Use of a colorimetric (DELI) test for the evaluation of chemoresistance of Plasmodium falciparum and Plasmodium vivax to commonly used anti-plasmodial drugs in the Brazilian Amazon
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/12683 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malaria. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária (CPD-Mal). Centro de Referência em Malária na Região Extra-Amazônica. Ministério da Saúde. Secretaria de Vigilância em Saúde. Rio de Janeiro, RJ, Brasil. |
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Riccio, Lilian R. PrattChehuan, Yonne F.Siqueira, Maria JoséAlecrim, Maria das GraçasBianco Junior, CesareDruilhe, PierreBrasseur, PhilippeCruz, Maria de Fátima Ferreira daDaniel-Ribeiro, Cláudio Tadeu2016-02-02T15:03:58Z2016-02-02T15:03:58Z2013RICCIO, Lilian R. Pratt; et al. Use of a colorimetric (DELI) test for the evaluation of chemoresistance of Plasmodium falciparum and Plasmodium vivax to commonly used anti-plasmodial drugs in the Brazilian Amazon. Malaria Journal, v.12:281, 18p, 2013.1475-2875https://www.arca.fiocruz.br/handle/icict/1268310.1186/1475-2875-12-281engBioMed CentralUse of a colorimetric (DELI) test for the evaluation of chemoresistance of Plasmodium falciparum and Plasmodium vivax to commonly used anti-plasmodial drugs in the Brazilian Amazoninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malaria. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária (CPD-Mal). Centro de Referência em Malária na Região Extra-Amazônica. Ministério da Saúde. Secretaria de Vigilância em Saúde. Rio de Janeiro, RJ, Brasil.Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Laboratório de Malária. Manaus, AM, Brasil.Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Laboratório de Malária. Manaus, AM, Brasil.Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Laboratório de Malária. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malaria. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária (CPD-Mal). Centro de Referência em Malária na Região Extra-Amazônica. Ministério da Saúde. Secretaria de Vigilância em Saúde. Rio de Janeiro, RJ, Brasil.Institut Pasteur. Paris, France.UMR 198, Institut de Recherche pour le Développement, Dakar, Sénégal. Bangladesh.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malaria. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária (CPD-Mal). Centro de Referência em Malária na Região Extra-Amazônica. Ministério da Saúde. Secretaria de Vigilância em Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malaria. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária (CPD-Mal). Centro de Referência em Malária na Região Extra-Amazônica. Ministério da Saúde. Secretaria de Vigilância em Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malaria. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária (CPD-Mal). Centro de Referência em Malária na Região Extra-Amazônica. Ministério da Saúde. Secretaria de Vigilância em Saúde. Rio de Janeiro, RJ, Brasil.Background: The emergence and spread of Plasmodium falciparum and Plasmodium vivax resistance to available anti-malarial drugs represents a major drawback in the control of malaria and its associated morbidity and mortality. The aim of this study was to evaluate the chemoresistance profile of P. falciparum and P. vivax to commonly used anti-plasmodial drugs in a malaria-endemic area in the Brazilian Amazon. Methods: The study was carried out in Manaus (Amazonas state), in the Brazilian Amazon. A total of 88 P. falciparum and 178 P. vivax isolates was collected from 2004 to 2007. The sensitivity of P. falciparum isolates was determined to chloroquine, quinine, mefloquine and artesunate and the sensitivity of P. vivax isolates was determined to chloroquine and mefloquine, by using the colorimetric DELI test. Results: As expected, a high prevalence of P. falciparum isolates resistant to chloroquine (78.1%) was observed. The prevalence of isolates with profile of resistance or decreased sensitivity for quinine, mefloquine and artesunate was 12.7, 21.2 and 11.7%, respectively. In the case of P. vivax, the prevalence of isolates with profile of resistance for chloroquine and mefloquine was 9.8 and 28%, respectively. No differences in the frequencies of isolates with profile of resistance or geometric mean IC50s were seen when comparing the data obtained in 2004, 2005, 2006 and 2007, for all tested anti-malarials. Conclusions: The great majority of P. falciparum isolates in the Brazilian malaria-endemic area remain resistant to chloroquine, and the decreased sensitivity to quinine, mefloquine and artesunate observed in 10–20% of the isolates must be taken with concern, especially for artesunate. Plasmodium vivax isolates also showed a significant proportion of isolates with decreased sensitivity to chloroquine (first-line drug) and mainly to mefloquine. The data presented here also confirm the usefulness of the DELI test to generate results able to impact on public health policies.MalariaPlasmodium falciparumPlasmodium vivaxResistanceAnti-malarialsDELI testMaláriaPlasmodium falciparumPlasmodium vivaxinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12683/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALlilian_ricio_etal_IOC_2013.pdflilian_ricio_etal_IOC_2013.pdfapplication/pdf290687https://www.arca.fiocruz.br/bitstream/icict/12683/2/lilian_ricio_etal_IOC_2013.pdf4fcb982b643c33a2ca46dc3187d423f9MD52TEXTlilian_ricio_etal_IOC_2013.pdf.txtlilian_ricio_etal_IOC_2013.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Use of a colorimetric (DELI) test for the evaluation of chemoresistance of Plasmodium falciparum and Plasmodium vivax to commonly used anti-plasmodial drugs in the Brazilian Amazon |
