LRRK2 gene variants associated with a higher risk for alcohol dependence in multiethnic populations
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/48242 |
Resumo: | Brazilian Ministry of Health (Departamento de Ciência e Tecnologia da Secretaria de Ciência, Tecnologia e Insumos estratégicos). |
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Oliveira, Pablo Rafael SilveiraMatos, Lorena Oliveira deAraujo, Nathalia MattaSant Anna, Hanaísa P.Silva, Daniel Almeida da Silva eDamasceno, Andresa K. AndradeCarvalho, Luana Martins deHorta, Bernardo LessaCosta, Maria Fernanda LimaBarreto, Mauricio LimaWiers, Corinde E.Volkow, Nora D.Godard, Ana Lúcia Brunialti2021-07-15T12:02:07Z2021-07-15T12:02:07Z2021OLIVEIRA, Pablo Rafael Silveira et al. LRRK2 gene variants associated with a higher risk for alcohol dependence in multiethnic populations. Frontiers in Psychiatry, v. 12, n. 665257, p. 1-12, 31 May 2021.1664-0640https://www.arca.fiocruz.br/handle/icict/4824210.3389/fpsyt.2021.665257Brazilian Ministry of Health (Departamento de Ciência e Tecnologia da Secretaria de Ciência, Tecnologia e Insumos estratégicos).Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES, Ministério da Educação, Brazil).Pró-Reitoria de Pesquisa (PRPq) and Pós-Graduação em Genética from the Universidade Federal de Minas Gerais (UFMG), Brazil.Universidade Federal da Bahia. Instituto de Biologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, Brasil.National Institutes of Health. National Institute on Alcohol Abuse and Alcoholism. Rockville, MD, United States.Universidade Federal da Bahia. Instituto de Biologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.University of Illinois. Center for Alcohol Research in Epigenetics. Department of Psychiatry. Chicago, IL, United States.Universidade Federal de Pelotas. Faculdade de Medicina. Programa de Pós-Graduação em Epidemiologia. Pelotas, RS, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.National Institutes of Health. National Institute on Alcohol Abuse and Alcoholism. Laboratory of Neuroimaging. Bethesda, MD, United States.National Institutes of Health. National Institute on Alcohol Abuse and Alcoholism. Laboratory of Neuroimaging. Bethesda, MD, United States.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, Brasil.Background: Genetics influence the vulnerability to alcohol use disorders, and among the implicated genes, three previous studies have provided evidences for the involvement of LRRK2 in alcohol dependence (AD). LRRK2 expression is broadly dysregulated in postmortem brain from AD humans, as well as in the brain of mice with alcohol dependent-like behaviors and in a zebrafish model of alcohol preference. The aim of the present study was to evaluate the association of variants in the LRRK2 gene with AD in multiethnic populations from South and North America. Methods: Alcohol-screening questionnaires [such as CAGE and Alcohol Use Disorders Identification Test (AUDIT)] were used to determine individual risk of AD. Multivariate logistic regression analyses were done in three independent populations (898 individuals from Bambuí, Brazil; 3,015 individuals from Pelotas, Brazil; and 1,316 from the United States). Linkage disequilibrium and conditional analyses, as well as in silico functional analyses, were also conducted. Results: Four LRRK2 variants were significantly associated with AD in our discovery cohort (Bambuí): rs4768231, rs4767971, rs7307310, and rs1465527. Two of these variants (rs4768231 and rs4767971) were replicated in both Pelotas and US cohorts. The consistent association signal (at the LRRK2 locus) found in populations with different genetic backgrounds reinforces the relevance of our findings. Conclusion: Taken together, these results support the notion that genetic variants in the LRRK2 locus are risk factors for AD in humans.engFrontiers MediaAlcoolismoInquéritos e questionáriosPolimorfismosPatrimônio genéticoFatores de riscoBrasilAlcohol dependenceCAGEAuditLRRK2PolymorphismsMultiethnicLRRK2 gene variants associated with a higher risk for alcohol dependence in multiethnic populationsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/48242/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALOliveira, Pablo Rafael Silveira LRRK2 Gene Variants....pdfOliveira, Pablo Rafael Silveira LRRK2 Gene 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| dc.title.en.fl_str_mv |
