Impact of pre-exposure prophylaxis uptake among gay, bisexual, and other men who have sex with men in urban centers in Brazil: a modeling study

Detalhes bibliográficos
Autor(a) principal: Luz, Paula M.
Data de Publicação: 2023
Outros Autores: Deshpande, Vijeta, Kazemian, Pooyan, Scott, Justine A., Shebl, Fatma M., Spaeth, Hailey, Pimenta, Cristina, Stern, Madeline, Pereira, Gerson, Struchiner, Claudio J., Grinsztejn, Beatriz, Veloso, Valdiléa G., Freedberg, Kenneth A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/59885
Resumo: This work was supported by the National Institute of Allergy and Infectious Diseases (R37 AI058736) and by the Department of Chronic Conditions and Sexually Transmitted Infections (DCCI) of the Ministry of Health of Brazil. This project was also made possible thanks to Unitaid’s funding and support. Unitaid accelerates access to innovative health products and lays the foundations for scale up by countries and partners. Unitaid is a hosted partnership of WHO. PML, BG, and CJS acknowledge funding from the National Council of Technological and Scientifc Development (CNPq) and the Research Funding Agency of the State of Rio de Janeiro (FAPERJ). The content is solely the responsibility of the authors and does not necessarily represent the ofcial views of the National Institute of Health or other funders.
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spelling Luz, Paula M.Deshpande, VijetaKazemian, PooyanScott, Justine A.Shebl, Fatma M.Spaeth, HaileyPimenta, CristinaStern, MadelinePereira, GersonStruchiner, Claudio J.Grinsztejn, BeatrizVeloso, Valdiléa G.Freedberg, Kenneth A.2023-08-02T20:36:23Z2023-08-02T20:36:23Z2023LUZ, Paula M. et al. Impact of pre-exposure prophylaxis uptake among gay, bisexual, and other men who have sex with men in urban centers in Brazil: a modeling study. BMC Public Health, v. 23, n. 1, p. 1-12, June 2023.1471-2458https://www.arca.fiocruz.br/handle/icict/5988510.1186/s12889-023-15994-01471-2458This work was supported by the National Institute of Allergy and Infectious Diseases (R37 AI058736) and by the Department of Chronic Conditions and Sexually Transmitted Infections (DCCI) of the Ministry of Health of Brazil. This project was also made possible thanks to Unitaid’s funding and support. Unitaid accelerates access to innovative health products and lays the foundations for scale up by countries and partners. Unitaid is a hosted partnership of WHO. PML, BG, and CJS acknowledge funding from the National Council of Technological and Scientifc Development (CNPq) and the Research Funding Agency of the State of Rio de Janeiro (FAPERJ). The content is solely the responsibility of the authors and does not necessarily represent the ofcial views of the National Institute of Health or other funders.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Medical Practice Evaluation Center. Massachusetts General Hospital. Boston, MA, USA.Department of Operations. Weatherhead School of Management. Case Western Reserve University. Cleveland, OH, USA.Medical Practice Evaluation Center. Massachusetts General Hospital. Boston, MA, USA.Medical Practice Evaluation Center. Massachusetts General Hospital. Boston, MA, USA.Medical Practice Evaluation Center. Massachusetts General Hospital. Boston, MA, USA.Ministry of Health of Brazil. Brasília, DF, Brazil.Medical Practice Evaluation Center. Massachusetts General Hospital. Boston, MA, USA.Ministry of Health of Brazil. Brasília, DF, Brazil.Fundação Getúlio Vargas. Escola de Matemática Aplicada. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Medical Practice Evaluation Center. Massachusetts General Hospital. Boston, MA, USA / Harvard University Center for AIDS Research. Harvard Medical School. Cambridge, MA, USA / Division of General Internal Medicine. Massachusetts General Hospital. Boston, MA, USA / Division of Infectious Diseases. Massachusetts General Hospital. Boston, MA, USA / Department of Health Policy and Management. Harvard School of Public Health. Boston, MA, USA.Background: Men who have sex with men (MSM) in Brazil remain disproportionately affected by HIV. We estimated the potential incidence reduction by five years with increased uptake of publicly-funded, daily, oral tenofovir/emtricitabine (TDF/FTC) for HIV pre-exposure prophylaxis (PrEP) among MSM using the Cost Effectiveness of Preventing AIDS Complications microsimulation model. We used national data, local studies, and literature to inform model parameters for three cities: Rio de Janeiro, Salvador, and Manaus. Results: In Rio de Janero, a PrEP intervention achieving 10% uptake within 60 months would decrease incidence by 2.3% whereas achieving 60% uptake within 24 months would decrease incidence by 29.7%; results were similar for Salvador and Manaus. In sensitivity analyses, decreasing mean age at PrEP initiation from 33 to 21 years increased incidence reduction by 34%; a discontinuation rate of 25% per year decreased it by 12%. Conclusion: Targeting PrEP to young MSM and minimizing discontinuation could substantially increase PrEP's impact.engBioMed CentralImpact of pre-exposure prophylaxis uptake among gay, bisexual, and other men who have sex with men in urban centers in Brazil: a modeling studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePre-exposure prophylaxis (PrEP)HIV preventionMen who have sex with menModelingLatin America and the CaribbeanKey and vulnerable populationsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.en_US.fl_str_mv Impact of pre-exposure prophylaxis uptake among gay, bisexual, and other men who have sex with men in urban centers in Brazil: a modeling study
title Impact of pre-exposure prophylaxis uptake among gay, bisexual, and other men who have sex with men in urban centers in Brazil: a modeling study
spellingShingle Impact of pre-exposure prophylaxis uptake among gay, bisexual, and other men who have sex with men in urban centers in Brazil: a modeling study
Luz, Paula M.