| title |
Use of a colorimetric (DELI) test for the evaluation of chemoresistance of Plasmodium falciparum and Plasmodium vivax to commonly used anti-plasmodial drugs in the Brazilian Amazon |
| spellingShingle |
Use of a colorimetric (DELI) test for the evaluation of chemoresistance of Plasmodium falciparum and Plasmodium vivax to commonly used anti-plasmodial drugs in the Brazilian Amazon Riccio, Lilian R. Pratt Malaria Plasmodium falciparum Plasmodium vivax Resistance Anti-malarials DELI test Malária Plasmodium falciparum Plasmodium vivax |
| title_short |
Use of a colorimetric (DELI) test for the evaluation of chemoresistance of Plasmodium falciparum and Plasmodium vivax to commonly used anti-plasmodial drugs in the Brazilian Amazon |
| title_full |
Use of a colorimetric (DELI) test for the evaluation of chemoresistance of Plasmodium falciparum and Plasmodium vivax to commonly used anti-plasmodial drugs in the Brazilian Amazon |
| title_fullStr |
Use of a colorimetric (DELI) test for the evaluation of chemoresistance of Plasmodium falciparum and Plasmodium vivax to commonly used anti-plasmodial drugs in the Brazilian Amazon |
| title_full_unstemmed |
Use of a colorimetric (DELI) test for the evaluation of chemoresistance of Plasmodium falciparum and Plasmodium vivax to commonly used anti-plasmodial drugs in the Brazilian Amazon |
| title_sort |
Use of a colorimetric (DELI) test for the evaluation of chemoresistance of Plasmodium falciparum and Plasmodium vivax to commonly used anti-plasmodial drugs in the Brazilian Amazon |
| author |
Riccio, Lilian R. Pratt |
| author_facet |
Riccio, Lilian R. Pratt Chehuan, Yonne F. Siqueira, Maria José Alecrim, Maria das Graças Bianco Junior, Cesare Druilhe, Pierre Brasseur, Philippe Cruz, Maria de Fátima Ferreira da Daniel-Ribeiro, Cláudio Tadeu |
| author_role |
author |
| author2 |
Chehuan, Yonne F. Siqueira, Maria José Alecrim, Maria das Graças Bianco Junior, Cesare Druilhe, Pierre Brasseur, Philippe Cruz, Maria de Fátima Ferreira da Daniel-Ribeiro, Cláudio Tadeu |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Riccio, Lilian R. Pratt Chehuan, Yonne F. Siqueira, Maria José Alecrim, Maria das Graças Bianco Junior, Cesare Druilhe, Pierre Brasseur, Philippe Cruz, Maria de Fátima Ferreira da Daniel-Ribeiro, Cláudio Tadeu |
| dc.subject.en.pt_BR.fl_str_mv |
Malaria Plasmodium falciparum Plasmodium vivax Resistance Anti-malarials DELI test |
| topic |
Malaria Plasmodium falciparum Plasmodium vivax Resistance Anti-malarials DELI test Malária Plasmodium falciparum Plasmodium vivax |
| dc.subject.decs.pt_BR.fl_str_mv |
Malária Plasmodium falciparum Plasmodium vivax |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malaria. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária (CPD-Mal). Centro de Referência em Malária na Região Extra-Amazônica. Ministério da Saúde. Secretaria de Vigilância em Saúde. Rio de Janeiro, RJ, Brasil. |
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2013 |
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2013 |
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2016-02-02T15:03:58Z |
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2016-02-02T15:03:58Z |
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RICCIO, Lilian R. Pratt; et al. Use of a colorimetric (DELI) test for the evaluation of chemoresistance of Plasmodium falciparum and Plasmodium vivax to commonly used anti-plasmodial drugs in the Brazilian Amazon. Malaria Journal, v.12:281, 18p, 2013. |
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https://www.arca.fiocruz.br/handle/icict/12683 |
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1475-2875 |
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10.1186/1475-2875-12-281 |
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RICCIO, Lilian R. Pratt; et al. Use of a colorimetric (DELI) test for the evaluation of chemoresistance of Plasmodium falciparum and Plasmodium vivax to commonly used anti-plasmodial drugs in the Brazilian Amazon. Malaria Journal, v.12:281, 18p, 2013. 1475-2875 10.1186/1475-2875-12-281 |
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BioMed Central |
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BioMed Central |
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