LRRK2 gene variants associated with a higher risk for alcohol dependence in multiethnic populations |
| title |
LRRK2 gene variants associated with a higher risk for alcohol dependence in multiethnic populations |
| spellingShingle |
LRRK2 gene variants associated with a higher risk for alcohol dependence in multiethnic populations Oliveira, Pablo Rafael Silveira Alcoolismo Inquéritos e questionários Polimorfismos Patrimônio genético Fatores de risco Brasil Alcohol dependence CAGE Audit LRRK2 Polymorphisms Multiethnic |
| title_short |
LRRK2 gene variants associated with a higher risk for alcohol dependence in multiethnic populations |
| title_full |
LRRK2 gene variants associated with a higher risk for alcohol dependence in multiethnic populations |
| title_fullStr |
LRRK2 gene variants associated with a higher risk for alcohol dependence in multiethnic populations |
| title_full_unstemmed |
LRRK2 gene variants associated with a higher risk for alcohol dependence in multiethnic populations |
| title_sort |
LRRK2 gene variants associated with a higher risk for alcohol dependence in multiethnic populations |
| author |
Oliveira, Pablo Rafael Silveira |
| author_facet |
Oliveira, Pablo Rafael Silveira Matos, Lorena Oliveira de Araujo, Nathalia Matta Sant Anna, Hanaísa P. Silva, Daniel Almeida da Silva e Damasceno, Andresa K. Andrade Carvalho, Luana Martins de Horta, Bernardo Lessa Costa, Maria Fernanda Lima Barreto, Mauricio Lima Wiers, Corinde E. Volkow, Nora D. Godard, Ana Lúcia Brunialti |
| author_role |
author |
| author2 |
Matos, Lorena Oliveira de Araujo, Nathalia Matta Sant Anna, Hanaísa P. Silva, Daniel Almeida da Silva e Damasceno, Andresa K. Andrade Carvalho, Luana Martins de Horta, Bernardo Lessa Costa, Maria Fernanda Lima Barreto, Mauricio Lima Wiers, Corinde E. Volkow, Nora D. Godard, Ana Lúcia Brunialti |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveira, Pablo Rafael Silveira Matos, Lorena Oliveira de Araujo, Nathalia Matta Sant Anna, Hanaísa P. Silva, Daniel Almeida da Silva e Damasceno, Andresa K. Andrade Carvalho, Luana Martins de Horta, Bernardo Lessa Costa, Maria Fernanda Lima Barreto, Mauricio Lima Wiers, Corinde E. Volkow, Nora D. Godard, Ana Lúcia Brunialti |
| dc.subject.other.pt_BR.fl_str_mv |
Alcoolismo Inquéritos e questionários Polimorfismos Patrimônio genético Fatores de risco Brasil |
| topic |
Alcoolismo Inquéritos e questionários Polimorfismos Patrimônio genético Fatores de risco Brasil Alcohol dependence CAGE Audit LRRK2 Polymorphisms Multiethnic |
| dc.subject.en.en.fl_str_mv |
Alcohol dependence CAGE Audit LRRK2 Polymorphisms Multiethnic |
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Brazilian Ministry of Health (Departamento de Ciência e Tecnologia da Secretaria de Ciência, Tecnologia e Insumos estratégicos). |
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2021 |
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2021-07-15T12:02:07Z |
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2021-07-15T12:02:07Z |
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2021 |
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info:eu-repo/semantics/article |
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OLIVEIRA, Pablo Rafael Silveira et al. LRRK2 gene variants associated with a higher risk for alcohol dependence in multiethnic populations. Frontiers in Psychiatry, v. 12, n. 665257, p. 1-12, 31 May 2021. |
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https://www.arca.fiocruz.br/handle/icict/48242 |
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1664-0640 |
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10.3389/fpsyt.2021.665257 |
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OLIVEIRA, Pablo Rafael Silveira et al. LRRK2 gene variants associated with a higher risk for alcohol dependence in multiethnic populations. Frontiers in Psychiatry, v. 12, n. 665257, p. 1-12, 31 May 2021. 1664-0640 10.3389/fpsyt.2021.665257 |
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