Anti-C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7517 |
Resumo: | Hospital Santo Antônio. Escola Bahiana de Medicina e Saude Publica. Salvador, BA, Brasil. |
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Moura, Carlos Geraldo Guerreiro deLima, IsabellaBarbosa, Lúcio MacedoAthanazio, Daniel AbensurReis, Eliana Almeida GomesReis, Mitermayer Galvão dosBurlingame, Rufus W.Santiago, Mittermayer Barreto2014-04-14T17:10:50Z2014-04-14T17:10:50Z2009MOURA, C. G. et al. Anti-C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus. Journal of Clinical Laboratory Analisis, v. 23, p. 19-23, 2009.1098-2825https://www.arca.fiocruz.br/handle/icict/751710.1002/jcla.20280engWiley PeriodicalsAnti-C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHospital Santo Antônio. Escola Bahiana de Medicina e Saude Publica. Salvador, BA, Brasil.Hospital do Santa Izabel. Serviço de Reumatologia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil.INOVA Diagnostics Inc. San Diego, Califórnia, USA.Escola Bahiana de Medicina e Saúde Publica. Serviço de Reumatologia do Hospital do Santa Izabel. Salvador, BA, Brasil.BACKGROUND: Anti-C1q antibodies have been described in systemic lupus erythematosus (SLE) as well as in other connective tissue diseases. They have been considered as a marker for disease activity and presence of nephritis. OBJECTIVE: The aim of this study was to determine the prevalence of anti-C1q antibodies in Brazilian lupus patients as well as analyze their association with different clinical and serologic parameters. METHODS: Sera from 81 SLE patients, based on the American College of Rheumatology (ACR) criteria, were collected from a lupus referral outpatient clinic in Salvador, Brazil. Antibodies to C1q were detected by an enzyme-linked immunoassay (ELISA) kit and antibodies to other cellular antigens identified by indirect immunofluorescence on HEp-2 cell substrate (ANA), or Crithidia luciliae (dsDNA), and to nucleosome by ELISA. A cutoff of 20 U was established for anti-C1q and anti nucleosome assays. RESULTS: Anti-C1q antibodies were detected in 39.5% (32/81) of SLE sera. The presence of anti-C1q antibodies was associated with proteinuria (P=0.028) but not with other laboratory or clinical features, such as anti nucleosome or anti-dsDNA antibodies, hematuria, urinary casts or renal failure, leukopenia, pericarditis, pleuritis, malar rash, seizures, and psychosis. There was a positive correlation between the titers of anti-C1q antibodies and the systemic lupuis erythematosus disease activity index (SLEDAI) score (r=0.370; P=0.001). CONCLUSION: This study in Brazilian SLE patients confirms previous findings of the association of anti-C1q antibodies with nephritis and disease activity.AutoantibodiesAnti-C1q antibodiesSystemic lupus erythematosusNephritisAutoanticorpos/análiseComplemento C1q/imunologiaLúpus Eritematoso Sistêmico/imunologiaNefrite/imunologiaAdultoBrasilEstudos TransversaisFemininoTécnica Indireta de Fluorescência para AnticorpoHumanosMasculinoMeia-IdadeEstatísticas não Paramétricasinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALMOURA CG Anti-C1q antibodies....pdfMOURA CG Anti-C1q antibodies....pdfapplication/pdf94099https://www.arca.fiocruz.br/bitstream/icict/7517/1/MOURA%20CG%20Anti-C1q%20antibodies....pdf0897d957ab43e924c753c192c9e53a07MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7517/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTMOURA CG Anti-C1q antibodies....pdf.txtMOURA CG Anti-C1q antibodies....pdf.txtExtracted texttext/plain19110https://www.arca.fiocruz.br/bitstream/icict/7517/5/MOURA%20CG%20Anti-C1q%20antibodies....pdf.txt6a1abe771921d34ac91871d134c8e77dMD55THUMBNAILMOURA CG Anti-C1q antibodies....pdf.jpgMOURA CG Anti-C1q antibodies....pdf.jpgGenerated Thumbnailimage/jpeg1992https://www.arca.fiocruz.br/bitstream/icict/7517/4/MOURA%20CG%20Anti-C1q%20antibodies....pdf.jpgb39d0f9c60b3fd0475930c841d3ab0f8MD54icict/75172023-03-15 14:33:03.986oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:03Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Anti-C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus |
