Peripheral blood fibrocytes: new information to explain the dynamics of Leishmania infection

Detalhes bibliográficos
Autor(a) principal: Macedo-Silva, Roger Magno
Data de Publicação: 2014
Outros Autores: Santos, Carina de Lima Pereira dos, Diniz, Vanessa Alvaro, Carvalho, Jorge José de, Guerra, Camila, Côrte-Real, Suzana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10220
Resumo: Fundação Oswaldo Cruz. Laboratório de Biologia Estrutural. Rio de Janeiro, RJ, Brasil.
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spelling Macedo-Silva, Roger MagnoSantos, Carina de Lima Pereira dosDiniz, Vanessa AlvaroCarvalho, Jorge José deGuerra, CamilaCôrte-Real, Suzana2015-05-04T17:07:32Z2015-05-04T17:07:32Z2014MACEDO-SILVA, Roger Magno. Peripheral blood fibrocytes: new information to explain the dynamics of Leishmania infection. Mem Inst Oswaldo Cruz,v.109, n.1, p.61-69, feb. 2014.0074-02761678-8060https://www.arca.fiocruz.br/handle/icict/1022010.1590/0074-0276130247engFundação Oswaldo CruzPeripheral blood fibrocytes: new information to explain the dynamics of Leishmania infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Laboratório de Biologia Estrutural. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Laboratório de Biologia Estrutural. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Laboratório de Biologia Estrutural. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro (UERJ). Departamento de Histologia e Embriologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Laboratório de Biologia Estrutural. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Laboratório de Biologia Estrutural. Rio de Janeiro, RJ, Brasil.Fibrocytes are important for understanding the progression of many diseases because they are present in areas where pathogenic lesions are generated. However, the morphology of fibrocytes and their interactions with parasites are poorly understood. In this study, we examined the morphology of peripheral blood fibrocytes and their interactions with Leishmania (L.) amazonensis. Through ultrastructural analysis, we describe the details of fibrocyte morphology and how fibrocytes rapidly internalise Leishmania promastigotes. The parasites differentiated into amastigotes after 2 h in phagolysosomes and the infection was completely resolved after 72 h. Early in the infection, we found increased nitric oxide production and large lysosomes with electron-dense material. These factors may regulate the proliferation and death of the parasites. Because fibrocytes are present at the infection site and are directly involved in developing cutaneous leishmaniasis, they are targets for effective, non-toxic cell-based therapies that control and treat leishmaniasis.FibrocyteLeishmania (L.) amazonensisCell biologyBiologia CelularLeishmaniaBiologia Celularinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/10220/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALroger_silvaetal_IOC_2014.pdfapplication/pdf2448992https://www.arca.fiocruz.br/bitstream/icict/10220/2/roger_silvaetal_IOC_2014.pdf376f02624e37f9013e7fe99750ae4cbaMD52TEXTroger_silvaetal_IOC_2014.pdf.txtroger_silvaetal_IOC_2014.pdf.txtExtracted texttext/plain39224https://www.arca.fiocruz.br/bitstream/icict/10220/3/roger_silvaetal_IOC_2014.pdf.txt283a8dcca5a3b26b23dbcd095d3ad6b7MD53icict/102202022-06-24 12:19:38.113oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T15:19:38Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Peripheral blood fibrocytes: new information to explain the dynamics of Leishmania infection
title Peripheral blood fibrocytes: new information to explain the dynamics of Leishmania infection
spellingShingle Peripheral blood fibrocytes: new information to explain the dynamics of Leishmania infection
Macedo-Silva, Roger Magno
Fibrocyte
Leishmania (L.) amazonensis
Cell biology
Biologia Celular
Leishmania
Biologia Celular
title_short Peripheral blood fibrocytes: new information to explain the dynamics of Leishmania infection
title_full Peripheral blood fibrocytes: new information to explain the dynamics of Leishmania infection
title_fullStr Peripheral blood fibrocytes: new information to explain the dynamics of Leishmania infection
title_full_unstemmed Peripheral blood fibrocytes: new information to explain the dynamics of Leishmania infection
title_sort Peripheral blood fibrocytes: new information to explain the dynamics of Leishmania infection
author Macedo-Silva, Roger Magno
author_facet Macedo-Silva, Roger Magno
Santos, Carina de Lima Pereira dos
Diniz, Vanessa Alvaro
Carvalho, Jorge José de
Guerra, Camila
Côrte-Real, Suzana
author_role author
author2 Santos, Carina de Lima Pereira dos
Diniz, Vanessa Alvaro
Carvalho, Jorge José de
Guerra, Camila
Côrte-Real, Suzana
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Macedo-Silva, Roger Magno
Santos, Carina de Lima Pereira dos
Diniz, Vanessa Alvaro
Carvalho, Jorge José de
Guerra, Camila
Côrte-Real, Suzana
dc.subject.en.pt_BR.fl_str_mv Fibrocyte
Leishmania (L.) amazonensis
Cell biology
topic Fibrocyte
Leishmania (L.) amazonensis
Cell biology
Biologia Celular
Leishmania
Biologia Celular
dc.subject.es.pt_BR.fl_str_mv Biologia Celular
dc.subject.decs.pt_BR.fl_str_mv Leishmania
Biologia Celular
description Fundação Oswaldo Cruz. Laboratório de Biologia Estrutural. Rio de Janeiro, RJ, Brasil.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-05-04T17:07:32Z
dc.date.available.fl_str_mv 2015-05-04T17:07:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MACEDO-SILVA, Roger Magno. Peripheral blood fibrocytes: new information to explain the dynamics of Leishmania infection. Mem Inst Oswaldo Cruz,v.109, n.1, p.61-69, feb. 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10220
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
1678-8060
dc.identifier.doi.pt_BR.fl_str_mv 10.1590/0074-0276130247
identifier_str_mv MACEDO-SILVA, Roger Magno. Peripheral blood fibrocytes: new information to explain the dynamics of Leishmania infection. Mem Inst Oswaldo Cruz,v.109, n.1, p.61-69, feb. 2014.
0074-0276
1678-8060
10.1590/0074-0276130247
url https://www.arca.fiocruz.br/handle/icict/10220
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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