Pre-exposure prophylaxis (PrEP)
HIV prevention
Men who have sex with men
Modeling
Latin America and the Caribbean
Key and vulnerable populations
title_short Impact of pre-exposure prophylaxis uptake among gay, bisexual, and other men who have sex with men in urban centers in Brazil: a modeling study
title_full Impact of pre-exposure prophylaxis uptake among gay, bisexual, and other men who have sex with men in urban centers in Brazil: a modeling study
title_fullStr Impact of pre-exposure prophylaxis uptake among gay, bisexual, and other men who have sex with men in urban centers in Brazil: a modeling study
title_full_unstemmed Impact of pre-exposure prophylaxis uptake among gay, bisexual, and other men who have sex with men in urban centers in Brazil: a modeling study
title_sort Impact of pre-exposure prophylaxis uptake among gay, bisexual, and other men who have sex with men in urban centers in Brazil: a modeling study
author Luz, Paula M.
author_facet Luz, Paula M.
Deshpande, Vijeta
Kazemian, Pooyan
Scott, Justine A.
Shebl, Fatma M.
Spaeth, Hailey
Pimenta, Cristina
Stern, Madeline
Pereira, Gerson
Struchiner, Claudio J.
Grinsztejn, Beatriz
Veloso, Valdiléa G.
Freedberg, Kenneth A.
author_role author
author2 Deshpande, Vijeta
Kazemian, Pooyan
Scott, Justine A.
Shebl, Fatma M.
Spaeth, Hailey
Pimenta, Cristina
Stern, Madeline
Pereira, Gerson
Struchiner, Claudio J.
Grinsztejn, Beatriz
Veloso, Valdiléa G.
Freedberg, Kenneth A.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Luz, Paula M.
Deshpande, Vijeta
Kazemian, Pooyan
Scott, Justine A.
Shebl, Fatma M.
Spaeth, Hailey
Pimenta, Cristina
Stern, Madeline
Pereira, Gerson
Struchiner, Claudio J.
Grinsztejn, Beatriz
Veloso, Valdiléa G.
Freedberg, Kenneth A.
dc.subject.en.en_US.fl_str_mv Pre-exposure prophylaxis (PrEP)
HIV prevention
Men who have sex with men
Modeling
Latin America and the Caribbean
Key and vulnerable populations
topic Pre-exposure prophylaxis (PrEP)
HIV prevention
Men who have sex with men
Modeling
Latin America and the Caribbean
Key and vulnerable populations
description This work was supported by the National Institute of Allergy and Infectious Diseases (R37 AI058736) and by the Department of Chronic Conditions and Sexually Transmitted Infections (DCCI) of the Ministry of Health of Brazil. This project was also made possible thanks to Unitaid’s funding and support. Unitaid accelerates access to innovative health products and lays the foundations for scale up by countries and partners. Unitaid is a hosted partnership of WHO. PML, BG, and CJS acknowledge funding from the National Council of Technological and Scientifc Development (CNPq) and the Research Funding Agency of the State of Rio de Janeiro (FAPERJ). The content is solely the responsibility of the authors and does not necessarily represent the ofcial views of the National Institute of Health or other funders.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-08-02T20:36:23Z
dc.date.available.fl_str_mv 2023-08-02T20:36:23Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LUZ, Paula M. et al. Impact of pre-exposure prophylaxis uptake among gay, bisexual, and other men who have sex with men in urban centers in Brazil: a modeling study. BMC Public Health, v. 23, n. 1, p. 1-12, June 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/59885
dc.identifier.issn.en_US.fl_str_mv 1471-2458
dc.identifier.doi.none.fl_str_mv 10.1186/s12889-023-15994-0
dc.identifier.eissn.none.fl_str_mv 1471-2458
identifier_str_mv LUZ, Paula M. et al. Impact of pre-exposure prophylaxis uptake among gay, bisexual, and other men who have sex with men in urban centers in Brazil: a modeling study. BMC Public Health, v. 23, n. 1, p. 1-12, June 2023.
1471-2458
10.1186/s12889-023-15994-0
url https://www.arca.fiocruz.br/handle/icict/59885
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/59885/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/59885/2/ve_Paula_Luz_etal_INI_2023.pdf
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