LRRK2 gene variants associated with a higher risk for alcohol dependence in multiethnic populations

Detalhes bibliográficos
Autor(a) principal: Oliveira, Pablo Rafael Silveira
Data de Publicação: 2021
Outros Autores: Matos, Lorena Oliveira de, Araujo, Nathalia Matta, Sant Anna, Hanaísa P., Silva, Daniel Almeida da Silva e, Damasceno, Andresa K. Andrade, Carvalho, Luana Martins de, Horta, Bernardo Lessa, Costa, Maria Fernanda Lima, Barreto, Mauricio Lima, Wiers, Corinde E., Volkow, Nora D., Godard, Ana Lúcia Brunialti
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/48242
Resumo: Brazilian Ministry of Health (Departamento de Ciência e Tecnologia da Secretaria de Ciência, Tecnologia e Insumos estratégicos).
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spelling Oliveira, Pablo Rafael SilveiraMatos, Lorena Oliveira deAraujo, Nathalia MattaSant Anna, Hanaísa P.Silva, Daniel Almeida da Silva eDamasceno, Andresa K. AndradeCarvalho, Luana Martins deHorta, Bernardo LessaCosta, Maria Fernanda LimaBarreto, Mauricio LimaWiers, Corinde E.Volkow, Nora D.Godard, Ana Lúcia Brunialti2021-07-15T12:02:07Z2021-07-15T12:02:07Z2021OLIVEIRA, Pablo Rafael Silveira et al. LRRK2 gene variants associated with a higher risk for alcohol dependence in multiethnic populations. Frontiers in Psychiatry, v. 12, n. 665257, p. 1-12, 31 May 2021.1664-0640https://www.arca.fiocruz.br/handle/icict/4824210.3389/fpsyt.2021.665257Brazilian Ministry of Health (Departamento de Ciência e Tecnologia da Secretaria de Ciência, Tecnologia e Insumos estratégicos).Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES, Ministério da Educação, Brazil).Pró-Reitoria de Pesquisa (PRPq) and Pós-Graduação em Genética from the Universidade Federal de Minas Gerais (UFMG), Brazil.Universidade Federal da Bahia. Instituto de Biologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, Brasil.National Institutes of Health. National Institute on Alcohol Abuse and Alcoholism. Rockville, MD, United States.Universidade Federal da Bahia. Instituto de Biologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.University of Illinois. Center for Alcohol Research in Epigenetics. Department of Psychiatry. Chicago, IL, United States.Universidade Federal de Pelotas. Faculdade de Medicina. Programa de Pós-Graduação em Epidemiologia. Pelotas, RS, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.National Institutes of Health. National Institute on Alcohol Abuse and Alcoholism. Laboratory of Neuroimaging. Bethesda, MD, United States.National Institutes of Health. National Institute on Alcohol Abuse and Alcoholism. Laboratory of Neuroimaging. Bethesda, MD, United States.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, Brasil.Background: Genetics influence the vulnerability to alcohol use disorders, and among the implicated genes, three previous studies have provided evidences for the involvement of LRRK2 in alcohol dependence (AD). LRRK2 expression is broadly dysregulated in postmortem brain from AD humans, as well as in the brain of mice with alcohol dependent-like behaviors and in a zebrafish model of alcohol preference. The aim of the present study was to evaluate the association of variants in the LRRK2 gene with AD in multiethnic populations from South and North America. Methods: Alcohol-screening questionnaires [such as CAGE and Alcohol Use Disorders Identification Test (AUDIT)] were used to determine individual risk of AD. Multivariate logistic regression analyses were done in three independent populations (898 individuals from Bambuí, Brazil; 3,015 individuals from Pelotas, Brazil; and 1,316 from the United States). Linkage disequilibrium and conditional analyses, as well as in silico functional analyses, were also conducted. Results: Four LRRK2 variants were significantly associated with AD in our discovery cohort (Bambuí): rs4768231, rs4767971, rs7307310, and rs1465527. Two of these variants (rs4768231 and rs4767971) were replicated in both Pelotas and US cohorts. The consistent association signal (at the LRRK2 locus) found in populations with different genetic backgrounds reinforces the relevance of our findings. Conclusion: Taken together, these results support the notion that genetic variants in the