CoronaVac vaccine is effective in preventing symptomatic and severe COVID‑19 in pregnant women in Brazil: a test‑negative case‑control study
| Autor(a) principal: | |
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| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/52591 |
Resumo: | Programa VigiVac Fiocruz. Programa “Fazer o bem faz bem”. Wellcome Trust. |
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Paixao, Enny S.Wong, Kerry L. M.Alves, Flavia Jôse OliveiraOliveira, Vinicius de AraújoSilva, Thiago CerqueiraBertoldo Júnior, JuracyMachado, Tales MotaPinto Junior, Elzo PereiraBoaventura, Viviane S.Penna, Gerson O.Werneck, Guilherme LoureiroRodrigues, Laura C.Pearce, NeilBarreto, Mauricio L.Barral Netto, Manoel2022-05-09T19:21:09Z2022-05-09T19:21:09Z2022PAIXÃO, Enny S. et al. CoronaVac vaccine is effective in preventing symptomatic and severe COVID‑19 in pregnant women in Brazil: a test‑negative case‑control study. BMC Medicine, v. 20, n. 146, p. 1-8, 2022.1741-7015https://www.arca.fiocruz.br/handle/icict/5259110.1186/s12916-022-02353-wPrograma VigiVac Fiocruz. Programa “Fazer o bem faz bem”. Wellcome Trust.London School of Hygiene and Tropical Medicine. London, UK / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil.London School of Hygiene and Tropical Medicine. London, UK.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Universidade Federal de Ouro Preto. Ouro Preto, MG, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Salvador, BA, Brasil.Centro de Medicina Tropical da Universidade de Brasília. Escola de Governo Fiocruz Brasília. Brasília, DF, Brasil.Universidade do Estado do Rio de Janeiro. Instituto de Medicina Social. Rio de Janeiro, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Estudos em Saúde Coletiva. Rio de Janeiro, RJ, Brasil.London School of Hygiene and Tropical Medicine. London, UK / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil.London School of Hygiene and Tropical Medicine. London, UK.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Background: More doses of CoronaVac have been administered worldwide than any other COVID-19 vaccine. However, the effectiveness of COVID-19 inactivated vaccines in pregnant women is still unknown. We estimated the vaccine effectiveness (VE) of CoronaVac against symptomatic and severe COVID-19 in pregnant women in Brazil. Methods: We conducted a test-negative design study in all pregnant women aged 18–49 years with COVID-19-related symptoms in Brazil from March 15, 2021, to October 03, 2021, linking records of negative and positive SARS-CoV-2 reverse transcription polymerase chain reaction (RT-PCR) tests to national vaccination records. We also linked records of test-positive cases with notifications of severe, hospitalised or fatal COVID-19. Using logistic regression, we estimated the adjusted odds ratio and VE against symptomatic COVID-19 and against severe COVID-19 by comparing vaccine status in test-negative subjects to test-positive symptomatic cases and severe cases. Results: Of the 19,838 tested pregnant women, 7424 (37.4%) tested positive for COVID-19 and 588 (7.9%) had severe disease. Only 83% of pregnant women who received the first dose of CoronaVac completed the vaccination scheme. A single dose of the CoronaVac vaccine was not effective at preventing symptomatic COVID-19. The effectiveness of two doses of CoronaVac was 41% (95% CI 27.1–52.2) against symptomatic COVID-19 and 85% (95% CI 59.5–94.8) against severe COVID-19. Conclusions: A complete regimen of CoronaVac in pregnant women was effective in preventing symptomatic COVID-19 and highly effective against severe illness in a setting that combined high disease burden and marked COVID-19-related maternal deaths.engBMCVaccinesCOVID-19SARS-CoV-2Eficácia da vacinaVacina inativadaMulheres grávidasCOVID-19SARS-CoV-2Vaccine effectivenessInactivated vaccinePregnant womenCOVID-19SARS-CoV-2Eficacia de la vacunaVacuna inactivadaMujeres embarazadasCOVID-19SARS-CoV-2Efficacité du vaccinVaccin inactivéFemmes enceintesCOVID-19SRAS-CoV-2VacinasVacinas de Produtos InativadosGestantesCOVID-19SARS-CoV-2CoronaVac vaccine is effective in preventing symptomatic and severe COVID‑19 in pregnant women in Brazil: a test‑negative case‑control studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/52591/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPaixao, Enny S. - CoronaVac vaccine is efective.pdfPaixao, Enny S. - CoronaVac vaccine is efective.pdfapplication/pdf1020411https://www.arca.fiocruz.br/bitstream/icict/52591/2/Paixao%2c%20Enny%20S.%20-%20CoronaVac%20vaccine%20is%20efective.pdf42259c0c13dfc18a437b8dc8bc45d7e8MD52icict/525912023-03-15 14:34:34.441oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:34Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
CoronaVac vaccine is effective in preventing symptomatic and severe COVID‑19 in pregnant women in Brazil: a test‑negative case‑control study |
| title |
CoronaVac vaccine is effective in preventing symptomatic and severe COVID‑19 in pregnant women in Brazil: a test‑negative case‑control study |
| spellingShingle |
