Peripheral blood fibrocytes: new information to explain the dynamics of Leishmania infection

Detalhes bibliográficos
Autor(a) principal: Macedo-Silva,Roger Magno
Data de Publicação: 2014
Outros Autores: Santos,Carina de Lima Pereira dos, Diniz,Vanessa Alvaro, Carvalho,Jorge José de, Guerra,Camila, Côrte-Real,Suzana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000100061
Resumo: Fibrocytes are important for understanding the progression of many diseases because they are present in areas where pathogenic lesions are generated. However, the morphology of fibrocytes and their interactions with parasites are poorly understood. In this study, we examined the morphology of peripheral blood fibrocytes and their interactions with Leishmania (L.) amazonensis . Through ultrastructural analysis, we describe the details of fibrocyte morphology and how fibrocytes rapidly internaliseLeishmania promastigotes. The parasites differentiated into amastigotes after 2 h in phagolysosomes and the infection was completely resolved after 72 h. Early in the infection, we found increased nitric oxide production and large lysosomes with electron-dense material. These factors may regulate the proliferation and death of the parasites. Because fibrocytes are present at the infection site and are directly involved in developing cutaneous leishmaniasis, they are targets for effective, non-toxic cell-based therapies that control and treat leishmaniasis.
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spelling Peripheral blood fibrocytes: new information to explain the dynamics of Leishmania infectionfibrocyteLeishmania (L.) amazonensiscell biologyFibrocytes are important for understanding the progression of many diseases because they are present in areas where pathogenic lesions are generated. However, the morphology of fibrocytes and their interactions with parasites are poorly understood. In this study, we examined the morphology of peripheral blood fibrocytes and their interactions with Leishmania (L.) amazonensis . Through ultrastructural analysis, we describe the details of fibrocyte morphology and how fibrocytes rapidly internaliseLeishmania promastigotes. The parasites differentiated into amastigotes after 2 h in phagolysosomes and the infection was completely resolved after 72 h. Early in the infection, we found increased nitric oxide production and large lysosomes with electron-dense material. These factors may regulate the proliferation and death of the parasites. Because fibrocytes are present at the infection site and are directly involved in developing cutaneous leishmaniasis, they are targets for effective, non-toxic cell-based therapies that control and treat leishmaniasis.Instituto Oswaldo Cruz, Ministério da Saúde2014-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000100061Memórias do Instituto Oswaldo Cruz v.109 n.1 2014reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/0074-0276130247info:eu-repo/semantics/openAccessMacedo-Silva,Roger MagnoSantos,Carina de Lima Pereira dosDiniz,Vanessa AlvaroCarvalho,Jorge José deGuerra,CamilaCôrte-Real,Suzanaeng2020-04-25T17:51:39Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:19:25.399Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Peripheral blood fibrocytes: new information to explain the dynamics of Leishmania infection
title Peripheral blood fibrocytes: new information to explain the dynamics of Leishmania infection
spellingShingle Peripheral blood fibrocytes: new information to explain the dynamics of Leishmania infection
Macedo-Silva,Roger Magno
fibrocyte
Leishmania (L.) amazonensis
cell biology
title_short Peripheral blood fibrocytes: new information to explain the dynamics of Leishmania infection
title_full Peripheral blood fibrocytes: new information to explain the dynamics of Leishmania infection
title_fullStr Peripheral blood fibrocytes: new information to explain the dynamics of Leishmania infection
title_full_unstemmed Peripheral blood fibrocytes: new information to explain the dynamics of Leishmania infection
title_sort Peripheral blood fibrocytes: new information to explain the dynamics of Leishmania infection
author Macedo-Silva,Roger Magno
author_facet Macedo-Silva,Roger Magno
Santos,Carina de Lima Pereira dos
Diniz,Vanessa Alvaro
Carvalho,Jorge José de
Guerra,Camila
Côrte-Real,Suzana
author_role author
author2 Santos,Carina de Lima Pereira dos
Diniz,Vanessa Alvaro
Carvalho,Jorge José de
Guerra,Camila
Côrte-Real,Suzana
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Macedo-Silva,Roger Magno
Santos,Carina de Lima Pereira dos
Diniz,Vanessa Alvaro
Carvalho,Jorge José de
Guerra,Camila
Côrte-Real,Suzana
dc.subject.por.fl_str_mv fibrocyte
Leishmania (L.) amazonensis
cell biology
topic fibrocyte
Leishmania (L.) amazonensis
cell biology
dc.description.none.fl_txt_mv Fibrocytes are important for understanding the progression of many diseases because they are present in areas where pathogenic lesions are generated. However, the morphology of fibrocytes and their interactions with parasites are poorly understood. In this study, we examined the morphology of peripheral blood fibrocytes and their interactions with Leishmania (L.) amazonensis . Through ultrastructural analysis, we describe the details of fibrocyte morphology and how fibrocytes rapidly internaliseLeishmania promastigotes. The parasites differentiated into amastigotes after 2 h in phagolysosomes and the infection was completely resolved after 72 h. Early in the infection, we found increased nitric oxide production and large lysosomes with electron-dense material. These factors may regulate the proliferation and death of the parasites. Because fibrocytes are present at the infection site and are directly involved in developing cutaneous leishmaniasis, they are targets for effective, non-toxic cell-based therapies that control and treat leishmaniasis.
description Fibrocytes are important for understanding the progression of many diseases because they are present in areas where pathogenic lesions are generated. However, the morphology of fibrocytes and their interactions with parasites are poorly understood. In this study, we examined the morphology of peripheral blood fibrocytes and their interactions with Leishmania (L.) amazonensis . Through ultrastructural analysis, we describe the details of fibrocyte morphology and how fibrocytes rapidly internaliseLeishmania promastigotes. The parasites differentiated into amastigotes after 2 h in phagolysosomes and the infection was completely resolved after 72 h. Early in the infection, we found increased nitric oxide production and large lysosomes with electron-dense material. These factors may regulate the proliferation and death of the parasites. Because fibrocytes are present at the infection site and are directly involved in developing cutaneous leishmaniasis, they are targets for effective, non-toxic cell-based therapies that control and treat leishmaniasis.
publishDate 2014
dc.date.none.fl_str_mv 2014-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000100061
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000100061
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0074-0276130247
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.109 n.1 2014
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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