title |
Anti-C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus |
spellingShingle |
Anti-C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus Moura, Carlos Geraldo Guerreiro de Autoantibodies Anti-C1q antibodies Systemic lupus erythematosus Nephritis Autoanticorpos/análise Complemento C1q/imunologia Lúpus Eritematoso Sistêmico/imunologia Nefrite/imunologia Adulto Brasil Estudos Transversais Feminino Técnica Indireta de Fluorescência para Anticorpo Humanos Masculino Meia-Idade Estatísticas não Paramétricas |
title_short |
Anti-C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus |
title_full |
Anti-C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus |
title_fullStr |
Anti-C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus |
title_full_unstemmed |
Anti-C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus |
title_sort |
Anti-C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus |
author |
Moura, Carlos Geraldo Guerreiro de |
author_facet |
Moura, Carlos Geraldo Guerreiro de Lima, Isabella Barbosa, Lúcio Macedo Athanazio, Daniel Abensur Reis, Eliana Almeida Gomes Reis, Mitermayer Galvão dos Burlingame, Rufus W. Santiago, Mittermayer Barreto |
author_role |
author |
author2 |
Lima, Isabella Barbosa, Lúcio Macedo Athanazio, Daniel Abensur Reis, Eliana Almeida Gomes Reis, Mitermayer Galvão dos Burlingame, Rufus W. Santiago, Mittermayer Barreto |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Moura, Carlos Geraldo Guerreiro de Lima, Isabella Barbosa, Lúcio Macedo Athanazio, Daniel Abensur Reis, Eliana Almeida Gomes Reis, Mitermayer Galvão dos Burlingame, Rufus W. Santiago, Mittermayer Barreto |
dc.subject.en.pt_BR.fl_str_mv |
Autoantibodies Anti-C1q antibodies Systemic lupus erythematosus Nephritis |
topic |
Autoantibodies Anti-C1q antibodies Systemic lupus erythematosus Nephritis Autoanticorpos/análise Complemento C1q/imunologia Lúpus Eritematoso Sistêmico/imunologia Nefrite/imunologia Adulto Brasil Estudos Transversais Feminino Técnica Indireta de Fluorescência para Anticorpo Humanos Masculino Meia-Idade Estatísticas não Paramétricas |
dc.subject.decs.pt_BR.fl_str_mv |
Autoanticorpos/análise Complemento C1q/imunologia Lúpus Eritematoso Sistêmico/imunologia Nefrite/imunologia Adulto Brasil Estudos Transversais Feminino Técnica Indireta de Fluorescência para Anticorpo Humanos Masculino Meia-Idade Estatísticas não Paramétricas |
description |
Hospital Santo Antônio. Escola Bahiana de Medicina e Saude Publica. Salvador, BA, Brasil. |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009 |
dc.date.accessioned.fl_str_mv |
2014-04-14T17:10:50Z |
dc.date.available.fl_str_mv |
2014-04-14T17:10:50Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MOURA, C. G. et al. Anti-C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus. Journal of Clinical Laboratory Analisis, v. 23, p. 19-23, 2009. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/7517 |
dc.identifier.issn.none.fl_str_mv |
1098-2825 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1002/jcla.20280 |
identifier_str_mv |
MOURA, C. G. et al. Anti-C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus. Journal of Clinical Laboratory Analisis, v. 23, p. 19-23, 2009. 1098-2825 10.1002/jcla.20280 |
url |
https://www.arca.fiocruz.br/handle/icict/7517 |
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eng |
language |
eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Wiley Periodicals |
publisher.none.fl_str_mv |
Wiley Periodicals |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Fundação Oswaldo Cruz (FIOCRUZ) |
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FIOCRUZ |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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Repositório Institucional da FIOCRUZ (ARCA) |
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