LRRK2 locus are risk factors for AD in humans.engFrontiers MediaAlcoolismoInquéritos e questionáriosPolimorfismosPatrimônio genéticoFatores de riscoBrasilAlcohol dependenceCAGEAuditLRRK2PolymorphismsMultiethnicLRRK2 gene variants associated with a higher risk for alcohol dependence in multiethnic populationsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/48242/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALOliveira, Pablo Rafael Silveira LRRK2 Gene Variants....pdfOliveira, Pablo Rafael Silveira LRRK2 Gene 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dc.title.en.fl_str_mv LRRK2 gene variants associated with a higher risk for alcohol dependence in multiethnic populations
title LRRK2 gene variants associated with a higher risk for alcohol dependence in multiethnic populations
spellingShingle LRRK2 gene variants associated with a higher risk for alcohol dependence in multiethnic populations
Oliveira, Pablo Rafael Silveira
Alcoolismo
Inquéritos e questionários
Polimorfismos
Patrimônio genético
Fatores de risco
Brasil
Alcohol dependence
CAGE
Audit
LRRK2
Polymorphisms
Multiethnic
title_short LRRK2 gene variants associated with a higher risk for alcohol dependence in multiethnic populations
title_full LRRK2 gene variants associated with a higher risk for alcohol dependence in multiethnic populations
title_fullStr LRRK2 gene variants associated with a higher risk for alcohol dependence in multiethnic populations
title_full_unstemmed LRRK2 gene variants associated with a higher risk for alcohol dependence in multiethnic populations
title_sort LRRK2 gene variants associated with a higher risk for alcohol dependence in multiethnic populations
author Oliveira, Pablo Rafael Silveira
author_facet Oliveira, Pablo Rafael Silveira
Matos, Lorena Oliveira de
Araujo, Nathalia Matta
Sant Anna, Hanaísa P.
Silva, Daniel Almeida da Silva e
Damasceno, Andresa K. Andrade
Carvalho, Luana Martins de
Horta, Bernardo Lessa
Costa, Maria Fernanda Lima
Barreto, Mauricio Lima
Wiers, Corinde E.
Volkow, Nora D.
Godard, Ana Lúcia Brunialti
author_role author
author2 Matos, Lorena Oliveira de
Araujo, Nathalia Matta
Sant Anna, Hanaísa P.
Silva, Daniel Almeida da Silva e
Damasceno, Andresa K. Andrade
Carvalho, Luana Martins de
Horta, Bernardo Lessa
Costa, Maria Fernanda Lima
Barreto, Mauricio Lima
Wiers, Corinde E.
Volkow, Nora D.
Godard, Ana Lúcia Brunialti
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Pablo Rafael Silveira
Matos, Lorena Oliveira de
Araujo, Nathalia Matta
Sant Anna, Hanaísa P.
Silva, Daniel Almeida da Silva e
Damasceno, Andresa K. Andrade
Carvalho, Luana Martins de
Horta, Bernardo Lessa
Costa, Maria Fernanda Lima
Barreto, Mauricio Lima
Wiers, Corinde E.
Volkow, Nora D.
Godard, Ana Lúcia Brunialti
dc.subject.other.pt_BR.fl_str_mv Alcoolismo
Inquéritos e questionários
Polimorfismos
Patrimônio genético
Fatores de risco
Brasil
topic Alcoolismo
Inquéritos e questionários
Polimorfismos
Patrimônio genético
Fatores de risco
Brasil
Alcohol dependence
CAGE
Audit
LRRK2
Polymorphisms
Multiethnic
dc.subject.en.en.fl_str_mv Alcohol dependence
CAGE
Audit
LRRK2
Polymorphisms
Multiethnic
description Brazilian Ministry of Health (Departamento de Ciência e Tecnologia da Secretaria de Ciência, Tecnologia e Insumos estratégicos).
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-07-15T12:02:07Z
dc.date.available.fl_str_mv 2021-07-15T12:02:07Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv OLIVEIRA, Pablo Rafael Silveira et al. LRRK2 gene variants associated with a higher risk for alcohol dependence in multiethnic populations. Frontiers in Psychiatry, v. 12, n. 665257, p. 1-12, 31 May 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/48242
dc.identifier.issn.pt_BR.fl_str_mv 1664-0640
dc.identifier.doi.pt_BR.fl_str_mv 10.3389/fpsyt.2021.665257
identifier_str_mv OLIVEIRA, Pablo Rafael Silveira et al. LRRK2 gene variants associated with a higher risk for alcohol dependence in multiethnic populations. Frontiers in Psychiatry, v. 12, n. 665257, p. 1-12, 31 May 2021.
1664-0640
10.3389/fpsyt.2021.665257
url https://www.arca.fiocruz.br/handle/icict/48242
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Frontiers Media
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