierrez
Zancopé-Oliveira, Rosely Maria
Fialho, Paulo Cezar Monteiro
Coelho, Janice Mery C. de Oliveira
Tavares, Patrícia Morais Silva
Valle, Antonio Carlos Francesconi do
author_role author
author2 Galhardo, Maria Clara Gutierrez
Zancopé-Oliveira, Rosely Maria
Fialho, Paulo Cezar Monteiro
Coelho, Janice Mery C. de Oliveira
Tavares, Patrícia Morais Silva
Valle, Antonio Carlos Francesconi do
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mouchalouat, Marcelle de F.
Galhardo, Maria Clara Gutierrez
Zancopé-Oliveira, Rosely Maria
Fialho, Paulo Cezar Monteiro
Coelho, Janice Mery C. de Oliveira
Tavares, Patrícia Morais Silva
Valle, Antonio Carlos Francesconi do
dc.subject.en.pt_BR.fl_str_mv Chromoblastomycosis
Rio de Janeiro
Brazil
topic Chromoblastomycosis
Rio de Janeiro
Brazil
description 2020-11-13
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2019-11-13T14:25:39Z
dc.date.available.fl_str_mv 2019-11-13T14:25:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv MOUCHALOUAT, Marcelle de F. de el al. Chromoblastomycosis: a clinical and molecular study of 18 cases in Rio de Janeiro, Brazil. International Journal of Dermatology, v. 50, p. 981-986, 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/37030
dc.identifier.issn.pt_BR.fl_str_mv 0011-9059
dc.identifier.doi.none.fl_str_mv 10.1111/j.1365-4632.2010.04729.x
dc.identifier.eissn.none.fl_str_mv 1365-4632
identifier_str_mv MOUCHALOUAT, Marcelle de F. de el al. Chromoblastomycosis: a clinical and molecular study of 18 cases in Rio de Janeiro, Brazil. International Journal of Dermatology, v. 50, p. 981-986, 2011.
0011-9059
10.1111/j.1365-4632.2010.04729.x
1365-4632
url https://www.arca.fiocruz.br/handle/icict/37030
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Wiley
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