CoronaVac vaccine is effective in preventing symptomatic and severe COVID‑19 in pregnant women in Brazil: a test‑negative case‑control study Paixao, Enny S. Vaccines COVID-19 SARS-CoV-2 Eficácia da vacina Vacina inativada Mulheres grávidas COVID-19 SARS-CoV-2 Vaccine effectiveness Inactivated vaccine Pregnant women COVID-19 SARS-CoV-2 Eficacia de la vacuna Vacuna inactivada Mujeres embarazadas COVID-19 SARS-CoV-2 Efficacité du vaccin Vaccin inactivé Femmes enceintes COVID-19 SRAS-CoV-2 Vacinas Vacinas de Produtos Inativados Gestantes COVID-19 SARS-CoV-2 |
| title_short |
CoronaVac vaccine is effective in preventing symptomatic and severe COVID‑19 in pregnant women in Brazil: a test‑negative case‑control study |
| title_full |
CoronaVac vaccine is effective in preventing symptomatic and severe COVID‑19 in pregnant women in Brazil: a test‑negative case‑control study |
| title_fullStr |
CoronaVac vaccine is effective in preventing symptomatic and severe COVID‑19 in pregnant women in Brazil: a test‑negative case‑control study |
| title_full_unstemmed |
CoronaVac vaccine is effective in preventing symptomatic and severe COVID‑19 in pregnant women in Brazil: a test‑negative case‑control study |
| title_sort |
CoronaVac vaccine is effective in preventing symptomatic and severe COVID‑19 in pregnant women in Brazil: a test‑negative case‑control study |
| author |
Paixao, Enny S. |
| author_facet |
Paixao, Enny S. Wong, Kerry L. M. Alves, Flavia Jôse Oliveira Oliveira, Vinicius de Araújo Silva, Thiago Cerqueira Bertoldo Júnior, Juracy Machado, Tales Mota Pinto Junior, Elzo Pereira Boaventura, Viviane S. Penna, Gerson O. Werneck, Guilherme Loureiro Rodrigues, Laura C. Pearce, Neil Barreto, Mauricio L. Barral Netto, Manoel |
| author_role |
author |
| author2 |
Wong, Kerry L. M. Alves, Flavia Jôse Oliveira Oliveira, Vinicius de Araújo Silva, Thiago Cerqueira Bertoldo Júnior, Juracy Machado, Tales Mota Pinto Junior, Elzo Pereira Boaventura, Viviane S. Penna, Gerson O. Werneck, Guilherme Loureiro Rodrigues, Laura C. Pearce, Neil Barreto, Mauricio L. Barral Netto, Manoel |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Paixao, Enny S. Wong, Kerry L. M. Alves, Flavia Jôse Oliveira Oliveira, Vinicius de Araújo Silva, Thiago Cerqueira Bertoldo Júnior, Juracy Machado, Tales Mota Pinto Junior, Elzo Pereira Boaventura, Viviane S. Penna, Gerson O. Werneck, Guilherme Loureiro Rodrigues, Laura C. Pearce, Neil Barreto, Mauricio L. Barral Netto, Manoel |
| dc.subject.mesh.pt_BR.fl_str_mv |
Vaccines COVID-19 SARS-CoV-2 |
| topic |
Vaccines COVID-19 SARS-CoV-2 Eficácia da vacina Vacina inativada Mulheres grávidas COVID-19 SARS-CoV-2 Vaccine effectiveness Inactivated vaccine Pregnant women COVID-19 SARS-CoV-2 Eficacia de la vacuna Vacuna inactivada Mujeres embarazadas COVID-19 SARS-CoV-2 Efficacité du vaccin Vaccin inactivé Femmes enceintes COVID-19 SRAS-CoV-2 Vacinas Vacinas de Produtos Inativados Gestantes COVID-19 SARS-CoV-2 |
| dc.subject.other.pt_BR.fl_str_mv |
Eficácia da vacina Vacina inativada Mulheres grávidas COVID-19 SARS-CoV-2 |
| dc.subject.en.pt_BR.fl_str_mv |
Vaccine effectiveness Inactivated vaccine Pregnant women COVID-19 SARS-CoV-2 |
| dc.subject.es.pt_BR.fl_str_mv |
Eficacia de la vacuna Vacuna inactivada Mujeres embarazadas COVID-19 SARS-CoV-2 |
| dc.subject.fr.pt_BR.fl_str_mv |
Efficacité du vaccin Vaccin inactivé Femmes enceintes COVID-19 SRAS-CoV-2 |
| dc.subject.decs.pt_BR.fl_str_mv |
Vacinas Vacinas de Produtos Inativados Gestantes COVID-19 SARS-CoV-2 |
| description |
Programa VigiVac Fiocruz. Programa “Fazer o bem faz bem”. Wellcome Trust. |
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2022 |
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2022-05-09T19:21:09Z |
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2022-05-09T19:21:09Z |
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2022 |
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info:eu-repo/semantics/article |
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PAIXÃO, Enny S. et al. CoronaVac vaccine is effective in preventing symptomatic and severe COVID‑19 in pregnant women in Brazil: a test‑negative case‑control study. BMC Medicine, v. 20, n. 146, p. 1-8, 2022. |
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https://www.arca.fiocruz.br/handle/icict/52591 |
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1741-7015 |
| dc.identifier.doi.none.fl_str_mv |
10.1186/s12916-022-02353-w |
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PAIXÃO, Enny S. et al. CoronaVac vaccine is effective in preventing symptomatic and severe COVID‑19 in pregnant women in Brazil: a test‑negative case‑control study. BMC Medicine, v. 20, n. 146, p. 1-8, 2022. 1741-7015 10.1186/s12916-022-02353-w |
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https://www.arca.fiocruz.br/handle/icict/52591 |
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eng |
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BMC |
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BMC |
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